Article
Clinical Neurology
Zhenqian Wang, Jiawen Lu, Weipin Weng, Li Zhang, Jie Zhang
Summary: This study uses Mendelian randomization to reveal causal associations between women's reproductive behaviors and ischemic stroke, and investigates the roles of body mass index and educational attainment in these associations. The findings can inform prevention strategies and interventions for ischemic stroke.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Zhi-bing Hu, Ze-xiong Lu, Feng Zhu
Summary: The study found that younger or older age at menarche, younger age at menopause, and shorter reproductive years in postmenopausal women were associated with an increased risk of fatal stroke.
Article
Medicine, General & Internal
Su-Min Jeong, Jung Eun Yoo, Keun Hye Jeon, Kyungdo Han, Heesun Lee, Dong-Yun Lee, Dong Wook Shin
Summary: This study examined the association between reproductive factors (age at menarche, age at menopause, and reproductive span) and the incidence of myocardial infarction (MI) and ischemic stroke (IS) in postmenopausal women. The findings revealed that late menarche, early menopause, and short reproductive span were associated with a higher risk of MI. In contrast, age at menarche showed a U-shaped association with the risk of IS. Therefore, it is important to consider female reproductive factors in addition to traditional cardiovascular risk factors when assessing overall cardiovascular risk in postmenopausal women.
Article
Clinical Neurology
Sabrina J. G. C. Welten, N. Charlotte Onland-Moret, Jolanda M. A. Boer, W. M. Monique Verschuren, Yvonne T. van der Schouw
Summary: This study found that earlier menopause is associated with increased risk of stroke in women, with a 2% lower stroke risk for each year menopause was delayed. The association with stroke risk was stronger for natural menopause.
Article
Endocrinology & Metabolism
Alexander D. Rebchuk, Michael D. Hill, Mayank Goyal, Andrew Demchuk, Shelagh B. Coutts, Negar Asdaghi, Dar Dowlatshahi, Jessalyn K. Holodinsky, Enrico Fainardi, Jai Shankar, Mohamed Najm, Marta Rubiera, Alexander Khaw, Wu Qiu, Bijoy K. Menon, Thalia S. Field
Summary: Women, especially postmenopausal women, have worse outcomes after acute ischemic stroke. One possible reason for this is the decrease in the vasculoprotective effects of estrogen in older women. This study investigated the effects of sex and age on neuroradiological predictors of recanalization in acute ischemic stroke patients. The results showed that there was no association between sex and radiological predictors of recanalization.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Erin S. LeBlanc, Kathleen M. Hovey, Jane A. Cauley, Marcia Stefanick, Rachel Peragallo, Michelle J. Naughton, Christopher A. Andrews, Carolyn J. Crandall
Summary: This study aimed to evaluate the relationship between cumulative endogenous estrogen exposure and fracture risk. The findings showed that women with fewer years of endogenous estrogen exposure had a higher risk of fractures, while women with longer exposure had a lower risk. Women with irregular menstrual cycles were also at higher risk of lower extremity fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jie Li, Wenting Hao, Chunying Fu, Chengchao Zhou, Dongshan Zhu
Summary: This study found that postmenopausal women are more likely to experience memory impairment compared to men, particularly in objective memory. Female reproductive factors such as age at menarche and menopause may influence the risk of memory problems.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Maryam Farahmand, Maryam Rahmati, Fereidoun Azizi, Samira Behboudi Gandevani, Fahimeh Ramezani Tehrani
Summary: This study investigated the relationship between duration of endogenous estrogen exposure (EEE) and fracture incidence using a longitudinal design. The findings suggest that a longer duration of EEE is associated with a reduced risk of fractures, highlighting the importance of considering EEE in fracture risk assessment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Environmental Sciences
Roberto Gonzalez-Martin, Maria Grau-Perez, Patricia Sebastian-Leon, Patricia Diaz-Gimeno, Carmen Vidal, Maria Tellez-Plaza, Francisco Dominguez
Summary: Cadmium and lead exposure can affect hormonally regulated processes and increase reproductive lifespan and prevalence of pregnancy loss in post-menopausal women. This study evaluated the association between blood cadmium and lead levels with reproductive lifespan and personal history of pregnancy loss in a sample of 5317 post-menopausal women. The results showed that higher blood cadmium and lead levels were associated with longer reproductive lifespan and increased prevalence of pregnancy loss, especially in smokers.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Bumhee Yang, Dong-Hwa Lee, Kyungdo Han, Hayoung Choi, Hyung Koo Kang, Dong Wook Shin, Hyun Lee
Summary: A population-based retrospective cohort study in South Korea found that female reproductive factors are associated with the risk of bronchiectasis, with shorter endogenous oestrogen exposure periods showing a higher risk of developing the condition.
Review
Obstetrics & Gynecology
S. R. Mishra, H-F Chung, M. Waller, G. D. Mishra
Summary: This study evaluated estrogen exposure measurement and the mutual effect of age at menarche and age at menopause on the risk of cardiovascular disease events. Reproductive lifespan was the most commonly used method for estrogen exposure measurement. The findings suggest that a shorter reproductive lifespan is associated with a higher risk of cardiovascular disease events, particularly stroke.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Clinical Neurology
Cynthia D. J. Kusters, Kimberly C. Paul, Aline Duarte Folle, Adrienne M. Keener, Jeff M. Bronstein, Lars Bertram, Johnni Hansen, Steve Horvath, Janet S. Sinsheimer, Christina M. Lill, Beate R. Ritz
Summary: The study found that a later age at menopause in women was associated with a decreased risk of PD, indicating that sex hormones or other factors related to late menopause may have neuroprotective effects on PD.
MOVEMENT DISORDERS
(2021)
Article
Psychiatry
Hyewon Kim, Juhwan Yoo, Kyungdo Han, Mi Jin Park, Hyun Soo Kim, Jihyun Baek, Hong Jin Jeon
Summary: This study investigated the association between female reproductive factors and the development of newly diagnosed bipolar disorder (BD). The study found that later menopause and breastfeeding for more than one year were associated with a decreased risk of BD occurrence, while receiving hormone therapy was associated with an increased risk.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Health Care Sciences & Services
Huaying Liang, Dianwu Li, Yiqun Zhu, Xin Zhou, Fengyu Lin, Danrong Jing, Xiaoli Su, Pinhua Pan, Yan Zhang
Summary: This study found significant associations between multiple reproductive factors and the risk of adult-onset asthma in females. Age at menarche and age of menopause showed a U-shaped relationship with asthma risk. Factors such as early age at first live birth, multiple miscarriages or stillbirths, more children, and shorter reproductive years were associated with an elevated risk of asthma. Additionally, history of hysterectomy or oophorectomy, as well as hormone replacement therapy, were linked to an increased incidence of adult-onset asthma.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Sharayu Mhatre, Ben Lacey, Paul Sherliker, Nilanjan Chatterjee, Preetha Rajaraman, Mahesh Goel, Shraddha Patkar, Vikas Ostwal, Prachi Patil, Shailesh Shrikhande, Garvit Chitkara, Rajendra Badwe, Sarah Lewington, Rajesh Dikshit
Summary: In India, the incidence of gall-bladder cancer is higher in women than in men. This study found a positive association between parity and GBC risk, suggesting that reproductive and hormonal factors play an important role in the development of GBC.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
