Article
Biochemistry & Molecular Biology
Sarah Bonk, Kevin Kirchner, Sabine Ameling, Linda Garvert, Henry Volzke, Matthias Nauck, Uwe Voelker, Hans J. Grabe, Sandra Van der Auwera
Summary: This study aimed to replicate the interaction between APOE epsilon 4 status and depression on memory function and explore the role of circulating plasma miRNAs. The results confirmed the effect of depressive symptoms and APOE epsilon 4 status on memory performance and identified hsa-miR-107 as a possible biological link between APOE epsilon 4, depressive symptoms, and cognitive impairment.
Article
Neurosciences
Dianxu Ren, Oscar L. Lopez, Jennifer H. Lingler, Yvette Conley
Summary: The study found that the APOE epsilon 2/epsilon 4 genotype is not significantly associated with the risk of Alzheimer's disease and mild cognitive impairment among African Americans.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Gemma Salvado, Daniel Ferreira, Gregory Operto, Irene Cumplido-Mayoral, Eider M. Arenaza-Urquijo, Raffaele Cacciaglia, Carles Falcon, Natalia Vilor-Tejedor, Carolina Minguillon, Colin Groot, Wiesje M. van der Flier, Frederik Barkhof, Philip Scheltens, Rik Ossenkoppele, Silke Kern, Anna Zettergren, Ingmar Skoog, Jakub Hort, Erik Stomrud, Danielle van Westen, Oskar Hansson, Jose Luis Molinuevo, Lars-Olof Wahlund, Eric Westman, Juan Domingo Gispert
Summary: Carrying the APOE ε2 allele is associated with larger gray matter volumes in brain regions affected by AD, providing additional protection against cognitive decline. Homozygotes for the ε2 allele exhibit larger GM volumes in regions related to successful aging.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Ying-Liang Larry Lai, Kuan Chen, Tzu-Wei Lee, Chao-Wei Tso, Hui-Hsien Lin, Li-Wei Kuo, Cheng-Yu Chen, Hua-Shan Liu
Summary: The study revealed significant differences in the associations between APOE-epsilon 4 and cholinergic structural changes among subjects with different levels of cognitive impairment, reflecting impaired brain function underlying neurocognitive degeneration in AD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cell Biology
Laura Madrid, Sonia Moreno-Grau, Shahzad Ahmad, Antonio Gonzalez-Perez, Itziar de Rojas, Rui Xia, Pamela V. Martino Adami, Pabio Garcia-Gonzalez, Luca Kleineidam, Qiong Yang, Vincent Damotte, Joshua C. Bis, Fuensanta Noguera-Perea, Celine Bellenguez, Xueqiu Jian, Juan Marin-Munoz, Benjamin Grenier-Boley, Adela Orellana, M. Arfan Ikram, Philippe Amouyel, Claudia L. Satizabal, Luis Miguel Real, Carmen Antunez-Almagro, Anita DeStefano, Alfredo Cabrera-Socorro, Rebecca Sims, Cornelia M. Van Duijn, Eric Boerwinkle, Alfredo Ramirez, Myriam Fornage, Jean-Charles Lambert, Julie Williams, Sudha Seshadri, Janina S. Ried, Agustin Ruiz, Maria Eugenia Saez
Summary: The study analyzed publicly available data of multiple OMICS technologies from both plasma and brain stratified by APOE haplotype and identified genes and pathways contributing to AD. They also identified a set of biomarkers that could serve as screening tools for a disease lacking specific blood biomarkers.
Article
Cell Biology
Alexander M. Kulminski, Ethan Jain-Washburn, Ian Philipp, Liang He, Yury Loika, Elena Loiko, Olivia Bagley, Svetlana Ukraintseva, Anatoliy Yashin, Konstantin Arbeev, Eric Stallard, Mary F. Feitosa, Nicole Schupf, Kaare Christensen, Irina Culminskaya
Summary: Age-related diseases are complex polygenic traits with intricate genetic architectures. We examined the impact of multiple combinations of genotypes on the chances of living to older ages and found that specific combinations of genetic variants were associated with increased risk for Alzheimer's disease and decreased survival chances.
Article
Neurosciences
Xiaocao Liu, Qingze Zeng, Xiao Luo, Kaicheng Li, Xiaopei Xu, Luwei Hong, Jixuan Li, Xiaojun Guan, Xiaojun Xu, Peiyu Huang, Min-Ming Zhang
Summary: This study investigated the effect of the APOE epsilon 2 allele on basal forebrain cholinergic system functional connectivity in cognitively normal and mild cognitive impairment patients. The results showed an interaction effect between APOE epsilon 2 genotype and functional connectivity, and the functional connectivity was associated with cognitive performance. Therefore, the APOE epsilon 2 genotype may have a protective role in mild cognitive impairment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Wei Qin, Wenwen Li, Qi Wang, Min Gong, Tingting Li, Yuqing Shi, Yang Song, Ying Li, Fangyu Li, Jianping Jia
Summary: The relationship between APOE genotypes and Alzheimer's disease varies among different races, providing insight into precision medicine for Alzheimer's disease across diverse populations.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Tingting Wang, Kevin Huynh, Corey Giles, Natalie A. Mellett, Thy Duong, Anh Nguyen, Wei Ling Florence Lim, Alex A. T. Smith, Gavriel Olshansky, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F. Watts, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Ashley Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Kevin Taddei, Vincent Dore, Juergen Fripp, Matthias Arnold, Gabi Kastenmueller, Kwangsik Nho, Andrew J. Saykin, Rebecca Baillie, Xianlin Han, Ralph N. Martins, Eric K. Moses, Rima Kaddurah-Daouk, Peter J. Meikle
Summary: The APOE genotype is strongly associated with late-onset Alzheimer's disease, with specific lipid species mediating up to 30% and 10% of the treatment effect of APOE epsilon 2 and epsilon 4, respectively. Plasma lipid species represent a potential therapeutic target for Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2022)
Article
Geriatrics & Gerontology
Li Shang, Liling Dong, Xinying Huang, Tianyi Wang, Chenhui Mao, Jie Li, Jie Wang, Caiyan Liu, Jing Gao
Summary: This study aimed to investigate the associations of APOE epsilon 4/epsilon 4 with fluid biomarkers in dementia and biomarker-diagnosed AD. The results showed that APOE epsilon 4/epsilon 4 was associated with decreased CSF A beta 42 levels in AD patients, but not with tau protein. In non-AD patients, APOE epsilon 4 carriers had lower CSF A beta 42 levels and higher T-tau/A beta 42 and P-tau181/A beta 42 ratios.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Jae Myeong Kang, Jeong-Hyeon Shin, Woo-Ram Kim, Seongho Seo, Haeun Seo, Sang-Yoon Lee, Kee Hyung Park, Duk L. Na, Nobuyuki Okamura, Joon-Kyoung Seong, Young Noh
Summary: This study found differential effects of APOE ε4 on the relationship between tau and amyloid in patients with early-onset and late-onset Alzheimer's disease. Early-onset Alzheimer's disease ε4- patients showed more tau retention in the association cortices, while ε4+ patients had more retention in the medial temporal areas. The tau topography of late-onset Alzheimer's disease ε4+ was similar to that of early-onset Alzheimer's disease ε4+.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Samantha A. Harker, Lamees Al-Hassan, Matthew J. Huentelman, B. Blair Braden, Candace R. Lewis
Summary: Autistic adults are more prone to Alzheimer's disease and other dementias compared to neurotypical adults. The APOE ε4 allele negatively affects verbal learning and short-term memory in middle-aged and older adults, with potential vulnerability in autistic men.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Raffaele Cacciaglia, Gregory Operto, Carles Falcon, Jose Maria Gonzalez De Echavarri-Gomez, Gonzalo Sanchez-Benavides, Anna Brugulat-Serrat, Marta Mila-Aloma, Kaj Blennow, Henrik Zetterberg, Jose Luis Molinuevo, Marc Suarez-Calvet, Juan Domingo Gispert
Summary: The investigation of resting-state functional connectivity (rsFC) in asymptomatic individuals at genetic risk for Alzheimer's disease (AD) enables discovering the earliest brain alterations in preclinical stages of the disease. The APOE-epsilon 4 variant is the major genetic risk factor for AD, and previous studies have reported rsFC abnormalities in carriers of the epsilon 4 allele. Yet, no study has assessed APOE-epsilon 4 gene-dose effects on rsFC measures, and only a few studies included measures of cognitive performance to aid a clinical interpretation. Our data indicate that APOE-epsilon 4 shapes the functional architecture of the resting brain and favor the idea of a network-based functional compensation.
Article
Cell Biology
Daniel Kolbe, Nicolas A. da Silva, Janina Dose, Guillermo G. Torres, Amke Caliebe, Ben Krause-Kyora, Almut Nebel
Summary: By analyzing ancient samples up to 12,000 years old, this study revealed the evolutionary history of the three major APOE alleles in Europe. Significant allele frequency shifts were detected between populations and over time. The differences in allele distributions between early European populations (i.e., hunter-gatherers vs. first farmers) were likely influenced by changes in diet/lifestyle, while admixture played an important role in shaping current APOE variation from around 4000 BCE onwards.
Article
Geriatrics & Gerontology
Boung Chul Lee, Young Min Choe, Guk-Hee Suh, Ihn-Geun Choi, Hyun Soo Kim, Jaeuk Hwang, Dahyun Yi, Jin Hyeong Jhoo, Jee Wook Kim
Summary: This study examines the association between ginseng intake and AD-specific cognition in older adults and the moderating effect of APOE4 status. The results suggest that ginseng intake (with high duration and midlife onset) has a beneficial effect on AD-specific cognitive decline, specifically in delayed episodic memory. Furthermore, APOE4 status moderates the association between ginseng intake and AD-specific cognitive decline.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Frederic Brosseron, Anne Maass, Luca Kleineidam, Kishore Aravind Ravichandran, Pablo Garcia Gonzalez, Roisin M. McManus, Christina Ising, Francesco Santarelli, Carl-Christian Kolbe, Lisa M. Haesler, Steffen Wolfsgruber, Marta Marquie, Merce Boada, Adelina Orellana, Itziar de Rojas, Sandra Roeske, Oliver Peters, Nicoleta-Carmen Cosma, Arda Cetindag, Xiao Wang, Josef Priller, Eike J. Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Bjorn H. Schott, Katharina Buerger, Daniel Janowitz, Martin Dichgans, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H. Munk, Emrah Duzel, Renat Yakupov, Laura Dobisch, Coraline D. Metzger, Wenzel Glanz, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Nina Roy, Ayda Rostamzadeh, Charlotte E. Teunissen, Natalie L. Marchant, Annika Spottke, Mathias Jucker, Eicke Latz, Michael Wagner, David Mengel, Matthis Synofzik, Frank Jessen, Alfredo Ramirez, Agustin Ruiz, Michael T. Heneka
Summary: Understanding neuroinflammation in Alzheimer's disease is crucial, as evident from the analysis of inflammatory biomarkers in pre-dementia individuals showing close interactions between inflammation and accumulating neurodegeneration. Additionally, higher levels of specific biomarkers are associated with larger brain structure and stable cognitive outcomes at follow-up.
Article
Psychology, Clinical
Marco Schlosser, Thorsten Barnhofer, Florence Requier, Yacila Deza-Araujo, Oussama Abdoun, Natalie L. Marchant, Gael Chetelat, Fabienne Collette, Olga M. Klimecki, Antoine Lutz
Summary: This study aims to investigate whether a theory-based taxonomy of meditation-related mechanisms can be used to create psychometrically sound composite scores. The results from three independent samples suggest that the three composite scores, reflecting attentional, constructive, and deconstructive practices, have adequate psychometric properties. This study provides preliminary support for using a theoretical model to create meaningful and reliable composite scores for meditation-related mechanisms.
Article
Psychiatry
Amber John, Roopal Desai, Rob Saunders, Joshua E. J. Buckman, Barbara Brown, Shirley Nurock, Stewart Michael, Paul Ware, Natalie L. Marchant, Elisa Aguirre, Miguel Rio, Claudia Cooper, Stephen Pilling, Marcus Richards, Darya Gaysina, Josh Stott
Summary: Using long-term data and path models, this study found that affective symptoms have a direct impact on cognitive function in midlife, but cortisol does not explain the association between depressive or anxiety symptoms and cognitive function. Additionally, cortisol levels were not significantly associated with subsequent affective symptoms or cognitive function at the age of 50.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Harriet Demnitz-King, Julie Gonneaud, Olga M. Klimecki, Anne Chocat, Fabienne Collette, Sophie Dautricourt, Frank Jessen, Pierre Krolak-Salmon, Antoine Lutz, Rachel M. Morse, Jose Luis Molinuevo, Geraldine Poisnel, Edelweiss Touron, Miranka Wirth, Zuzana Walker, Gael Chetelat, Natalie L. Marchant
Summary: This study aims to explore the association between self-reflection and Alzheimer's disease (AD)-sensitive markers. The results show that self-reflection is associated with better global cognition and higher glucose metabolism, but not with amyloid deposition. However, further research is needed to determine whether these associations are independent of health and lifestyle factors.
Article
Medicine, Research & Experimental
M. Poppe, L. Duffy, N. L. Marchant, J. A. Barber, R. Hunter, N. Bass, A. M. Minihane, K. Walters, P. Higgs, P. Rapaport, I. A. Lang, S. Morgan-Trimmer, J. Huntley, Z. Walker, H. Brodaty, H. C. Kales, K. Ritchie, A. Burton, J. Wenborn, A. Betz, C. Cooper
Summary: This study aims to determine if a personally tailored secondary dementia prevention program, delivered remotely and facilitated by non-clinical interventionists, can reduce cognitive decline in older adults. The intervention focuses on promoting healthy lifestyle, increasing pleasurable activities and social connections, and improving self-management. The results of this study could greatly benefit older adults with memory concerns by providing them with effective interventions.
Article
Geriatrics & Gerontology
Ines Moulinet, Edelweiss Touron, Florence Mezenge, Sophie Dautricourt, Vincent de la Sayette, Denis Vivien, Natalie L. Marchant, Geraldine Poisnel, Gael Chetelat
Summary: This study found that depressive symptoms are more severe in patients with subjective cognitive decline and cognitively impaired patients on the Alzheimer's continuum compared to healthy controls. Depressive symptoms were associated with higher amyloid load in subjective cognitive decline patients, while they were related to higher cognition and glucose metabolism in cognitively impaired patients on the Alzheimer's continuum.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Letter
Clinical Neurology
Harriet Demnitz-King, Natalie L. Marchant
Article
Geriatrics & Gerontology
Cristina Sole-Padulles, Gabriele Cattaneo, Natalie L. Marchant, Maria Cabello-Toscano, Lidia Mulet-Pons, Javier Solana, Nuria Bargallo, Josep M. Tormos, Alvaro Pascual-Leone, David Bartres-Faz
Summary: This study explored the relationship between Repetitive Negative Thinking (RNT) and system segregation of the Anterior Salience Network (ASN), Default Mode Network (DMN), and Executive Control Network (ECN) in healthy middle-aged adults. Results showed that RNT was associated with depression, emotional stability, cognitive complaints, age, and segregation of LECN and ASN. Additionally, RNT was found to increase connectivity between ventral DMN and ASN, while decreasing connectivity with LECN.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychology, Clinical
Florence Requier, Anne Sophia Hendy, Marco Schlosser, Harriet Demnitz-King, Tim Whitfield, Gael Chetelat, Olga Klimecki, Antoine Lutz, Natalie L. Marchant, Fabienne Collette
Summary: This study aimed to assess the association between dispositional mindfulness (or more generally trait meditation capacities) and cognition in older adults. The results showed a positive relationship between the "deconstructive capacity" associated with self-inquiry and downregulation of maladaptive affective schemes, and global cognition in healthy aging. However, it remains unclear to what extent explicit training in meditation positively influences these capacities and whether these changes contribute to better cognition in aging.
Article
Cardiac & Cardiovascular Systems
Celine El Baou, Roopal Desai, Claudia Cooper, Natalie L. Marchant, Steve Pilling, Marcus Richards, Rob Saunders, Joshua E. J. Buckman, Elisa Aguirre, Amber John, Joshua Stott
Summary: This study aims to examine the association between psychotherapy outcomes for depression and incident cardiovascular disease (CVD). Through the analysis of national healthcare data in England, the study found that reliable improvement from depression symptoms through psychotherapy was associated with a lower risk of new onset of CVD.
EUROPEAN HEART JOURNAL
(2023)
Review
Geriatrics & Gerontology
Emilia Severs, Tiffeny James, Pilar Letrondo, Lise Lovland, Natalie Marchant, Naaheed Mukadam
Summary: This study conducted a systematic review and meta-analysis to investigate the association between traumatic life events (TLE) and dementia risk. The findings indicated that TLE, including general trauma, war/Holocaust trauma, and childhood trauma, were associated with an increased risk of dementia.
Article
Cell Biology
Sebastian Baez-Lugo, Yacila Deza-Araujo, Christel Maradan, Fabienne Collette, Antoine Lutz, Natalie L. Marchant, Gael Chetelat, Patrik Vuilleumier, Olga Klimecki
Summary: Basic emotional functions appear intact in older adults, but their response to and recovery from negative social events are not well understood. The researchers used a 'task-rest' paradigm and functional MRI to investigate the neural dynamics of empathy-related functions in older adults. They found that emotional elicitation during the task enhanced resting-state connectivity between the default mode network and amygdala in older adults, and this connectivity was associated with higher anxiety, rumination, and negative thoughts.
Letter
Clinical Neurology
Harriet Demnitz-King, Natalie L. Marchant
Summary: This study responds to Dr. Daly's query on the social determinants of brain health and finds that the association between self-reflection and AD-sensitive markers remains even after adjusting for education.
Article
Cell Biology
Valentin Ourry, Stephane Rehel, Claire Andre, Alison Mary, Leo Paly, Marion Delarue, Florence Requier, Anne Hendy, Fabienne Collette, Natalie L. Marchant, Francesca Felisatti, Cassandre Palix, Denis Vivien, Vincent de la Sayette, Gael Chetelat, Julie Gonneaud, Geraldine Rauchs
Summary: Sleep, especially slow wave sleep, plays a crucial role in cognitive functioning, but it is reduced in older adults. Cognitive reserve (CR) may modulate the impact of sleep on cognition. This study found that individuals with higher CR were able to maintain cognitive performance despite lower amounts of slow wave sleep, suggesting that CR may protect against age-related sleep changes on cognition.
Article
Psychology, Multidisciplinary
Marco Schlosser, Natalie G. Pfaff, Stefan R. Schweinberger, Natalie L. Marchant, Olga M. Klimecki
Summary: An increasing body of scientific research on compassion has been conducted, but there is still no consensus on its conceptualization and the existing measurement tools are often lacking in quality. Recent publications of longer compassion measures have made progress in addressing these issues, but there is still a need for short scales that are psychometrically sound for time-constrained research settings. This study validated the Compassionate Love Scale (CLS) and developed a new short scale called Compassion for Others Scale (COS-7) using items from the CLS. The COS-7 demonstrated adequate psychometric properties and can be used as a reliable short scale for measuring compassion for others.
CURRENT PSYCHOLOGY
(2023)
