Article
Medicine, General & Internal
Raquel Diez, Raquel Cadenas, Julen Susperregui, Ana M. Sahagun, Nelida Fernandez, Juan J. Garcia, Matilde Sierra, Cristina Lopez
Summary: Inappropriate prescribing in the elderly is a risk factor for adverse drug reactions, hospitalization, and mortality. This study aimed to examine and compare the prevalence of potentially inappropriate medications in nursing home residents and determine the prevalence of potential prescribing omissions. The results showed that benzodiazepines and proton pump inhibitors were the most frequent inappropriate medications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Mengnan Zhao, Zhaoyan Chen, Fangyuan Tian, Ting Xu
Summary: This study explored the prevalence of potentially inappropriate medication (PIM) among older outpatients with dementia in eight cities in China and identified the potential factors increasing the number of PIMs. The results showed a high prevalence of PIM use, with increasing age, female sex, and number of medications being associated risk factors. Clinicians most frequently prescribed antipsychotic drugs for these patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Hyun-Woo Chae, Jing Zhao, Young-Mi Ah, Kyung Hee Choi, Ju-Yeun Lee
Summary: This study estimated the nationwide prevalence of potentially inappropriate medication (PIM) use among nursing home residents and assessed their associations with hospitalization or emergency department visits. The use of PIMs was found to be associated with a higher risk of hospitalization or ED visits.
Article
Clinical Neurology
Amy K. Liu, Katherine L. Possin, Kristen M. Cook, Shalini Lynch, Sarah Dulaney, Jennifer J. Merrilees, Tamara Braley, Rachel E. Kiekhofer, Stephen J. Bonasera, Isabel E. Allen, Winston Chiong, Amy M. Clark, Julie Feuer, Joan Ewalt, Elan L. Guterman, Rosalie Gearhart, Bruce L. Miller, Kirby P. Lee
Summary: This study evaluated the effect of the Care Ecosystem (CE) collaborative dementia care program on medication use among community-dwelling persons living with dementia (PLWD). The results showed that the CE program significantly reduced the use of potentially inappropriate medications (PIMs), as well as the total number of medications and specific medication classes.
ALZHEIMERS & DEMENTIA
(2023)
Article
Pharmacology & Pharmacy
Manuel Enrique Machado-Duque, Luis Fernando Valladales-Restrepo, Juan Alberto Ospina-Cano, Maria Jose Londono-Serna, Jorge Enrique Machado-Alba
Summary: Dementias are neurodegenerative diseases, with over one-third of patients with dementia receiving antipsychotic prescriptions, which may be considered inappropriate as they can exacerbate cognitive decline and lead to adverse events.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Yuna H. Bae-Shaaw, Victoria Shier, Neeraj Sood, Seth A. Seabury, Geoffrey Joyce
Summary: The aim of this study was to estimate the prevalence and persistence of potentially inappropriate medication (PIM) use among community-dwelling older adults with dementia from 2011 to 2017. Medicare claims data was used to analyze the prevalence and drug classes of PIM use. The study found that 32.7% of the sample used one or more PIMs, with antipsychotic use being a significant problem.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Gastroenterology & Hepatology
Mary J. Thomson, Anna S. F. Lok, Elliot B. Tapper
Summary: Patients with decompensated cirrhosis are not consistently filling indicated medications as often or as long as recommended, and are also filling potentially harmful medications. Integrating pharmacy records with medical records and counseling on medication use with patients at each visit are suggested for future steps.
Article
Pharmacology & Pharmacy
Folgerdiena M. de Vries, Julia C. Stingl, Monique M. B. Breteler
Summary: The study found that medication use is common and the individual risk for adverse drug reactions is high in the population, suggesting the need for improvement in general medication use.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Environmental Sciences
Kyungwon Yoon, Jung-Tae Kim, Won-Gun Kwack, Donghyun Kim, Kyung-Tae Lee, Seungwon Yang, Sangmin Lee, Yeo-Jin Choi, Eun-Kyoung Chung
Summary: This study found that DPIMs were commonly used in elderly patients with dementia in Korea, with benzodiazepines being the most frequently prescribed. Female patients using polypharmacy with multiple comorbidities should be closely monitored to minimize unnecessary DPIM use.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
Kun-Pin Hsieh, Ru-Yu Huang, Yi-Hsin Yang, Pei-Shan Ho, Kuang-Peng Chen, Chun-Liong Tung, Ya-Lan Chu, Jui-Hsiu Tsai
Summary: This study compared the ability of PIM-Taiwan, PRISCUS, and Beers criteria to predict 90-day rehospitalization in older patients. The results showed that Beers criteria was more effective in predicting 90-day rehospitalization among older adults experiencing potentially inappropriate medication.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mengnan Zhao, Zhaoyan Chen, Ting Xu, Ping Fan, Fangyuan Tian
Summary: The global prevalence of polypharmacy and potentially inappropriate medication (PIM) in older patients with dementia was estimated in this study. Factors associated with PIM were also explored. Polypharmacy and PIM were found to be highly prevalent in older patients with dementia, and there were variations in their prevalence in different regions.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yuping Wang, Jie Zhu, Luchen Shan, Ling Wu, Cunchuan Wang, Wah Yang
Summary: This study investigated the occurrence and risk factors of potentially inappropriate medications (PIM) in older diabetic kidney disease (DKD) patients during hospitalization, and explored the association with polypharmacy. The results showed that PIM was common during hospitalization and that polypharmacy was an independent risk factor for PIM.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Emily Buckley, Agnes Jonsson, Zoe Flood, Maria Lavelle, Noelle O'Sullivan, Nadra Nurdin, Philip Dowling, Eoin Duggan, Elizabeth Callaly, Colm Byrne, Cora McGreevy, Joseph Duggan, Lorraine Kyne, John J. McCabe
Summary: The use of potentially inappropriate medications in patients with cognitive impairment is associated with all-cause mortality and vascular death.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Ebony King, Mohsen Bazargan, Nana Entsuah, Sayaka W. W. Tokumitsu, Cheryl Wisseh, Edward K. K. Adinkrah
Summary: This study aimed to investigate the prevalence of potentially inappropriate medication (PIM) use among underserved older Latino adults. The results showed that one-third of the participants had at least one use of PIM, over half of the sample had polypharmacy, and 46% of the sample took drugs to be used with caution. Regression analysis revealed that PIM use was associated with the number of prescription medications, chronic conditions, sleep difficulty, lack of access to primary care, financial strain, and poor self-rated health.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Jung Min Yoon, Alison M. Trinkoff, Miyoung Kim, Eunjin Kim
Summary: Although non-pharmacological interventions are recommended for dementia-related behavioral symptoms, nursing homes often prescribe psychotropics due to insufficient staffing and dementia care training. This study examines the relationship between additional in-service dementia training requirements and F-758 citation occurrence, as well as the impact of nurse staffing levels on this relationship.
Article
Geriatrics & Gerontology
Fred B. Ketchum, Jessica Monsees, Alice J. Kim, Tim Schmachtenberg, Amy Kind, Manish Shah, Wolfgang Hoffmann, Jochen Rene Thyrian, Andrea Gilmore-Bykovskyi
Summary: The objective of this study is to identify barriers and facilitators to the use of formal dementia services among underserved and minority groups in the United States and Germany. Through qualitative interviews with caregivers, it was found that limited knowledge, challenges in interacting with healthcare systems, and the alignment of formal services with cultural or ethnic/racial identity were important factors influencing the utilization of dementia care services.
AGING & MENTAL HEALTH
(2023)
Review
Geriatrics & Gerontology
Clarissa Giebel, Katarzyna M. Lion, Klara Lorenz-Dant, Aida Suarez-Gonzalez, Catherine Talbot, Emily Wharton, Jacqueline Cannon, Hilary Tetlow, Jochen Rene Thyrian
Summary: This systematic review examines the impact of the COVID-19 pandemic on people with dementia living in the community or in residential care. The findings indicate that the pandemic has had negative effects on the cognition, physical functioning, and behavior of people with dementia, as well as limited access to care and poorer mental and social health.
AGING & MENTAL HEALTH
(2023)
Review
Geriatrics & Gerontology
Clarissa Giebel, Catherine V. Talbot, Emily Wharton, Klara Lorenz-Dant, Aida Suarez-Gonzalez, Jacqueline Cannon, Hilary Tetlow, Katarzyna M. Lion, Jochen Rene Thyrian
Summary: This study aimed to comprehensively evaluate the early impacts of the COVID-19 pandemic on unpaid dementia carers worldwide. The findings indicated that the pandemic had negative effects on the caregiving tasks, burden, and well-being of unpaid dementia carers. Policy initiatives should focus on providing better mental health support and formal care services for unpaid carers and their relatives with dementia, and further research is needed to explore the long-term implications of carer needs in light of care home restrictions and care delivery.
AGING & MENTAL HEALTH
(2023)
Article
Geriatrics & Gerontology
Jan Dreyer, Johannes Michael Bergmann, Kerstin Koehler, Iris Hochgraeber, Christiane Pinkert, Martina Roes, Jochen Rene Thyrian, Henrik Wiegelmann, Bernhard Holle
Summary: This study analyzed 320 care arrangements for persons with dementia and identified the underlying structures and types of these arrangements. The results contribute to a better understanding of informal dementia home care and can guide the development of tailored support for persons with dementia and their families.
Article
Medicine, General & Internal
Flora Wendel, Alexander Bauer, Iris Blotenberg, Christian Brettschneider, Maresa Buchholz, David Czock, Juliane Doehring, Catharina Escales, Thomas Frese, Wolfgang Hoffmann, Hanna Kaduszkiewicz, Hans-Helmut Koenig, Margrit Loebner, Melanie Luppa, Rosemarie Schwenker, Jochen Rene Thyrian, Marina Weissenborn, Birgitt Wiese, Isabel Zollinger, Steffi G. Riedel-Heller, Jochen Gensichen
Summary: This study describes the associations between social network, social participation, and depressive symptoms in older individuals at risk for dementia in Germany. The findings suggest that depressive symptoms are associated with smaller social networks and less social participation. Sufficient non-family contacts and weekly social activities play an important role in maintaining mental health among elderly primary care patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Bernhard Michalowsky, Adel Afi, Bernhard Holle, Jochen Rene Thyrian, Wolfgang Hoffmann
Summary: The study aims to describe the characteristics, financing structures, and challenges of regional dementia care networks and the usage of regional financial network support according to SGB XI. The results show that regional dementia networks are highly diverse in structure, and certain factors significantly affect the number of partners and funding sources. The implementation of the amendment may increase the utilization of regional network funding.
Article
Health Care Sciences & Services
Tim Schmachtenberg, Jessica Monsees, Jochen Rene Thyrian
Summary: This study examines the current state and gaps in dementia-specific care in 17 European countries, identifying differences between countries and suggesting the need for transnational concepts and guidelines to address structural inequalities and establish minimum standards in dementia care.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Neurosciences
Roaa Zayed Atef, Bernhard Michalowsky, Anika Raedke, Moritz Platen, Wiebke Mohr, Franka Muehlichen, Jochen Rene Thyrian, Wolfgang Hoffmann
Summary: Hearing loss is common in people with dementia and can lead to social isolation and depression. This study suggests that the use of hearing aids may be associated with improvements in cognitive function, depression, and health-related quality of life in dementia patients.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Emrah Duezel, Jochen Rene Thyrian
Summary: It is important to combine treatment and preventive measures for Alzheimer's disease to maintain cognitive functions as long as possible. However, there are challenges in developing and researching treatment concepts. The use of mobile everyday-life digital technologies can help address these challenges by coordinating prevention efforts and focusing on cognitive health and safety. Relevant digital technologies include mobile apps for recording cognitive functions, coaching lifestyle changes, reducing treatment risks, and improving health competence. These medical products are at different stages of development.
Article
Clinical Neurology
Jochen Rene Thyrian
Summary: Background: Aging healthily and prevention of diseases are national health targets, and there is compelling evidence on modifiable risk factors suitable for preventive measures. Objective: This article defines terms, presents the roots of prevention in laws, strategies, and guidelines, and outlines the risk factors for dementia and effective preventive measures. Material and methods: The available evidence on risk factors, health behavior, and preventive measures is analyzed, and a multimodal intervention and the impact of motivation on behavior change are discussed.
Article
Public, Environmental & Occupational Health
Felix G. Wittmann, Andrea Zuelke, Alexander Pabst, Melanie Luppa, Jochen Rene Thyrian, Anika Kaestner, Wolfgang Hoffmann, Hanna Kaduszkiewicz, Juliane Doehring, Catharina Escales, Jochen Gensichen, Isabel Zoellinger, Robert Philipp Kosilek, Birgitt Wiese, Anke Oey, Hans-Helmut Koenig, Christian Brettschneider, Thomas Frese, Steffi G. G. Riedel-Heller
Summary: This study analyzed the impact of perceived restriction due to government measures on depressive symptoms in older adults at increased risk for dementia in Germany. The results showed that feeling restricted due to COVID-19 measures was associated with higher levels of depressive symptoms, and this association was mediated by perceived stress.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Maria Isabel Cardona, Jessica Monsees, Tim Schmachtenberg, Anna Gruenewald, Jochen Rene Thyrian
Summary: Despite the health benefits of physical activity for people with dementia, their engagement remains low. Previous research has not used implementation science frameworks to explore the barriers and facilitators of physical activity initiatives in this population. Therefore, a more comprehensive understanding of these mediating factors is needed.
Article
Medicine, General & Internal
Isabel Zoellinger, Alexander Bauer, Iris Blotenberg, Christian Brettschneider, Maresa Buchholz, David Czock, Juliane Doehring, Catharina Escales, Thomas Fankhaenel, Thomas Frese, Wolfgang Hoffmann, Hanna Kaduszkiewicz, Hans-Helmut Koenig, Melanie Luppa, Anke Oey, Alexander Pabst, Linda Sanftenberg, Jochen Rene Thyrian, Julian Weiss, Flora Wendel, Birgitt Wiese, Steffi G. Riedel-Heller, Jochen Gensichen, Piotr Galecki
Summary: In order to develop effective dementia prevention strategies, it is important to understand the risk factors, associated factors, and early signs of dementia. This study found that depressive symptoms, sleeping problems, and higher education levels are significantly associated with subjective cognitive decline (SCD), which is an early form of dementia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Public, Environmental & Occupational Health
F. Wittmann, D. Czock, T. Frese, J. Gensichen, W. Haefeli, W. Hoffmann, H. Kaduszkiewicz, H-H Koenig, J. R. Thyrian, B. Wiese, M. Luppa, S. G. Riedel-Heller
Meeting Abstract
Public, Environmental & Occupational Health
M. Claus, M. Luppa, D. Czock, T. Frese, J. Gensichen, W. Haefeli, W. Hoffmann, H. Kaduszkiewicz, H-H Koenig, B. Wiese, J. R. Thyrian, S. G. Riedel-Heller