Article
Immunology
Haitao Hu, Ting Ma, Nanqi Liu, Hong Hong, Lujiao Yu, Dantong Lyu, Xin Meng, Biao Wang, Xuefeng Jiang
Summary: Vasculogenic mimicry (VM) is a vessel-like structure independent of endothelial cells, commonly found in solid tumors. It is closely associated with tumor proliferation, invasion, metastasis, and poor patient prognosis. Various factors, including immune cells, cytokines, and signaling molecules, have been reported to be involved in ovarian cancer progression and VM formation. This review discusses the mechanisms regulating VM formation in ovarian cancer, the impact of cells, cytokines, and signaling molecules in the tumor microenvironment on VM formation, and the current clinical application of drugs targeting VM formation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Maria Sol Recouvreux, Jiangyong Miao, Maricel C. Gozo, Jingni Wu, Ann E. Walts, Beth Y. Karlan, Sandra Orsulic
Summary: Tumors require a continuous supply of oxygen and nutrients for growth, and vasculogenic mimicry is a coping mechanism where cancer cells form vascular-like structures. FOXC2 gene expression is associated with vasculogenic mimicry and aggressive cancer behavior.
Article
Oncology
Ping Liu, Huiqiong Huang, Xiaorong Qi, Ce Bian, Meng Cheng, Lili Liu, Luqi Xue, Xia Zhao, Tao Yi, Yi Quan
Summary: The lncRNA-MIR210HG is induced by hypoxia in ovarian cancer, mainly located in the cytosol, and promotes cancer progression by inhibiting HIF-1 alpha degradation. Its upregulation is associated with tumor progression and poor prognosis in ovarian cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Nasim Kheshtchin, Jamshid Hadjati
Summary: Hypoxia, a common characteristic of solid tumors, contributes to different aspects of tumor progression and limits the efficacy of immunotherapies. Developing new immunotherapy strategies involving therapeutic targeting of HIF-1 molecules associated with hypoxia may enhance the clinical effectiveness of immunotherapy. Targeting hypoxia presents a potential opportunity to improve the clinical benefit of cancer immunotherapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cell Biology
Depanwita Saha, Debarpan Mitra, Neyaz Alam, Sagar Sen, Saunak Mitra Mustafi, Pradip K. Majumder, Biswanath Majumder, Nabendu Murmu
Summary: In this study, we found that the upregulation of HIF-1α induced by hypoxia led to enhanced extracellular matrix remodeling and EMT phenotypes, resulting in increased VM formation. Knockdown of HIF-1α disrupted the signaling cascade and inhibited VM formation. Additionally, the combination of Lupeol and Paclitaxel induced apoptosis and disrupted VM-associated phenotypes.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biology
Wenli Chen, Xing Cheng, Xiaobo Wang, Wenjie Hu, Jinshan Wang, Chuangxin Liao
Summary: Our study identified Cav-1 as an important regulator of glioma cell proliferation and VM formation, contributing to glioma development and progression. Cav-1 overexpression promoted U251 glioma cell proliferation and VM formation, while siCav-1 suppressed VM-associated factors such as HIF-1 alpha and p-Akt in U251 cells.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Oncology
Di Zeng, Peng Zhou, Rong Jiang, Xiao-Peng Li, Shi-Ying Huang, Dan-Yang Li, Guo-Li Li, Li-Sha Li, Shuang Zhao, Ling Hu, Jian-Hua Ran, Di-Long Chen, Ya-Ping Wang, Jing Li
Summary: The study demonstrated that Evodiamine (Evo) can inhibit vasculogenic mimicry (VM) in human colorectal cancer cells and reduce the expression of relevant proteins.
Review
Cell Biology
Minghui Zhang, Yu Zhang, Yubo Ding, Jialu Huang, Jingwei Yao, Zhuoyi Xie, Yufan Lv, Jianhong Zuo
Summary: This review examines the regulatory roles of HIF-1 alpha and lncRNAs in the EMT process of tumor cells and their relationship with tumorigenesis, and summarizes current drugs that inhibit tumor progression by modulating HIF-1 alpha.
Article
Oncology
Leah Davis, Matthias Recktenwald, Evan Hutt, Schuyler Fuller, Madison Briggs, Arnav Goel, Nichole Daringer
Summary: Hypoxia, or inadequate oxygen supply, is a characteristic of the tumor microenvironment and is associated with a poor prognosis and resistance to therapy. HIF-alpha, specifically the HIF-1 alpha and HIF-2 alpha subunits, play a crucial role in mediating the transcription of important proteins involved in tumor progression. While HIF-1 alpha has been extensively studied, the role of HIF-2 alpha is often overlooked. HIF-2 alpha can enhance the aggressive behavior of tumors, promoting metastasis, tissue remodeling, angiogenesis, and the upregulation of cancer stem cell factors. This review highlights the structure, function, hypoxic response, and roles of HIF-2 alpha in cancer progression, as well as discussing current therapeutic strategies and future directions.
Article
Biochemistry & Molecular Biology
Yijie Wang, Xiong Liu, Min Wang, Yu Wang, Shuo Wang, Lai Jin, Min Liu, Jun Zhou, Yan Chen
Summary: This study reveals that UBE3B is an E3 ligase for HIF-2 & alpha; and its depletion inhibits breast cancer progression. UBE3B physically interacts with HIF-2 & alpha; and promotes its polyubiquitination, thereby inhibiting its degradation. UBE3B depletion also inhibits breast cancer cell proliferation, migration, and invasion, and suppresses tumor growth and metastasis.
Article
Biochemistry & Molecular Biology
Yijie Wang, Xiong Liu, Min Liu, Yu Wang, Shuo Wang, Lai Jin, Min Liu, Jun Zhou, Yan Chen
Summary: It has been found that UBE3B acts as an E3 ligase for HIF-2 alpha, promoting its polyubiquitination and inhibiting its degradation, which plays a crucial role in breast cancer growth and metastasis.
Review
Biochemistry & Molecular Biology
Xiaoxu Wei, Yunhua Chen, Xianjie Jiang, Miao Peng, Yiduo Liu, Yongzhen Mo, Daixi Ren, Yuze Hua, Boyao Yu, Yujuan Zhou, Qianjin Liao, Hui Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Guiyuan Li, Yong Li, Wei Xiong, Zhaoyang Zeng
Summary: Overall, the use of VM inhibitors in combination with conventional anti-angiogenesis treatments is a promising strategy for improving the effectiveness of targeted angiogenesis treatments; further, considering the importance of hypoxia in tumor invasion and metastasis, drugs targeting the hypoxia signaling pathway seem to achieve good results.
Review
Biochemistry & Molecular Biology
Jan Korbecki, Donata Siminska, Magdalena Gassowska-Dobrowolska, Joanna Listos, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: This paper discusses the mechanisms and effects of chronic low-grade inflammation caused by chronic hypoxia and cycling hypoxia in malignant tumors, as well as their impact on the tumor microenvironment and cell recruitment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Kreon Koukoulas, Antonis Giakountis, Angeliki Karagiota, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis
Summary: ERK-mediated phosphorylation of HIF-1 alpha enhances its interaction with NPM1, which influences the transcriptional activation of HIF-1 target genes. NPM1 and HIF-1 co-regulate genes enriched in different cancer types, and their expression correlates with hypoxic tumor status and patient prognosis.
MOLECULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sho Koyasu, Shoichiro Horita, Keisuke Saito, Minoru Kobayashi, Hiroshi Ishikita, Christalle C. T. Chow, Gouki Kambe, Shigeto Nishikawa, Toshi Menju, Akiyo Morinibu, Yasushi Okochi, Yoshiaki Tabuchi, Yasuhito Onodera, Norihiko Takeda, Hiroshi Date, Gregg L. Semenza, Ester M. Hammond, Hiroshi Harada
Summary: p53 deficiency triggers the activation of HIF-1 and ZBTB2 plays a crucial role in this process. ZBTB2 promotes invasion and growth of p53-deficient cancers and is associated with poor prognosis in lung cancer patients. ZBTB2 N-terminus-mimetic polypeptides inhibit ZBTB2 activity and suppress tumor aggressiveness.