Article
Oncology
Frederic Amant, Valentina Nekljudova, Charlotte Maggen, Fenja Seither, Patrick Neven, Elyce H. Cardonick, Sabine Schmatloch, Kristel Van Calsteren, Tatjana Cordes, Jorine de Haan, Christianne A. R. Lok, Felix Flock, Ingrid A. Boere, Mina M. Gziri, Christine Solbach, Hanne Lefrere, Andreas Schneeweiss, Isabell Witzel, Sabine Seiler, Sibylle Loibl
Summary: The survival of breast cancer patients undergoing chemotherapy during pregnancy is comparable to that of young non-pregnant patients, indicating the efficacy of chemotherapy for PrBC when necessary.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Oncology
Silvia Triarico, Serena Rivetti, Michele Antonio Capozza, Alberto Romano, Palma Maurizi, Stefano Mastrangelo, Giorgio Attina, Antonio Ruggiero
Summary: This paper provides an overview of pregnancy-associated cancer (PAC) and the transplacental passage of antineoplastic agents. It discusses the therapeutic use and potential toxic effects of various chemotherapy drugs and targeted agents during pregnancy. The management of PAC is challenging for clinicians as they need to consider both maternal benefits and potential fetal risks associated with antineoplastic treatment. Although PAC is relatively rare among pregnant women, its incidence has been gradually increasing in recent years. None of the antineoplastic drugs are completely risk-free during pregnancy, and the timing of exposure and transplacental transfer properties can influence fetal toxicity. Despite the lack of guidelines, several studies have described the use and potential adverse events of antineoplastic drugs in pregnancy. This review aims to guide clinicians in making appropriate treatment choices for PAC.
Review
Pharmacology & Pharmacy
Antonios Koutras, Thomas Ntounis, Zacharias Fasoulakis, Theodoros Papalios, Savia Pittokopitou, Ioannis Prokopakis, Athanasios Syllaios, Asimina Valsamaki, Athanasios Chionis, Panagiotis Symeonidis, Athina A. Samara, Athanasios Pagkalos, Vasilios Pergialiotis, Marianna Theodora, Panos Antsaklis, Georgios Daskalakis, Emmanuel N. Kontomanolis
Summary: With the expansion of immunotherapy indications, more pregnant women diagnosed with cancer are eligible for receiving immunotherapy. The treatment process requires considerations for protecting both the mother and the fetus, with the efficacy depending on the selection and timing of various treatment methods.
Article
Agriculture, Dairy & Animal Science
Lisa-Helene Wagner, Joerg Aurich, Maria Melchert, Carolina T. C. Okada, Camille Gautier, Martim Kaps, Svenja Claassen, Christine Aurich
Summary: Low progesterone concentration in the early luteal phase delays conceptus growth and increases the risk of pregnancy loss.
ANIMAL REPRODUCTION SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jorge Lopez-Tello, Zoe Schofield, Raymond Kiu, Matthew J. Dalby, Douwe van Sinderen, Gwenaelle Le Gall, Amanda N. Sferruzzi-Perri, Lindsay J. Hall
Summary: This study demonstrates that the bacterium Bifidobacterium breve UCC2003, a key member of the maternal gut microbiota, modulates maternal body adaptations, placental structure, and nutrient transporter capacity, with implications for fetal metabolism and growth.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
De-cui Cheng, Yao Su, Feifei Li, Xianming Xu
Summary: This study aimed to investigate the efficiency of insulin on reducing gestational lipid profiles and propose a real-world approach to assist clinicians. The results showed that the use of insulin in the management of gestational hypertriglyceridemia is safe and efficient, and it can improve the outcomes of newborns and mothers.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Thorsten Braun, Loreen Ehrlich, Wolfgang Henrich, Sebastian Koeppel, Ievgeniia Lomako, Philipp Schwabl, Bettina Liebmann
Summary: The study identified the presence of microplastics (> 50 μm) in placenta and meconium samples from caesarean deliveries, with polyethylene, polypropylene, polystyrene, and polyurethane being the main types detected. However, airborne polyurethane microplastics were also found in the operating room, indicating potential contamination sources. Further research into nano-sized plastics in human tissues is recommended.
Article
Chemistry, Physical
Constantin Kappas
Summary: This article discusses the management and evaluation of radiation doses for pregnant women and pregnant workers in clinical settings where ionizing radiation is used. The study found that the majority of conventional radiographic procedures and diagnostic procedures in nuclear medicine are at doses much lower than the exposure associated with fetal harm. However, certain therapies in nuclear medicine, Radiation Therapy, multiple CT scans, and invasive radiology have the potential to cause serious damage to the fetus.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Agriculture, Dairy & Animal Science
Maria Grazia Cappai, Petra Wolf, Annette Liesegang, Giovanni Paolo Biggio, Andrea Podda, Antonio Varcasia, Claudia Tamponi, Fiammetta Berlinguer, Ignazio Cossu, Walter Pinna, Raffaele Cherchi
Summary: Monitoring serum protein fraction (SPF) levels, including metabolic profiling, in pregnant jennies can provide insights into the overall health status of the mother. Adequate dietary nutrient supplementation during mid-gestation is crucial to prevent homeostasis perturbation of jennies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaofeng Jiang, Hengyu Zhao, Oliver Lester Saldanha, Sven Nebelung, Christiane Kuhl, Iakovos Amygdalos, Sven Arke Lang, Xiaojian Wu, Xiaochun Meng, Daniel Truhn, Jakob Nikolas Kather, Jia Ke
Summary: A deep learning model based on preoperative MRI scans was developed and validated to predict survival in patients with rectal cancer.
Article
Obstetrics & Gynecology
L. Barreau, S. Gau, L. Loussert, C. Vaysse, A. Weyl, M. Groussolles
Summary: This study describes the situation of cancer patients during pregnancy in terms of oncological, obstetrical, and neonatal care, and proposes suggestions for optimizing the care pathway. It identifies some weaknesses in the management of cancer patients during pregnancy and suggests regional improvement opportunities.
GYNECOLOGIE OBSTETRIQUE FERTILITE & SENOLOGIE
(2022)
Article
Oncology
Cristina Saura, Olga Sanchez, Sandra Martinez, Carmen Dominguez, Rodrigo Dienstmann, Fiorella Ruiz-Pace, Maria Concepcio Cespedes, Angeles Penuelas, Javier Cortes, Elisa Llurba, Octavi Cordoba
Summary: Anthracyclines and taxanes are used as standard treatment for breast cancer diagnosed during pregnancy, allowing continuation of pregnancy with good outcomes. However, their effects on placental function and fetal development require further research. Maternal serum angiogenic factors may be useful in clinical obstetric management for pregnant women with breast cancer undergoing chemotherapy, although more studies are needed.
Review
Health Care Sciences & Services
Petra Tesarova, David Pavlista, Antonin Parizek
Summary: Precision medicine aims to tailor treatment for breast cancer patients based on genetic makeup, but pregnancy-associated breast cancer poses a complex challenge as both maternal and fetal outcomes must be considered. Current treatment outcomes are unsatisfactory due to delayed diagnosis, indicating a need for centralized care to improve survival and quality of life.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Chiara Pagamici, Roger Stephan
Summary: This study assessed the prevalence of pregnant sheep and lambs being slaughtered in Switzerland and found that 7.6% of female animals were pregnant at slaughter, with 25.5% in the third trimester of pregnancy. As it is uncertain whether fetuses can feel pain, measures should be taken to minimize the slaughter of pregnant animals.
Article
Clinical Neurology
Erez Berman, Natalia Erenburg, Ron Beloosesky, Sara Eyal, Michal Kovo
Summary: The study found that CBD is sequestered in placental tissue, with lower concentrations in the fetal compartment. CBD did not significantly alter placental gene expression. While the placenta acts as a depot for CBD, there are still potential risks associated with its use during pregnancy.
Article
Oncology
Pinar Gursoy, Ali Murat Tatli, Dilek Erdem, Erdem Goker, Emir Celik, Nebi Serkan Demirci, Abdullah Sakin, Muhammed Mustafa Atci, Ertugrul Bayram, Tugba Akin Telli, Burak Bilgin, Ahmet Bilici, Baran Akangunduz, Sevinc Balli, Ahmet Demirkazik, Fatih Selcukbiricik, Serkan Menekse, Eyyup Cavdar, Akin Ozturk, Esma Turkmen Bekmez, Serdal Turhal, Sadettin Kilickap, Hasan Cagri Yildirim, Basak Oyan, Asude Aksoy, Fatma Paksoy Turkoz, Engin Kut, Nuran Katgi, Teoman Sakalar, Murat Akyol, Halil Ibrahim Ellez, Atakan Topcu, Atike Pinar Erdogan, Kezban Nur Pilanci, Engin Hedem, Haci Arak, Nadiye Akdeniz, Ozkan Alan, Burcu Yapar, Deniz Nart, Perran Fulden Yumuk
Summary: This study compares the survival of NSCLC patients with rare EGFR exon 18 and exon 20 mutations who received first- and second-generation TKIs. The results show that patients with complex mutations exhibit similar sensitivity to TKI treatment as those with classical mutations, suggesting that both first- and second-generation EGFR-TKIs should be considered for patients with rare exon 18 and exon 20 EGFR mutations.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Levent Emirzeoglu, Serdar Arici, Ahmet Bilgehan Sahin, Birol Ocak, Naziye Ak, Seval Ay, Elkhan Mammadov, Hande Turna, Ahmet Bilici
Summary: This study investigated the effects of BMI on the response to neoadjuvant chemotherapy in Turkish patients with breast cancer. The results showed that a high BMI and HR positivity were associated with a poor response to treatment.
Article
Oncology
Ahmet Bilici, Omer Fatih Olmez, Muhammed Ali Kaplan, Berna Oksuzoglu, Ahmet Sezer, Nuri Karadurmus, Erdem Cubukcu, Mehmet Ali Nahit Sendur, Sercan Aksoy, Dilek Erdem, Gul Basaran, Burcu Cakar, Abdallah T. M. Shbair, Cagatay Arslan, Ahmet Taner Sumbul, Sema Sezgin Goksu, Ibrahim Karadag, Irfan Cicin, Mahmut Gumus, Fatih Selcukbiricik, Hakan Harputluoglu, Umut Demirci
Summary: This real-life study suggests that adding pertuzumab to neoadjuvant chemotherapy with trastuzumab enables a higher pathological complete response rate in HER2+ breast cancer patients. Additionally, pathological complete response is associated with lower relapse rates and better event-free survival time.
Article
Environmental Sciences
Ahmet Bilici, Ismail Kocak, Sevim Bilici, Mirac Kamislioglu, Serpil Akozcan, Bulent Buyuk, S. Selin
Summary: The concentrations of natural and artificial radionuclides were measured in soil samples, and radiological hazard indices were calculated. The results showed that the measured radioactivity concentrations were below the world average.
ENVIRONMENTAL FORENSICS
(2023)
Article
Geochemistry & Geophysics
Ahmet Bilici, Fatih Kulahci, Sevim Bilici, Zekai Sen
Summary: Markov Chain models are used to subdivide data based on mean value and standard deviations. The transition probabilities between these categories are calculated, and the procedure is repeated until steady-state transition probability values are obtained. This modeling approach is convenient for radon gas transient measurement records.
JOURNAL OF ATMOSPHERIC AND SOLAR-TERRESTRIAL PHYSICS
(2023)
Article
Oncology
Ahmet Bilici, Sinan Koca, Mustafa Karaagac, Sabin Goktas Aydin, Emrah Eraslan, Muhammed Ali Kaplan, Birol Ocak, Sema Sezgin Goksu, Semra Paydas, Fahri Akgul, Sumeyye Derin, Yakup Ergun, Emre Yekeduz, Cihan Erol, Deniz Tataroglu Ozyukseler, Atike Gokcen Demiray, Mustafa Karaca, Zeynep Gulsum Guc, Serkan Menekse, Havva Yesil Cinkir, Ozge Gumusay, Abdullah Sakin, Ozlem Ozkul, Hacer Demir, Dilek Erdem, Mehmet Besiroglu, Olcun Umit Unal, Ramazan Acar, Lokman Koral, Suleyman Sahin, Teoman Sakalar, Aykut Bahceci, Ahmet Ozveren, Ulug Mutlu Gunaydin, Mehmet Metin Seker, Veli Sunar, Pinar Dal, Mehmet Artac, Serdar Turhal
Summary: This study retrospectively analyzed the medical records of patients with non-adipocytic metastatic soft tissue sarcoma treated with pazopanib in 37 oncology clinics in Turkey. The results showed that pazopanib is effective and well-tolerated in the treatment of this disease, with better outcomes observed when used earlier and in patients with good performance status.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Yasin Kutlu, Sabin Goktas Aydin, Ahmet Bilici, Bala Basak Oven, Omer Fatih Olmez, Ozgur Acikgoz, Jamshid Hamdard
Summary: This study investigated the prognostic role of inflammatory markers in ES-SCLC patients treated with atezolizumab plus chemotherapy and evaluated the efficacy and safety of this treatment. The results showed that the addition of atezolizumab to chemotherapy had a high objective response rate and improved overall survival. Prognostic factors such as limited-stage disease, the presence of prophylactic cranial irradiation, liver metastasis, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) were identified.
Article
Oncology
Sabin Goktas Aydin, Omer Fatih Olmez, Oguzhan Selvi, Caglayan Geredeli, Ferhat Ozden, Ahmet Bilici, Ozgur Acikgoz, Ebru Karci, Yasin Kutlu, Jamshid Hamdard, Ahmet Aydin
Summary: This study investigated the role of MSI and CDX-2 status determined by immunohistochemistry, along with inflammatory markers and pathological parameters, in predicting disease recurrence in stage II and III colon cancer. The loss of CDX-2 was found to be an independent prognostic factor for DFS and disease recurrence in early-stage colon cancer.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Medicine, General & Internal
Sabin Goktas Aydin, Yasin Kutlu, Harun Muglu, Ozgur Acikgoz, Ahmet Aydin, Ahmet Bilici, Omer Fatih Olmez, Dilek Unal, Ebru Karci, Ozcan Yildiz
Summary: This study investigated the effects of metastasis-directed stereotactic body radiotherapy (SBRT) on survival in patients with metastatic castration-resistant prostate cancer who developed oligo-progression under anti-androgen therapy. The results showed that patients who received SBRT while continuing the same antiandrogen therapy had a higher 12-month progression-free survival rate. Therefore, metastasis-directed SBRT with continuation of the same antiandrogen therapy should be prioritized only in selected cases.
JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
(2023)
Meeting Abstract
Oncology
Atilla Soran, Lutfi Dogan, Arda Isik, Serdar Ozbas, Didem Can-Trabulus, Umut Demirci, Hasan Karanlik, Aykut Soyder, Ahmet Dag, Ahmet Bilici, Mutlu Dogan, Mehmet Ali Nahit Sendur, Hande Koksal, Mehmet Ali Gulcelik, Neslihan Cabioglu, Levent Yeniay, Zafer Utkan, Nuri Karadurmus, Gul Daglar, Turgay Simsek, Birol Yildiz, Cihan Uras, Mustafa Tukenmez, Cihangir Ozaslan, Gokturk Maralcan, Suat Kutun, Niyazi Karaman, Osman Toktas, Ahmet Ozgen Yildirim, Mufide Nuran Akcay, Vahit Ozmen, Efe Sezgin
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Fatma Olmez, Suleyman Cemil Oglak, Sedat Akgol, Omer Fatih Olmez, Ahmet Bilici, Ozgur Akbayr, Zeynep Gedik Ozkose, Esra Can, Omer Unal, Hicran Acar Sirinoglu
Summary: This study aimed to evaluate the clinicopathological characteristics and clinical outcomes of mismatch repair (MMR) deficiency in serous ovarian cancer (SOC) through immunohistochemistry (IHC) for MMR genes. The results showed that MMR-deficient SOC were diagnosed at earlier stages compared to MMR proficient cases. PD-1 expression was significantly higher in MMR-deficient cases, and MMR status was significantly associated with disease-free survival (DFS) and overall survival (OS).
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2023)
Meeting Abstract
Oncology
Omer Fatih Olmez, Burcu Tunay, Ahmet Bilici, Ayberk Bayramgil, Gunes Dorukhan Cavusoglu, Huseyin Oz
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Ahmet Bilici, Sinan Koca, Mustafa Karaagac, Emrah Eraslan, Birol Ocak, Sabin Goktas Aydin, Sema Sezgin Goksu, Semra Paydas, Sumeyye Derin, Yakup Ergun, Emre Yekegunduz, Cihan Erol, Deniz Tataroglu Ozyukseler, Atike Gokcen Demiray, Mustafa Karaca, Zeynep Gulsum Guc, Serkan Menekse, Havva Yesil Cinkir, Ozge Gumusay, Abdullah Sakin
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Ahmet Bilici, Omer Fatih Olmez, Ahmet Sezer, Berna Oksuzoglu, Muhammet Ali Kaplan, Nuri Karadurmus, Erdem Cubukcu, Mehmet A. N. Sendur, Sercan Aksoy, Dilek Erdem, Gul Basaran, Burcu Cakar, Mesut Seker, Cagatay Arslan, Sema Sezgin Goksu, Irfan Cicin, Mahmut Gumus, Fatih Selcukbiricik, Hakan Harputluoglu, Kaan Helvaci
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Emine Yildirim, Sibel Bektas, Sabin Goktas Aydin, Ahmet E. R. Muzaffer, Irem Yanik, Perihan Ozkan Gumuskaya, Barbaros Utku Yilmaz, Ahmet Bilici, Mustafa Oncel
Summary: This study investigated the effect of hematological and histopathological parameters on the response to chemotherapy in patients with gastric cancer. The results showed that patients without perineural invasion had a better pathological complete response to chemotherapy.
JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
(2022)