Article
Emergency Medicine
J. R. Krenz, M. E. O'Brien, J. Lee, B. D. Hayes
Summary: This study evaluated the efficacy and safety of esmolol for heart rate control in patients with acute aortic dissection, showing that lenient heart rate control was achieved in most patients within the first hour of treatment. However, a small percentage of patients experienced hypotension during the initial treatment period, highlighting the need for further investigation.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Kung-Ming Laio, Chuan-Wei Shen, Yun-Hui Huang, Chun-Hui Lu, Hsuan-Lin Lai, Chung-Yu Chen
Summary: The prescription pattern and effectiveness of antihypertensive drugs in surgical patients with aortic dissection were investigated. The study found that no specific type of antihypertensive drug was associated with a better outcome in patients with type A aortic dissection, while the use of beta-blockers and calcium channel blockers (CCBs) was related to a significantly lower risk of the composite outcome in patients with type B aortic dissection.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nupoor Narula, Richard B. Devereux, Grace P. Malonga, Ingrid Hriljac, Mary J. Roman
Summary: The study found that there is an increased risk of aortic dissection during pregnancy in Marfan syndrome patients, especially in those unaware of their diagnosis. Additionally, most patients maintained stable aortic dimensions during pregnancy, leading to favorable pregnancy outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Gabriella Ricciardi, Jerome Soquet, Osama Abou-Arab, Agnes Mugnier, Stephanie Delangue, Celine Goeminne, Mouhamed Djahoum Moussa, Andre Vincentelli
Summary: This report presents a case of a 14-year-old patient with Marfan syndrome who underwent an emergency Bentall procedure for acute type A aortic dissection. The patient required postoperative extracorporeal membrane oxygenation and was listed for heart transplantation due to persistent left ventricular failure caused by an intimal tear and thrombosis of the left main coronary artery. The heart transplantation was performed 5 days after the initial procedure, and the patient was discharged 60 days after admission.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Nupoor Narula, Richard B. Devereux, Eloisa Arbustini, Xiaoyue Ma, Jonathan W. Weinsaft, Leonard Girardi, Grace P. Malonga, Mary J. Roman
Summary: The study explores the determinants of type B dissection risk in patients with Marfan syndrome (MFS) and finds that patients who undergo aortic root replacement surgery, independent mitral valve surgery, and have type II dissection are more likely to develop type B dissection.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Scott A. LeMaire, Lin Zhang, Nicholas S. Zhang, Wei Luo, James P. Barrish, Qianzi Zhang, Joseph S. Coselli, Ying H. Shen
Summary: The study found that ciprofloxacin accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture in Marfan mice. This effect is partially due to the suppression of lysyl oxidase expression, further compromising the inherited defect in aortic elastic fibers.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Genetics & Heredity
Benjamin J. Landis, Courtney E. Vujakovich, Lindsey R. Elmore, Saila T. Pillai, Lawrence S. Lee, Jeffrey E. Everett, Larry W. Markham, John W. Brown, Phillip J. Hess, Joel S. Corvera
Summary: This study analyzed the association between connective tissue abnormalities and clinical endpoints in adults with aortopathy. The results showed that skin striae were significantly associated with the occurrence of aortic dissection and were more common in younger patients. Skin striae were also more frequently observed in patients with aortic dissection compared to age- and sex-matched controls.
Article
Medicine, General & Internal
Maddalena Ardissino, Eric A. W. Slob, Skanda Rajasundaram, Rohin K. Reddy, Benjamin Woolf, Joanna Girling, Mark R. Johnson, Fu Siong Ng, Dipender Gill
Summary: This study investigates the effects of beta-blocker and calcium channel blocker antihypertensive drugs on maternal and foetal outcomes. The results suggest that beta-blocker use may lower birthweight, while calcium channel blocker use may reduce the risk of pre-eclampsia and eclampsia.
Article
Cardiac & Cardiovascular Systems
Mina Farag, Christopher Buesch, Bartosz Rylski, Jochen Poeling, Daniel S. Dohle, Konstantinos Sarvanakis, Christian Hagl, Tobias Krueger, Christian Detter, Tomas Holubec, Michael A. Borger, Andreas Boening, Matthias Karck, Rawa Arif
Summary: Through a comparison study of patients with Marfan syndrome and patients without Marfan syndrome, it was found that Marfan syndrome does not have an adverse effect on 30-day outcomes after surgical repair for acute aortic Stanford type A dissection.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Pharmacology & Pharmacy
Sheilabi Seeburun, Shichao Wu, Darshi Hemani, Lucynda Pham, Donghong Ju, Youming Xie, Priyaranjan Kata, Li Li
Summary: This review summarizes the role of elastic fiber fragmentation in the pathogenesis of Marfan syndrome-associated aortic aneurysms and highlights its clinical significance for targeted interventions and potential therapeutic strategies.
VASCULAR PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Keiichi Asano, Anna Cantalupo, Lauriane Sedes, Francesco Ramirez
Summary: This article describes a series of studies on Marfan syndrome that have implicated endothelial dysfunction and improper angiotensin II and TGF beta signaling in driving thoracic aortic disease in Marfan syndrome mice. These investigations have influenced the conceptualization of possible new therapies to slow down or even halt aneurysm progression in this relatively common connective tissue disorder.
Article
Surgery
Heepeel Chang, Caron B. Rockman, Bhama Ramkhelawon, Thomas S. Maldonado, Neal S. Cayne, Frank J. Veith, Glenn R. Jacobowitz, Virendra I. Patel, Igor Laskowski, Karan Garg
Summary: This study evaluated the effects of beta-blocker (BB) use on the outcomes of thoracic endovascular aortic repair (TEVAR) in patients with acute type B aortic dissection (TBAD). The results showed that BB use was associated with complete false lumen thrombosis and did not affect mortality or aortic-related reintervention. BB use may improve aortic remodeling, especially in patients with chronic TBAD.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Engineering, Environmental
Zahra Aghaei, John G. Sled, John C. Kingdom, Ahmet A. Baschat, Paul A. Helm, Karl J. Jobst, Lindsay S. Cahill
Summary: This study investigated the effects of maternal exposure to microplastics and nanoplastics on fetal and placental growth using experimental mice. The results showed that fetuses from dams exposed to plastics exhibited growth restriction in late gestation, with a 12% decrease in fetal weight at the highest exposure concentration.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Review
Health Care Sciences & Services
Eduardo Bossone, Andreina Carbone, Kim A. Eagle
Summary: Cardiovascular disease (CVD) is the leading cause of death and morbidity worldwide, and there are differences in the epidemiology and management of CVD between male and female patients. In the case of acute aortic dissection (AAD), women are typically older than men at the time of diagnosis and have a less abrupt onset of pain, leading to delayed presentation to the emergency department. Women also have a higher prevalence of hypertension and chronic obstructive pulmonary disease. In type A AAD, women are more prone to pleural effusion and coronary artery compromise, but experience fewer neurological and malperfusion symptoms. They undergo surgical treatment less frequently and have higher in-hospital mortality rates. In contrast, there are no significant differences in in-hospital mortality between genders in type B AAD. Further studies are needed to develop gender-specific strategies for preventive, diagnostic, and therapeutic approaches to AAD.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Obstetrics & Gynecology
Ting Xiong, Yuanjue Wu, Li Huang, Xi Chen, Yu Zhang, Chunrong Zhong, Qin Gao, Miao Hong, Xingwen Hu, Xuefeng Yang, Nianhong Yang, Liping Hao
Summary: This study aimed to investigate the association between maternal serum albumin (MAlb) levels and fetal growth as well as the risk of fetal growth restriction (FGR). The findings revealed a reverse U-shaped relationship between MAlb and fetal growth, indicating an increased risk of FGR when MAlb levels were either too low or too high. These findings are important for understanding the relationship between maternal serum albumin and fetal health.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Timothy Wen, Lillian Liao, Adina Kern-Goldberger, Jean Guglielminotti, Cynthia Gyamfi-Bannerman, Jason D. Wright, Mary E. D'Alton, Alexander M. Friedman
Summary: The study found that the composite rate of cesarean surgical complications was 1.14%, with surgical site complications occurring in 0.60%, surgical injuries in 0.49%, and reoperations in 0.10%.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Teresa C. Logue, Timothy Wen, Catherine Monk, Jean Guglielminotti, Yongmei Huang, Jason D. Wright, Mary E. D'Alton, Alexander M. Friedman
Summary: This study aimed to characterize the prevalence of maternal mental health condition diagnoses and associated risk during delivery hospitalizations in the United States. The findings showed that the proportion of delivery hospitalizations with mental health condition diagnoses increased significantly throughout the study period and were associated with other chronic health conditions and a range of adverse outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Timothy Wen, Christina N. Schmidt, Nasim C. Sobhani, Jean Guglielminotti, Eliza C. Miller, Desmond Sutton, Yael Lahtermaher, Mary E. D'Alton, Alexander M. Friedman
Summary: This study analyzed the trends, risk factors, and outcomes related to hypertensive disorders of pregnancy (HDP). The prevalence of HDP doubled from 6.0% in 2000 to 12.0% in 2018, while the proportion of deliveries with risk factors for HDP increased from 9.6% to 24.6%. Adjusted models showed that HDP was associated with an increased risk of stroke (adjusted risk ratio [aRR] 15.9), acute renal failure (aRR 13.8), and acute liver injury (aRR 1.2). Acute renal failure and acute liver injury increased among deliveries with HDP, while stroke decreased.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Obstetrics & Gynecology
Eric P. Sun, Jean Guglielminotti, Stanford Chihuri, Guohua Li
Summary: This study synthesized empirical research evidence on the association between Medicaid expansion under the ACA and increased perinatal care access and utilization among low-income women. The results showed that Medicaid expansion was associated with a modest increase in Medicaid enrollment for pregnant women and an increase in perinatal care utilization.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Alexander M. Friedman, Emily A. DiMango, Jean R. Guglielminotti, Yongmei Huang, Jason D. Wright, Mary E. D'Alton, Timothy Wen
Summary: This study characterized the prevalence and outcomes of asthma during delivery hospitalizations in the United States. The results showed an increasing trend in asthma diagnosis over the past 18 years, and asthma was associated with adverse maternal outcomes and comorbid conditions. Although the risk of severe respiratory complications decreased among deliveries with asthma, it remained stable on a population level.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Jean Guglielminotti, Ruth Landau, Jamie Daw, Alexander M. Friedman, Stanford Chihuri, Guohua Li
Summary: This study aims to assess the association between the use of labor neuraxial analgesia for vaginal delivery and severe maternal morbidity (SMM). The findings suggest that the use of neuraxial analgesia for vaginal delivery is associated with a 14% decrease in the risk of SMM.
Article
Obstetrics & Gynecology
Alice H. Linder, Timothy Wen, Jean R. Guglielminotti, Lisa D. Levine, Yuli Y. Kim, Stephanie E. Purisch, Mary E. D'Alton, Alexander M. Friedman
Summary: The study found that maternal congenital heart disease is becoming more common among US deliveries, and the risk of severe maternal morbidity is increasing among deliveries with maternal CHD, indicating an increasing burden of risk from maternal CHD in the obstetric population.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Anesthesiology
Jean Guglielminotti, Jamie R. Daw, Ruth Landau, Alexander M. Friedman, Guohua Li
Summary: This study investigated the impact of the 2010 Dependent Coverage Provision of the Patient Protection and Affordable Care Act on the utilization of labor neuraxial analgesia during childbirth. The results showed that the implementation of the Dependent Coverage Provision was associated with a slight increase in the utilization rate of labor neuraxial analgesia, particularly among women aged 21 to 25 years. However, the effect size was too small to be clinically significant.
Article
Obstetrics & Gynecology
Jean Guglielminotti, Jamie R. Daw, Alexander M. Friedman, Ruth Landau, Guohua Li
Summary: This study aimed to assess the association of Medicaid expansion under the Affordable Care Act with eclampsia incidence. The results showed that expanding Medicaid coverage was associated with a decrease in the incidence of eclampsia. However, the clinical significance and cost-effectiveness of this association require further investigation.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Anesthesiology
Jose Sanchez, Rohan Prabhu, Jean Guglielminotti, Ruth Landau
Summary: This study evaluates the incidence of self-reported pain and the administration of intravenous medication (IVM) during cesarean delivery. The results show that 11.5% of women reported pain during the procedure, and a proportion of them received analgesic IVM. Risk factors for pain included substance use disorder and intrapartum epidural extension.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2024)
Article
Obstetrics & Gynecology
M. Mesnil, N. Ranisavljevic, S. Brouillet, B. Ducrocq, A. Reignier, C. Yazbeck, C. Metzler-guillemain, J. Ohl, L. Brunet, H. Letur, C. Ravel
Summary: The French law of August 2, 2021 opened up new possibilities for using preserved gametes within a couple by allowing Assisted Reproductive Techniques (ART) for all women, eliminating the need for gamete donation. This study aimed to evaluate the perception of these new uses by ART practitioners through a questionnaire sent to professionals involved in gamete donation. The majority of the respondents approved of the Reception of Oocytes from the Partner (ROPA), particularly when there is a medical indication. Requests for the care of trans* individuals were less common and raised more questions. Although less supportive of using eggs from trans* men, more professionals were in favor of the practice as an alternative to oocyte donation. The acronym EUGIC (Extension of the Use of Gametes in Intra-Conjugal) was proposed to encompass these new situations resulting from the change in French law.
GYNECOLOGIE OBSTETRIQUE FERTILITE & SENOLOGIE
(2023)
Article
Public, Environmental & Occupational Health
Jean Guglielminotti, Goleen Samari, Alexander M. Friedman, Ruth Landau, Guohua Li
Summary: This study examines the association between state-level indicators of structural racism and severe adverse maternal outcomes during childbirth. The findings indicate that higher unemployment rates and incarceration rates are associated with increased odds of severe adverse maternal outcomes.
MATERNAL AND CHILD HEALTH JOURNAL
(2023)
Article
Obstetrics & Gynecology
Jean Guglielminotti, Goleen Samari, Alexander M. Friedman, Allison Lee, Ruth Landau, Guohua Li
Summary: A diverse state registered nurse workforce is associated with a reduced risk of severe adverse maternal outcomes during childbirth.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Anesthesiology
Bushra Taha, Jean Guglielminotti, Guohua Li, Ruth Landau
Summary: This study shows that the utilization rate of ECMO in obstetric patients in the United States has significantly increased, and the maternal prognosis has improved during the study period.
ANESTHESIA AND ANALGESIA
(2022)
Meeting Abstract
Obstetrics & Gynecology
Kathleen Yu, Adam Faye, Timothy Wen, Jean Guglielminotti, Yongmei Huang, Jason D. Wright, Mary E. D'Alton, Alexander M. Friedman
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
