Article
Plant Sciences
Ge Wang, Lu Li, Yan Li, Li-Hong Zhang
Summary: This study aimed to investigate the effects of toosendanin (TSN) on cisplatin (DDP) resistance in ovarian cancer (OC) and explore the underlying molecular mechanism. The results showed that TSN could reduce the DDP resistance in OC by modulating the miR-195/ERK/beta-catenin pathway, suggesting its potential as an effective agent to overcome clinical DDP resistance in OC.
Article
Oncology
Yunting Jian, Lingzhi Kong, Hongyi Xu, Yawei Shi, Xinjian Huang, Wenjing Zhong, Shumei Huang, Yue Li, Dongni Shi, Yunyun Xiao, Muwen Yang, Siqi Li, Xiangfu Chen, Ying Ouyang, Yameng Hu, Xin Chen, Libing Song, Runyi Ye, Weidong Wei
Summary: PPP1R14C is upregulated in TNBC and associated with poor prognosis. Overexpression of PPP1R14C promotes cell proliferation and the aggressive phenotype in TNBC cells, while depletion of PPP1R14C has the opposite effect. Additionally, phosphorylated PPP1R14C inhibits the phosphorylation of GSK3β and recruits E3 ligase TRIM25 for ubiquitylation and degradation of non-phosphorylated GSK3β.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Karolina Liska, Tereza Dockal, Pavel Houdek, Martin Sladek, Vendula Luzna, Kateryna Semenovykh, Milica Drapsin, Alena Sumova
Summary: Lithium affects the circadian clock in the ventricle barrier complex, and its therapeutic effects may be related to improving brain function in psychiatric patients. The study suggests that personalized timing of lithium treatment is important for bipolar disorder patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Chia-Lung Tsai, Shih-Ming Jung, Lang-Ming Chi, Chi-Neu Tsai, Chiao-Yun Lin, Angel Chao, Yun-Shien Lee
Summary: This study demonstrated that GSK3β forms a complex with ETS1 and promotes the stability of ETS1 and induces the transcriptional activation of MMP-9 and cell migration through phosphorylation at threonine 265 and serine 269. The GSK3β/ETS1/MMP-9 axis may regulate the biological aggressiveness of ovarian cancer and serve as a prognostic factor in patients with this malignancy.
Article
Pharmacology & Pharmacy
Zhe Wang, Yating Cheng, Ye Lu, Guoqiang Sun, Lin Pei
Summary: This study demonstrates that baicalin promotes the proliferation and development of PC-12 cells by regulating the GSK3 beta pathway, thus reversing the depressive-like pathological changes induced by corticosterone. The effect is enhanced when baicalin is coadministered with lithium chloride.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Medicine, Research & Experimental
Kohji Sato
Summary: Bipolar disorder is characterized by swings between depression and mania in patients, with lithium being a common treatment that stabilizes mood through inhibiting the activity of GSK3β kinase. The levels of GSK3β activity directly influence neuronal excitability, resulting in mood swings seen in individuals with BD.
MEDICAL HYPOTHESES
(2021)
Article
Cell Biology
Yongrong Yan, Peipei Zhao, Zihuan Wang, Zhen Liu, Zhizhi Wang, Jinglan Zhang, Yanqing Ding, Xing Hua, Lina Yu
Summary: PRMT5 is highly expressed in colorectal cancer and controls the proliferation, cell cycle progression, and EMT of CRC cells by regulating the EGFR/Akt/GSK3 beta signaling cascades.
Article
Oncology
Brittany A. Borden, Yasmine Baca, Joanne Xiu, Fabio Tavora, Ira Winer, Benjamin A. Weinberg, Ari M. Vanderwalde, Sourat Darabi, W. Michael Korn, Andrew P. Mazar, Francis J. Giles, Lorin Crawford, Howard Safran, Wafik S. El-Deiry, Benedito A. Carneiro
Summary: The study analyzed GSK-3β alterations in tumors, finding that most mutations occurred in the kinase domain, with uterine endometrioid carcinoma having the highest mutation rate. Moreover, tumors with GSK-3β mutations displayed a microenvironment with increased B cell infiltration and were associated with increased PD-L1 expression in certain tissues.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Oncology
Jesse J. Lipp, Limei Wang, Haitang Yang, Feng Yao, Nathalie Harrer, Stefan Muller, Sabina Berezowska, Patrick Dorn, Thomas M. Marti, Ralph A. Schmid, Belazs Hegedus, Abdallah Souabni, Sebastian Carotta, Mark A. Pearson, Wolfgang Sommergruber, Greg J. Kocher, Sean R. R. Hall
Summary: This study investigates the effect of PD1 expression on the functional and molecular profiles of tumor-resident T cells in non-small cell lung cancer patients. They find that PD1+ CD8+ T cells have elevated expression of the transcriptional regulator ID3 and that knocking down ID3 improves the cytotoxic potential of these cells. Additionally, PD1+ CD4+ memory T cells can facilitate B cell activation and expansion. Restoring WNT signaling by blocking GSK3 beta improves the effector function of PD1+ CD8+ T cells.
Article
Multidisciplinary Sciences
Yanlin Chen, Liping Yang, Yilu Qin, Shuiqing Liu, Yina Qiao, Xueying Wan, Huan Zeng, Xiaoli Tang, Manran Liu, Yixuan Hou
Summary: The study revealed that the cellular localization of JUP in gastric cancer is closely related to tumor progression and invasion, with a loss of membrane and/or cytoplasmic JUP exacerbating the malignancy, while the nuclear function of JUP in cooperation with B-catenin promotes gastric cancer cell invasion.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yurie Fukiyama, Takahisa Hirokawa, Shinji Takai, Teruyo Kida, Hidehiro Oku
Summary: Tauopathy is associated with the death of retinal ganglion cells. Inhibiting GSK3 beta can reduce phosphorylated tau levels and preserve the number of RGCs.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemical Research Methods
Li Gao, Ying Lu, Hai-Ning Chen, Zhigui Li, Meng Hu, Rou Zhang, Xiuxuan Wang, Zhiqiang Xu, Yanqiu Gong, Rui Wang, Dan Du, Shan Hai, Shuangqing Li, Dan Su, Yuan Li, Heng Xu, Zong-Guang Zhou, Lunzhi Dai
Summary: This study found that the expression of GSK3 alpha, but not GSK30, was significantly correlated with the overall survival of colon cancer patients. Through analysis of its phosphorylation substrates and protein interactions, specific functions of GSK3 alpha in colon cancer were revealed, suggesting it as a potential therapeutic target.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Article
Pharmacology & Pharmacy
Young Yun Jung, Jae-Young Um, Arunachalam Chinnathambi, Chandramohan Govindasamy, Acharan S. Narula, Ojas A. Namjoshi, Bruce E. Blough, Gautam Sethi, Kwang Seok Ahn
Summary: This study investigated the effects of Withaferin A (WFA) on apoptosis and autophagy in human colorectal cancer cells. The results showed that WFA could induce cell cycle arrest, increase apoptotic cell death, and activate autophagy. The WFA-induced effects on apoptosis and autophagy were mediated through the modulation of the beta-catenin pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Pengfei Zhang, Weiwei Tao, Cai Lu, Lu Fan, Qihang Jiang, Chengbin Yang, Erxin Shang, Haibo Cheng, Chuntao Che, Jinao Duan, Ming Zhao
Summary: Bruceine A exhibits strong anti-tumor activity against human pancreatic cancer cells in vitro and in vivo by targeting PFKFB4 and its downstream target GSK3 beta to inhibit glycolysis, thereby inducing cell growth inhibition and apoptosis. This suggests that bruceine A may serve as a potent agent for treating human pancreatic cancer.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Yan Zhou, Leping Yang, Li Xiong, Kunpeng Wang, Xuyang Hou, Qinglong Li, Fanhua Kong, Xi Liu, Jun He
Summary: Colorectal cancer is a common cancer of the digestive tract, often treated with chemotherapy drugs like oxaliplatin. KIF11, a key protein in cell division, is overexpressed in CRC tissues and its knockdown leads to tumor growth arrest and increased sensitivity to oxaliplatin. This suggests KIF11 could potentially serve as an oncogene and biomarker for assessing chemotherapy sensitivity in CRC.
Meeting Abstract
Oncology
L. M. Kuroki, M. M. Mullen, L. S. Massad, N. Wu, J. Liu, M. A. Powell, D. G. Mutch, A. R. Hagemann, P. H. Thaker, C. K. McCourt, A. P. Novetsky
GYNECOLOGIC ONCOLOGY
(2017)
Meeting Abstract
Oncology
N. S. Nevadunsky, C. Zanartu, P. Pinto, R. Barrera, A. R. Van Arsdale, Y. S. Kuo, B. D. Rapkin, A. P. Novetsky, G. L. Goldberg, S. Eti
GYNECOLOGIC ONCOLOGY
(2017)
Meeting Abstract
Oncology
G. M. Gressel, S. M. Dioun, M. Richley, A. R. Van Arsdale, S. Isani, N. S. Nevadunsky, D. Smotkin, H. O. Smith, D. Y. S. Kuo, A. P. Novetsky
GYNECOLOGIC ONCOLOGY
(2018)
Meeting Abstract
Oncology
L. B. Turker, S. M. Dioun, G. M. Gressel, A. P. Novetsky, D. Y. S. Kuo, N. S. Nevadunsky
GYNECOLOGIC ONCOLOGY
(2018)
Article
Oncology
Eirwen M. Miller, Joan Tymon-Rosario, Jaya Sunkara, Bryan E. Harmon, Rouzan G. Karabakhtsian, Akiva P. Novetsky
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2018)
Article
Oncology
Gregory M. Gressel, Shayan M. Dioun, Michael Richley, David W. Lounsbury, Bruce D. Rapkin, Sara Isani, Nicole S. Nevadunsky, D. Y. S. Kuo, Akiva P. Novetsky
GYNECOLOGIC ONCOLOGY
(2019)
Article
Oncology
Mary M. Mullen, Bree P. Porcelli, James Cripe, L. Stewart Massad, Lindsay M. Kuroki, Akiva P. Novetsky, Leping Wan, Matthew A. Powell, David G. Mutch, Premal H. Thaker
GYNECOLOGIC ONCOLOGY
(2020)
Article
Oncology
Zhiyun Xue, Akiva P. Novetsky, Mark H. Einstein, Jenna Z. Marcus, Brian Befano, Peng Guo, Maria Demarco, Nicolas Wentzensen, Leonard Rodney Long, Mark Schiffman, Sameer Antani
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Kanan T. Desai, Kayode O. Ajenifuja, Adekunbiola Banjo, Clement A. Adepiti, Akiva Novetsky, Cathy Sebag, Mark H. Einstein, Temitope Oyinloye, Tamara R. Litwin, Matt Horning, Fatai Olatunde Olanrewaju, Mufutau Muphy Oripelaye, Esther Afolabi, Oluwole O. Odujoko, Philip E. Castle, Sameer Antani, Ben Wilson, Liming Hu, Courosh Mehanian, Maria Demarco, Julia C. Gage, Zhiyun Xue, Leonard R. Long, Li Cheung, Didem Egemen, Nicolas Wentzensen, Mark Schiffman
INFECTIOUS AGENTS AND CANCER
(2020)
Review
Oncology
D. Teoh, E. K. Hill, W. Goldsberry, L. Levine, A. Novetsky, L. Downs
GYNECOLOGIC ONCOLOGY
(2021)
Editorial Material
Oncology
Ana Ribeiro, Flavia Correa, Arn Migowski, Aline Leal, Sandro Martins, Taina Raiol, Carla P. Marques, Katia L. Torres, Akiva P. Novetsky, Jenna Z. Marcus, Nicolas Wentzensen, Mark Schiffman, Ana Cecilia Rodriguez, Julia C. Gage
Summary: Brazil's Unified Health System offers free cervical cancer screening services, but disparities in healthcare networks across the country lead to large differences in cervical cancer incidence and mortality rates. An effective screening program requires multiple strategies tailored to each community's needs, to improve coverage and follow-up adherence.
CANCER PREVENTION RESEARCH
(2021)
Article
Microbiology
Kanan T. Desai, Karla Alfaro, Laura Mendoza, Matthew Faron, Brian Mesich, Mauricio Maza, Rhina Dominguez, Adriana Valenzuela, Chyntia Diaz Acosta, Magaly Martinez, Juan C. Felix, Rachel Masch, Jennifer S. Smith, Sofia Gabrilovich, Tracy Wu, Michael Plump, Akiva P. Novetsky, Mark H. Einstein, Nataki C. Douglas, Miriam Cremer, Nicolas Wentzensen
Summary: Two isothermal amplification-based tests, Atila iAMP test and OptiGene direct plus RT-LAMP test, were compared with clinical RT-PCR assays. Atila iAMP test showed higher sensitivity and specificity for SARS-CoV-2 detection compared to OptiGene test across different sampling strategies. Sensitivity varied based on sampling site, with midturbinate sampling showing the highest sensitivity.
MICROBIOLOGY SPECTRUM
(2021)
Article
Oncology
Rebecca Perkins, Jose Jeronimo, Anne Hammer, Akiva Novetsky, Richard Guido, Marta del Pino, Jaqueline Louwers, Jenna Marcus, Ceres Resende, Katie Smith, Didem Egemen, Brian Befano, Debi Smith, Sameer Antani, Silvia de Sanjose, Mark Schiffman
Summary: This study compared the accuracy and reproducibility of colposcopic impression based on single images versus a time-series of sequential images. The results showed substantial variation in single image assessment, with the use of time-series improving classification but fair inter-rater reliability.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
David Samuel, Gregory M. Gressel, Sara Isani, Akiva P. Novetsky, Nicole S. Nevadunsky
GYNECOLOGIC ONCOLOGY REPORTS
(2018)
Article
Obstetrics & Gynecology
Dhanalakshmi Thiyagarajan, Michael Hughes, Frank Tamarkin, Israel Zighelboim
GYNECOLOGIC ONCOLOGY REPORTS
(2018)