Article
Health Care Sciences & Services
Lindsay White, Bailey Ingraham, Eric Larson, Paul Fishman, Sungchul Park, Norma B. Coe
Summary: Timely diagnosis of cognitive impairment is a key goal of the National Plan to Address Alzheimer's Disease, but studies on factors contributing to timely diagnosis are limited. This retrospective observational study found that only 26% of respondents with incident dementia and 11.4% with incident MCI received a timely diagnosis. Non-Hispanic Black and individuals with lower educational attainment were less likely to receive timely diagnosis of dementia or MCI compared to Non-Hispanic White respondents or those with a college degree.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Kirsty Burkinshaw, George Tsourtos, Monica Cations
Summary: This study aims to investigate health professionals' insights for a timely and accurate diagnosis of young onset dementia (YOD) at the system level. The study found that a complex web of systemic and system level barriers contributes to the delay of accurate and timely diagnosis for YOD, and diverse and marginalized groups experience greater inequitable disadvantage regarding diagnostic care.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Review
Medicine, General & Internal
J. L. Liss, S. Seleri Assuncao, J. Cummings, A. Atri, D. S. Geldmacher, S. F. Candela, D. P. Devanand, H. M. Fillit, J. Susman, J. Mintzer, T. Bittner, S. A. Brunton, D. R. Kerwin, W. C. Jackson, G. W. Small, G. T. Grossberg, C. K. Clevenger, V. Cotter, R. Stefanacci, A. Wise-Brown, M. N. Sabbagh
Summary: Timely diagnosis and collaboration between primary care clinicians and specialists are crucial in adapting to new treatment paradigms and disease-modifying therapies in Alzheimer's disease care.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Biology
Fadi Hassan, Helana Jeries, Mohammad E. Naffaa
Summary: Behcet's disease is a chronic inflammatory disorder characterized by oral and genital ulcers, skin lesions, and uveitis. The diagnosis is solely based on clinical features as there is no specific laboratory test. International diagnostic criteria were introduced in 1990, but they have limitations in diagnosing atypical presentations. In 2013, new criteria were introduced to improve sensitivity with minimal compromise on specificity. Efforts should continue to enhance the currently accepted international classification criteria, possibly by incorporating genetic testing and ethnicity-specific features.
Review
Cardiac & Cardiovascular Systems
Sahrai Saeed, Ronak Rajani, Eivind Solheim
Summary: The BRASH syndrome is a newly recognized condition that can lead to life-threatening complications if not identified and treated early. This case report presents a 74-year-old woman with type 2 diabetes, hypertension, and atrial flutter who presented with dizziness, presyncope, and bradycardia. Laboratory tests revealed severe hyperkalemia and other abnormalities. The patient was stabilized with treatment and her condition improved. Clinicians should be aware of the importance of timely intervention in patients with BRASH or BRAHH, as it can prevent potentially fatal arrhythmias.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Mechanics
Ram Sudhir Sharma, Michael Berhanu, Arshad Kudrolli
Summary: The study demonstrates the conditions for cave-like features on dissolving cliffsides and shows that alcoves with tapered bottoms and sharp-edged ceilings develop on vertical solid surfaces dissolving in aqueous solvents. The evolution of sufficiently large indentations into alcoves is controlled by a solutal Rayleigh-Bénard density inversion instability.
Article
Physics, Multidisciplinary
Adam Brus, Jiri Hrivnak, Lenka Motlochova
Summary: Discrete quantum models have been constructed to describe a free non-relativistic quantum particle propagating on rescaled and shifted dual root lattices inside closures of Weyl alcoves. The boundary conditions of the systems are controlled by specific combinations of Dirichlet and Neumann walls, and the amplitudes of the particle's jumps are determined by a complex-valued dual root lattice hopping function with finite support. The solutions of the time-independent Schrodinger equation and the eigenenergies of the quantum systems are explicitly determined in this study.
JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL
(2021)
Review
Obstetrics & Gynecology
Sophie Davenport, Diane Smith, Dan J. Green
Summary: This study identified barriers to timely diagnosis of endometriosis from both patient and healthcare professional perspectives. The key themes included individual factors, interpersonal influences, health system factors, and factors specific to endometriosis. These findings may guide future strategies to reduce diagnostic delays.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Immunology
Helene C. A. Zondag, Alje P. van Dam, Jeffrey Bosch, Damon Getman, Ashley Nenninger, Henry J. C. de Vries, Sylvia M. Bruisten
Summary: By adding the TP-TMA assay to routine diagnostics, 7% additional syphilis infections were identified among participants of the national PrEP program, highlighting the importance of this diagnostic tool in increasing syphilis case finding and limiting transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Computer Science, Information Systems
Tania Esteves, Ricardo Macedo, Rui Oliveira, Joao Paulo
Summary: DIO is a generic tool for observing inefficient and erroneous I/O interactions between applications and in-kernel storage backends. It provides analysis and visualization for complex I/O patterns in data-intensive applications, with high event capture rate and low performance overhead.
Article
Psychology, Multidisciplinary
Sandro Iannaccone, Elise Houdayer, Alfio Spina, Gianluca Nocera, Federica Alemanno
Summary: This study investigated the use of electroencephalography quantified with statistical pattern recognition (qEEG-SPR) as a tool for diagnosing dementia and differentiating dementia with Lewy bodies (DLB). The results showed that qEEG-SPR had high sensitivity and specificity for identifying dementia and DLB. It is a non-invasive, low-cost, and environmentally friendly method that can be implemented in healthcare settings.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Hamish Naismith, Robert Howard, Robert Stewart, Alexandra Pitman, Christoph Mueller
Summary: This study examines factors associated with suicidal ideation around the time of dementia diagnosis. The findings suggest that depression, dementia with Lewy bodies, impaired activities of daily living, and vascular dementia are associated with a higher risk of suicidal ideation. The study highlights the importance of identifying and treating depressive symptoms in individuals with dementia and encourages further research on under-researched dementia subtypes.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Otorhinolaryngology
Emily E. Karp, Linda X. Yin, Eric J. Moore, Anna J. Elias, Thomas J. O'Byrne, Amy E. Glasgow, Elizabeth B. Habermann, Daniel L. Price, Jan L. Kasperbauer, Kathryn M. Van Abel
Summary: This study found that patient delays in seeking medical attention and provider delays in recognizing the appropriate diagnosis both contribute to delays in care for HPV(+)OPSCC, highlighting the need for improved patient and provider education to expedite diagnosis.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Chemistry, Multidisciplinary
Sahar Masoumeh Ghorbanpour, Shihui Wen, Tu'uhevaha J. Kaitu'u-Lino, Natalie J. Hannan, Dayong Jin, Lana McClements
Summary: In this study, a novel strip-based lateral flow assay (LFA) using lanthanide-doped upconversion nanoparticles conjugated to antibodies was developed for detecting preeclampsia. The CD44/FKBPL ratio was found to be reduced in early-onset preeclampsia (EOPE) with good diagnostic potential. The improved LFA prototypes achieved a lower limit of detection for FKBPL and CD44, making it more sensitive than the standard ELISA method. The LFA showed promise as a rapid and highly sensitive point-of-care test for preeclampsia, with a 100% positive predictive value and 91% negative predictive value using clinical samples.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Otorhinolaryngology
Katrin Jaradeh, Elizabeth N. N. Liao, Lara Z. Z. Chehab, Kathleen P. P. Tebb, Michelle M. M. Florentine, Silvia Bellfort-Salinas, Dylan K. K. Chan
Summary: The objective of this study was to identify the age at diagnosis and intervention of immigrant and/or non-English-speaking children with hearing loss and to identify the barriers faced by non-English-speaking caregivers of deaf/hard-of-hearing children. The study found significant delays in diagnosis and intervention for foreign-born children, and non-English-speaking parents faced challenges in caring for their children with hearing loss.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Review
Geriatrics & Gerontology
Shirley Evans, Simon Evans, Dawn Brooker, Cate Henderson, Dorota Szczesniak, Teresa Atkinson, Jennifer Bray, Rehill Amritpal, Francesca Lea Saibene, Alessia d'Arma, Claudia Scorolli, Rabih Chattat, Elisabetta Farina, Katarzyna Urbanska, Joanna Rymaszewska, Franka Meiland, Rose-Marie Droes
AGING & MENTAL HEALTH
(2020)
Article
Geriatrics & Gerontology
Katarzyna Malgorzata Lion, Dorota Szczesniak, Katarzyna Bulinska, Shirley Barbara Evans, Simon C. Evans, Francesca Lea Saibene, Alessia d'Arma, Elisabetta Farina, Dawn June Brooker, Rabih Chattat, Franka J. M. Meiland, Rose-Marie Droes, Joanna Rymaszewska
AGING & MENTAL HEALTH
(2020)
Article
Psychology, Clinical
Jennifer Bray, Dawn Brooker, Isabelle Latham, Faith Wray, Darrin Baines
INTERNATIONAL PSYCHOGERIATRICS
(2020)
Article
Geriatrics & Gerontology
Dorota Szczesniak, Joanna Rymaszewska, Francesca Lea Saibene, Katarzyna Malgorzata Lion, Alessia D'arma, Dawn Brooker, Shirley B. Evans, Simon C. Evans, Rabih Chattat, Claudia Scorolli, Franka Meiland, Iris Hendriks, Rose-Marie Droes, Elisabetta Farina
Summary: The study found that the MCSP is highly appreciated by people with dementia and carers in Italy, Poland, and the UK. People with dementia showed a significant increase in satisfaction with the program over time. The majority of carers reported feeling less burdened after three months of participation in MCSP.
AGING & MENTAL HEALTH
(2021)
Article
Geriatrics & Gerontology
Katarzyna Malgorzata Lion, Dorota Szczesniak, Katarzyna Bulinska, Justyna Mazurek, Shirley B. Evans, Simon C. Evans, Francesca Lea Saibene, Alessia d'Arma, Claudia Scorolli, Elisabetta Farina, Dawn Brooker, Rabih Chattat, Franka J. M. Meiland, Rose-Marie Droes, Joanna Rymaszewska
Summary: This study focused on the impact of the Meeting Centre Support Programme (MCSP) on people living with dementia and MCI in Italy, Poland, and the UK. While there were no significant differences overall, individual country results varied, suggesting complex experiences of stigma that require further research.
AGING & MENTAL HEALTH
(2021)
Article
Environmental Sciences
Isabelle Latham, Dawn Brooker, Jennifer Bray, Nicola Jacobson-Wright, Faith Frost
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Geriatrics & Gerontology
Iris Hendriks, Raquel Demetrio, Franka J. M. Meiland, Rabih Chattat, Dorota Szczesniak, Joanna Rymaszewska, Teake P. Ettema, Shirley B. Evans, Dawn Brooker, Simon C. Evans, Teresa Atkinson, Elisabetta Farina, Francesca L. Saibene, Debby L. Gerritsen, Rose-Marie Droes
Summary: Personalized QOL scales have important implications for measuring quality of life in dementia patients, but are not more effective than standard versions. Additionally, differences were found in the importance of QOL domains between countries.
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
(2021)
Article
Public, Environmental & Occupational Health
Catherine Henderson, Amritpal Rehill, Dawn Brooker, Simon C. Evans, Shirley B. Evans, Jennifer Bray, Francesca Lea Saibene, Claudia Scorolli, Dorota Szczesniak, Alessia d'Arma, Katarzyna Lion, Teresa Atkinson, Elisabetta Farina, Joanna Rymaszewska, Rabih Chattat, Franka Meiland, Rose-Marie Droes, Martin Knapp
Summary: The study suggests that the Meeting Centre Support Programme may be cost-effective in providing support for people with dementia and carers, but the evidence for cost-effectiveness is mixed.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2021)
Review
Gerontology
Jennifer Bray, Dawn J. Brooker, Claire Garabedian
Summary: The study assessed the quality of research evidence for different activity components in Namaste Care intervention for care home residents with advanced dementia. Activities such as touch, music, nature, sensory experiences, aromas, and interactions with objects were found to have proven efficacy with people living with advanced dementia.
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2021)
Article
Gerontology
Eleanor K. Johnson, Ailsa Cameron, Liz Lloyd, Simon Evans, Robin Darton, Randall Smith, Teresa Atkinson, Jeremy Porteus
Article
Gerontology
Simon Chester Evans, Teresa Atkinson, Ailsa Cameron, Eleanor K. Johnson, Randall Smith, Robin Darton, Jeremy Porteus, Liz Lloyd
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2020)