Experimental evolution can unravel the complex causes of natural selection in clinical infections

Divergent, CoexistingPseudomonas aeruginosaLineages in Chronic Cystic Fibrosis Lung Infections

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Coevolution with Bacteriophages Drives Genome-Wide Host Evolution and Constrains the Acquisition of Abiotic-Beneficial Mutations

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Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system

(2015) Tiffany B. Taylor et al.   SCIENCE

Development of anEx VivoPorcine Lung Model for Studying Growth, Virulence, and Signaling of Pseudomonas aeruginosa

(2014) Freya Harrison et al.   INFECTION AND IMMUNITY

Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

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Loss of Social Behaviours in Populations of Pseudomonas aeruginosa Infecting Lungs of Patients with Cystic Fibrosis

(2014) Natalie Jiricny et al.   PLoS One

Running with the Red Queen: the role of biotic conflicts in evolution

(2014) M. A. Brockhurst et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs

(2014) Joanne L. Fothergill et al.   Nature Communications

Sub-inhibitory concentrations of some antibiotics can drive diversification of Pseudomonas aeruginosa populations in artificial sputum medium

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Evolution of Staphylococcus aureus during human colonization and infection

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Extensive diversification is a common feature of Pseudomonas aeruginosa populations during respiratory infections in cystic fibrosis

(2013) Abdul Ashish et al.   Journal of Cystic Fibrosis

Genome dynamics during experimental evolution

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Phenotypic Heterogeneity of Pseudomonas aeruginosa Populations in a Cystic Fibrosis Patient

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Clonal Dissemination, Emergence of Mutator Lineages and Antibiotic Resistance Evolution in Pseudomonas aeruginosa Cystic Fibrosis Chronic Lung Infection

(2013) Carla López-Causapé et al.   PLoS One

Experimental coevolution of species interactions

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Therapeutic antimicrobial peptides may compromise natural immunity

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Transmissible strains ofPseudomonas aeruginosain cystic fibrosis lung infections

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Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

(2012) Anders Folkesson et al.   NATURE REVIEWS MICROBIOLOGY

Basic science for the chest physician:Pseudomonas aeruginosaand the cystic fibrosis airway: Figure 1

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Genomics of Adaptation during Experimental Evolution of the Opportunistic Pathogen Pseudomonas aeruginosa

(2012) Alex Wong et al.   PLoS Genetics

Pseudomonas aeruginosaPopulation Diversity and Turnover in Cystic Fibrosis Chronic Infections

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PmrB Mutations Promote Polymyxin Resistance of Pseudomonas aeruginosa Isolated from Colistin-Treated Cystic Fibrosis Patients

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Coevolving parasites enhance the diversity-decreasing effect of dispersal

(2011) T. Vogwill et al.   Biology Letters

Antagonistic coevolution limits population persistence of a virus in a thermally deteriorating environment

(2011) Quan-Guo Zhang et al.   ECOLOGY LETTERS

Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection

(2011) Susse Kirkelund Hansen et al.   ISME Journal

Evolutionary dynamics of bacteria in a human host environment

(2011) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antagonistic coevolution accelerates molecular evolution

(2010) Steve Paterson et al.   NATURE

Fluctuations in phenotypes and genotypes within populations of Pseudomonas aeruginosa in the cystic fibrosis lung during pulmonary exacerbations

(2009) J. L. Fothergill et al.   JOURNAL OF MEDICAL MICROBIOLOGY

The Beagle in a bottle

(2009) Angus Buckling et al.   NATURE

Genome evolution and adaptation in a long-term experiment with Escherichia coli

(2009) Jeffrey E. Barrick et al.   NATURE

Resource supply and the evolution of public-goods cooperation in bacteria

(2008) Michael A Brockhurst et al.   BMC BIOLOGY

Genetic Adaptation of Pseudomonas aeruginosa to the Airways of Cystic Fibrosis Patients Is Catalyzed by Hypermutation

(2008) A. Mena et al.   JOURNAL OF BACTERIOLOGY

Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression

(2008) Lucas R. Hoffman et al.   Journal of Cystic Fibrosis