Article
Cell Biology
John D. Da Silva, Shy Chwen Ni, Cliff Lee, Hawazin Elani, Kailing Ho, Carlos Thomas, Yukinori Kuwajima, Yoshiki Ishida, Takuya Kobayashi, Shigemi Ishikawa-Nagai
Summary: The study found a correlation between the decline in cognitive health and the loss of teeth affecting masticatory function. Patients in Japan aged 65 and over who have lost masticatory function are more likely to have cognitive impairments, highlighting the importance of oral health and masticatory conditions in relation to cognitive health.
Article
Gerontology
Yoko Aihara, Kiyoshi Maeda
Summary: The study aimed to assess the challenges faced by dementia supporters in conducting activities for people with dementia. Results showed that only half of the supporters had commenced new support activities after six months post-training. Future studies should examine the impact activities conducted by dementia supporters have on people with dementia and their family caregivers.
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2021)
Article
Clinical Neurology
Frank Jessen
Summary: The National Dementia Strategy in Germany aims to improve the lives and care of people with dementia by addressing social participation, support, advice, nursing, medical care, and research. It involves various stakeholders and sets specific goals and measures. However, there are areas for improvement, such as inpatient care and the integration of outpatient memory clinics. The strategy also lacks a conceptual reference to the current medical understanding of dementia and prevention measures.
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
(2022)
Article
Genetics & Heredity
Eleanor Wong, Nicolas Bertin, Maxime Hebrard, Roberto Tirado-Magallanes, Claire Bellis, Weng Khong Lim, Chee Yong Chua, Philomena Mei Lin Tong, Raymond Chua, Kenneth Mak, Tit Meng Lim, Wei Yang Cheong, Kwee Eng Thien, Khean Teik Goh, Jin-Fang Chai, Jimmy Lee, Joseph Jao-Yiu Sung, Tien Yin Wong, Calvin Woon Loong D. Chin, Peter Gluckman, Liuh Ling Goh, Kenneth Hon Kim Ban, Tin Wee M. Tan, Rob M. Van Dam, Yik Ying Teo, Marie Loh, Paul Eillot, Eng Sing Lee, Joanne Ngeow, Elio Riboli, Rinkoo Dalan, Irfahan Kassam, Lakshmi Narayanan Lakshmanan, Tock Han Lim, Hong Kiat Ng, Theresia Mina, Darwin Tay, Charumathi Sabanayagam, Yih Chung Tham, Tyler Rim, Tin Aung, Miao Ling Chee, Hengtong Li, Miao Li Chee, Khung Keong Yeo, Stuart Alexander Cook, Chee Jian Pua, Chengxi Yang, Yap Seng Chong, Johan Gunnar Eriksson, Kok Hian Tan, Fabian Yap, Chia Wei Lim, Pi Kuang Tsai, Wen Jie Chew, Wey Ching Sim, Li-xian Grace Toh, Clarabelle Bitong Lin, Yee Yen Sia, Tat Hung Koh, Wee Yang Meah, Joanna Hui Juan Tan, Justin Jeyakani, Jack Ow, Shimin Ang, Ashar J. Malik, Dimitar Kenanov, Xueling Sim, Ching-Yu Cheng, Sonia Davila, Neerja Karnani, Khai Pang Leong, Jianjun Liu, Shyam Prabhakar, Sebastian Maurer-Stroh, Chandra Shekhar Verma, Pavitra Krishnaswamy, Rick Siow Mong Goh, Irenaeus Chia, Clarissa Ho, Doreen Low, Suchin Virabhak, Jacklyn Yong, Weiling Zheng, Shih Wee Seow, Yee Kwang Seck, Mingshi Koh, John C. Chambers, E. Shyong Tai, Patrick Tan
Summary: This article discusses Singapore's efforts to establish a National Precision Medicine Strategy by integrating genomic, clinical, and lifestyle data of up to one million individuals. Precision medicine has the potential to revolutionize healthcare by detecting diseases early, refining diagnoses, and tailoring treatments for groups and individuals. The lack of representation of Asian ancestries in existing genomic-phenotypic databases presents a missed opportunity for new discoveries, especially for diseases relevant to these populations. The Singapore National Precision Medicine initiative aims to generate integrated data from various sources over a 10-year period, including genomic, lifestyle, health, social, and environmental data, in order to promote precision medicine adoption and address social, ethical, legal, and regulatory challenges.
Article
Geriatrics & Gerontology
Nobue Nakahori, Michikazu Sekine, Masaaki Yamada, Takashi Tatsuse, Hideki Kido, Michio Suzuki
Summary: Based on the Toyama Dementia Survey data and population projections, it is projected that the prevalence of dementia in people aged 65 years and older in Japan will exceed 25% nationwide in the next 25 years. Rural areas might have higher prevalence rates compared to metropolitan areas.
Article
Neurosciences
Melissa J. Armstrong, Shangchen Song, Andrea M. Kurasz, Zhigang Li
Summary: This study aims to identify predictors of death in individuals with Alzheimer's disease, Lewy body dementia, vascular dementia, and frontotemporal dementia. The results showed that the type of dementia, gender, and race were the strongest predictors of death. The findings can help clinicians provide counseling on average dementia trajectories to patients and their families, and personalize expectations.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Shuji Tsuda, Hiroki Inagaki, Tsuyoshi Okamura, Mika Sugiyama, Madoka Ogawa, Fumiko Miyamae, Ayako Edahiro, Chiaki Ura, Naoko Sakuma, Shuichi Awata
Summary: The study conducted an intervention program focusing on nurturing community social capital in a large apartment complex in Tokyo, which led to significant improvements in social interaction and confidence in living in the community among male residents, especially those living with impaired cognitive function.
Article
Clinical Neurology
Jinkook Lee, Erik Meijer, Kenneth M. Langa, Mary Ganguli, Mathew Varghese, Joyita Banerjee, Pranali Khobragade, Marco Angrisani, Ravi Kurup, Sankha Shubhra Chakrabarti, Indrajeet Singh Gambhir, Parvaiz A. Koul, Debabrata Goswami, Arunanshu Talukdar, Rashmi Ranjan Mohanty, Raju Sathyanarayana Yadati, Mekala Padmaja, Lalit Sankhe, Chhaya Rajguru, Monica Gupta, Govind Kumar, Minakshi Dhar, Prasun Chatterjee, Sunny Singhal, Rishav Bansal, Swati Bajpai, Gaurav Desai, Abhijith R. Rao, Palanimuthu T. Sivakumar, Krishna Prasad Muliyala, Swaroop Bhatankar, Aparajita Chattopadhyay, Dipti Govil, Sarang Pedgaonkar, T. V. Sekher, David E. Bloom, Eileen M. Crimmins, Aparajit Ballav Dey
Summary: According to the Longitudinal Aging Study in India (LASI), the prevalence of dementia among adults aged 60+ in India is 7.4%, with significant variations based on age, education, sex, and urban/rural areas. It is estimated that there are over 8.8 million elderly Indians living with dementia, and the burden of dementia cases varies across states and subpopulations, requiring different levels of local planning and support.
ALZHEIMERS & DEMENTIA
(2023)
Article
Oncology
Takashi Kohno, Mamoru Kato, Shinji Kohsaka, Tomohisa Sudo, Ikuo Tamai, Yuichi Shiraishi, Yusuke Okuma, Daisuke Ogasawara, Tatsuya Suzuki, Teruhiko Yoshida, Hiroyuki Mano
Summary: Since June 2019, Japan has implemented cancer genomic medicine under the national health insurance system. With the establishment of a network of CGM hospitals and a national datacenter, clinical and genomic data from comprehensive genomic profiling tests are securely transferred and aggregated. The data are used to generate reports containing clinical annotation and information on matched clinical trials, which are now open for sharing with CGM hospitals, academic institutions, and industries.
Article
Multidisciplinary Sciences
Midori Tsuneishi, Tatsuo Yamamoto, Takeyuki Yamaguchi, Tsuyoshi Kodama, Tamotsu Sato
Summary: Using Japanese dental claims data, the study found that older individuals with fewer teeth present and a greater number of missing teeth are more likely to have Alzheimer's disease.
Article
Neurosciences
Perla Werner, Sarang Kim
Summary: Cross-national study found that dementia stigma was significantly higher in Australia than in Israel, and lower levels of subjective knowledge and higher levels of ageism were associated with increased stigmatic beliefs about dementia. Male participants reported higher levels of public stigma than women, and providing knowledge and decreasing ageist attitudes should be key considerations in dementia awareness and stigma reduction campaigns.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Oncology
Teruhiko Yoshida, Yasushi Yatabe, Ken Kato, Genichiro Ishii, Akinobu Hamada, Hiroyuki Mano, Kuniko Sunami, Noboru Yamamoto, Takashi Kohno
Summary: The journey to implement cancer genomic medicine began in the 1980s, leading to the development of targeted therapies. The National Cancer Center of Japan has made significant contributions to this field. The future of cancer genomic medicine is predicted to involve the development of biobanks, introduction of new technologies, fast translational research, collaborations, and investment in personalized preventive medicine.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Geriatrics & Gerontology
Shohei Okamoto, Erika Kobayashi, Hiroshi Murayama, Jersey Liang, Taro Fukaya, Shoji Shinkai
Summary: This empirical study found that differences in cognitive functioning and decline between men and women can be attributed to various individual attributes, such as education and occupation. Men seem to engage in activities that enhance cognitive functioning more than women, supporting the cognitive reserve hypothesis.
Article
Neurosciences
Shunya Ikeda, Masaru Mimura, Manabu Ikeda, Kenji Wada-Isoe, Mie Azuma, Sachie Inoue, Kiyoyuki Tomita
Summary: This study estimated the annual healthcare and long-term care costs for adults over 65 years of age with Alzheimer's disease dementia (ADD) in Japan in fiscal year 2018. The results showed that the costs of ADD have a significant impact on public-funded healthcare, long-term care systems, and families in Japan. To minimize the economic burden of ADD, prolonging healthy life expectancy is crucial.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Health Care Sciences & Services
Nobutaka Ayani, Nozomu Oya, Riki Kitaoka, Akiko Kuwahara, Takeshi Morimoto, Mio Sakuma, Jin Narumoto
Summary: A study in four nursing homes for older people in Japan found that ADEs and MEs were common among elderly residents, with around one-third of ADEs being preventable. MEs were most frequently observed during the monitoring stage, with inadequate observation following physician's prescriptions being a common cause. Assessment and appropriate adjustment of medication preadmission and postadmission to nursing homes are needed to improve medication safety.
BMJ QUALITY & SAFETY
(2022)
Article
Geriatrics & Gerontology
Asuna Arai, Yumiko Arai
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2015)
Article
Geriatrics & Gerontology
Takashi Ozaki, Yuriko Katsumata, Asuna Arai
AGING & MENTAL HEALTH
(2017)
Article
Geriatrics & Gerontology
Asuna Arai, Takashi Ozaki, Yuriko Katsumata
AGING & MENTAL HEALTH
(2017)
Article
Geriatrics & Gerontology
Amartuvshin Khaltar, Neelawala G. W. Priyadarshani, Nisansala Y. Delpitiya, Chandrika Jayasinghe, Ananda Jayasinghe, Asuna Arai, Hiko Tamashiro
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2017)
Article
Public, Environmental & Occupational Health
Yan Liu, Ying Zhang, Asuna Arai, Yoshihide Obayashi, Hiko Tamashiro
ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH
(2015)
Article
Public, Environmental & Occupational Health
Yan Liu, Asuna Arai, Koji Kanda, Romeo B. Lee, Jay Glasser, Hiko Tamashiro
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2013)
Article
Geriatrics & Gerontology
Yan Liu, Asuna Arai, Yoshihide Obayashi, Koji Kanda, Eugene Boostrom, Romeo B. Lee, Hiko Tamashiro
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2013)
Letter
Geriatrics & Gerontology
Yumiko Arai, Keigo Kumamoto, Yoko Mizuno, Asuna Arai
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2012)
Article
Clinical Neurology
Y. Liu, Y. Zhang, Y. T. Cho, Y. Obayashi, A. Arai, H. Tamashiro
JOURNAL OF AFFECTIVE DISORDERS
(2013)
Article
Public, Environmental & Occupational Health
Bongani Kaimila, Hiroko Yamashina, Asuna Arai, Hiko Tamashiro
TRAFFIC INJURY PREVENTION
(2013)
Article
Geriatrics & Gerontology
Takashi Ozaki, Yuriko Katsumata, Asuna Arai
Article
Geriatrics & Gerontology
Asuna Arai, Amartuvshin Khaltar, Takashi Ozaki, Yuriko Katsumata
Summary: This study found that older adult residents in long-term care facilities who are less active in activities, have poor relationships with other residents, and have less communication with family members may have more severe BPSD symptoms at baseline and experience an increase in severity over the course of 1 year.
Article
Public, Environmental & Occupational Health
Kumi Kono, Sharareh Eskandarieh, Yoshihide Obayashi, Asuna Arai, Hiko Tamashiro
JOURNAL OF IMMIGRANT AND MINORITY HEALTH
(2015)
Article
Health Policy & Services
Samidi Navaratna, Koji Kanda, Samath D. Dharmaratne, Sampath Tennakoon, Ananda Jayasinghe, Niroshan Jayasekara, Katsutoshi Nagano, Yoshihide Obayashi, Asuna Arai, Hiko Tamashiro
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2015)
Article
Public, Environmental & Occupational Health
Koji Kanda, Ananda Jayasinghe, K. Tudor Silva, N. G. W. Priyadarshani, N. Y. Delpitiya, Yoshihide Obayashi, Asuna Arai, Chandika D. Gamage, Hiko Tamashiro
GLOBAL PUBLIC HEALTH
(2013)
