Review
Obstetrics & Gynecology
Alice Beardmore-Gray, Paul T. Seed, Jessica Fleminger, Eva Zwertbroek, Thomas Bernardes, Ben W. Mol, Cheryl Battersby, Corine Koopmans, Kim Broekhuijsen, Kim Boers, Michelle Y. Owens, Jim Thornton, Marcus Green, Andrew H. Shennan, Henk Groen, Lucy C. Chappell
Summary: This individual participant data meta-analysis compared planned delivery to expectant management in women with preeclampsia. The results showed that planned delivery from 34 weeks gestation onward reduced the risk of maternal morbidity and the likelihood of the infant being born small for gestational age. However, it also increased the risk of short-term neonatal respiratory morbidity.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Ji Yeon Lee, Seung Mi Lee, Mina Jeong, Sohee Oh, Subeen Hong, Seung-Ah Choe, Jong Kwan Jun
Summary: Reproductive endocrinologists suggest selective multifetal pregnancy reduction to save at least one or two babies in triplet pregnancies. However, recent advancements in obstetric and neonatal care may change the outcomes. This study compared the outcomes of expectant management and reduction to twins in triplet pregnancies, showing that expectant management could improve neonatal survival and reduce the risk of developmental delay.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Obstetrics & Gynecology
Helena C. Bartels, Donal J. Brennan, Ilan E. Timor-Tritsch, Andrea Kaelin Agten
Summary: The incidence of Cesarean scar pregnancies (CSPs) is increasing globally and there is considerable variation in the management of this condition. The diagnosis and expectant management of CSP in low-resource settings is lacking. Standardization in reporting different types of CSPs and correlating these with pregnancy outcomes is important for developing guidance for expectant management. © 2023 Published by Elsevier Ltd.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Peripheral Vascular Disease
Sukainah Al Khalaf, Lucy C. C. Chappell, Ali S. S. Khashan, Fergus P. P. McCarthy, Eilis J. O'Reilly
Summary: There is a strong association between chronic hypertension and the risk of cardiovascular disease (CVD) in mothers, especially those with adverse pregnancy outcomes (APOs). This risk can lead to premature CVD, thus intervention programs targeting these high-risk groups might reduce their risk of subsequent CVD.
Article
Medicine, General & Internal
Nadine Corbach, Charlotte Berlier, Mona Lichtblau, Esther I. Schwarz, Fiorenza Gautschi, Alexandra Groth, Rolf Schuepbach, Franziska Kraehenmann, Stephanie Saxer, Silvia Ulrich
Summary: This study retrospectively analyzed seven pregnancies of five women with PAH, showing that these women had favorable outcomes during and after pregnancy, resulting in successful deliveries of healthy newborns.
FRONTIERS IN MEDICINE
(2021)
Article
Genetics & Heredity
Xinlu Meng, Jiaqi Huang, Pengbo Yuan, Xueju Wang, Xiaoming Shi, Yangyu Zhao, Yuan Wei
Summary: This study compared the outcomes of different management strategies for DCTA triplets. It found that fetal reduction to singletons or dichorionic twins can reduce the risk of prematurity compared to ongoing triplets. However, there was no survival advantage with fetal reduction. Additionally, reducing to singletons may result in more favorable outcomes than reducing to dichorionic twins.
PRENATAL DIAGNOSIS
(2023)
Article
Transplantation
Kate Wiles, Philip Webster, Paul T. Seed, Katy Bennett-Richards, Kate Bramham, Nigel Brunskill, Sue Carr, Matt Hall, Rehan Khan, Catherine Nelson-Piercy, Louise M. Webster, Lucy C. Chappell, Liz Lightstone
Summary: This study found that pregnancies in women with CKD Stages 3-5 are complicated by high rates of preterm delivery, low birthweight, and maternal renal function loss. Chronic hypertension, pre- or early pregnancy proteinuria, and a gestational fall in serum creatinine of <10% are key predictors of adverse obstetric and renal outcomes. Pregnancy in women with CKD Stages 3-5 advances the need for dialysis or transplantation by 2.5 years.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Obstetrics & Gynecology
Jesrine Hong, Kylie Crawford, Anthony O. Odibo, Sailesh Kumar
Summary: This study evaluated the risks of stillbirth, neonatal mortality, and severe neonatal morbidity in relation to the timing of birth between 37 and 40 weeks of gestation. The results suggest that the optimal time of birth varies depending on the infant's birthweight centile, with 37 to 37+6 weeks being optimal for infants below the third centile, 38 to 38+6 weeks for infants between the third and tenth centiles and above the ninetieth centile, and 39 weeks for infants in other birthweight centiles.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Medicine, General & Internal
Patrick J. Gleeson, Conall M. O'Seaghdha
Summary: The study suggests that active treatment for mild chronic hypertension in pregnant women leads to better pregnancy outcomes, while treatment only for severe hypertension does not increase the risk of adverse fetal outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Letter
Medicine, General & Internal
Patrick J. Gleeson, Conall M. O'Seaghdha
Summary: The study demonstrates that active treatment for mild chronic hypertension in pregnant women leads to better outcomes compared to treating only severe hypertension, without increasing adverse fetal outcomes. Based on the data, withdrawal of labetalol may be necessary to achieve the observed blood pressure difference between the trial groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Obstetrics & Gynecology
Diep Ngoc Le, Phuc Nhon Nguyen, Phuong Hai Huynh
Summary: This is a case report on retroperitoneal ectopic pregnancy. The patient successfully managed a 7-9 week gestation period through expectant management, highlighting the importance of awareness among healthcare providers, especially in low-resource settings.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Obstetrics & Gynecology
Aya Mohr-Sasson, Mordechai Tamir, Dimitry Mugilevsky, Raanan Meyer, Roy Mashiach
Summary: Both expectant and interventional managements are acceptable for cases of heterotopic pregnancy, with high rates of ongoing intra-uterine pregnancy and term deliveries.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Review
Obstetrics & Gynecology
Sarah Annie Solangon, Madelon Van Wely, Norah Van Mello, Ben W. Mol, Jackie A. Ross, Davor Jurkovic
Summary: Ectopic pregnancy is a common health condition affecting 1 in 100 women. Methotrexate (MTX) and expectant management are both viable treatment options for women with mild symptoms and low hCG levels. A systematic review and meta-analysis of randomized controlled trials showed no statistically significant difference in treatment efficacy between MTX and expectant management, suggesting that initial expectant management may be preferred due to fewer side-effects.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Biochemistry & Molecular Biology
Mohammed Elsherbini, Kaori Koga, Eiko Maki, Keiichi Kumasawa, Erina Satake, Ayumi Taguchi, Tomoko Makabe, Arisa Takeuchi, Gentaro Izumi, Masashi Takamura, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Osamu Wada-Hiraike, Yutaka Osuga
Summary: The study aimed to establish a new mouse model of endometriosis and evaluate the impact of chronic exposure to endometriosis on perinatal outcome. The results indicate that chronic exposure to endometriosis affects perinatal outcomes, leading to increased resorptions and decreased body weight.
Article
Immunology
Michael M. Dagher, Emily M. Eichenberger, Kateena L. Addae-Konadu, Sarah K. Dotters-Katz, Celia L. Kohler, Vance G. Fowler, Jerome J. Federspiel
Summary: Maternity-associated IE does not appear to confer additional risk for adverse outcomes over nonmaternity-associated infection. Patients who deliver with IE have worse maternal and fetal outcomes than those whose deliveries are not complicated by IE.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Obstetrics & Gynecology
Hossam O. Hamed, Salah R. Ahmed, Abdallatif Alzolibani, Manal M. Kamal, Marwa S. Mostafa, Rania M. Gamal, Dalia A. A. Atallah, Diaa-Eldeen M. Abd-El-Aall
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2013)
Article
Medical Laboratory Technology
Ragaa H. M. Salama, Abdullah Alghasham, Marwa S. Mostafa, Alaa E. A. El-Moniem
CLINICAL BIOCHEMISTRY
(2012)
Article
Obstetrics & Gynecology
Mahmoud S. Zakherah, Manal M. Kamal, Hossam O. Hamed
FERTILITY AND STERILITY
(2011)
Article
Oncology
Enas A. Hamed, Nagwa A. Mohamed, Tarek H. EL-Metwally, Manal M. Kamal
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2010)
Article
Hematology
Mai M. Aly, Taghreed S. Meshref, Marwa A. Abdelhameid, Shimaa A. Ahmed, Asmaa S. Shaltout, Alaa Eldin Abdel-Monienn, Dina A. Hamad
Summary: This study aimed to investigate the role of hematological ratios in predicting the outcome of COVID-19 Egyptian patients. The results indicated that NLR is a predictor for the severity of COVID-19, while LMR, d-NLR, and PLR may assist in risk stratification.
JOURNAL OF BLOOD MEDICINE
(2021)
Article
Infectious Diseases
Alaa Thabet Hassan, Alaa E. Abd Elmoniem, Marwa Mahmoud Abdelrady, Mona Embarek Mohamed, Mohamed A. Mokhtar, Abdelhalim A. Elsherif, Ghada Mohamed Saied, Soheir M. Kasem
Summary: This study aimed to assess the most suitable treatment modality for severe COVID-19 pneumonia patients and found that a combination of methylprednisolone and therapeutic Enoxaparin had the highest cure rate, lowest lung fibrosis rate, and lowest mortality rate. This treatment approach not only helped prevent disease complications, but also improved clinical outcomes.
Article
Clinical Neurology
E. M. Khedr, O. Galal, A. Said, M. Abd-elsameea, J. C. Rothwell
EUROPEAN JOURNAL OF NEUROLOGY
(2007)
Article
Pathology
MR Hussein, HI Hassan, ERM Hofny, M Elkholy, NA Fatehy, AEA Abd Elmoniem, AME El-Din, OA Afifi, HG Rashed
JOURNAL OF CLINICAL PATHOLOGY
(2005)