Journal
INTERNATIONAL JOURNAL OF HEMATOLOGY
Volume 91, Issue 5, Pages 753-757Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12185-010-0618-5
Keywords
Leukemia; Hematopoietic stem cell; EVI-1
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Funding
- Japan Society for the Promotion of Science
- Ministry of Health, Labour and Welfare
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Ecotropic viral integration site-1 (EVI-1) has been recognized as one of the dominant oncogenes associated with murine and human myeloid leukemia. Recent clinical studies demonstrated that high EVI-1 expression was an independent negative prognostic indicator of survival in leukemia patients. In addition, gene-targeting studies in mice reveal that Evi-1 is preferentially expressed in hematopoietic stem cells (HSCs) and plays an essential role in proliferation/maintenance of HSCs. Proteins associated with EVI-1, signaling pathways regulated by EVI-1, and downstream mediators of EVI-1 transcriptional regulation have been described and characterized. In this study, we summarize current knowledge regarding biochemical properties and biological functions of EVI-1, which provides a foundation for the development of novel therapeutic strategies.
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