Review
Oncology
Mingzhou Guo, Yang Niu, Min Xie, Xiansheng Liu, Xiaochen Li
Summary: Notch signaling is important in cell fate determination and dysregulated in human solid tumors. Hypoxia, an important feature of many solid tumors, activates hypoxia-induced factors (HIFs) and their downstream targets to promote tumorigenesis and cancer development. Recently, HIFs have been found to trigger the Notch signaling pathway in various organisms and tissues. This review focuses on the pro- and anti-tumorigenic functions of Notch signaling, discusses the crosstalk between Notch signaling and cellular hypoxic response in cancer pathogenesis, and explores pharmacological strategies targeting Notch signaling and hypoxia in cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Michelle McMullen, Ainhoa Madariaga, Stephanie Lheureux
Summary: Platinum drugs are crucial in ovarian cancer treatment, but resistance is a major challenge, with complex mechanisms involving both intracellular and microenvironment factors. Clinical trials are essential for improving outcomes, and future research should focus on understanding the biology of the disease and enhancing quality of life and survival for patients.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
David Schweer, J. Robert McCorkle, Jurgen Rohr, Oleg V. Tsodikov, Frederick Ueland, Jill Kolesar
Summary: Ovarian cancer is a highly deadly malignancy with poor outcomes in cases of platinum-based chemotherapy resistance, highlighting the importance of novel therapeutic approaches. Recent advancements in semisynthetic methods have led to mithramycin analogs with improved pharmacological properties that show potential in treating platinum-resistant ovarian cancer by inhibiting the activity of the transcription factor Sp1.
Review
Oncology
Yumin Qiu, Yan Chen, Oluwatobi Agbede, Esra Eshaghi, Chun Peng
Summary: Epithelial ovarian cancer (EOC) is the deadliest cancer in the female reproductive system, with no effective early detection methods available and low success rate in treating advanced stages. Circular RNAs (circRNAs), noncoding RNAs generated from precursor mRNAs, have been found to be aberrantly expressed in EOC tumor tissues and plasma, regulating EOC cell activity and tumor growth. This review provides an overview of EOC and circRNA biology, summarizes dysregulated circRNAs with tumor-promoting or tumor-suppressive effects in EOC, discusses the potential of circRNAs as diagnostic/prognostic markers and therapeutic targets.
Review
Medicine, Research & Experimental
Pratibha Pandey, Fahad Khan, Min Choi, Sujeet Kumar Singh, Han Na Kang, Moon Nyeo Park, Seong-Gyu Ko, Sanjeev Kumar Sahu, Rupa Mazumder, Bonglee Kim
Summary: Natural products have been an unmatched source of anticancer medications in the current drug development period. They modify the cancer microenvironment and various signaling pathways, playing a significant role in cancer treatment. These substances are effective against multiple signaling pathways, particularly in cell death and embryonic developmental pathways. More research is needed to fully understand their function in cancer treatments and their potential as therapeutic agents.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Mia C. Borlongan, Hongbin Wang
Summary: Tumorigenic cancer stem cells (CSCs) are a subset of cells within tumors that have distinct genetic and phenotypic profiles and signaling pathways compared to other tumor cells. Targeting the unique self-renewal and differentiation properties of CSCs could revolutionize cancer therapy. Understanding the signaling mechanisms of CSCs will improve our knowledge of cancer pathology and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Oncology
Kharimat Lora Alatise, Samantha Gardner, Angela Alexander-Bryant
Summary: This article reviews several novel and well-studied genes that can be investigated as potential gene targets in ovarian cancer to increase chemotherapeutic response. A precision medicine approach, such as gene therapy, can be used to exploit genes at the molecular level and resensitize tumors to therapeutics.
Review
Oncology
Wojciech Szymanowski, Anna Szymanowska, Anna Bielawska, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Paola Amero
Summary: Aptamers are highly versatile molecules with potential applications in cancer treatment, particularly in ovarian cancer. They have the ability to selectively bind to cancer-related molecules and receptors, revolutionizing drug discovery and biomarker identification. Aptamers also hold promise as drug delivery systems, enabling targeted delivery of therapeutics with minimal off-target effects and systemic toxicity.
Review
Biochemistry & Molecular Biology
Misung Park, Soohyun Choe, Miyoung Shin, Ayoung Kim, Kyumin Mo, Hyeonseok Kwon, Hyunho Yoon
Summary: Ovarian cancer has high mortality rates due to late diagnosis and chemotherapy resistance. Autophagy and metabolism have been proposed as potential targets for cancer therapy. Understanding and controlling autophagy is relevant for cancer treatment.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Biochemistry & Molecular Biology
Lara Hillemeyer, Nancy Adriana Espinoza-Sanchez, Burkhard Greve, Nourhan Hassan, Anca Chelariu-Raicu, Ludwig Kiesel, Martin Goette
Summary: Syndecan-3 is dysregulated in ovarian cancer and its high expression is associated with reduced survival in patients. Syndecan-3 depletion impairs growth and survival of ovarian cancer cells, and affects cell resistance to chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Mehmet Neset ozel, Felix Simon, Shadi Jafari, Isabel Holguera, Yen-Chung Chen, Najate Benhra, Rana Naja El-Danaf, Katarina Kapuralin, Jennifer Amy Malin, Nikolaos Konstantinides, Claude Desplan
Summary: Deciphering neuronal diversity in the Drosophila optic lobe during pupal development reveals transient extrinsic neurons and dorsoventral asymmetry in visual circuits.
Review
Cell Biology
Pankaj Trivedi, Sandesh Kumar Patel, Diana Bellavia, Elena Messina, Rocco Palermo, Simona Ceccarelli, Cinzia Marchese, Eleni Anastasiadou, Lisa M. Minter, Maria Pia Felli
Summary: The aberrant regulation of developmental pathways plays a key role in tumorigenesis, with tumor cells acquiring their characteristics through dysregulated signaling pathways. Viruses affect cancer cell hallmarks and promote tumor growth by influencing gene regulatory pathways, highlighting the importance of understanding the intersection between oncogenic viruses and developmental pathways in viral tumorigenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Pankaj Trivedi, Sandesh Kumar Patel, Diana Bellavia, Elena Messina, Rocco Palermo, Simona Ceccarelli, Cinzia Marchese, Eleni Anastasiadou, Lisa M. Minter, Maria Pia Felli
Summary: Aberrant regulation of developmental pathways is crucial in tumorigenesis, with tumor cells acquiring features through dysregulated signaling pathways. Human tumor viruses impact cancer cell hallmarks by encoding oncogenic proteins and affecting genomic stability, while understanding how viruses intersect with developmental pathways is crucial in viral tumorigenesis research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tanya Singh, Adam S. Neal, Neda A. Moatamed, Sanaz Memarzadeh
Summary: One major challenge in cancer treatment is the diverse responses of patients to anti-cancer drugs, which precision medicine aims to address by considering individual molecular alterations. Predictive, in vitro drug-response assays are a promising tool in precision medicine for identifying the most effective treatments for cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
News Item
Multidisciplinary Sciences
Jeanne Erdmann
Summary: Faecal transplants have been effective in overcoming resistance to immunotherapies, leading to numerous trials investigating the link between cancer and the microbiome.
