Article
Biochemistry & Molecular Biology
Kamiya Bridges, Humphrey H-C Yao, Barbara Nicol
Summary: This study reveals the significance of the Runx1 gene in mouse ovarian development. Loss of Runx1 leads to an increased prevalence of ovarian tumors and also affects normal granulosa cell differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Reproductive Biology
Dennis Jung, Katrin Almstedt, Marco J. Battista, Alexander Seeger, Joerg Jaekel, Walburgis Brenner, Annette Hasenburg
Summary: Granulosa cell tumors (GCT) are rare malignant ovarian tumors, with adult and juvenile subtypes having different characteristics. GCTs are generally low-malignant tumors with favorable prognosis, but relapses can occur even years after diagnosis. This review aims to provide an overview of prognostic markers for GCT, to identify patients at high risk of recurrence.
JOURNAL OF OVARIAN RESEARCH
(2023)
Review
Oncology
Amelia Barcellini, Giorgia Mangili, Andrei Fodor, Simona Secondino, Flavia Zerbetto, Alexandra Charalampopoulou, Sandro Pignata, Ester Orlandi, Alice Bergamini
Summary: Granulosa cell tumors of the ovary have a good prognosis but a high risk of local recurrence. The best treatment for recurrent cases is unclear, and there is a lack of randomized clinical trials in this setting. The role of radiotherapy in adjuvant settings is controversial and unknown for post-surgery relapse. This review aims to summarize the evidence level of radiation treatments for granulosa cell tumors of the ovary.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Obstetrics & Gynecology
Elijah Ndhlovu, Lili Liu, Jun Dai, Xiyuan Dong, Wen Zhang, Biao Chen
Summary: The majority of JGCT patients are diagnosed with FIGO stage I tumors and have favorable clinical outcomes. Adjuvant chemotherapy appears to improve outcomes for advanced-stage patients; however, the value in stage Ic patients remains uncertain. Fertility-sparing surgery may be considered for young patients wishing to bear children.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Pathology
Pauline Baillard, Catherine Genestie, Sabrina Croce, Francoise Descotes, Etienne Rouleau, Isabelle Treilleux, Sebastien Gouy, Philippe Morice, Isabelle Ray-Coquard, W. Glenn McCluggage, Mojgan Devouassoux-Shisheboran
Summary: FOXL2 mutations were not detected in JGCTs in this study, while only a small percentage of these neoplasms exhibited DICER1 mutations.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Oncology
Ruirui Zhang, Ruiheng Zhao, Qian Shen
Summary: This report describes a rare case of ovarian granulosa cell tumor torsion in a 17-year-old patient. The patient presented with lower abdominal pain, nausea, and vomiting one day after defecation. After gynecological examination and ultrasound, the diagnosis of ovarian tumor torsion was made, and an urgent surgical resection was performed. Postoperative pathology report confirmed a juvenile granulosa cell tumor.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Editorial Material
Obstetrics & Gynecology
Joana Seabra, Andre Silva, Isa Santos, Joana Almeida, Lucia Correia, Margarida Correia
Summary: Retroperitoneal recurrence after excision of a juvenile granulosa cell tumor is rare and can mimic other conditions with nonspecific symptoms.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Pathology
Katrina Collins, Lynette M. Sholl, Sara O. Vargas, Kristine M. Cornejo, Oleksandr Kravtsov, Brendan C. Dickson, Muhammad T. Idrees, Thomas M. Ulbright, Andres M. Acosta
Summary: Testicular juvenile granulosa cell tumors (JGCTs) are rare and genetically different from their ovarian counterparts. This study found that JGCTs frequently exhibit recurrent loss of chromosome 10 and lack specific genetic variants. The findings contribute to a better understanding of the molecular alterations associated with JGCTs. Rating: 7.5/10.
Review
Obstetrics & Gynecology
Elijah Ndhlovu, Hui Deng, Jun Dai, Xiyuan Dong, Lili Liu, Biao Chen
Summary: Pregnancy complicated with juvenile granulosa cell tumor (JGCT) is rare, and surgery can be delayed without affecting the fetus in non-emergency situations. Further research is needed to determine the value of chemotherapy in FIGO stage I patients.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Review
Oncology
Xiuwen Lil, Bo Tian, Mengyan Liu, Chunlei Miao, Di Wang
Summary: Adult-type Granulosa Cell Tumor of the Ovary (AGCT) is a rare subtype of ovarian cancer originating from normal preovulatory granulosa cells, with hormonal features aiding in clinical diagnosis and recurrence prediction. Surgery plays a crucial role in treatment, while ongoing research focuses on molecular pathogenesis to identify potential factors for targeted treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Obstetrics & Gynecology
Yu Gu, Dan Wang, Congwei Jia, Lihua Chen, Wei Cang, Xirun Wan, Junjun Yang, Yang Xiang
Summary: This study aimed to describe the clinicopathological characteristics of recurrent adult granulosa cell tumor and identify the risk factors for recurrence. A retrospective review of 70 recurrent adult granulosa cell tumor patients treated between 2000 and 2020 was conducted. The results showed that the recurrence pattern was characterized by late and repeated, multifocal, and distant relapse. Risk factors for progression-free survival after first recurrence (PFS-R) were identified as PFS1 <= 60 months and distant lesion at recurrence, while PFS-R <= 33 months was a risk factor for overall survival after first recurrence (OS-R). The PWP-CP model suggested that the transabdominal approach and achieving R0 could decrease recurrence frequency.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Pathology
Gupta Parikshaa, Zaidi Ariba, Dey Pranab, Gupta Nalini, Rohilla Manish, Suri Vanita, Rai Bhavana, Dayal Devi, Samujh Ram, Menon Prema, Rajwanshi Arvind, Srinivasan Radhika
Summary: Juvenile granulosa cell tumor (JGCT) is a rare ovarian tumor that primarily affects young women and children, with diverse clinical and histopathologic features. Despite aggressive histopathology, these tumors have a good prognosis when diagnosed at an early stage.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2021)
Review
Endocrinology & Metabolism
Madeleine Birgersson, Rajitha Indukuri, Per Antonson, Ivan Nalvarte, Amena Archer, Cecilia Williams
Summary: Granulosa cell tumors (GCTs) are rare ovarian tumors with good prognosis, but become more dangerous in late-stage or recurring cases. Lack of research on GCTs has resulted in a lack of specific treatment strategies for this tumor type. High expression of estrogen receptor beta (ER beta/ESR2) in GCTs suggests that it could be a potential therapeutic target. This review aims to summarize the current understanding of ER beta's role in the ovary and its potential significance in GCTs.
Article
Medicine, General & Internal
Sarah A. Singh, Basem Dahshan, Rebecca F. Krc, David M. McDermott, Geraldine M. Jacobson
Summary: Granulosa cell tumors of the ovary are rare, with a tendency for metastasis and recurrence, leading to a poor prognosis in many cases. The optimal management of relapsed disease is controversial, with treatments such as surgical debulking, chemotherapy, and radiation therapy showing varying levels of success.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Oncology
Jeffrey A. How, Amir Jazaeri, Shannon N. Westin, Anil K. Sood, Lois M. Ramondetta, Mingxuan Xu, Abdulrahman Abonofal, Daniel D. Karp, Vivek Subbiah, Bettzy Stephen, Jordi A. Rodon, Fei Yang, Aung Naing
Summary: Treatment of recurrent, unresectable granulosa cell tumor of the ovary can be challenging, and there are currently no reports on the use of immune checkpoint inhibitors in GCT patients. However, a case series showed that some adult-type GCT patients treated with pembrolizumab experienced disease control for over 12 months with low toxicity, suggesting potential clinical benefit in this subset of patients. Further studies are needed to explore the role of immunotherapy in GCT and identify predictors of clinical benefit.
INVESTIGATIONAL NEW DRUGS
(2021)
