Fell-Muir lecture: connective tissue growth factor (CCN2) - a pernicious and pleiotropic player in the development of kidney fibrosis

MicroRNAs and fibrosis

(2012) Vishal Patel et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Hyperglycemia Causes Renal Cell Damage via CCN2-Induced Activation of the TrkA Receptor: Implications for Diabetic Nephropathy

(2012) M. Fragiadaki et al.   DIABETES

The p65 subunit of NF-κB and PARP1 assist Snail1 in activating fibronectin transcription

(2012) Jelena Stanisavljevic et al.   JOURNAL OF CELL SCIENCE

Integrin Targeted Therapeutics

(2012) Melissa Millard et al.   Theranostics

Connective tissue growth factor antagonizes transforming growth factor-β1/Smad signalling in renal mesangial cells

(2011) Helen C. O'Donovan et al.   BIOCHEMICAL JOURNAL

Role of TGF-β in chronic kidney disease: an integration of tubular, glomerular and vascular effects

(2011) Francisco J. López-Hernández et al.   CELL AND TISSUE RESEARCH

Mechanisms of fibrosis: the role of the pericyte

(2011) Claudia Schrimpf et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Wnt-signaling pathways in progressive renal fibrosis

(2011) Peter J Nelson et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy

(2011) Brian Rooney et al.   FEBS LETTERS

Epithelial-mesenchymal transition in renal fibrosis - evidence for and against

(2011) Maria Fragiadaki et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Activation of Bone Morphogenetic Protein 4 Signaling Leads to Glomerulosclerosis That Mimics Diabetic Nephropathy

(2011) Tatsuya Tominaga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Brain- and Tumor-Derived Connective Tissue Growth Factor on Glioma Invasion

(2011) Lincoln A. Edwards et al.   JNCI-Journal of the National Cancer Institute

Interstitial fibrosis is associated with increased COL1A2 transcription in AA-injured renal tubular epithelial cells in vivo

(2011) Maria Fragiadaki et al.   MATRIX BIOLOGY

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

(2011) Joon-Il Jun et al.   NATURE REVIEWS DRUG DISCOVERY

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

CCN2 Is Required for the TGF-β Induced Activation of Smad1 - Erk1/2 Signaling Network

(2011) Sashidhar S. Nakerakanti et al.   PLoS One

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

CCN2 is required for bleomycin-induced skin fibrosis in mice

(2010) Shangxi Liu et al.   ARTHRITIS AND RHEUMATISM

Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis

(2010) Sonali Sonnylal et al.   ARTHRITIS AND RHEUMATISM

Phase 1 Study of Anti-CTGF Monoclonal Antibody in Patients with Diabetes and Microalbuminuria

(2010) S. G. Adler et al.   Clinical Journal of the American Society of Nephrology

CCN3 (NOV) Is a Negative Regulator of CCN2 (CTGF) and a Novel Endogenous Inhibitor of the Fibrotic Pathway in an in Vitro Model of Renal Disease

(2009) Bruce L. Riser et al.   AMERICAN JOURNAL OF PATHOLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Noncanonical transforming growth factor β signaling in scleroderma fibrosis

(2009) Maria Trojanowska   CURRENT OPINION IN RHEUMATOLOGY

Transforming Growth Factor-β1 Up-Regulation of Human α1(I) Collagen Is Mediated by Sp1 and Smad2 Transacting Factors

(2009) Polina Sysa et al.   DNA AND CELL BIOLOGY

CTGF Promotes Inflammatory Cell Infiltration of the Renal Interstitium by Activating NF- B

(2009) E. Sanchez-Lopez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-β2 by impeding CTGF expression

(2009) Shuyu Ren et al.   KIDNEY INTERNATIONAL

Connective Tissue Growth Factor Overexpression in Cardiomyocytes Promotes Cardiac Hypertrophy and Protection against Pressure Overload

(2009) Anna N. Panek et al.   PLoS One

Connective tissue growth factor(CCN2), a pathogenic factor in diabetic nephropathy. What does it do? How does it do it?

(2009) Roger M. Mason   Journal of Cell Communication and Signaling

Alternative splicing of CCN mRNAs …. it has been upon us

(2009) Bernard Perbal   Journal of Cell Communication and Signaling

Connective tissue growth factor is induced in bleomycin-induced skin scleroderma

(2009) Shangxi Liu et al.   Journal of Cell Communication and Signaling

Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?

(2009) Andrew Leask et al.   Journal of Cell Communication and Signaling

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

(2008) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

A large multicentre analysis of CTGF -945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype

(2008) B Rueda et al.   ANNALS OF THE RHEUMATIC DISEASES

Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate

(2008) Jaspreet Pannu et al.   ARTHRITIS AND RHEUMATISM

miR-133 and miR-30 Regulate Connective Tissue Growth Factor

(2008) Rudy F. Duisters et al.   CIRCULATION RESEARCH

Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis

(2008) Xu Shi-Wen et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Signal transduction involved in CTGF-induced production of chemokines in mesangial cells

(2008) Sheng-Hua Wu et al.   GROWTH FACTORS

Connective tissue growth factor: Structure–function relationships of a mosaic, multifunctional protein

(2008) Patricia De Winter et al.   GROWTH FACTORS

Functions and mechanisms of action of CCN matricellular proteins

(2008) Chih-Chiun Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Integrin-linked kinase - essential roles in physiology and cancer biology

(2008) P. C. McDonald et al.   JOURNAL OF CELL SCIENCE

Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy

(2008) Sally E. Thomson et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

CTGF Inhibits BMP-7 Signaling in Diabetic Nephropathy

(2008) T. Q. Nguyen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Podocyte-Selective Deletion of Dicer Induces Proteinuria and Glomerulosclerosis

(2008) S. Shi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activation of Erk1/2 and Akt following unilateral ureteral obstruction

(2008) Ana B. Rodríguez-Peña et al.   KIDNEY INTERNATIONAL

Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-β responsiveness

(2007) Yasuji Mori et al.   EXPERIMENTAL CELL RESEARCH

Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice

(2007) H. Yokoi et al.   KIDNEY INTERNATIONAL