Polymorphisms in the Genes Related to Angiogenesis Are Associated With Uterine Cervical Cancerf

Introduction: The expression of plasminogen activator inhibitor type 1 (PAI-1), vascular endothelial growth factor (VEGF), and transforming growth factor beta 1 (TGF-beta 1) participates in the angiogenesis of several cancer types. The goal of this study was to investigate polymorphisms in genes related to angiogenesis (PAI-1-675 4G/5G, VEGF C936T, and TGF-beta 1 G-800A) to evaluate the risk for developing uterine cervical cancer (UCC). Methods: In a case-control study, 100 healthy subjects and 100 patients with UCC from Mexico were included. We determined the genetic profile of the polymorphic markers, which were evaluated by polymerase chain reaction using a sequence-specific primer. Results: There was no statistical difference in the allele distribution from the intergroup comparisons of PAI-1 675 4G/5G and VEGF C936T data; however, a significant difference was observed within TGF-beta 1 G-800A. The linkage disequilibrium analysis revealed that PAI-1 -675 4G and TGF-beta 1 -800A pair-haplotype was in strong linkage disequilibrium with a significantly increased risk (odds ratio, 3.44; 95% confidence interval, 1.66-7.25) to UCC. Conclusions: The polymorphisms in the genes related to angiogenesis -675 4G/5G PAI-1 and G-800A TGF-beta 1, segregated solely or combined, might contribute to the increased susceptibility to UCC in a Mexican population.