Journal
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
Volume 30, Issue 3, Pages 316-323Publisher
WILEY
DOI: 10.1002/gps.4144
Keywords
Parkinson's disease; FDG PET; cerebral metabolism; DLB; visual hallucination; extracampine hallucination
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Funding
- Anti-Aging Research Center of the Juntendo University School of Medicine
- Ogasawara Foundation for the Promotion of Science and Engineering
- Ministry of Education, Culture, Sports, Science and Technology in Japan [20536924]
- Nihon Medi-Physics
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ObjectivesIt is well known that Alzheimer's disease (AD)-type pathology is commonly present in dementia with Lewy bodies (DLB) brains and that the degree of AD-type pathology has an influence on the clinical characteristics of DLB. Although significant hypometabolism in the temporoparietal/precuneus on [F-18]fluoro-d-glucose (F-18-FDG) positron emission tomography (PET) scans is considered to support a diagnosis of AD, some DLB patients also exhibit this metabolic pattern. The clinical significance of the metabolic pattern on DLB remains unknown. MethodsTwenty-three DLB patients, 10 AD patients, and 11 controls underwent F-18-FDG PET scans. According to the degree of hypometabolism in the parietal/precuneus regions, representing the AD-like metabolic pattern, 12 patients were placed in the DLB-AD(+) group and 11 patients were placed in the DLB-AD(-) group. The demographics and clinical variables were compared among the four groups. ResultsIn addition to the parietal/precuneus regions, the DLB-AD(+) group exhibited significantly greater posterior cingulate hypometabolism than the DLB-AD(-) group, although occipital metabolism did not differ. The prevalence of visual hallucinations and extracampine hallucinations, and the Bender-Gestalt test score were significantly higher in the DLB-AD(+) group than the DLB-AD(-) group, although there were no differences in the demographics and other examined clinical variables between the two DLB groups. These clinical differences were absent in the DLB-AD(-) group, AD group, and controls. ConclusionsParietal/precuneus hypometabolism may be associated with clinical characteristics in DLB patients. Further multiple imaging modalities that are sensitive to AD-type pathology are needed to reveal the neurobiological basis of the AD-like metabolic pattern. Copyright (c) 2014 John Wiley & Sons, Ltd.
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