Review
Engineering, Biomedical
Patrick M. Williamson, Benjamin R. Freedman, Nicholas Kwok, Indeevar Beeram, Jan Pennings, Jeremy Johnson, Daron Hamparian, Emily Cohen, Jenna L. Galloway, Arun J. Ramappa, Joseph P. DeAngelis, Ara Nazarian
Summary: Tendinopathy is a debilitating disease that causes 30% of musculoskeletal consultations, with varying treatment efficacy possibly due to incomplete characterization of its pathophysiology. Mechanical load has both beneficial and detrimental effects on tendons based on the degree, frequency, timing, and magnitude. Utilization of small animal models to mimic human tendinopathy could provide insights into the continuum between normal tendon and tendinopathy.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Chun-Kai Chang, Wu-Chien Chien, Wan-Fu Hsu, Hao-Yu Chiao, Chi-Hsiang Chung, Yuan-Sheng Tzeng, Shao-Wei Huang, Kuang-Ling Ou, Chih-Chien Wang, Shyi-Jou Chen, Der-Shiun Wang
Summary: This cohort study in Taiwan found that patients exposed to fluoroquinolones were at a significantly higher risk of tendon disorders. Patients under 18 and over 60 years old, those with chronic kidney disease, diabetes, rheumatologic disease, cardiac disease, lipid disorder, or obesity, as well as those who concomitantly used statins, aromatase inhibitors, or glucocorticoids, had a significantly higher risk of tendon disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Bill Pass, Philip Robinson, Alice Ha, Benjamin Levine, Corrie M. Yablon, Emma Rowbotham
Summary: This article discusses the role of ultrasound and MRI in evaluating Achilles tendon pathology, and describes common diagnoses and key imaging findings. It also reviews the application of image-guided interventions and summarizes the supporting evidence.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Orthopedics
Octavian Andronic, Ines Unterfrauner, Lukas Jud, Benjamin Fritz, Arnd F. Viehoefer, Stefan Froehlich, Florian B. Imhoff, Stephan H. Wirth
Summary: A study compared the outcomes of autograft and allograft reconstruction of the tibialis anterior tendon, finding no significant differences in patient-reported outcomes, functional outcomes, and imaging results between the two types of grafts.
FOOT & ANKLE INTERNATIONAL
(2022)
Article
Biophysics
Colin R. Firminger, W. Brent Edwards
Summary: Patellar tendinopathy is a common overuse injury in sports due to microdamage accumulation. The reduction in Young's modulus and increase in residual strain mechanically characterize the damage. The study found that peak cyclic strain and modulus loss rates showed high correlations with the number of cycles to failure, indicating potential for non-invasive monitoring of tendon strain in predicting overuse injury.
JOURNAL OF BIOMECHANICS
(2021)
Article
Sport Sciences
Dorthe Skovgaard, Volkert D. Siersma, Soren Bering Klausen, Havard Visnes, Inger Haukenes, Christine W. Bang, Peter Bager, Karin Gravare Silbernagel, Jamie Gaida, Stig Peter Magnusson, Michael Kjaer, Christian Couppe
Summary: The study identified a relationship between metabolic disorder markers and tendon injuries, with prediabetes, hypercholesterolemia, and metabolic syndrome increasing the risk of tendon injuries. These findings suggest that indicators of metabolic syndrome are a significant determinant of tendon injury risk.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Firoozeh Shomal Zadeh, Mehrzad Shafiei, Mostafa Shomalzadeh, Jennifer Pierce, Peter Christian Thurlow, Majid Chalian
Summary: This study systematically evaluated the efficacy of percutaneous ultrasound-guided needle tenotomy (PUNT) in the treatment of chronic tendinopathy and fasciopathy. The results showed that PUNT significantly improved pain and function in the short-term, intermediate-term, and long-term follow-up intervals.
EUROPEAN RADIOLOGY
(2023)
Review
Orthopedics
Kyle M. Griffith, Liisa Charie Hammer, Nicholas P. Iannuzzi, Karen C. Takatani, Jason Edward Hsu, James D. Cotton, Albert O. Gee, Richard J. Gardner, William D. Lack
Summary: Overuse injuries of the rotator cuff, especially the supraspinatus tendon, are common and disabling. The understanding of the pathophysiology, treatment options, and assessment methods for these injuries is still uncertain. Fatigue damage to the tendon results in an adaptive or maladaptive response, which is different from acute rupture. Factors such as age, smoking, hypercholesterolemia, sex, diabetes, and excessive load after fatigue damage are associated with degenerative response. Healing rate of tendon is influenced by sex and load post damage. MRI is the gold standard for assessing acute tears and tendinopathy, while ultrasonography is valuable for real-time evaluation of tendinopathy. Ultrasonography can provide information on mechanical and structural changes in the supraspinatus tendon due to overuse, and help determine the activity level that increases the risk of rupture.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2022)
Article
Orthopedics
Xiang Geng, Xiong-gang Yang, Zhao-lin Teng, Xing-xi Hu, Chen Wang, Chao Zhang, Li Chen, Jia-zhang Huang, Xu Wang, Xin Ma
Summary: The aim of this study was to investigate the diagnostic value of MRI in identifying the presence of Achilles tendon degeneration, the rupture site, and the rupture shape for acute closed Achilles tendon rupture. The results showed that MRI scanning can help determine the degeneration of the Achilles tendon, as well as the location and shape of the rupture, which can guide the selection of the optimal operation method for orthopedic surgeons.
ORTHOPAEDIC SURGERY
(2023)
Article
Veterinary Sciences
Thomas C. Haeussler, Matthias Kornmayer, Miriam Scheich, Andreas Fischer, Christian J. Feichtenschlager, Thomas Rohwedder
Summary: The study aimed to describe the surgical techniques used for treating common calcaneal tendon injuries and evaluate their short- and long-term outcomes and complications. Medical records from five different veterinary hospitals were reviewed, and the results showed that regardless of treatment modality, all limbs were immobilised for an average of 48.2 days. External skeletal fixators and calcaneotibial screws were the most commonly used immobilisation techniques, but the use of external fixators was associated with a higher rate of short-term complications. Overall, surgical treatment had slightly better long-term outcomes compared to conservative treatment.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2023)
Article
Veterinary Sciences
Thomas C. Haeussler, Matthias Kornmayer, Miriam Scheich, Andreas Fischer, Christian J. Feichtenschlager, Thomas Rohwedder
Summary: This retrospective multicentre study analyzed calcaneal tendon injuries in 66 cats and found that the most common type of injury was Meutstege type IIc. Cats with atraumatic injuries had a higher mean body weight than cats with traumatic injuries, but the difference was not statistically significant. Older cats were more likely to have atraumatic calcaneal tendon injuries.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2023)
Article
Multidisciplinary Sciences
Pawel Szaro, Khaldun Ghali Gataa
Summary: This comparative study revealed that tendinopathy alters correlations between dimensions of the Achilles tendon, with significant differences in thickness and midportion width. Tendinopathy also showed positive correlations between certain dimensions that were negative in normal tendons, highlighting significant differences in dimensions correlations between healthy and tendinopathic tendons.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Christine Lehner, Gabriel Spitzer, Patrick Langthaler, Dominika Jakubecova, Barbara Klein, Nadja Weissenbacher, Andrea Wagner, Renate Gehwolf, Eugen Trinka, Bernhard Iglseder, Bernhard Paulweber, Ludwig Aigner, Sebastien Couillard-Despres, Richard Weiss, Herbert Tempfer, Andreas Traweger
Summary: This study demonstrates that systemic inflammation accompanying allergic conditions negatively affects tendon structure and function. The research findings from mice and humans show that allergic reactions induce a reduction in tendon elasticity and tensile stress, as well as alterations in the tendon matrix. Furthermore, individuals with allergies are more likely to develop tendinopathy.
Editorial Material
Orthopedics
Nicola Maffulli, Katarina Nilsson Helander, Filippo Migliorini
Summary: In both tendon repair and tendinopathy, symptoms may not align with the appearance of the affected tendon on imaging, suggesting a dissociation between morphology and symptoms. Asymptomatic abnormal findings have limited predictive value, and interventions based on imaging are inappropriate. Patient education and clinical monitoring are recommended. Planning interventions based on sonographic abnormalities in symptomatic tendinopathy may not be warranted. Current evidence is limited and caution is needed when interpreting incidental findings in athletes.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Review
Cell Biology
Marguerite Meeremans, Gerlinde R. van de Walle, Sandra Van Vlierberghe, Catharina De Schauwer
Summary: Overuse tendon injuries are a major cause of musculoskeletal morbidity in human and equine athletes, leading to the formation of inferior scar tissue during the healing process. Mesenchymal stem cell (MSC)-based strategies show promise for tendon repair, but the lack of physiologically representative tendinopathy models hinders research progress. Existing in vitro tendon models often lack extracellular tendon matrix and vascular supply, pointing towards the need for improved models to advance MSC therapies for tendon injuries.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Materials Science, Biomaterials
Ashutosh Naik, David V. Shepherd, Jennifer H. Shepherd, Serena M. Best, Ruth E. Cameron
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2017)
Article
Engineering, Biomedical
David V. Shepherd, Jennifer H. Shepherd, Serena M. Best, Ruth E. Cameron
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2018)
Article
Engineering, Biomedical
Jennifer H. Shepherd, Daniel Howard, Amie K. Waller, Holly Rebecca Foster, Annett Mueller, Thomas Moreau, Amanda L. Evans, Meera Arumugam, Guenaelle Bouet Chalon, Eleonora Vriend, Natalia Davidenko, Cedric Ghevaert, Serena M. Best, Ruth E. Cameron
Article
Biochemistry & Molecular Biology
Renjie Liu, Caglar Remzi Becer, Hazel R. C. Screen
MACROMOLECULAR BIOSCIENCE
(2018)
Article
Sport Sciences
Chineye P. Udeze, Eleanor R. Jones, Graham P. Riley, Dylan Morrissey, Hazel R. C. Screen
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2019)
Review
Medicine, General & Internal
Zafar Ahmad, Asif Parkar, Jennifer Shepherd, Neil Rushton
POSTGRADUATE MEDICAL JOURNAL
(2020)
Article
Multidisciplinary Sciences
Malavika Nair, Jennifer H. Shepherd, Serena M. Best, Ruth E. Cameron
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2020)
Review
Pharmacology & Pharmacy
Yasmine Alyassin, Elshaimaa G. Sayed, Prina Mehta, Ketan Ruparelia, Muhammad S. Arshad, Manoochehr Rasekh, Jennifer Shepherd, Israfil Kucuk, Philippe B. Wilson, Neenu Singh, Ming-Wei Chang, Dimitrios G. Fatouros, Zeeshan Ahmad
DRUG DISCOVERY TODAY
(2020)
Article
Chemistry, Physical
Gareth Sheppard, Karl Tassenberg, Bogdan Nenchev, Joel Strickland, Ramy Mesalam, Jennifer Shepherd, Hugo Williams
Summary: The novel porosity characterization algorithm proposed in this study allows for rapid and accurate analysis of 2D bulk porous structures. It provides insights into spatial feature variation and has the potential to optimize and enhance scaffolds within tissue engineering.
Article
Engineering, Biomedical
Dharmesh Patel, Danae E. Zamboulis, Ewa M. Spiesz, Helen L. Birch, Peter D. Clegg, Chavaunne T. Thorpe, Hazel R. C. Screen
Summary: The study compared the IFM structure-function specialization in human positional anterior tibial tendon and energy storing Achilles tendons, showing greater elasticity and fatigue resistance in the Achilles tendon. Changes in the proteome of the Achilles IFM with aging likely contribute to decreased fatigue resistance. Understanding these specializations and changes with aging is crucial for developing treatments and preventative measures for tendinopathy.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Kyung-Ah Kwon, Daniel Bax, Jennifer H. Shepherd, Ruth E. Cameron, Serena M. Best
Summary: X-ray micro-computed tomography (mu-CT) is used to visualize the structure of hydrated collagen scaffolds by using phosphotungstic acid (PTA) as a contrast agent. The choice of processing and staining conditions is crucial for accurate visualization of crosslinked samples, while non-crosslinked or lightly crosslinked samples may cause structural artifacts.
BIOACTIVE MATERIALS
(2022)
Review
Oncology
Joanne Nolan, Oliver M. T. Pearce, Hazel R. C. Screen, Martin M. Knight, Stefaan W. Verbruggen
Summary: Organ-on-a-chip models, or organ chips, are tiny devices that accurately recreate the physiological and mechanical forces experienced by cells in the human body. These chips, lined with living human cells, can reproduce blood and airflow, and simulate breathing motions and muscle contractions. They offer a unique opportunity to build models of human organs and study cancer development and spread. They are simpler and cheaper than animal models, and could speed up drug discovery and testing in cancer research. The UK is actively researching organ chip technology for various cancer types.
Article
Materials Science, Multidisciplinary
Xiaoan Yang, G. M. A. M. El-Fallah, Qing Tao, Jun Fu, Chenlei Leng, Jenny Shepherd, Hongbiao Dong
Summary: Steel manufacturing is a complex process with numerous process parameters affecting the mechanical properties of final products. Machine learning models have been used to predict these properties, but interpretability is a challenge. This study uses iGATE to reduce input dimensions and successfully predict mechanical properties of hot-rolled steel plates.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Remo N. Widmer, Giulio I. Lampronti, Benjamin Kunz, Corsin Battaglia, Jennifer H. Shepherd, Simon A. T. Redfern, Thomas D. Bennett
ACS APPLIED NANO MATERIALS
(2018)
Article
Chemistry, Physical
Jennifer Shepherd, Daniel Bax, Serena Best, Ruth Cameron