☆ 4.5 Article

Prognostic Importance of Vascular Endothelial Growth Factor-A Expression and Vascular Endothelial Growth Factor Polymorphisms in Epithelial Ovarian Cancer

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2009)

Journal

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Volume 19, Issue 4, Pages 578-584

Publisher

LIPPINCOTT WILLIAMS & WILKINS

DOI: 10.1111/IGC.0b013e3181a13168

Keywords

Ovarian cancer; VEGF polymorphisms; VEGF-A expression; Survival

Categories

Oncology Obstetrics & Gynecology

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Abstract

Introduction: Vascular endothelial growth factors (VEGFs) play a central role in angiogenesis and consequently, in various steps of ovarian carcinogenesis. Gene polymorphisms within the VEGF system have revealed a correlation with prognosis in some malignancies. The aim of the present study was to examine the possible importance of 2 VEGF polymorphisms and VEGF-A expression in ovarian cancer. Methods: We investigated 2 single nucleotide polymorphisms VEGF +405G/C and VEGF -460C/T by polymerase chain reaction and also analyzed VEGF-A expression by immunohistochemistry in 159 women with ovarian cancer. Results: Vascular endothelial growth factor-A expression revealed a significant correlation with survival in a Cox proportional hazards regression model (P = 0.012). Germline polymorphisms were not correlated with clinicopathological parameters such as stage, type, and histology. Heterozygous genotype in VEGF +405G/C predicted a better survival compared with homozygous genotypes (P = 0.034), and the heterozygous genotype in VEGF -460C/T pointed to the same direction. A multivariate analysis also indicated that heterozygosity of either of the 2 polymorphisms held independent prognostic significance (P = 0.01). Conclusions: Vascular endothelial growth factor polymorphisms +405G/C and VEGF expression seem to have independent prognostic importance.

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Review Biochemistry & Molecular Biology

Prognostic immunologic signatures in epithelial ovarian cancer

Nicole E. James, Morgan Woodman, Jennifer R. Ribeiro

Summary: EOC patients have low response rates to immunotherapies, but evidence suggests ovarian tumors are immunogenic and immune-related genomic profiles can serve as prognostic markers. Specific research areas that need to be addressed include developing immune-based prognostic signatures and driving advancements in this field.

ONCOGENE (2022)

Add to Collection

Article Multidisciplinary Sciences

Connections between prolactin and ovarian cancer

Amira Alkharusi, Abdullah AlMuslahi, Najwa AlBalushi, Radiya AlAjmi, Sami AlRawahi, Asmaa AlFarqani, Gunnar Norstedt, Fahad Zadjali

Summary: This study investigates the effects of prolactin on ovarian cancer cells, analyzes the expression of PRL receptors in tissue, and links PRLR expression to ovarian cancer survival. The results suggest that PRLR may play a role in promoting tumor aggressiveness and influencing survival rates in ovarian cancer.

PLOS ONE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

TARDBP promotes ovarian cancer progression by altering vascular endothelial growth factor splicing

Yutian He, Zhenbo OuYang, Wenwen Liu, Yu Chen, Qiushi Zhang

Summary: Disruptions in alternative splicing regulation play a critical role in the progression of ovarian cancer. This study found that TARDBP, a DNA-binding protein, is significantly upregulated in OC tissue samples, especially in cases of metastasis and poor prognosis. TARDBP regulates the alternative splicing of VEGF, promoting angiogenesis in OC.

ONCOGENE (2023)

Add to Collection

Article Oncology

Pazopanib based oral metronomic therapy for platinum resistant/refractory epithelial ovarian cancer: A phase II, open label, randomized, controlled trial

Aparna Sharma, Mayank Singh, Ravi Chauhan, Prabhat Singh Malik, Sachin Khurana, Sandeep Mathur, Sunesh Kumar, Vishnubhatla Sreenivas, Lalit Kumar

Summary: This study evaluated the role of oral metronomic therapy in patients with platinum resistant/refractory epithelial ovarian cancer, and found that the addition of pazopanib can improve survival outcomes. However, there may be some side effects such as oral mucositis and fatigue.

GYNECOLOGIC ONCOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Protein analysis of extracellular vesicles to monitor and predict therapeutic response in metastatic breast cancer

Fei Tian, Shaohua Zhang, Chao Liu, Ziwei Han, Yuan Liu, Jinqi Deng, Yike Li, Xia Wu, Lili Cai, Lili Qin, Qinghua Chen, Yang Yuan, Yi Liu, Yulong Cong, Baoquan Ding, Zefei Jiang, Jiashu Sun

Summary: A thermophoretic aptasensor is utilized to profile cancer-associated proteins of extracellular vesicles (EVs) in patients' plasma, leading to the development of an EV signature capable of discriminating metastatic breast cancer, monitoring treatment response, and predicting patients' progression-free survival.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Medicine, Research & Experimental

Macrophage-mediated vascular permeability via VLA4/VCAM1 pathway dictates ascites development in ovarian cancer

Shibo Zhang, Bingfan Xie, Lijie Wang, Hua Yang, Haopei Zhang, Yuming Chen, Feng Wang, Changqing Liu, Huanhuan He

Summary: The research revealed that M2 macrophages regulate the vascular barrier through the VCAM1/RAC1/ROS/p-PYK2/p-VE-cad cascade, providing specific therapeutic targets for the treatment of malignant ascites.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Article Multidisciplinary Sciences

Development of a novel transcription factors-related prognostic signature for serous ovarian cancer

He Li, Nayiyuan Wu, Zhao-Yi Liu, Yong-Chang Chen, Quan Cheng, Jing Wang

Summary: This study highlights the important roles of transcription factors (TFs) in serous ovarian cancer (SOC) and develops a 17-TFs related prognostic signature to accurately predict the survival of SOC patients. Analysis of immune infiltration and treatment responses show significant differences between high-risk and low-risk groups, providing insights for personalized therapy.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Oncology

Conditional Relative Survival of Ovarian Cancer: A Korean National Cancer Registry Study

Dong Wook Shin, Jaeman Bae, Johyun Ha, Kyu-Won Jung

Summary: The study presents 5-year relative conditional survival probabilities for ovarian cancer patients from 1997-2016. The results showed that the conditional survival rates increased with each year survived, but even after 5 years, the excess mortality did not reach 'no excess mortality' level. Patients with poorer initial prognoses showed the largest improvements in conditional survival rates.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection

Article Oncology

Bevacizumab May Differentially Improve Prognosis of Advanced Ovarian Cancer Patients with Low Expression of VEGF-A165b, an Antiangiogenic VEGF-A Splice Variant

Pauline Wimberger, Mara Julia Gerber, Jacobus Pfisterer, Kati Erdmann, Susanne Fuessel, Theresa Link, Andreas du Bois, Stefan Kommoss, Florian Heitz, Jalid Sehouli, Rainer Kimmig, Nikolaus de Gregorio, Barbara Schmalfeldt, Tjoung-Won Park-Simon, Klaus Baumann, Felix Hilpert, Marcel Grube, Willibald Schroder, Alexander Burges, Antje Belau, Lars Harser, Jan Dominik Kuhlmann

Summary: A study on 413 patients from the ICON7 trial found that the addition of bevacizumab to standard platinum-based chemotherapy significantly improved survival rates in patients with low expression of VEGF-A165b.

CLINICAL CANCER RESEARCH (2022)

Add to Collection

Article Oncology

RIPK1 polymorphisms and expression levels: impact on genetic susceptibility and clinical outcome of epithelial ovarian cancer

Xuedong Wang, Kui Deng, Jing Tao, Juan Zou, Yiting Du, Li Dai

Summary: This study found that RIPK1 gene polymorphisms are associated with susceptibility to epithelial ovarian cancer (EOC) and clinical outcomes. Specifically, certain SNPs and genotypes variants are associated with early-onset EOC and better survival outcomes. Furthermore, the study also observed increased plasma levels of RIPK1 and reduced RIPK1 mRNA expression in EOC patients.

CANCER CELL INTERNATIONAL (2023)

Add to Collection

Article Multidisciplinary Sciences

A machine learning approach to identify predictive molecular markers for cisplatin chemosensitivity following surgical resection in ovarian cancer

Nicholas Brian Shannon, Laura Ling Ying Tan, Qiu Xuan Tan, Joey Wee-Shan Tan, Josephine Hendrikson, Wai Har Ng, Gillian Ng, Ying Liu, Xing-Yi Sarah Ong, Ravichandran Nadarajah, Jolene Si Min Wong, Grace Hwei Ching Tan, Khee Chee Soo, Melissa Ching Ching Teo, Claramae Shulyn Chia, Chin-Ann Johnny Ong

Summary: This study aimed to identify molecular markers for predicting platinum sensitivity in ovarian cancer patients. Four potential biomarkers were found to have comparable prognostication as clinical information for two-year survival and chemosensitivity prediction. Assessment of tumor biology through gene expression may provide additional information for therapeutic decision making.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

BCL-2 isoform beta promotes angiogenesis by TRiC-mediated upregulation of VEGF-A in lymphoma

Xiaohang Hang, Lei Zhao, Baohong Wu, Shujun Li, Pengpeng Liu, Jing Xu, Xinyuan Wang, Pengliang Chi, Chong Chen, Ting Niu, Lunzhi Dai, Yu Liu

Summary: This study found a significant positive correlation between the expressions of Bcl-2 alpha and Bcl-2 beta in diffuse large B-cell lymphoma. Using CRISPR/Cas9 technology, researchers discovered that Bcl-2 beta promotes angiogenesis through interaction with TRiC, which affects tumor growth.

ONCOGENE (2022)

Add to Collection

Review Oncology

Surgery in Recurrent Ovarian Cancer: A Meta-Analysis

Maria Teresa Climent, Anna Serra, Maria Llueca, Antoni Llueca

Summary: Ovarian cancer has a high mortality rate due to advanced diagnosis and high recurrence rate. Systemic chemotherapy is the standard treatment for recurrent ovarian cancer, but secondary cytoreductive surgery may also be effective. This study analyzed multiple randomized controlled trials and found significant improvements in overall survival and disease-free survival for patients who underwent complete secondary cytoreductive surgery.

CANCERS (2023)

Add to Collection

Article Biochemistry & Molecular Biology

RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to promote ROS-mediated NF-κB activation and ovarian cancer progression

Xiao Yu, Pengfei Zhao, Qingyu Luo, Xiaowei Wu, Yating Wang, Yabing Nan, Shi Liu, Wenyan Gao, Bin Li, Zhihua Liu, Zhumei Cui

Summary: This study reveals that lncRNA RUNX1-IT1 plays a critical role in the progression of ovarian cancer. Its overexpression is associated with shorter survival and worse prognosis in patients. Knockdown of RUNX1-IT1 suppresses the proliferation, migration, and invasion of ovarian cancer cells and reduces metastasis formation. Mechanistically, RUNX1-IT1 regulates intracellular reactive oxygen homeostasis by altering histone modification status and activates NF-κB signaling. Targeting RUNX1-IT1 may be a promising therapeutic strategy for ovarian cancer treatment.

ONCOGENE (2023)

Add to Collection

Article Multidisciplinary Sciences

A prognostic model for ovarian neoplasms established by an integrated analysis of 1580 transcriptomic profiles

Yanjiao Hua, Du Cai, Cole Andrea Shirley, Sien Mo, Ruyun Chen, Feng Gao, Fangying Chen

Summary: A predictive model called the Ovarian Cancer Disease Free Survival Predictor (ODFSP) was created to identify high-risk ovarian cancer patients with early recurrence. ODFSP showed high prognostic value and could help with treatment decisions by identifying individuals who might benefit from a more aggressive treatment plan or clinical trial.

SCIENTIFIC REPORTS (2023)

Add to Collection

Article Medical Laboratory Technology

POCT urine dipstick versus central laboratory analyses: Diagnostic performance and logistics in the medical emergency department

Eline Sandvig Andersen, Claus Ostergaard, Richard Roettger, Anne Friesgaard Christensen, Ivan Brandslund, Claus Lohman Brasen

Summary: The study aimed to evaluate the logistics and diagnostic performances of dipstick analyses compared to central laboratory analyses for detecting bacteriuria, proteinuria, hyperglycemia, ketosis, and hematuria. The sensitivity of traditional dipstick analysis reached up to 90% for proteinuria, bacteriuria, and ketosis, but only 59% for hyperglycemia. Flow cytometry outperformed dipstick analysis in detecting bacteriuria. Central laboratory analyses had better performance for detecting bacteriuria and albuminuria, while achieving acceptable turn-around-times. However, dipstick analysis may not adequately diagnose ketosis and hyperglycemia, which may be better diagnosed by point-of-care blood test. The use of dipstick hemoglobin analysis, flow cytometry, and microscopic evaluation are relevant in emergency departments.

CLINICAL BIOCHEMISTRY (2023)

Add to Collection

Article Oncology

Comparison of human papillomavirus-based cervical cancer screening strategies in Tanzania among women with and without HIV

Crispin Kahesa, Louise T. Thomsen, Ditte S. Linde, Bariki Mchome, Johnson Katanga, Patricia Swai, Rachel Manongi, Myassa Kjaerem, Thomas Iftner, Marianne Waldstrom, Julius Mwaiselage, Vibeke Rasch, Susanne K. Kjaer

Summary: This study from Tanzania compared nine HPV-based cervical cancer screening strategies and suggested that HPV testing alone, or HPV testing with extended genotyping or increased viral load cut-offs, may improve cervical cancer screening in Sub-Saharan Africa.

INTERNATIONAL JOURNAL OF CANCER (2023)

Add to Collection

Article Oncology

Assessment of circulating biomarkers for detection of lung cancer in a high-risk cohort

Morten Borg, Line Nederby, Sara Witting Christensen Wen, Torben Frostrup Hansen, Anders Jakobsen, Rikke Fredslund Andersen, Ulla Moller Weinreich, Ole Hilberg

Summary: This study assessed the diagnostic properties of a biomarker panel consisting of CYFRA 21-1, CEA, and CA125 for lung cancer detection. The results showed that the biomarkers had high sensitivity and specificity for detecting lung cancer, but their ability to detect early-stage lung cancer was low.

CANCER BIOMARKERS (2023)

Add to Collection

Article Anesthesiology

Neurofilament light chain as a biomarker of axonal damage in sensory neurons and paclitaxel-induced peripheral neuropathy in patients with ovarian cancer

Christina Mortensen, Karina Dahl Steffensen, Emma Simonsen, Kamille Herskind, Jonna Skov Madsen, Dorte Aalund Olsen, Ditte Bork Iversen, Troels Korshoj Bergmann, Anton Pottegard, Tore Bjerregaard Stage

Summary: Using a translational approach, this study assessed the utility of neurofilament light chain (NFL) as a biomarker for paclitaxel-induced peripheral neuropathy (PIPN) in a human cell model and in ovarian cancer patients, finding that high serum NFL levels predicted adverse outcomes related to PIPN.

PAIN (2023)

Add to Collection

Article Multidisciplinary Sciences

SDM:HOSP- a generic model for hospital-based implementation of shared decision making

Karina Dahl Steffensen, Dorte Gilsa Hansen, Kurt Espersen, Susanne Lauth, Peter Fosgrau, Anders Meinert Pedersen, Peter Sigerseth Groen, Christian Sauvr, Karina Olling

Summary: This paper describes the development of a model called SDM:HOSP, which aims to achieve lasting shared decision making (SDM) between patients and healthcare professionals. Through four phases of development, including the development of conceptual elements, field testing, evaluation, and the development of the final model, SDM:HOSP can be easily adapted to different organizations and cultures.

PLOS ONE (2023)

Add to Collection

Article Cell Biology

Specific prediction of mortality by oxidative stress-induced damage to RNA vs. DNA in humans

Anders Jorgensen, Ivan Brandslund, Christina Ellervik, Trine Henriksen, Allan Weimann, Per Kragh Andersen, Henrik E. E. Poulsen

Summary: Modifications of nucleic acids (DNA and RNA) from oxidative stress are potential drivers of aging and mortality in age-associated medical disorders such as type 2 diabetes (T2D). A marker of RNA oxidation was found to strongly predict all-cause mortality in T2D patients and nondiabetic control subjects, even after adjusting for established modifiers of oxidative stress. On the other hand, DNA damage from oxidation, which has traditionally been linked to T2D and aging, failed to predict mortality. These findings were subsequently replicated in an independent general population study, highlighting the specific importance of RNA damage from oxidation in T2D and general aging.

AGING CELL (2023)

Add to Collection

Article Oncology

NK cell activity and methylated HOXA9 ctDNA as prognostic biomarkers in patients with non-small cell lung cancer treated with PD-1/PD-L1 inhibitors

Sara Witting Christensen Wen, Line Nederby, Rikke Fredslund Andersen, Torben Schjodt Hansen, Christa Haugaard Nyhus, Ole Hilberg, Anders Jakobsen, Torben Frostrup Hansen

Summary: Natural killer cell activity (NKA) and methylated HOXA9 circulating tumor DNA (ctDNA) can serve as prognostic biomarkers in patients with non-small cell lung cancer (NSCLC) treated with PD-1/PD-L1 inhibitors. Evaluating the NKA and ctDNA status after one treatment cycle can accurately predict patient survival.

BRITISH JOURNAL OF CANCER (2023)

Add to Collection

Article Endocrinology & Metabolism

CRP, C-Peptide, and Risk of First-Time Cardiovascular Events and Mortality in Early Type 2 Diabetes: A Danish Cohort Study

Anne Gedebjerg, Mette Bjerre, Alisa Devedzic Kjaergaard, Jens Steen Nielsen, Jorgen Rungby, Ivan Brandslund, Michael Maeng, Henning Beck-Nielsen, Allan Vaag, Henrik Toft Sorensen, Troels Krarup Hansen, Reimar Wernich Thomsen

Summary: We investigated the relationship between hs-CRP and C-peptide in patients with recently diagnosed T2D and found that high levels of hs-CRP were associated with increased risk of CVEs and all-cause mortality. Patients with high levels of both biomarkers had the highest risk. These findings have important implications for early detection and prevention of deadly diseases beyond CVEs.

DIABETES CARE (2023)

Add to Collection

Correction Multidisciplinary Sciences

The power of genetic diversity in genome-wide association studies of lipids (vol 600, pg 675, 2021)

Sarah E. Graham, Shoa L. Clarke, Kuan-Han H. Wu, Stavroula Kanoni, Greg J. M. Zajac, Shweta Ramdas, Ida Surakka, Ioanna Ntalla, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, Mi Yeong Hwang, Sohee Han, Akira Narita, Ananyo Choudhury, Amy R. Bentley, Kenneth Ekoru, Anurag Verma, Bhavi Trivedi, Hilary C. Martin, Karen A. Hunt, Qin Hui, Derek Klarin, Xiang Zhu, Gudmar Thorleifsson, Anna Helgadottir, Daniel F. Gudbjartsson, Hilma Holm, Isleifur Olafsson, Masato Akiyama, Saori Sakaue, Chikashi Terao, Masahiro Kanai, Wei Zhou, Ben M. Brumpton, Humaira Rasheed, Sanni E. Ruotsalainen, Aki S. Havulinna, Yogasudha Veturi, QiPing Feng, Elisabeth A. Rosenthal, Todd Lingren, Jennifer Allen Pacheco, Sarah A. Pendergrass, Jeffrey Haessler, Franco Giulianini, Yuki Bradford, Jason E. Miller, Archie Campbell, Kuang Lin, Iona Y. Millwood, George Hindy, Asif Rasheed, Jessica D. Faul, Wei Zhao, David R. Weir, Constance Turman, Hongyan Huang, Mariaelisa Graff, Anubha Mahajan, Michael R. Brown, Weihua Zhang, Ketian Yu, Ellen M. Schmidt, Anita Pandit, Stefan Gustafsson, Xianyong Yin, Jian'an Luan, Jing-Hua Zhao, Fumihiko Matsuda, Hye-Mi Jang, Kyungheon Yoon, Carolina Medina-Gomez, Achilleas Pitsillides, Jouke Jan Hottenga, Gonneke Willemsen, Andrew R. Wood, Yingji Ji, Zishan Gao, Simon Haworth, Ruth E. Mitchell, Jin Fang Chai, Mette Aadahl, Jie Yao, Ani Manichaikul, Helen R. Warren, Julia Ramirez, Jette Bork-Jensen, Line L. Karhus, Anuj Goel, Maria Sabater-Lleal, Raymond Noordam, Carlo Sidore, Edoardo Fiorillo, Aaron F. McDaid, Pedro Marques-Vidal, Matthias Wielscher, Stella Trompet, Naveed Sattar, Line T. Mollehave, Betina H. Thuesen, Matthias Munz, Lingyao Zeng, Jianfeng Huang, Bin Yang, Alaitz Poveda, Azra Kurbasic, Claudia Lamina, Lukas Forer, Markus Scholz, Tessel E. Galesloot, Jonathan P. Bradfield, E. Warwick Daw, Joseph M. Zmuda, Jonathan S. Mitchell, Christian Fuchsberger, Henry Christensen, Jennifer A. Brody, Mary F. Feitosa, Mary K. Wojczynski, Michael Preuss, Massimo Mangino, Paraskevi Christofidou, Niek Verweij, Jan W. Benjamins, Jorgen Engmann, Rachel L. Kember, Roderick C. Slieker, Ken Sin Lo, Nuno R. Zilhao, Phuong Le, Marcus E. Kleber, Graciela E. Delgado, Shaofeng Huo, Daisuke D. Ikeda, Hiroyuki Iha, Jian Yang, Jun Liu, Hampton L. Leonard, Jonathan Marten, Boerge Schmidt, Marina Arendt, Laura J. Smyth, Marisa Canadas-Garre, Chaolong Wang, Masahiro Nakatochi, Andrew Wong, Nina Hutri-Kahonen, Xueling Sim, Rui Xia, Alicia Huerta-Chagoya, Juan Carlos Fernandez-Lopez, Valeriya Lyssenko, Meraj Ahmed, Anne U. Jackson, Noha A. Yousri, Marguerite R. Irvin, Christopher Oldmeadow, Han-Na Kim, Seungho Ryu, Paul R. H. J. Timmers, Liubov Arbeeva, Rajkumar Dorajoo, Leslie A. Lange, Xiaoran Chai, Gauri Prasad, Laura Lores-Motta, Marc Pauper, Jirong Long, Xiaohui Li, Elizabeth Theusch, Fumihiko Takeuchi, Cassandra N. Spracklen, Anu Loukola, Sailalitha Bollepalli, Sophie C. Warner, Ya Xing Wang, Wen B. Wei, Teresa Nutile, Daniela Ruggiero, Yun Ju Sung, Yi-Jen Hung, Shufeng Chen, Fangchao Liu, Jingyun Yang, Katherine A. Kentistou, Mathias Gorski, Marco Brumat, Karina Meidtner, Lawrence F. Bielak, Jennifer A. Smith, Prashantha Hebbar, Aliki-Eleni Farmaki, Edith Hofer, Maoxuan Lin, Chao Xue, Jifeng Zhang, Maria Pina Concas, Simona Vaccargiu, Peter J. van der Most, Niina Pitkanen, Brian E. Cade, Jiwon Lee, Sander W. van der Laan, Kumaraswamy Naidu Chitrala, Stefan Weiss, Martina E. Zimmermann, Jong Young Lee, Hyeok Sun Choi, Maria Nethander, Sandra Freitag-Wolf, Lorraine Southam, Nigel W. Rayner, Carol A. Wang, Shih-Yi Lin, Jun-Sing Wang, Christian Couture, Leo-Pekka Lyytikainen, Kjell Nikus, Gabriel Cuellar-Partida, Henrik Vestergaard, Bertha Hildalgo, Olga Giannakopoulou, Qiuyin Cai, Morgan O. Obura, Jessica van Setten, Xiaoyin Li, Karen Schwander, Natalie Terzikhan, Jae Hun Shin, Rebecca D. Jackson, Alexander P. Reiner, Lisa Warsinger Martin, Zhengming Chen, Liming Li, Heather M. Highland, Kristin L. Young, Takahisa Kawaguchi, Joachim Thiery, Joshua C. Bis, Girish N. Nadkarni, Lenore J. Launer, Huaixing Li, Mike A. Nalls, Olli T. Raitakari, Sahoko Ichihara, Sarah H. Wild, Christopher P. Nelson, Harry Campbell, Susanne Jaeger, Toru Nabika, Fahd Al-Mulla, Harri Niinikoski, Peter S. Braund, Ivana Kolcic, Peter Kovacs, Tota Giardoglou, Tomohiro Katsuya, Konain Fatima Bhatti, Dominique de Kleijn, Gert J. de Borst, Eung Kweon Kim, Hieab H. H. Adams, M. Arfan Ikram, Xiaofeng Zhu, Folkert W. Asselbergs, Adriaan O. Kraaijeveld, Joline W. J. Beulens, Xiao-Ou Shu, Loukianos S. Rallidis, Oluf Pedersen, Torben Hansen, Paul Mitchell, Alex W. Hewitt, Mika Kahonen, Louis Perusse, Claude Bouchard, Anke Toenjes, Yii-Der Ida Chen, Craig E. Pennell, Trevor A. Mori, Wolfgang Lieb, Andre Franke, Claes Ohlsson, Dan Mellstrom, Yoon Shin Cho, Hyejin Lee, Jian-Min Yuan, Woon-Puay Koh, Sang Youl Rhee, Jeong-Taek Woo, Iris M. Heid, Klaus J. Stark, Henry Voelzke, Georg Homuth, Michele K. Evans, Alan B. Zonderman, Ozren Polasek, Gerard Pasterkamp, Imo E. Hoefer, Susan Redline, Katja Pahkala, Albertine J. Oldehinkel, Harold Snieder, Ginevra Biino, Reinhold Schmidt, Helena Schmidt, Y. Eugene Chen, Stefania Bandinelli, George Dedoussis, Thangavel Alphonse Thanaraj, Sharon L. R. Kardia, Norihiro Kato, Matthias B. Schulze, Giorgia Girotto, Bettina Jung, Carsten A. Boeger, Peter K. Joshi, David A. Bennett, Philip L. De Jager, Xiangfeng Lu, Vasiliki Mamakou, Morris Brown, Mark J. Caulfield, Patricia B. Munroe, Xiuqing Guo, Marina Ciullo, Jost B. Jonas, Nilesh J. Samani, Jaakko Kaprio, Paeivi Pajukanta, Linda S. Adair, Sonny Augustin Bechayda, H. Janaka de Silva, Ananda R. Wickremasinghe, Ronald M. Krauss, Jer-Yuarn Wu, Wei Zheng, Anneke I. den Hollander, Dwaipayan Bharadwaj, Adolfo Correa, James G. Wilson, Lars Lind, Chew-Kiat Heng, Amanda E. Nelson, Yvonne M. Golightly, James F. Wilson, Brenda Penninx, Hyung-Lae Kim, John Attia, Rodney J. Scott, D. C. Rao, Donna K. Arnett, Steven C. Hunt, Mark Walker, Heikki A. Koistinen, Giriraj R. Chandak, Chittaranjan S. Yajnik, Josep M. Mercader, Teresa Tusie-Luna, Carlos A. Aguilar-Salinas, Clicerio Gonzalez Villalpando, Lorena Orozco, Myriam Fornage, E. Shyong Tai, Rob M. van Dam, Terho Lehtimaki, Nish Chaturvedi, Mitsuhiro Yokota, Jianjun Liu, Dermot F. Reilly, Amy Jayne McKnight, Frank Kee, Karl-Heinz Joeckel, Mark I. McCarthy, Colin N. A. Palmer, Veronique Vitart, Caroline Hayward, Eleanor Simonsick, Cornelia M. van Duijn, Fan Lu, Jia Qu, Haretsugu Hishigaki, Xu Lin, Winfried Maerz, Esteban J. Parra, Miguel Cruz, Vilmundur Gudnason, Jean-Claude Tardif, Guillaume Lettre, Leen M. 't Hart, Petra J. M. Elders, Scott M. Damrauer, Meena Kumari, Mika Kivimaki, Pim van der Harst, Tim D. Spector, Ruth J. F. Loos, Michael A. Province, Bruce M. Psaty, Ivan Brandslund, Peter P. Pramstaller, Kaare Christensen, Samuli Ripatti, Elisabeth Widen, Hakon Hakonarson, Struan F. A. Grant, Lambertus A. L. M. Kiemeney, Jacqueline de Graaf, Markus Loeffler, Florian Kronenberg, Dongfeng Gu, Jeanette Erdmann, Heribert Schunkert, Paul W. Franks, Allan Linneberg, J. Wouter Jukema, Amit V. Khera, Minna Mannikko, Marjo-Riitta Jarvelin, Zoltan Kutalik, Francesco Cucca, Dennis O. Mook-Kanamori, Ko Willems van Dijk, Hugh Watkins, David P. Strachan, Niels Grarup, Peter Sever, Neil Poulter, Jerome I. Rotter, Thomas M. Dantoft, Fredrik Karpe, Matt J. Neville, Nicholas J. Timpson, Ching-Yu Cheng, Tien-Yin Wong, Chiea Chuen Khor, Charumathi Sabanayagam, Annette Peters, Christian Gieger, Andrew T. Hattersley, Nancy L. Pedersen, Patrik K. E. Magnusson, Dorret I. Boomsma, Eco J. C. de Geus, L. Adrienne Cupples, Joyce B. J. van Meurs, Mohsen Ghanbari, Penny Gordon-Larsen, Wei Huang, Young Jin Kim, Yasuharu Tabara, Nicholas J. Wareham, Claudia Langenberg, Eleftheria Zeggini, Johanna Kuusisto, Markku Laakso, Erik Ingelsson, Goncalo Abecasis, John C. Chambers, Jaspal S. Kooner, Paul S. de Vries, Alanna C. Morrison, Kari E. North, Martha Daviglus, Peter Kraft, Nicholas G. Martin, John B. Whitfield, Shahid Abbas, Danish Saleheen, Robin G. Walters, Michael V. Holmes, Corri Black, Blair H. Smith, Anne E. Justice, Aris Baras, Julie E. Buring, Paul M. Ridker, Daniel I. Chasman, Charles Kooperberg, Wei-Qi Wei, Gail P. Jarvik, Bahram Namjou, M. Geoffrey Hayes, Marylyn D. Ritchie, Pekka Jousilahti, Veikko Salomaa, Kristian Hveem, Bjorn Olav Asvold, Michiaki Kubo, Yoichiro Kamatani, Yukinori Okada, Yoshinori Murakami, Unnur Thorsteinsdottir, Kari Stefansson, Yuk-Lam Ho, Julie A. Lynch, Daniel J. Rader, Philip S. Tsao, Kyong-Mi Chang, Kelly Cho, Christopher J. O'Donnell, John M. Gaziano, Peter Wilson, Charles N. Rotimi, Scott Hazelhurst, Michele Ramsay, Richard C. Trembath, David A. van Heel, Gen Tamiya, Masayuki Yamamoto, Bong-Jo Kim, Karen L. Mohlke, Timothy M. Frayling, Joel N. Hirschhorn, Sekar Kathiresan, Michael Boehnke, Pradeep Natarajan, Gina M. Peloso, Christopher D. Brown, Andrew P. Morris, Themistocles L. Assimes, Panos Deloukas, Yan V. Sun, Cristen J. Willer

NATURE (2023)

Add to Collection

Article Multidisciplinary Sciences

Sensitivity and performance of three novel quantitative assays of SARS-CoV-2 nucleoprotein in blood

Thore Hillig, Josephine R. Kristensen, Claus L. Brasen, Ivan Brandslund, Dorte A. Olsen, Camilla Davidsen, Jonna S. Madsen, Claus A. Jensen, Young B. L. Hansen, Lennart Friis-Hansen

Summary: This study compared the performance of three commercial SARS-CoV-2 nucleoprotein (N) assays in plasma to assess their ability to determine systemic COVID-19 disease. The assays were analyzed on 272 plasma samples obtained in November-December 2021, as well as a dilution series of inactivated virus culture. The assays showed poor agreement on patient samples but excellent performance on virus culture, with differing levels of detection.

SCIENTIFIC REPORTS (2023)

Add to Collection

Review Public, Environmental & Occupational Health

A Review of Major Danish Biobanks: Advantages and Possibilities of Health Research in Denmark

Kristina Laugesen, Jonas Mengel-From, Kaare Christensen, Jorn Olsen, David M. Hougaard, Lasse Boding, Anja Olsen, Christian Erikstrup, Merete Lund Hetland, Estrid Hogdall, Alisa Kjaergaard, Erik Sorensen, Anja Brugmann, Eva Rabing Brix Petersen, Ivan Brandslund, Borge Nordestgaard, Gorm B. Jensen, Nils Skajaa, Frederikke Schonfeldt Troelsen, Cecilia Hvitfeldt Fuglsang, Lise Skovgaard Svingel, Henrik T. Sorensen

Summary: Denmark has a rich source of biobanks and a comprehensive healthcare system, which allows for the integration of biological specimens with clinical and demographic data for biobank research. This can contribute to a better understanding of disease etiology and personalized medicine.

CLINICAL EPIDEMIOLOGY (2023)

Add to Collection

Letter Hematology

An international real-world analysis of relapsed/refractory lymphoma occurring during pregnancy

Faheem Farooq, Justin S. Brandt, Elyce Cardonick, Evgeniya Polushkina, Julie Vose, Sairah Ahmed, Praveen Ramakrishnan Geethakumari, Adam J. Olszewski, Hesham Yasin, Umar Farooq, Nada Hamad, Yong Lin, Charlotte Maggen, Robert Fruscio, Mina Mhallem Gziri, Karina Dahl Steffensen, Frederic Amant, Andrew M. Evens

BLOOD ADVANCES (2023)

Add to Collection

Article Endocrinology & Metabolism

Associations between insulin-like growth factor binding protein-2 and insulin sensitivity, metformin, and mortality in persons with T2D

Rikke Hjortebjerg, Maja R. Kristiansen, Ivan Brandslund, Dorte Aa. Olsen, Jacob V. Stidsen, Jens S. Nielsen, Jan Frystyk

Summary: In individuals with type 2 diabetes, high levels of IGFBP-2 are associated with low glucose and insulin secretion, are unaffected by metformin treatment, and are associated with the risk of prior comorbidity and mortality.

DIABETES RESEARCH AND CLINICAL PRACTICE (2023)

Add to Collection

Article Multidisciplinary Sciences

Circulating DNA and frequency of colorectal cancer brain metastases in a presumed high-risk group

Louise Bach Callesen, Anders Kindberg Boysen, Rikke Fredslund Andersen, Rikke Beese Dalby, Karen-Lise Garm Spindler

Summary: This exploratory prospective observational pilot study investigated the potential benefits of suggested risk factors in detecting asymptomatic brain metastases in patients with colorectal cancer. The study also examined prognostic biological aspects through translational analysis of plasma samples. The results showed a low incidence of brain metastases in the selected population, indicating that routine MRI may not be necessary for this group.

SCIENTIFIC REPORTS (2023)

Add to Collection

Review Oncology

Methylated Circulating Tumor DNA in Blood as a Tool for Diagnosing Lung Cancer: A Systematic Review and Meta-Analysis

Morten Borg, Sara Witting Christensen Wen, Rikke Fredslund Andersen, Signe Timm, Torben Frostrup Hansen, Ole Hilberg

Summary: Lung cancer is the leading cause of cancer-related deaths, and early detection is crucial for improving patient outcomes. Non-invasive diagnostic tools, such as methylated circulating tumor DNA (ctDNA), show potential for lung cancer diagnosis. This systematic review and meta-analysis evaluated the current evidence on the use of methylated ctDNA in blood samples as a diagnostic tool for lung cancer.

CANCERS (2023)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.