Article
Pathology
Emanuela D'Angelo, Inigo Espinosa, Valentina Cipriani, Justyna Szafranska, Mattia Barbareschi, Jaime Prat
Summary: This study highlights the significance of nuclear atypia in predicting the risk of detecting carcinoma during hysterectomy, with high reproducibility within and between observers for the diagnosis of low-grade and high-grade AEH. Most cases of AEH exhibit low-grade nuclear atypia.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Review
Oncology
W. Glenn McCluggage, Tjalling Bosse, C. Blake Gilks, Brooke E. Howitt, Jessica N. McAlpine, Marisa R. Nucci, Joseph T. Rabban, Naveena Singh, Karen L. Talia, Carlos Parra-Herran
Summary: An updated FIGO staging system for endometrial carcinoma was introduced in June 2023, incorporating non-anatomical parameters to make staging more personalized and relevant. The authors propose a global evaluation to understand the impact, scope, and supporting evidence of the proposed changes.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Dimitrios Nasioudis, Maureen Byrne, Emily M. Ko, Robert L. Giuntoli, Ashley F. Haggerty, Lori Cory, Sarah H. Kim, Mark A. Morgan, Nawar A. Latif
Summary: The study found that performing SLNBx on patients with endometrioid endometrial carcinoma did not have a negative impact on survival rates. After controlling for confounders, SLNBx showed similar survival outcomes compared to systematic lymphadenectomy. This research provides a minimally invasive option for treating these patients.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Jonathan S. Berek, Xavier Matias-Guiu, Carien Creutzberg, Christina Fotopoulou, David Gaffney, Sean Kehoe, Kristina Lindemann, David Mutch, Endometrial Canc Staging Subcomm, FIGO Womens Canc Comm
Summary: Since the 2009 update of the FIGO staging system, there have been significant advances in understanding the pathologic and molecular features of endometrial cancer. The new staging system aims to better define prognostic groups and create substages to guide more appropriate treatment.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Jonathan Berek, Xavier Matias-Guiu, Carien Creutzberg, Christina Fotopoulou, David Gaffney, Sean Kehoe, Kristina Lindemann, David Mutch, Nicole Concin, Endometrial Canc Staging Subcomm, FIGO Womens Canc Comm
Summary: Since the last update of the FIGO staging system in 2009, significant advancements have been made in understanding the pathology and molecular features of endometrial cancer. The new staging system aims to better define prognostic groups and create substages that guide appropriate treatment options. The proposed system incorporates data from molecular and histological classifications, providing a more comprehensive understanding of the complex nature of endometrial carcinoma and its biological behavior.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Medicine, General & Internal
Seong Eun Bak, Ji Geun Yoo, Sung Jong Lee, Joo Hee Yoon, Dong Choon Park, Sang Il Kim
Summary: This study investigates the risk factors for recurrence in patients with low-risk endometrial cancer and identifies histological grade as an independent risk factor.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Pathology
Marie Boennelycke, Elke E. M. Peters, Alicia Leon-Castillo, Vincent T. H. B. M. Smit, Tjalling Bosse, Ib Jarle Christensen, Gitte Ortoft, Claus Hogdall, Estrid Hogdall
Summary: This study aimed to investigate the outcome of histological subtype review of high-grade endometrial carcinoma (EC) and its prognostic impact in a large Danish cohort. The results showed a substantial shift in histological subtype in high-grade EC after pathology review, with GR3 EEC demonstrating a stronger prognostic benefit compared to other subtypes upon revision. This study supports the importance of maintaining a low threshold for pathology revision of high-grade EC in clinical practice.
Article
Oncology
Mingjun Zheng, Yuexin Hu, Rui Gou, Siting Li, Xin Nie, Xiao Li, Bei Lin
Summary: A seven-gene prognostic stratification system based on tumor microenvironment has been developed to predict the prognosis of high-risk endometrial cancer patients and guide more effective immunotherapy strategies. Subgroups with low Riskscore showed better prognosis and immune cell infiltration, while subgroups with high Riskscore exhibited progressive disease.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Oncology
Dimitrios Nasioudis, Spyridon A. Mastroyannis, Emily M. Ko, Ashley F. Haggerty, Lori Cory, Robert L. Giuntoli, Sarah H. Kim, Nawar A. Latif
Summary: This study found that ovarian preservation is rarely performed for patients with stage I grade 2 and 3 endometrioid endometrial carcinoma undergoing hysterectomy, however, it does not have a significant negative effect on overall survival.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Obstetrics & Gynecology
Zhifang Zhang, Jing Wang, Xiaomei Wu, Yuan Liu, Xiaowei Xi
Summary: The aim of this study was to summarize the clinical characteristics and analyze the independent prognostic factors in patients with high-grade endometrial neuroendocrine carcinoma (ENC). The results showed that ENC had the poorest prognosis, and surgical treatment and chemotherapy were necessary for improving prognosis. Early diagnosis favored better prognosis.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Biology
Jiaoqi Wu, Xiaozhu Zhou, Jie Ren, Zhen Zhang, Haoyu Ju, Xiaoqi Diao, Shuyi Jiang, Jing Zhang
Summary: This study predicted the relationship between the expression of glycosyltransferase-related genes (GTs) and the diagnosis and prognosis of uterine corpus endometrial carcinoma (UCEC) using bioinformatics methods. Diagnostic and prognostic models were established based on the validated biomarkers, providing valuable tools for individualized and precision medicine in UCEC. The risk score was also found to be closely related to immune microenvironment, immune infiltration, mutation, immunotherapy, and chemotherapy.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mingli Zhao, Feng Wen, Jiaxin Shi, Jing Song, Jiaqi Zhao, Qingling Song, Qingyuan Lai, Yahong Luo, Tao Yu, Xiran Jiang, Wenyan Jiang, Yue Dong
Summary: A nomogram based on MRI radiomics and clinical imaging indicators can improve the diagnosis of deep myometrial invasion (DMI) in patients with FIGO stage I endometrial carcinoma (EC).
Article
Pathology
Amy Joehlin-Price, Jessica Van Ziffle, Nancy K. Hills, Nicholas Ladwig, Joseph T. Rabban, Karuna Garg
Summary: This study evaluated the prognostic impact of molecular classification on FIGO grade 3 endometrioid endometrial carcinoma, using POLE mutation analysis and immunohistochemistry. The POLE mutation group and multiple classifier group showed excellent clinical outcomes, while the p53-ab group showed the worst clinical outcomes. Overall, there was no correlation between molecular grouping and tumor immunophenotypic findings.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Oncology
Colton Ladbury, Richard Li, Jay Shiao, Jason Liu, Mihaela Cristea, Ernest Han, Thanh Dellinger, Stephen Lee, Edward Wang, Christine Fisher, Yi-Jen Chen, Arya Amini, Tyler Robin, Scott Glaser
Summary: The number of involved lymph nodes is a stronger prognostic and predictive factor compared to pelvic node involvement in endometrial cancer. The choice of adjuvant therapy can have an impact on the 3-year overall survival rate for patients with 1-3 involved lymph nodes and those with 6 or more involved lymph nodes.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Mayumi Kobayashi Kato, Hiroshi Yoshida, Yasuhito Tanase, Masaya Uno, Mitsuya Ishikawa, Tomoyasu Kato
Summary: The study found that the expression status of ARID1A is a prognostic factor for early-stage G3EEC patients without adjuvant therapy, while the expression status of p53 and MMR does not significantly impact survival outcomes. Therefore, ARID1A may become a useful biomarker for stratification of adjuvant treatment for early-stage G3EEC patients.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Meeting Abstract
Surgery
Ramesh B. Batchu, Aamer M. Qazi, Oksana V. Gruzdyn, Jaskiran Kaur, Ebrahem M. Mahmud, Donald W. Weaver, Scott A. Gruber
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2015)
Article
Pathology
Sudeshna Bandyopadhyay, Stephanie Barak, Kinda Hayek, Sumi Thomas, Haleema Saeed, Rafic Beydoun, Dongping Shi, Haitham Arabi, Julie Ruterbusch, Michele Cote, Rouba Ali-Fehmi
Article
Pathology
Haitham Arabi, Hatim Al-Maghraby, Arwa Yamani, Yasmin Yousef, Hassan Huwait
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2016)
Review
Oncology
Arif Malik, Misbah Sultana, Aamer Qazi, Mahmood Husain Qazi, Gulshan Parveen, Sulayman Waquar, Abdul Basit Ashraf, Mahmood Rasool
ANALYTICAL CELLULAR PATHOLOGY
(2016)
Letter
Surgery
Ramesh B. Batchu, Oksana V. Gruzdyn, Aamer M. Qazi, Ebrahem M. Mahmud, Gamal Mostafa, Donald W. Weaver, Scott A. Gruber
Article
Oncology
Mahmood Rasool, Arif Malik, Ahmad Ashar Ghuman, Muhammad Abdul Basit Ashraf, Mahwish Arooj, Sulayman Waquar, Sara Zahid, Sumera Shaheen, Aamer Qazi, Muhammad Imran Naseer, Mazin A. Zamzami, Ayat Al-Ghafari, Othman A. Baothman, Mustafa Zeyadi, Nawal Helmi, Hani Choudhry, Mohammad Sarwar Jamal, Mohammed Hussein Al-Qahtani
FRONTIERS IN ONCOLOGY
(2018)
Article
Medicine, General & Internal
Wedad Al-Madani, Anwar E. Ahmed, Haitham Arabi, Sumaiah Al Khodairy, Nashmia Al Mutairi, Abdul Rahman Jazieh
SAUDI MEDICAL JOURNAL
(2019)
Article
Biochemistry & Molecular Biology
Fatima Ali, Nadia Wajid, Maryam Ghulam Sarwar, Aamer Mahmood Qazi
Summary: The study found that oral administration of Aloe vera promotes early healing of excisional wounds in Sprague Dawley rats, with gradual improvement in wound areas and collagen content. Aloe vera also increased the expression of IGF-1 and VEGF in skin and bone marrow, indicating enhanced angiogenesis. RT-PCR analysis showed upregulation of genes related to chemotaxis in skin and bone marrow.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Pathology
Abdulmohsen Alkushi, Haitham Arabi, Lolwah Al-Riyees, Abdulelah M. Aldakheel, Raed Al Zarah, Faisal Alhussein, Abdullah Mohammed Altamimi, Yazeed Abdulsalam Alsulaiman, Ahmad Omair
Summary: Phyllodes tumors are rare breast tumors with variable biological behavior and heterogeneous clinicopathological findings. Young, premenopausal women with large tumors may have malignant phyllodes tumors with a risk of recurrence and metastasis. Core needle biopsy is reliable for diagnosis, with strict follow-up recommended for large tumors initially diagnosed as fibroadenoma. Surgical management should ensure tumor-free margins to reduce recurrence.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Amal Abdulwahab Alhaidary, Haitham Arabi, Manar Elessawy, Abdulmohsen Alkushi
Summary: Metaplastic breast carcinoma is a rare type of aggressive breast cancer with no definite characteristic imaging. It presents as a mass with irregular shape and indistinct margins, and rarely contains microcalcifications. Correlation with pathological findings is crucial for diagnosis and appropriate treatment.
EGYPTIAN JOURNAL OF RADIOLOGY AND NUCLEAR MEDICINE
(2022)
Article
Medicine, General & Internal
Shahd S. Almohsen, Hala Alnuaim, Alaa A. Salim, Haitham Arabi
Summary: Radiation-induced sarcomas (RIS) are a rare long-term complication of radiation therapy, often developing several years post-exposure, with common subtypes including undifferentiated pleomorphic sarcoma, angiosarcoma, and leiomyosarcoma. Breast cancer is the most common primary malignancy preceding RIS.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Latifa Almusalam, Nuorh Alghtani, Abdulmohsen Alkushi, Haitham Arabi
Article
Oncology
Abdulmohsen Alkushi, Ahmad Omair, Haitham Arabi, Emad Masuadi, Omalkhair Abualkhair
BREAST CANCER-BASIC AND CLINICAL RESEARCH
(2020)
Article
Medicine, General & Internal
Nadia Wajid, Muhammad Azam, Seemab Khalid, Fatima Ali, Aamer Qazi, M. H. Qazi
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2017)
Review
Nanoscience & Nanotechnology
Arif Malik, Tariq Tahir Butt, Sara Zahid, Fatima Zahid, Sulayman Waquar, Mahmood Rasool, Mahmood Husain Qazi, Aamer Mahmood Qazi
JOURNAL OF NANOTECHNOLOGY
(2017)