Article
Pharmacology & Pharmacy
Olga Maliszewska, Anna Roszkowska, Marcin Lipinski, Natalia Treder, Ilona Oledzka, Piotr Kowalski, Tomasz Baczek, Ewa Bien, Malgorzata Anna Krawczyk, Alina Plenis
Summary: Therapeutic drug monitoring (TDM) is essential for precise control of pharmacokinetic parameters in docetaxel (DOC)-based anticancer therapy. This study presents a new method for isolating DOC from plasma and urine samples using ultrasound-assisted dispersive liquid-liquid microextraction (UA-DLLME) and liquid chromatography with tandem mass spectrometry (LC-MS/MS). The method was validated and successfully applied to monitor DOC levels in a pediatric patient with cardiac angiosarcoma (AS). The study provides valuable pharmacokinetic information and demonstrates the usefulness of the method for routine DOC monitoring.
Article
Chemistry, Analytical
Valfredo Azevedo Lemos, Jeferson Alves Barreto, Luana Bastos Santos, Rosivan dos Santos de Assis, Cleber Galvao Novaes, Ricardo J. Cassella
Summary: Dispersive liquid-liquid microextraction (DLLME) is widely used for the separation and preconcentration of various chemical species, with some systems using a syringe as an extraction environment. This review discusses methods utilizing this approach, critical aspects like dispersion promotion, analytical characteristics, and the pros and cons of the methods, as well as future trends in in-syringe microextraction systems.
Article
Chemistry, Multidisciplinary
Qian Liu, Zhiqiang Li, Liulin Wei, Xiaomei Chen, Yidong Xu, Jingchan Zhao
Summary: In this study, a thermo-switchable deep eutectic solvent was used to improve the extraction of organophosphorus pesticides and pyrethroids in water samples. The method showed fast extraction, high precision, and low detection limit.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Article
Biochemical Research Methods
Laura Carbonell-Rozas, Romina Canales, Francisco J. Lara, Ana M. Garcia-Campana, Maria Fernanda Silva
Summary: By utilizing natural deep eutectic solvents (NADES) as extracting solvents, combined with dispersive liquid-liquid microextraction (DLLME-SFO) method, pesticide residues in environmental water and white wine samples were successfully extracted and preconcentrated, achieving high recoveries and low detection limits. This method demonstrates a new application for NADES in sample preparation and highlights its greenness compared to other reported approaches.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Helina Heino, Lassi Rieppo, Tuija Mannisto, Mikko J. Sillanpaa, Vesa Mantynen, Simo Saarakkala
Summary: ATR-FTIR spectroscopy coupled with machine learning-based PLS-DA was used to study the detection of SARS-CoV-2 from nasopharyngeal swab samples. The results indicate that the ATR-FTIR spectrum contains specific information for SARS-CoV-2 infection, but the diagnostic performance is moderate.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Analytical
Muhammad Sajid
Summary: Since 2006, dispersive liquid-liquid microextraction (DLLME) has undergone several improvements in various aspects, including extraction device design, extractant dispersion strategies, solvent selection, and phase separation approaches. It has also been combined with other extraction techniques for wider applications. This review critically evaluates the advancements in simultaneous derivatization, automation, and instrumental coupling.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ahmed Mostafa, Heba Shaaban, Abdulmalik M. Alqarni, Meshal Alghamdi, Semat Alsultan, Jenan Saleh Al-Saeed, Sahar Alsaba, Amal AlMoslem, Yasir Alshehry, Rizwan Ahmad
Summary: This study explores the use of natural deep eutectic solvents (NDESs) for the extraction and trace analysis of sulfonamides. The results show that using a thymol/acetic acid mixture as the extracting solvent yields the best extraction recovery. The proposed method is found to be superior to other methods based on ecological assessments and other metrics. Overall, this method can serve as a valid eco-friendly alternative for the routine analysis of sulfonamides in different water samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Julia Martinelli Magalhaes Kahl, Kelly Francisco da Cunha, Leonardo Costalonga Rodrigues, Kaue de Oliveira Chinaglia, Karina Diniz Oliveira, Jose Luiz Costa
Summary: The study developed an analytical method using DLLME combined with LC-MS/MS to quantify amphetamine and derivatives in oral fluid samples. The method reduces solvent usage in samples preparation, lowers the amount of solvents and reagents used in analytical-instrumental stage, and requires a minimal sample volume.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Chemistry, Analytical
Ali Mohebbi, Abolghasem Jouyban, Mir Ali Farajzadeh, Mahboob Nemati, Samine Raha, Yosra Vaez Gharamaleki, Mustafa Tuzen, Mohammad Reza Afshar Mogaddam
Summary: In this study, a combination of mixed mode dispersive solid phase extraction and dispersive liquid-liquid microextraction was used for the effective isolation and quantification of three anticoagulant drugs from urine samples. The method showed satisfactory analytical results with wide linear ranges, high enrichment factors, and low detection limits. By optimizing the adsorbents and solvents, the researchers obtained successful analytical outcomes.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Kawin Khachornsakkul, Ruben Del-Rio-Ruiz, Lita Chheang, Sameer Sonkusale
Summary: This study reports the use of distance-based thread analytical devices (dTADs) combined with dispersive liquid-liquid microextraction (DLLME) method for monitoring trace melatonin levels in human samples and dietary supplements. The proposed method is simple, inexpensive, sensitive, and exhibits remarkable reproducibility and selectivity.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Environmental Sciences
Sukriye Nihan Karuk Elmas
Summary: The purpose of this study is to develop a novel strategy for determining Al3+ ions using dispersive liquid-liquid microextraction (DLLME) and UV-Vis spectrophotometry. The method relies on the complexation between a new antipyrine-based Schiff base reagent (EHMP) and Al3+ ions. After optimizing the experimental conditions, the new strategy was successfully applied to determine Al3+ ions in natural water samples.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2022)
Article
Chemistry, Analytical
Naci Polat
Summary: This study aimed to develop a sensitive and accurate method for the determination of lead in urine by using dispersive liquid-liquid microextraction prior to slotted quartz tube - flame atomic absorption spectrometry. The developed method showed a detection limit of 0.5 μg L-1 and a wide linear range from 2.0 to 250 μg L-1, with a high regression coefficient of 0.9998. The practical application of the method on urine samples demonstrated recovery values between 98.2 and 107.0%.
ANALYTICAL LETTERS
(2022)
Article
Chemistry, Analytical
Mojdeh Mohammadi, Sara Khosravi, Amir Nili-Ahmadabadi, Mahdie Kamalabadi, Vahid Ghasemzadeh-Mohammadi, Abbas Afkhami
Summary: In this research, a novel method combining ion mobility spectrometry (IMS) and dispersive liquid-liquid microextraction was developed and validated for the fast and quantitative analysis of Ampyra (AMP) in real samples. The method utilized silver nanoparticles as modifier agents and improved sensitivity through the delay of carrier gas flow after sample injection. Under the optimized conditions, AMP was detected in the linear range of 0.4-16 µmol L-1 with a detection limit of 0.12 µmol L-1. The developed method was successfully applied to quantify AMP in urine samples and validated against HPLC-UV/Vis. The proposed method opens up new possibilities for developing simple, fast, and effective analytical methods.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medical Laboratory Technology
Aniello Primiano, Silvia Persichilli, Flavio Di Giacinto, Gabriele Ciasca, Silvia Baroni, Pietro Manuel Ferraro, Marco De Spirito, Andrea Urbani, Jacopo Gervasoni
Summary: The study evaluated the combination of infrared spectroscopy with chemometric analysis as a screening method to identify patients requiring confirmation by HPLC-FL analysis for cystinuria diagnosis. The results showed that this approach was both sensitive and specific for detection of the disorder.
CLINICA CHIMICA ACTA
(2021)
Article
Biochemical Research Methods
Panagiotis Giamougiannis, Camilo L. M. Morais, Brice Rodriguez, Nicholas J. Wood, Pierre L. Martin-Hirsch, Francis L. Martin
Summary: This study confirms the capacity of biofluids' ATR-FTIR spectroscopy (mainly blood serum) to diagnose ovarian cancer with high accuracy and demonstrates its potential in monitoring response to chemotherapy, which is reported for the first time. Serum was found to be the best biofluid for ovarian cancer detection, achieving 76% sensitivity and 98% specificity, while urine exhibited poor performance. The decrease in sensitivities for the NACT ovarian cancer group in plasma and serum indicates the potential of ATR-FTIR spectroscopy to identify chemotherapy-related spectral changes.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Patharee Oungsakul, David Perez-Guaita, Alok K. Shah, David Duffy, Bayden R. Wood, Helle Bielefeldt-Ohmann, Michelle M. Hill
Summary: Spectral histopathology shows promise in tumor classification, and FTIR imaging without paraffin removal can be used in tumors with diffuse morphology, making it a promising tool for differential diagnosis of canine splenic HSA.
ANALYTICAL CHEMISTRY
(2021)
Correction
Chemistry, Analytical
David Perez-Guaita, Guillermo Quintas, Zeineb Farhane, Roma Tauler, Hugh J. Byrne
Review
Chemistry, Analytical
Jakub Dybas, Fatih Celal Alcicek, Aleksandra Wajda, Magdalena Kaczmarska, Anna Zimna, Katarzyna Bulat, Aneta Blat, Tetiana Stepanenko, Tasnim Mohaissen, Ewa Szczesny-Malysiak, David Perez-Guaita, Bayden R. Wood, Katarzyna Maria Marzec
Summary: The application of modern and innovative spectroscopic and microscopic approaches in biomedical analysis has provided new insights into the analysis of red blood cells (RBCs). This review critically summarizes the latest Raman-based methodologies for RBC analysis and compares them with other techniques. It highlights the advantages, disadvantages, and capabilities of each technique for detecting RBC deteriorations and RBC-related diseases. Classical techniques currently used in medical analysis are insufficient in providing molecular-level insights into RBC alterations, therefore non-destructive and label-free analytical techniques are in demand for rapid detection and diagnosis of erythropathies.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Review
Pediatrics
Alvaro Solaz-Garcia, Inmaculada Lara-Canton, Alejandro Pinilla-Gonzalez, Raimunda Montejano-Lozoya, Ana Gimeno-Navarro, Angel Sanchez-Illana, Andrea Marco-Pinol, Maximo Vento, Pilar Saenz-Gonzalez
Summary: Kangaroo care is an effective method for promoting health and well-being of premature infants and their families. Physiological parameters (heart rate, arterial oxygen saturation, regional cerebral oxygen saturation, and fractional oxygen extraction) show no significant changes during kangaroo care. Further studies with higher methodological quality are needed to confirm these findings.
Article
Pediatrics
Alejandro Pinilla-Gonzalez, Inmaculada Lara-Canton, Laura Torrejon-Rodriguez, Anna Parra-Llorca, Marta Aguar, Julia Kuligowski, Jose David Pineiro-Ramos, Angel Sanchez-Illana, Ana Gimeno Navarro, Maximo Vento, Maria Cernada
Summary: This study evaluated the reliability of cytokines and oxidative stress/inflammation biomarkers as early diagnostic markers for ventilator-associated pneumonia (VAP) in preterm infants. The results showed that TNF-alpha and GSA can be used as early biomarkers for VAP.
PEDIATRIC RESEARCH
(2023)
Article
Chemistry, Analytical
Monika Kujdowicz, David Perez-Guaita, Piotr Chlosta, Krzysztof Okon, Kamilla Malek
Summary: A novel approach combining infrared microscopy and machine learning was proposed to automatically predict the presence of cancer, invasiveness, and grade in urothelial bladder carcinoma (BC). The study found that the infrared imaging showed high sensitivity in identifying cancer, invasiveness, and grade, providing a potential ancillary platform for screening bladder biopsies.
Article
Multidisciplinary Sciences
Jakub Dybas, Aleksandra Wajda, Fatih Celal Alcicek, Magdalena Kaczmarska, Katarzyna Bulat, Ewa Szczesny-Malysiak, Agnieszka Martyna, David Perez-Guaita, Tomasz Sacha, Katarzyna M. M. Marzec
Summary: This article introduces an innovative, label-free, noninvasive, and rapid Raman spectroscopy-based method for evaluating the quality of pRBCs. The method allows the evaluation of pRBC quality in a rapid and noninvasive manner, without unsealing the pRBCs bag, by collecting Raman spectra from the pRBCs supernatant mixture and conducting chemometric analysis. The spectroscopic data are compared with predefined reference values to assess their utility for transfusion to patients with AML and ALL.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Thomas M. Raffay, Juliann M. Di Fiore, Zhengyi Chen, Angel Sanchez-Illana, Maximo Vento, Jose David Pineiro-Ramos, Julia Kuligowski, Richard J. Martin, Curtis Tatsuoka, Nori M. Minich, Peter M. MacFarlane, Anna Maria Hibbs
Summary: Intermittent hypoxemia (IH) events in preterm neonates are associated with oxidative stress and damage to lipids, proteins, and DNA. This study explores the relationship between IH parameters and oxidative stress biomarkers in urine samples. The findings suggest that these biomarkers may be useful in identifying high-risk neonates.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Peter Mathew MacFarlane, Richard John Martin, Juliann Marie Di Fiore, Thomas Michael Raffay, Curtis Tatsuoka, Zhengyi Chen, Nori Minich, Guillermo Quintas, Angel Sanchez-Illana, Julia Kuligowski, Jose David Pineiro-Ramos, Maximo Vento, Anna Maria Hibbs
Summary: This study investigated the relationship between neurotransmitter plasma levels and hypoxemia parameters in preterm neonates. The results showed that plasma levels of serotonin and kynurenic acid may serve as biomarkers for hypoxemia in preterm neonates. This research helps identify newborns at risk of short- and long-term adverse outcomes.
PEDIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Emilie Rugemalira, Irmeli Roine, Julia Kuligowski, Angel Sanchez-Illana, Jose David Pineiro-Ramos, Sture Andersson, Manuel Leite Cruzeiro, Maximo Vento, Tuula Pelkonen
Summary: We investigated the association between cerebrospinal fluid (CSF) biomarkers indicating oxidative damage to proteins and the course of illness and outcome in childhood bacterial meningitis (BM) in Angola. We found that children with a lower o-Tyr/Phe ratio in their CSF upon admission were more likely to experience focal convulsions and secondary fever during recovery and have a suboptimal outcome at Day 7 and one month after discharge. The most common sequelae observed in these children were ataxia. This suggests that a higher admission CSF o-Tyr/Phe ratio is associated with a better course and outcome in pediatric BM.
Article
Chemistry, Analytical
Ivan Rienda, Erika Moro, Alvaro Perez-Rubio, Ramon Trullenque-Juan, David Perez-Guaita, Bernhard Lendl, Julia Kuligowski, Jose V. Castell, Judith Perez-Rojas, Eugenia Pareja, Guillermo Quintas
Summary: Near-infrared and attenuated total reflectance-Fourier transform mid-infrared spectroscopy can be used for real-time quantitative assessment of liver steatosis, playing a crucial role in the success of liver transplantation surgery.
Article
Pediatrics
Alvaro Solaz-Garcia, Angel Sanchez-Illana, Inmaculada Lara-Canton, Raimunda Montejano-Lozoya, Ana Gimeno-Navarro, Alejandro Pinilla-Gonzalez, Laura Torrejon-Rodriguez, Maximo Vento, Pilar Saenz-Gonzalez
Summary: This study aimed to investigate the effect of kangaroo care on cerebral fractional tissue oxygen extraction (FtOE) in premature infants and compare the stability of cardiorespiratory parameters and the occurrence of hypoxic or bradycardic events between kangaroo care and incubator care. The results showed that during kangaroo care, cerebral metabolic demand was lower and cerebral oxygenation was higher compared to post-kangaroo care period, indicating the advantage of kangaroo care in promoting cerebral oxygenation and reducing metabolic demand in premature infants.
Article
Chemistry, Analytical
D. Gallart-Mateu, A. Gallardo, S. Garrigues, M. de la Guardia
Summary: A methodology based on ultrasound-assisted extraction with ethanol and DF-ATR-FTIR measurement was developed for fast evaluation of non-conventional solid-sized cocaine samples. The method provides quantitative results in less than three minutes with a low limit of detection of 1.6 μg/g. The greenness of the proposed procedure was evaluated using analytical ecoscale, GAPI, and AGREE.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Zack Richardson, Adele Kincses, Elif Ekinci, David Perez-Guaita, Karin Jandeleit-Dahm, Bayden R. Wood
Summary: In this study, a method combining ultracentrifugation, infrared spectroscopy, and machine learning was developed to accurately quantify low level microalbuminuria in urine samples. The results showed high sensitivity and specificity in discriminating between normal and micro/macroalbuminuric samples, and regression analysis provided quantification of albumin concentration. This approach is cost-effective, quick, and portable, making it a valuable tool for early screening of diabetic kidney disease.
ANALYSIS & SENSING
(2023)
Article
Chemistry, Analytical
Michel Rocha Baqueta, Augusto Cesar Costa-Santos, Ana Paula Rebellato, Gisele Marcondes Luz, Juliana Azevedo Lima Pallone, Federico Marini, Alexsandro Lara Teixeira, Douglas N. Rutledge, Patricia Valderrama
Summary: This study reports the essential element composition of new Brazilian Canephora coffees and applies chemometric tools for analysis. The results demonstrate the suitability of this method for origin and species discrimination based on the inorganic fraction of coffee.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mengjie Li, Jiapeng Wang, You Zhou, Yang Chen, Lingying Xia
Summary: A novel photoelectrochemical biosensor based on gold nanoparticles and specific structures was developed for highly sensitive detection of mercury ion. The multiple sandwich structures hindered electron supply and light harvesting, resulting in a weakened PEC signal, while the specific structures extinguished the PEC signal, enabling quantitative detection of Hg2+. The sensor exhibited high selectivity and stability, with potential applications in environmental detection, biological analysis, and medical research.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mohamed A. Korany, Rasha M. Youssef, Marwa A. A. Ragab, Mostafa A. Afify
Summary: A stability-indicating fit-for-purpose method was developed for the determination of HC, TL, and PS in syrup dosage form. The method successfully separated CL from THY and quantified the analytes using HPLC-DAD. The robustness of the method was assessed through statistical analysis and self-validation.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Lingling Lin, Minyu Li, Ping Li, Chenqing Ye, Huanglong Zhuang, Shaohuang Weng, Feng Chen
Summary: This study developed a highly sensitive and selective electrochemical sensor for simultaneous detection of dopamine and uric acid. The sensor exhibited excellent anti-interference and stability, and could accurately measure dopamine and uric acid in human urine samples.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma
Summary: In this study, a high-performance SERS-active aptasensor was successfully developed for the quantitative analysis of AFB1 in cereal grains, which is of great significance in the field of food safety.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
E. Abas, C. Marina-Montes, C. Perez-Marin, J. Puimedon, J. Anzano
Summary: This study conducted a comprehensive measurement of natural and anthropogenic radionuclides in soil, water, and air in different locations around Deception Island in Antarctica. The results revealed significant levels of 210Pb and anthropogenic 137Cs in soil samples near old human settlements and facilities, as well as detectable levels of 137Cs and 60Co in water samples from old hunting areas. The findings also suggested potential resuspension processes based on higher-than-expected air quality results.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Joao Franciso Allochio, Nayara A. dos Santos, Nathalia dos S. Conceicao, Clara S. D. Baptista, Keyller B. Borges, Valdemar Lacerda Jr, Wanderson Roma
Summary: This study developed a fiber spray ionization mass spectrometry (FSI-MS) method, which shows great potential in detecting illicit drugs. Compared with paper spray ionization mass spectrometry (PSI-MS), FSI-MS demonstrates higher sensitivity in COC detection.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Dina A. Ahmed, Ola G. Hussein, Mamdouh R. Rezk, Mohamed Abdelkawy, Yasmin Rostom
Summary: The main goal of this study was to develop two green chromatographic techniques, HPLC and TLC, for the determination of alcaftadine (ALF) in pharmaceutical formulation and biological samples. The developed HPLC technique showed high efficiency and minimal environmental impact, successfully identifying ALF in the presence of its degradate. The TLC method provided a stability indicating study for ALF and was determined to be safe, green, and eco-friendly.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Abdullah Taner Bisgin
Summary: A green, speedy, and handy method for separation and determination of four commonly used food colorants was established using vortex assisted sequential-simultaneous liquid phase micro-extraction (VA-SS-LPME). The method does not require any instrumental chromatographic techniques. The procedure includes sequential separation steps using different extractants and simultaneous UV-vis spectrophotometric determination steps. The method is environmentally friendly and applicable for determination of colorants in food and pharmaceuticals.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Yifan Zhang, Tong Zhang, Wenjing Ba, Li Liu, Yuan Rao, Xiaodan Zhang, Hanhan Zhang, Xiu Jin
Summary: This paper proposes a novel spectral transfer modelling method based on neural network architecture searching for the asymptomatic prediction of Akizuki pear cork spot disorder. The experiments show that the model by this method is more effective, achieving an accuracy of 82.61%.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Krzysztof Greda, Maja Welna, Anna Szymczycha-Madeja, Pawel Pohl
Summary: For the first time, a dispersive micro-solid phase extraction (D-mu SPE) based on graphene oxide was used for the ultrasensitive determination of Cd. With this method, Cd can be efficiently extracted from a mixture of alkali and alkaline earth metals without the need for an elution step. The combination of D-mu SPE and SAGD OES significantly reduces matrix effects and improves the tolerance of Cd to alkali metals. The method shows simplicity in the measurement system and the commercially available nanosorbent used.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
P. K. Fathima Anjila, G. R. Tharani, Anand Sundaramoorthy, Venkat Kumar Shanmugam, Karthikeyan Subramani, Shanmugavel Chinnathambi, Ganesh N. Pandian, Vimala Raghavan, Andrews Nirmala Grace, Singaravelu Ganesan, Mangaiyarkarasi Rajendiran
Summary: This work proposes a rapid and sensitive spectroscopic method for detecting melamine in food products using rare-earth Terbium-doped Graphene Quantum Dots (Tb-GQDs) synthesized by microwave and simple chemical conjugation methods. The synthesized Tb-GQDs show a spherical shape with a size of approximately 6 nm and a quantum yield of 52%. The maximum detection limit for melamine concentration in milk and milk products is found to be 0.31 μM. The dual emitting Tb-GQDs provide a sensitive and effective platform for real-time detection of melamine in food samples, particularly in milk, and show promising potential in the food industry.
MICROCHEMICAL JOURNAL
(2024)
Review
Chemistry, Analytical
Piyush Dey, Mandeep Kaur, Akhil Khajuria, Dilmeet Kaur, Manpreet Singh, Hema Kumari Alajangi, Neha Singla, Gurpal Singh, Ravi Pratap Barnwal
Summary: Environmental issues, such as the uncontrolled release of dangerous pollutants, have significant impacts on human health. Traditional methods for detecting pollutants require specialized personnel and equipment, but nanotechnology has improved the performance of biosensors. This article discusses the use of nanotechnology in pollutant detection and the associated techniques.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Sa Dong, Qiuyun Shi, Lingjun Guan, Yulong Wang, Pengyan Liu, Cunzheng Zhang, Jianguo Feng
Summary: In this study, a highly sensitive indirect competitive chemiluminescence enzyme immunoassay (icCLEIA) method was developed for the determination of sodium pentachlorophenolate (PCP-Na) and its metabolite pentachlorophenol (PCP). The method showed high specificity and affinity with a detection limit of 0.0032 ng/mL for PCP-Na and 0.0192 ng/mL for PCP. The method had no cross reaction with other chlorophenols compounds except for PCP. The average recoveries in chicken, pork and fish samples were 81.3-105.8% with low coefficient of variation (CV).
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Palaniappan Ilayaraja, Murugan Manivannan, Paramasivam Parthiban
Summary: Nirmatrelvir, an antiviral drug used for the treatment of COVID-19, has been recommended by the World Health Organization. We developed an optimized analytical method for the quantification of Nirmatrelvir and its products, with high sensitivity and a wide linear range. The method also meets the requirements for greenness evaluation.
MICROCHEMICAL JOURNAL
(2024)