Article
Allergy
Teodorikez-Wilfox Jimenez-Rodriguez, Leticia de las Vecillas, Marina Labella, Donna-Marie Lynch, Kylie Marie Besz, Kathleen Marquis, Amparo Burgos, Victor Soriano Gomis, Inmaculada Lozano, Rosa Ana Montoyo Anton, Francisco Marco de la Calle, Maria Purificacion Gonzalez Delgado, Aurora Gutierrez, Estefania Montenegro, Fernando Rodriguez, Francisco Javier Fernandez Sanchez, Mariana Castells
Summary: This study investigated the phenotypes, endotypes, and biomarkers of reactions to carboplatin and oxaliplatin and their response to drug desensitization (DD). The findings showed that these two drugs induced different types of reactions with defined phenotypes and endotypes. The oxaliplatin reactions were characterized by unique cytokine release reactions. During DD, carboplatin-reactive patients mainly experienced type I breakthrough reactions, while oxaliplatin-reactive patients frequently switched from type I to cytokine release reactions, highlighting the need for personalized DD protocols.
Article
Medicine, General & Internal
Cornelia Nitipir, Andreea Parosanu, Ana Maria Popa, Horia Cotan, Mihaela Olaru, Cristian Iaciu, Cristina Orlov Slavu
Summary: This technical report provides details of the desensitization protocol for carboplatin used in the Oncology Clinic of the University Emergency Hospital in Bucharest, aiming to prevent hypersensitivity reactions.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Nail Paksoy, Nijat Khanmammadov, Izzet Dogan, Ferhat Ferhatoglu, Anil Yildiz, Naziye Ak, Adnan Aydiner
Summary: This study retrospectively analyzed the efficacy and safety of CP-desensitization therapy in the treatment of recurrent EOC patients. The results showed that CP-D is a beneficial and safe method to treat EOC patients with CP-induced hypersensitivity reactions.
Review
Pediatrics
Silvia Caimmi, Giuseppe Crisafulli, Fabrizio Franceschini, Lucia Liotti, Annamaria Bianchi, Paolo Bottau, Francesca Mori, Paolo Triggiano, Claudia Paglialunga, Francesca Saretta, Arianna Giannetti, Giampaolo Ricci, Carlo Caffarelli
Summary: Intravenous iron is commonly used for iron deficiency anemia, but it can lead to rare but life-threatening hypersensitivity reactions. Prompt recognition and intervention by well-trained medical staff is crucial in managing these reactions.
Article
Oncology
Rosalaura V. Villarreal-Gonzalez, Sandra N. Gonzalez-Diaz, Oscar Vidal-Gutierrez, Omar A. Zayas-Villanueva, Hugo Solis-Lara, Wendy J. Santos-Fernandez, Claudio A. Casas-Murillo, Alfonso Lopez-Mendez
Summary: This case report describes a patient with high-grade ovarian cancer who developed a severe allergic reaction to carboplatin, but was successfully treated with a desensitization protocol to continue carboplatin therapy.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2022)
Article
Allergy
Mauro Pagani, Sevim Bavbek, Emilio Alvarez-Cuesta, Adile Berna Dursun, Patrizia Bonadonna, Mariana Castells, Josefina Cernadas, Anca Chiriac, Hamadi Sahar, Ricardo Madrigal-Burgaleta, Soledad Sanchez Sanchez
Summary: Chemotherapeutic drugs can induce hypersensitivity reactions, being the third leading cause of fatal drug-induced anaphylaxis. Deaths related to chemotherapy have been reported in Europe and the United States. The European Network on Drug Allergy organized a task force to provide data and recommendations regarding allergological work-up in this field.
Review
Pharmacology & Pharmacy
Marina Labella, Rocio Saenz de Santa Maria, Gador Bogas, Maria Salas, Tahia D. Fernandez, Cristobalina Mayorga, Maria Jose Torres, Inmaculada Dona
Summary: Drug hypersensitivity is increasing due to increased drug consumption, and it often presents in complex clinical settings with co-existing illnesses and polypharmacotherapy. Recent studies have improved the understanding of immediate drug hypersensitivity reactions by categorizing them based on endotypes, biomarkers, and phenotypes. This review focuses on the diagnosis and management of anaphylaxis, discussing both in vivo and in vitro diagnostic methods and highlighting the importance of clinical management, hidden allergens, and delabeling. Endophenotyping plays a crucial role in correctly identifying and treating patients with immediate drug hypersensitivity reactions, with drug desensitization being an effective approach to prevent future episodes.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Oncology
Meiko Nishimura, Hideki Sakai, Takuma Onoe, Shogen Boku, Takaaki Yokoyama, Genmu Kadokura, Satoshi Morita, Noriyuki Katsumata, Koji Matsumoto
Summary: The 4-step, 2-hour carboplatin desensitization protocol is safe and feasible for treating ovarian cancer patients. Patients require careful monitoring and rapid response to hypersensitivity reactions, especially during the administration of undiluted solutions.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Laura Pedraza-Nieto, Monica Beunza-Sola, Cesar A. Rodriguez, Esther Moreno, Maria Jose Otero
Summary: Skin tests can help physicians identify patients most susceptible to platinum derivative allergies, thereby allowing for the resumption of platinum-based therapy in many patients where no suitable therapeutic alternative is clinically acceptable.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2021)
Article
Immunology
Carmen Maria Cabrera, Miriam Clarcast, Alberto Palacios-Canas
Summary: The basophil activation test (BAT) has been found to be an effective method for diagnosing hypersensitivity reactions to gadolinium based contrast agents (GBCAs), especially for patients who cannot be diagnosed through other testing methods.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Allergy
Saliha Esenboga, Aysegul Akarsu, Melike Ocak, Pinar Gur Cetinkaya, Umit Murat Sahiner, Bulent Enis Sekerel, Ozge Soyer
Summary: This study aimed to evaluate the characteristics, safety, and efficacy of rapid drug desensitization (RDD) in children with hypersensitivity reactions (HSRs), as well as the management of breakthrough reactions. The results demonstrated the safety and efficacy of RDD in childhood, offering a first-line treatment option for children with chronic diseases and HSRs.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Allergy
Ji-Hyang Lee, Youngsang Yoo, Sung-Ryeol Kim, Jae-Hyun Lee, Seo-Young Kim, Jin An, So-Young Park, Han-ki Park, Sujeong Kim, Woo-Jung Song, Min-suk Yang, Hyouk-Soo Kwon, Hye-Kyung Park, Jaechun Lee, Gyu-Young Hur, Gang-Jee Ko, Sang-Heon Kim, Sae-Hoon Kim, Young-min Ye, Young-Il Koh, Byung-Jae Lee, You Sook Cho, Hwan Seok Yong, Tae-Bum Kim
Summary: This study aimed to propose an intradermal skin test-guided strategy to prevent recurrence of drug-induced immediate hypersensitivity reaction (IHR) to iodinated contrast media (ICM). The study found that following this strategy could reduce the recurrence rate of IHR and mitigate the severity in recurred cases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Oncology
Naoki Shibata, Kazuyoshi Kawakami, Shimizu Hisanori, Kazuo Kobayashi, Mayu Yunokawa, Hiroyuki Kanao, Iori Taki, Remi Murase, Daisuke Kamei, Masakazu Yamaguchi
Summary: This study retrospectively reviewed the cases of ovarian cancer patients undergoing carboplatin desensitization therapy. The completion rate of desensitization was found to be 86.5%. The main toxicity observed was erythema, most commonly affecting the arm. Patients with two or more target organs affected had significantly lower completion rates of desensitization.
ANTICANCER RESEARCH
(2022)
Review
Immunology
Rakesh D. Bansie, A. Faiz Karim, Maurits S. van Maaren, Maud A. W. Hermans, Paul L. A. van Daele, Roy Gerth van Wijk, Saskia M. Rombach
Summary: Skin tests and provocation tests are recommended for evaluating hypersensitivity reactions to contrast agents, showing a high risk of immediate repeat hypersensitivity reactions for skin-test-positive patients. However, provocation tests are not common in clinical practice.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Oncology
Dallas Lawry, Allegra Bell, Amanda McKaig, Rayna McParlane
Summary: Hypersensitivity reactions are reproducible pathophysiologic responses, and desensitization protocols offer a safe process to gradually increase therapeutic doses. Nursing staff require thorough education and training to effectively manage hypersensitivity reactions during chemotherapy desensitization.
SEMINARS IN ONCOLOGY NURSING
(2021)