Article
Obstetrics & Gynecology
Martin Koskas, Frederic Amant, Mansoor Raza Mirza, Carien L. Creutzberg
Summary: Endometrial cancer is the most common gynecological malignancy in high- and middle-income countries, with a tendency for high-grade cancers to recur. Tailoring treatment to tumor biology is crucial for balancing efficacy and toxicity, with molecular factors increasingly used for defining prognosis and treatment. Standard treatment includes surgery and adjuvant therapy based on risk factors, with chemotherapy particularly used in non-endometrioid cancers and those with TP53 mutation.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Oncology
Guanhua Yu, Ran Wei, Shuofeng Li, Yongjiao Wang, Hengchang Liu, Tianli Chen, Xu Guan, Xishan Wang, Zheng Jiang
Summary: This study found that radiotherapy for primary pelvic cancers is associated with a higher risk of developing second corpus uteri cancer (SCUC). The incidence of SCUC was higher in patients who received radiotherapy compared to the general population, while the incidence was lower in patients who did not receive radiotherapy. The overall survival rate was lower in patients who developed SCUC after radiotherapy. Therefore, it is recommended that patients who undergo pelvic radiotherapy, especially young patients, should be closely monitored for the risk of developing SCUC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Reproductive Biology
Albert Strohmeyer, Claudia Strohmeyer, Judith Reischl, Stephan Wallenhorst, Wolfgang Holtz
Summary: Successful non-surgical transfer of embryos to the uterine body in pigs has been achieved, but it was found that the low pregnancy rates experienced may be due to the unsuitable conditions for embryo development in the uterus.
Article
Obstetrics & Gynecology
Neerja Bhatla, Daisuke Aoki, Daya Nand Sharma, Rengaswamy Sankaranarayanan
Summary: Since the publication of the 2018 FIGO Cancer Report, significant progress has been made in reducing the burden of cervical cancer globally, with initiatives such as the WHO's global strategy for cervical cancer elimination, HPV vaccination programs, and wider implementation of HPV testing. While these interventions will take time to show their impact, over half a million new cases of cervical cancer are still added each year.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Junjie Huang, Wing Chung Chan, Chun Ho Ngai, Veeleah Lok, Lin Zhang, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: The objective of this study is to evaluate the global distribution, risk factors, and temporal trends of corpus uteri cancer for different countries and age groups. Data from the Global Cancer Observatory database, Cancer Incidence in Five Continents, and the WHO mortality database were analyzed to calculate age-standardized rates and estimate the annual average percent change. The results showed a substantial increasing trend of corpus uteri cancer, with high-income countries having the highest incidence. Intensive lifestyle modifications are needed, especially among younger women.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Agriculture, Dairy & Animal Science
Bartlomiej Maria Jaskowski, Hartwig Bostedt, Marek Gehrke, Jedrzej Maria Jaskowski
Summary: The study shows that recipients with a cavitary corpus luteum have higher progesterone levels and pregnancy rates during embryo transfer. Therefore, the presence of a cavity inside the corpus luteum should not be a reason to exclude recipients from embryo transfer.
Article
Agriculture, Dairy & Animal Science
Panagiotis Ballas, Christoph Gabler, Karen Wagener, Marc Drillich, Monika Ehling-Schulz
Summary: The pathogenicity of B. pumilus strains isolated from cows with and without endometritis was evaluated in this study using a cell-culture-based approach. These strains were found to possess specific genes related to enzyme production and caused damage to endometrial bovine cells in a dose-dependent manner. These findings have important implications for understanding the role of this pathogen in the disease.
Article
Biochemistry & Molecular Biology
Aeman Zahra, Marcia Hall, Jayanta Chatterjee, Cristina Sisu, Emmanouil Karteris
Summary: This study analyzed the association between seven genes and female cancers, and identified a mutation that potentially causes structural damage and decreases protein stability. Further in vitro studies can provide more insight into the role of this transporter protein in uterine corpus endometrial carcinomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Multidisciplinary
Rizhong Shen
Summary: Information education has been widely promoted in many countries, leading to the popularization of information technology in language education. The combination of information technology and Japanese learning can serve as a practical tool to enhance students' thinking and cognitive abilities. The study shows that the internet corpus learning method has a positive impact on students' learning performance and effective learning.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Qin Liu, Minghua Yu, Tao Zhang
Summary: This study explores the potential link between oxidative stress and uterine corpus endometrial carcinoma (UCEC). The results demonstrate that a biomarker based on oxidative stress-related genes can reliably predict the clinical outcome of UCEC patients. Furthermore, oxidative stress is found to be associated with immune cell infiltration in UCEC, suggesting its role in UCEC development by activating immune cells.
Review
Agriculture, Dairy & Animal Science
Massimo Zerani, Angela Polisca, Cristiano Boiti, Margherita Maranesi
Summary: Corpora lutea are temporary endocrine structures that secrete progesterone, essential for a healthy pregnancy. Research using the pseudopregnant rabbit model has shed light on the multifactorial mechanisms regulating CL lifespan, providing valuable insights for overcoming reproductive challenges in mammalian species.
Article
Multidisciplinary Sciences
Chuhan Wu, Fangzhao Wu, Lingjuan Lyu, Yongfeng Huang, Xing Xie
Summary: This article introduces a federated learning method called FedKD, which is both communication-efficient and effective in preserving privacy. The validation shows that FedKD can significantly reduce communication costs and achieve competitive results with centralized model learning in scenarios that require privacy protection. This method has the potential to efficiently deploy privacy-preserving intelligent systems in various domains, such as intelligent healthcare and personalization.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Wen-li Cheng, Rui-min Wang, Yi Zhao, Juan Chen
Summary: This study developed a predictive model for the cancer-specific survival (CSS) of uterine clear cell carcinoma (UCCC) patients. The model was based on data from the SEER database between 2000 and 2018. Age, tumor size, SEER stage, surgery, lymph node status, radiotherapy, and chemotherapy were identified as independent prognostic factors. A nomogram was constructed and validated using various statistical analyses.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Danielle Rayee, Pamela Meneses Iack, Raissa R. Christoff, Michele R. Lourenco, Christiane Bonifacio, Jurgen Boltz, Roberto Lent, Patricia P. Garcez
Summary: The corpus callosum (CC) is a major interhemispheric commissure of placental mammals. During typical cortical development, axonal bifurcation rates in the cerebral cortex rise from embryonic day (E)17 and are reduced by postnatal day (P)9. In a CC dysgenesis mouse model, increased rates of axonal bifurcations were observed, suggesting a possible facilitation of aberrant connections in the absence of midline guidepost signaling.
Article
Computer Science, Artificial Intelligence
Mike Thelwall
Summary: Identifying neologisms in social web text is important for natural language processing, especially when informal language and youth slang are prevalent. This article proposes a method based on orthographic pleonasm to identify emotion-related neologisms in the social web, finding words with the most different letter repetition spelling variations. This method successfully identified new sentiment slang in comments on YouTube influencers, categorizing them as positive terms.
IEEE INTELLIGENT SYSTEMS
(2021)
Article
Oncology
Emiel A. De Jaeghere, Sandra Tuyaerts, An M. T. Van Nuffel, Ann Belmans, Kris Bogaerts, Regina Baiden-Amissah, Lien Lippens, Peter Vuylsteke, Stephanie Henry, Xuan Bich Trinh, Peter A. van Dam, Sandrine Aspeslagh, Alex De Caluwe, Eline Naert, Diether Lambrechts, An Hendrix, Olivier De Wever, Koen K. Van de Vijver, Frederic Amant, Katrien Vandecasteele, Hannelore G. Denys
Summary: The PRIMMO study conducted a phase II trial on patients with pretreated persistent/recurrent/metastatic cervical or endometrial cancer. The study found that pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail had modest but durable antitumor activity, with acceptable but not negligible toxicity.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Joosje H. Heimovaara, Ingrid A. Boere, Jorine de Haan, Kristel van Calsteren, Frederic Amant, Lia van Zuylen, Christine A. R. Lok
Summary: The Dutch multidisciplinary tumor board for cancer, infertility, and pregnancy (CIP-MDT) provides consultation services for physicians regarding cancer treatment during pregnancy and has achieved a high level of satisfaction. The study also identifies common types of cancer and consultation topics.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Surgery
Maurits Lange, J. Joris Hage, Refaat B. Karim, Frederic Amant
Summary: Various techniques have been introduced for reduction labiaplasty, but there is no single technique that is optimal for every patient. The choice of technique should be based on anatomical, configurational, and technical considerations, as well as the patient's personal preferences. An algorithm has been developed to guide the choice of technique, considering factors such as resection or retention of the labial free rim, required labial width reduction, labial vascular status, prevention of iatrogenic labial thickening, and preservation of labial sensibility. The choice of techniques includes edge trimming, central spindle form de-epithelialization or full-thickness resection, and modifications of the wedge resection or de-epithelialization technique.
ARCHIVES OF PLASTIC SURGERY-APS
(2023)
Article
Oncology
Lisa J. Vermij, Jan J. Jobsen, Alicia Leon-Castillo, Mariel Brinkhuis, Suzan E. Roothaan, Melanie E. M. Powell, Stephanie M. de Boer, Pearly R. Khaw, Linda R. Mileshkin, Anthony Fyles, Alexandra Leary, Catherine M. Genestie, Ina M. J. Jurgenliemk-Schulz, Emma J. J. Crosbie, Helen J. Mackay, Hans. W. A. Nijman, Remi A. Nout, Vincent T. H. B. M. L. Smit, Carien L. Creutzberg, Nanda Horeweg, Tjalling M. Bosse, Stephanie M. de Boer
Summary: This study aimed to investigate whether adding hormone receptor expression, L1CAM expression or CTNNB1 status can improve the accuracy of risk assessment in endometrial cancer (EC). The study found that the expression of ER, PR, L1CAM, and CTNNB1 did not have independent prognostic value in EC, while age, stage, and adjuvant chemotherapy had an independent impact on the risk of recurrence. However, in high-risk EC of non-serous/mixed papillary (NSMP) subgroup, ER positivity was independently associated with a reduced risk of recurrence.
BRITISH JOURNAL OF CANCER
(2023)
Article
Environmental Sciences
Ilana Struys, Eline Verscheure, Liesbeth Lenaerts, Frederic Amant, Lode Godderis, Manosij Ghosh
Summary: Due to the genotoxic consequences of antineoplastic agents on non-cancerous tissue, it is crucial to understand their effects. This study aimed to characterize the genotoxic profile of different classes of antineoplastic drugs using a cell line assay. The results showed increased micronucleus formation with all tested drugs, as well as specific abnormalities for each drug class. These findings can aid in interpreting genotoxic aberrations in patients treated with these drugs.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Oncology
Pien Lof, Ellen G. Engelhardt, Mignon D. J. M. van Gent, Constantijne H. Mom, Fleur M. F. Rosier-van Dunne, W. Marchien van Baal, Harold R. Verhoeve, Brenda B. J. Hermsen, Marjolijn B. Verbruggen, Majoie Hemelaar, Jojanneke M. G. van de Swaluw, Haye C. Knipscheer, Judith A. F. Huirne, Steven M. Westenberg, Willemien J. van Driel, Eveline M. A. Bleiker, Frederic Amant, Christianne A. R. Lok
Summary: This study evaluated cancer-specific distress and treatment satisfaction in patients with an ovarian mass. It found that many patients experienced high cancer-specific distress during the work-up process. However, patients were generally satisfied with their treatment regardless of the diagnosis and treatment location. This suggests that patients' preferences should be considered when developing risk assessment strategies.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
T. Bosse, C. L. Creutzberg, E. J. Crosbie, K. Han, N. Horeweg, A. Leary, J. R. Kroep, J. N. McAlpine, M. E. Powell, F. Blanc-Durand, M. de Bruyn, D. N. Church, V. H. Koelzer, S. Kommoss, N. Singh, A. Bardet, N. Counsell, H. Putter, D. Tu, R. Edmondson, C. Gordon, J. Ledermann, P. Morice, H. MacKay, H. Nijman, R. A. Nout, V. T. H. B. M. Smit, H. White, J. Alexandre, S. M. de Boer, I Boere, R. Cooper, J. L. Ethier, J. S. Frenel, J. McGrane, A. Taylor, S. Welch, A. M. Westermann, H. Dijcker-van der Linden, L. Farrelly, A. Feeney, M. Kaya, W. Liu, A. Melis, F. Ngadjeua-Tchouatieu, W. Parulekar, K. Verhoeven-Adema, RAINBO Res Consortium
Summary: The RAINBO program aims to investigate molecular class-directed adjuvant treatment strategies for endometrial cancer, with the goal of improving clinical outcomes and reducing toxicity. It consists of four international clinical trials and an overarching research program to advance knowledge of predictive and prognostic markers.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Review
Oncology
Fabian De Smedt, Frederique Dessy, Luciano Carestia, Pamela Baldin, Frank Aboubakar Nana, Philippe Clapuyt, Veronique Boon, Frederic Amant, Mina Mhallem Gziri
Summary: Oncogenic rearrangements in the ALK gene are responsible for 5% of NSCLC cases, and ALK inhibitors have significantly improved the outcomes in ALK(+) mNSCLC patients. ALK(+) NSCLC accounts for 38% of cases in women of childbearing age, presenting new challenges in lung cancer and obstetrics research. This study reported a case of a pregnant HIV-infected patient with ALK(+) mNSCLC who had no fetal developmental abnormalities or obstetric complications during treatment with alectinib.
Article
Orthopedics
Maurits Lange, J. Joris Hage, Arend Aalbers, Esther M. K. Wit, Frederic Amant, Marije J. Hoornweg
Summary: Primary intra- or transabdominal transplantation of extended rectus abdominis myocutaneous (ERAM) flap can prevent surgical complications. Delaying the flap can reduce the risk of intra-abdominal flap loss. However, it may lead to other complications.
JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
(2023)
Article
Pharmacology & Pharmacy
David Damoiseaux, Daniel Centanni, Jos H. Beijnen, Frederic Amant, Alwin D. R. Huitema, Thomas P. C. Dorlo
Summary: Information on the distribution of chemotherapeutic drugs to breast milk is limited, and our study aimed to predict chemotherapy distribution in a more realistic breastfeeding population and evaluate the effect of discarding breast milk on potential chemotherapy exposure in infants.
CLINICAL PHARMACOKINETICS
(2023)
Article
Oncology
I. Suvaal, K. Kirchheiner, R. A. Nout, A. E. Sturdza, E. Van Limbergen, J. C. Lindegaard, H. Putter, I. M. Jurgenliemk-Schulz, C. Chargari, K. Tanderup, R. Poetter, C. L. Creutzberg, M. M. ter Kuile
Summary: The study prospectively evaluated vaginal changes and patient-reported outcomes after image-guided radio(chemo)therapy and brachytherapy for locally advanced cervical cancer. Mild vaginal changes were reported, and a significant proportion of patients experienced vaginal and sexual functioning problems. However, the rate of substantial problems and distress was low, and there was no clear association between vaginal changes and sexual functioning problems.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Jenneke C. Kasius, Rita Trozzi, Johanna Pijnenborg, Thais Baert, Annouschka Laenen, Anne-Sophie Van Rompuy, Ignacio Zapardiel, Giuseppe Vizzielli, Jure Knez, Francesco Fanfani, Frederic Amant
Summary: The study aims to determine the association between molecular classification and disease stage in endometrial cancer, in order to guide surgical approach. 1000 female patients aged 18 or above will be enrolled, and results on staging and oncological outcomes are expected in 2027 and 2029 respectively.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Sander Dumont, Vincent Vandecaveye, Raphaela Carmen Dresen, Els Van Nieuwenhuysen, Thais Baert, Frederic Amant, Valerie Broeckhoven, Toon Van Gorp
Summary: This study aimed to evaluate the diagnostic value of whole-body diffusion-weighted magnetic resonance imaging (WB-DWI/MRI) in predicting resectable disease during secondary cytoreductive surgery for relapsed epithelial ovarian cancer. The study found that WB-DWI/MRI accurately predicted resectable disease and was associated with improved progression-free and overall survival of the patients.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Jonathan S. Berek, Xavier Matias-Guiu, Carien Creutzberg, Christina Fotopoulou, David Gaffney, Sean Kehoe, Kristina Lindemann, David Mutch, Endometrial Canc Staging Subcomm, FIGO Womens Canc Comm
Summary: Since the 2009 update of the FIGO staging system, there have been significant advances in understanding the pathologic and molecular features of endometrial cancer. The new staging system aims to better define prognostic groups and create substages to guide more appropriate treatment.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Teska Schuurman, Ji-Ying Song, Vera Wolters, Marieke van de Ven, Nienke van Trommel, Ina Beerendonk, Frederic Amant, Christianne Lok
Summary: This study found that chemotherapy can cause damage to the maternal ovaries during pregnancy, and the extent of this damage depends on the type of chemotherapy and the duration of exposure. Short-term exposure leads to more severe damage, but it might be temporary. Chemotherapy also results in the loss of primordial follicles and DNA damage, with paclitaxel causing the least damage.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
