Article
Medicine, General & Internal
Fabio Moretti, Jvan Gianini, Rosaria Del Giorno, Luca Gabutti
Summary: This study investigated the impact of white-coat effect on the circadian rhythm of urinary water and salt excretion. It found a higher night/day ratio of urinary water excretion in the white-coat effect group, but no significant differences in the circadian pattern of urinary sodium excretion. This has potential implications for hypertension prevention, but further research is needed to understand the clinical significance of the impact on the night/day ratio of water excretion.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Xavier Humbert, Sophie Fedrizzi, Agnes Hofferer, Mathieu Bansard, Anne-Laure Huet, Christiane Bedier, Andry Rabiaza, Jeanne Le Bas, Francois Le Bas, Joachim Alexandre, Paolo Emilio Puddu
Summary: The study found that the office white-coat effect tail (OWCET) increases the risk of cardiovascular disease, coronary heart disease, and stroke in women over a long-term follow-up, but does not significantly impact men.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Peripheral Vascular Disease
Alec Saunders, Gani N. Nuredini, Frances A. Kirkham, Erin Drazich, Eva Bunting, Philip Rankin, Khalid Ali, Michael Okorie, Chakravarthi Rajkumar
Summary: This study reveals a relationship between white-coat hypertension/effect (WCH/E) and markers of cardiovascular risk and cerebrovascular events. Patients with WCH/E have higher arterial stiffness and a higher prevalence of lacunar strokes.
JOURNAL OF HYPERTENSION
(2022)
Article
Computer Science, Interdisciplinary Applications
Haokai Ma, Yulong Bian, Yingbin Wang, Chao Zhou, Wenxiu Geng, Fan Zhang, Juan Liu, Chenglei Yang
Summary: Virtual reality technology can help avoid White Coat Hypertension and improve the accuracy of blood pressure measurement by presenting relaxation scenes. It assists in relaxing patients psychologically and reducing errors in blood pressure readings.
JOURNAL OF BIOMEDICAL INFORMATICS
(2021)
Article
Clinical Neurology
Mirthe Coenen, Hugo J. Kuijf, Irene M. C. Huenges Wajer, Marco Duering, Frank J. Wolters, Evan F. Fletcher, Pauline M. Maillard, Frederik Barkhof, Josephine Barnes, Thomas Benke, Jooske M. F. Boomsma, Christopher P. L. H. Chen, Peter Dal-Bianco, Anna Dewenter, Christian Enzinger, Michael G. Ewers, Lieza Exalto, Nicolai Franzmeier, Onno Groeneveld, Saima Hilal, Edith L. Hofer, Dineke B. Koek, Andrea R. Maier, Cheryl S. McCreary, Catarina M. Padilla, Janne W. Papma, Ross Paterson, Yolande A. L. Pijnenburg, Anna Rubinski, Reinhold M. Schmidt, Jonathan F. Schott, Catherine E. Slattery, Eric Smith, Rebecca M. E. H. Steketee, Carole Sudre, Esther M. van den Berg, Wiesje van der Flier, Narayanaswamy W. Venketasubramanian, Meike Vernooij, Xu Xin, Charles DeCarli, Geert Jan Biessels, J. Matthijs Biesbroek
Summary: This study aimed to identify the strategic locations of white matter hyperintensities (WMH) and their impact on cognition in a large multicenter study. The results showed that the impact of WMH on cognition is dependent on lesion location, primarily involving four strategic white matter tracts. Evaluating the location of WMH may facilitate the diagnosis of vascular cognitive impairment.
ALZHEIMERS & DEMENTIA
(2022)
Article
Cardiac & Cardiovascular Systems
Pasquale Mone, Jessica Gambardella, Angela Lombardi, Antonella Pansini, Stefano De Gennaro, Anna Luisa Leo, Michele Famiglietti, Anna Marro, Maria Morgante, Salvatore Frullone, Antonio De Luca, Gaetano Santulli
Summary: This is the first study to show a significant correlation between 5-m gait speed test and MoCA score in frail diabetic and hypertensive older adults. These results highlight the association between cognitive and physical function, providing valuable information for improving the overall health status of these patients.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Clinical Neurology
Alessandra Nicoletti, Antonina Luca, Roberta Baschi, Calogero Edoardo Cicero, Giovanni Mostile, Marco Davi, Giuseppe La Bianca, Vincenzo Restivo, Mario Zappia, Roberto Monastero
Summary: This study found that hypertension is the most important modifiable risk factor for PD-MCI in PD patients, increasing the risk of the disease about four times. Additionally, the presence of cognitive impairment at baseline and a severe burden of white matter lesions were identified as the strongest predictors of PDD.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Chintan Shah, Dhivya Srinivasan, Guray Erus, James E. Schmitt, Adhish Agarwal, Monique E. Cho, Alan J. Lerner, William E. Haley, Manjula Kurella Tamura, Christos Davatzikos, Robert N. Bryan, Yong Fan, Ilya M. Nasrallah
Summary: In hypertensive patients, greater white matter lesion (WML) volume is associated with lower functional connectivity (FC) of the default mode network (DMN), which in turn is related to poorer cognitive test performance. Other functional networks also demonstrated correlations with WML, but did not show an association with cognition.
Article
Medicine, General & Internal
Paolo Palatini, Lucio Mos, Francesca Saladini, Olga Vriz, Claudio Fania, Andrea Ermolao, Francesca Battista, Marcello Rattazzi
Summary: The aim of this study was to investigate the reproducibility of white-coat hypertension (WCH) and its predictive capacity for hypertension needing antihypertensive treatment (HT) in young to middle-age subjects. The results showed that WCH has limited reproducibility, and the risk of future hypertension increased when diagnosed with two sets of blood pressure measurements instead of one.
Article
Clinical Neurology
Cally Xiao, Ioannis M. Pappas, Leon E. Aksman, Sid W. O'Bryant, Arthur Toga, HABS HD Study Team, Alzheimers Dis Neuroimaging Initiat
Summary: This study compared risk factors for mild cognitive impairment (MCI) and Alzheimer's disease (AD) between Hispanic and non-Hispanic white participants, and found that APOE genotype was associated with fewer MCI cases and depression was associated with more AD cases in Hispanic participants.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Caixia Zang, Hui Liu, Cheng Ju, Fangyu Yuan, Jingwen Ning, Meiyu Shang, Xiuqi Bao, Yang Yu, Xinsheng Yao, Dan Zhang
Summary: The study found that GJ-4 has the ability to repair white matter damage, possibly by promoting the expression of myelin-related proteins and regulating neuroinflammatory function to improve cognition. These findings support GJ-4 as a potential therapeutic agent for Alzheimer's disease and white matter related diseases.
Article
Peripheral Vascular Disease
Koichi Yamamoto, Hiroshi Akasaka, Yukiko Yasunobe, Atsuya Shimizu, Kenichiro Nomoto, Kumiko Nagai, Hiroyuki Umegaki, Yuichi Akasaki, Taro Kojima, Koichi Kozaki, Masafumi Kuzuya, Mitsuru Ohishi, Masahiro Akishita, Yoichi Takami, Hiromi Rakugi
Summary: Early detection of cognitive impairment is crucial for treating older patients with hypertension, as it can impact treatment efficacy and functional prognosis. This study aimed to identify the incidence and determinants of cognitive impairment in hypertensive patients aged 65 years and above. Among the patients, 35% had cognitive impairment and 7.7% had dementia. Older age, lower education levels, and lower instrumental activities of daily living scores were associated with cognitive impairment. Treatment for hypertension did not differ between patients with and without cognitive impairment. Unrecognized cognitive impairment in hypertensive patients showed distinct clinical characteristics compared to other subtypes of mild cognitive impairment.
HYPERTENSION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Giuseppe Mancia, Rita Facchetti, Fosca Quarti-Trevano, Guido Grassi
Summary: This study analyzed the effects of antihypertensive treatment on office and ambulatory blood pressure in patients with white-coat hypertension (WCH). The results showed that antihypertensive treatment effectively reduced office blood pressure in WCH patients, but had no effect on ambulatory blood pressure. These findings were consistent regardless of the type of treatment used.
JOURNAL OF HYPERTENSION
(2022)
Review
Medicine, General & Internal
Steven G. Chrysant
Summary: White-coat hypertension refers to an increase in blood pressure in the doctor's office but normal blood pressure outside the office, as measured by 24-hour ambulatory blood pressure monitoring or home blood pressure measurement. Initially considered benign, recent studies have shown that it is associated with hypertension-related organ damage and cardiovascular events. The prevalence of white-coat hypertension ranges from 15% to 40% and can be higher in older individuals.
POSTGRADUATE MEDICINE
(2023)
Article
Geriatrics & Gerontology
Anna Cristina Aberg, Johanna R. Petersson, Vilmantas Giedraitis, Kevin J. Mckee, Erik Rosendahl, Kjartan Halvorsen, Lars Berglund
Summary: This study aimed to investigate whether the results of the TUGdt test can predict the incidence of cognitive impairment in older adults. The study found that the words/time parameter of TUGdt can be used as an effective tool for predicting the incidence of cognitive impairment in older adults.