Article
Cardiac & Cardiovascular Systems
Julien Solinc, Jessica Raimbault-Machado, France Dierick, Lamiaa El Bernoussi, Ly Tu, Raphael Thuillet, Nathalie Mougenot, Benedicte Hoareau-Coudert, Virginie Monceau, Catherine Pavoine, Fabrice Atassi, David Sassoon, Giovanna Marazzi, Richard P. Harvey, Peter Schofield, Daniel Christ, Marc Humbert, Christophe Guignabert, Florent Soubrier, Sophie Nadaud
Summary: This study demonstrates the significant role of the platelet-derived growth factor receptor alpha (PDGFR alpha) pathway in progenitor cell-dependent vascular remodeling and neomuscularization associated with pulmonary arterial hypertension (PAH). Inhibition of PDGFR alpha activity reduces pulmonary vessel neomuscularization, while constitutive activation of PDGFR alpha leads to neomuscularization and PH development. These findings suggest that PDGFR alpha blockers may be a promising therapeutic strategy for reducing vascular remodeling in PAH patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Hematology
Julian Leberzammer, Stijn M. Agten, Xavier Blanchet, Rundan Duan, Hans Ippel, Remco T. A. Megens, Christian Schulz, Maria Aslani, Johan Duchene, Yvonne Doring, Natalie J. Jooss, Pengyu Zhang, Richard Brandl, Konstantin Stark, Wolfgang Siess, Kerstin Jurk, Johan W. M. Heemskerk, Tilman M. Hackeng, Kevin H. Mayo, Christian Weber, Philipp von Hundelshausen
Summary: The study explored the molecular mechanisms of CXCL12 in arterial thrombosis, revealing that inhibition of CXCR4 can attenuate platelet aggregation and limit arterial thrombosis. Mechanistically, CXCL12 activates Btk leading to platelet aggregation, while the interaction between CXCL12 and CCL5 can inhibit this process. A novel peptide was found to inhibit CXCL12-induced platelet aggregation without prolonging bleeding time.
Article
Neurosciences
Jelena Medved, William M. Wood, Michael D. van Heyst, Amin Sherafat, Ju-Young Song, Sagune Sakya, Dennis L. Wright, Akiko Nishiyama
Summary: Oligodendrocyte precursor cells play a crucial role in brain development and have the potential to be targeted for the treatment of brain tumors.
Article
Cell & Tissue Engineering
Toshiya Nishimura, Fabian P. Suchy, Joydeep Bhadury, Kyomi J. Igarashi, Carsten T. Charlesworth, Hiromitsu Nakauchi
Summary: The deletion of Igf1r in mouse embryos creates a permissive cell-competitive niche in multiple organs, significantly increasing both mouse intraspecies and mouse/rat interspecies donor chimerism.
Article
Chemistry, Multidisciplinary
Ana L. Graca, Manuel Gomez-Florit, Hugo Osorio, Marcia T. Rodrigues, Rui M. A. Domingues, Rui L. Reis, Manuela E. Gomes
Summary: This study produced and characterized platelet-derived EVs and investigated their effects on different cell types. The EVs were found to regulate stem cell differentiation, promote angiogenesis, and modulate macrophage polarization, suggesting their potential as therapeutic tools in tissue engineering and regenerative medicine.
Article
Biochemistry & Molecular Biology
Susan Y. S. Li, Rebecca Johnson, Leon C. D. Smyth, Mike Dragunow
Summary: This review provides an updated overview of the actions of platelet-derived growth factors on neurovascular function, their role in regulating perivascular cell types, and their clinical relevance and therapeutic potential for neurological diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Microbiology
Minmin Zhou, Shaobo Wang, Jiao Guo, Yang Liu, Junyuan Cao, Xiaohao Lan, Xiaoying Jia, Bo Zhang, Gengfu Xiao, Wei Wang
Summary: PDGFR beta was identified as a potential therapeutic target against JEV infection, with the inhibitor imatinib showing protection against JEV-induced lethality by reducing viral load in the brain and preventing histopathological changes.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Wanting Niu, Teck Chuan Lim, Abdulmonem Alshihri, Ravikumar Rajappa, Lishan Wang, Motoichi Kurisawa, Myron Spector
Summary: This study demonstrated the high viability of bone marrow mesenchymal stem cells (bMSCs) in Gelatin-hydroxyphenyl propionic acid (Gtn-HPA) covalent cross-linking gelation. The incorporation of platelet-derived growth factor (PDGF)-BB directly into the gel or released from polyelectrolyte complex nanoparticles (PCNs) stimulated bMSC migration and proliferation effectively. Stromal cell-derived factor (SDF)-1 alpha enhanced migration and proliferation when released from PCNs, highlighting the potential of using Gtn-HPA/PDGF-BB as an injectable therapeutic agent for musculoskeletal tissue defects.
Article
Oncology
Virginie Joubert, Lara Chalabreysse, Delphine Gamondes, Francois Tronc, Jean-Michel Maury, Nicolas Girard
Summary: Non-neoplastic thymic lesions are rare findings that can be difficult to differentiate from thymic malignancies. A multidisciplinary approach that integrates clinical and imaging features, as well as follow-up, can help in the management and selection of patients for surgery.
Article
Biochemistry & Molecular Biology
Rimma Sergeevna Kamentseva, Marianna Viktorovna Kharchenko, Gulnara Vladikovna Gabdrahmanova, Michael Alexandrovich Kotov, Vera Vladislavovna Kosheverova, Elena Sergeevna Kornilova
Summary: This study compared the effects of EGF, TGF-α, and AREG on physiological responses in endometrial MSCs and HeLa cells, and investigated the internalization and degradation of EGFR stimulated by these ligands. The study found that while EGF and TGF-α stimulated cell proliferation and prevented differentiation in enMSCs in an EGFR-dependent manner, AREG had no effect. Additionally, differences were observed in the degradation and recovery of EGFR in different cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Doaa Alqaidy, Cesar A. Moran
Summary: The diagnosis of thymic carcinoma can be challenging due to difficulties in determining its specific origin and the lack of a definitive immunohistochemical stain. This article discusses the challenges encountered by diagnostic surgical pathologists in assessing thymic carcinoma and staging these tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Biomedical
Harsha Kabra, Tanaya Walimbe, Kate Stuart, Camille Indey, Swati Jalgaonkar, Elvis Ikwa, Taylor Skurnac, Julia Chen, Andrew Woolley, Nicholas M. Snead, Nathan Bachtell, Diana J. Leeming, Morten Karsdal, Glenn Prestwich, Alyssa Panitch, John Paderi
Summary: SBR-294, targeting collagen-mediated platelet activation and PDGF activity, showed potential therapeutic benefits in reducing liver fibrosis in the CCl4 mouse model. Further investigation is warranted to explore its potential as a treatment for liver fibrosis.
Article
Oncology
Sangmin Kim, Daeun You, Yisun Jeong, Sun Young Yoon, Sung A. Kim, Jeong Eon Lee
Summary: The study investigated the expression of the PDGF family in ER-α(+) breast cancer patients and the effects of PDGFR inhibitors on cell cycle, growth, and metastasis-related gene expression. The results suggest that PDGFR inhibitors can be used for the treatment of ER-α(+) breast cancer.
Article
Pharmacology & Pharmacy
Georges Jourdi, Imane Boukhatem, Pablo F. Barcelona, Samuel Fleury, Melanie Welman, H. Uri Saragovi, Samuela Pasquali, Marie Lordkipanidze
Summary: Recent research has shown that brain-derived neurotrophic factor (BDNF) has activating effects on isolated platelets. However, since BDNF circulates in plasma, it is necessary to find a mechanism to prevent constant activation of platelets. In this study, α2M was identified as a physiological regulator of BDNF bioavailability and an inhibitor of BDNF-induced platelet activation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Doaa Alqaidy
Summary: This article discusses the naming, classification, and staging of thymomas, which are one of the most common types of mediastinal epithelial tumors. There is controversy over the significance of thymoma histologic classifications, and the challenges that diagnostic surgical pathologists may face in evaluating the histopathology of these tumors and staging them are presented. The clinical characteristics and current management strategy of these distinct tumors are also briefly reviewed.
Article
Oncology
Marius Raica, Amalia Raluca Ceausu, Anca Maria Cimpean, Serban Comsa, Simona Sarb
Summary: The study investigated the expression of CLIC1, Ecad, and Pcad in breast cancer, revealing their association with molecular subtypes and the ability to define new high-risk subgroups. This stratification may explain variations in treatment response and aggressiveness observed by different authors within the same molecular subtype.
ANTICANCER RESEARCH
(2021)
Article
Oncology
Iulia Florentina Burcea, Valeria Nicoleta Nastase, Anca Maria Cimpean, Amalia Raluca Ceausu, Ionela Baciu, Cristina Capatina, Roxana Dusceac, Simona Galoiu, Dan Niculescu, Serban Radian, Raluca Trifanescu, Anda Dumitrascu, Laurentiu Catalin Cocosila, Marius Raica, Catalina Poiana
Summary: Among 32 acromegaly patients, 93.75% had macroadenomas; Ki-67 labelling index did not predict remission, while PIT-1 was positive in all specimens with weak expression in two; there was no correlation between GH serum levels and IHC expression.
ANTICANCER RESEARCH
(2021)
Article
Oncology
Serban Comsa, Amalia-Raluca Ceausu, Roxana Popescu, Anca-Maria Cimpean, Simona Sarb, Marius Raica
Summary: This study aimed to analyze the patterns of tumor vasculogenesis by generating an in vivo breast cancer environment. Results showed that tumor and embryonic vasculogenesis share a common paradigm, with CD105, AC133, and Oct3/4 playing important roles in establishing the vasculogenic and hematopoietic stage.
ANTICANCER RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Adrian Carabineanu, Ramona Gadea, Dan Costachescu, Adelina Mocanu, Dan Navolan, Daniel Malita, Raluca Ceausu, Cristina Saracin, Octavian Cretu, Alexandru Blidisel
Summary: The study aimed to develop an experimental model to test the MRI ability to accurately locate surgical plastic meshes, finding that T1fl2D sequence is optimal for highlighting the best visible mesh. The experimental model was successful in testing MRI's ability to identify different plastic meshes, suggesting selection of an optimal MRI protocol for post-implantation monitoring.
MATERIALE PLASTICE
(2021)
Article
Chemistry, Multidisciplinary
Vlad Bloanca, Horia Haragus, Anca-Maria Campean, Andrei Cosma, Tiberiu Bratu, Zorin Crainiceanu
Summary: The study aimed to analyze the involvement of adipose-sourced mast cells in nerve repair. Results showed that mechanically processed adipose tissue augmented nerve repair does not seem to increase mast cell expression but may support angiogenesis in an experimental model.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Andrei Dan Radu-Cosnita, Alexandru Nesiu, Patricia Lorena Berzava, Simona Cerbu, Andrei Cosma, Serban Comsa, Simona Sarb, Adela Maria Ferician, Ovidiu Catalin Ferician, Anca Maria Cimpean
Summary: This study evaluated the effect of anti-CLIC1 antibodies on human cc-RCC xenografts in rabbit cornea and chick embryo CAM models. The results showed that the antibodies induced tumor necrosis and regression of tumor vasculature, suggesting a potential therapeutic strategy for RCC.
ANTICANCER RESEARCH
(2022)
Article
Medicine, General & Internal
Ciprian Roi, Pusa Nela Gaje, Raluca Amalia Ceausu, Alexandra Roi, Laura Cristina Rusu, Eugen Radu Boia, Simina Boia, Ruxandra Elena Luca, Mircea Rivis
Summary: Gingivitis is a common oral disease that can progress to periodontitis if left untreated. Inflammation of the gingiva is associated with pathological angiogenesis and changes in blood vessel morphology. The severity of gingival lesions is correlated with increased microvessel density.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pediatrics
Rodica Elena Heredea, Eugen Melnic, Laura Elena Cirligeriu, Patricia Lorena Berzava, Maria Corina Stanciulescu, Calin Marius Popoiu, Anca Maria Cimpean
Summary: This study compared the gene expression profile of involuting and recurrent infantile hemangiomas, identifying several genes with differential expression. Further research is needed to accurately map the gene expression profile and establish a gene expression-based classification for hemangiomas.
Article
Biochemistry & Molecular Biology
Cristina Stefania Dumitru, Amalia Raluca Ceausu, Nela Pusa Gaje, Cristian Silviu Suciu, Marius Raica
Summary: This study demonstrates the importance of double immunolabeling in assessing lymphangiogenesis and tumor proliferation in correlation with histopathological grades in HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dorin Novacescu, Talida Georgiana Cut, Alin Adrian Cumpanas, Felix Bratosin, Raluca Amalia Ceausu, Marius Raica
Summary: Despite advancements in RCC detection and molecular pathology, mortality rates are increasing and better clinical management tools are needed. The study found TD expression in RCC tissue and healthy renal parenchyma, with possible prognostic relevance. Further molecular analysis is required to fully understand the biological significance of this newly documented TD expression in RCC.
Article
Biochemistry & Molecular Biology
Ciprian Roi, Meda Lavinia Negrutiu, Alexandra Roi, Mircea Rivis, Ruxandra Elena Luca, Marius Raica, Raluca Amalia Ceausu, Alexandru Catalin Motofelea, Pusa Nela Gaje
Summary: This study aimed to quantify the existence of microvessel density, mast cell density, and the heterogeneity of blood vessels in patients with periapical odontogenic granulomas. The results showed a high number of mast cells, particularly in inflamed tissue, high heterogeneity of blood vessels, and increased microvessel density with positive CD34. The study concludes that mast cells play a key role in angiogenesis and the host's inflammatory response.
Article
Biochemistry & Molecular Biology
Amalia Raluca Ceausu, Alexandru Ciolofan, Alexandru Blidisel, Andrei Alexandru Cosma, Pusa Nela Gaje, Octavian Cretu
Summary: This study aimed to evaluate the relation between CLIC1 expression, growth patterns of liver metastasis, and angiogenesis. The study found a correlation between CLIC1 expression in primary tumors and the growth patterns and angiogenesis of metastatic tumors. The results suggest that the CLIC1 score may have prognostic and therapeutic value for liver metastasis with different growth patterns.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Oncology
Adela Maria Ferician, Ovidiu Catalin Ferician, Andrei Dragos Cumpanas, Patricia Lorena Berzava, Alexandru Nesiu, Ariana Barmayoun, Anca Maria Cimpean
Summary: This study identified three subgroups of renal cell carcinoma (RCC) with different vascular patterns and gene expression profiles. These findings may contribute to the development of personalized targeted therapies.
CANCER GENOMICS & PROTEOMICS
(2022)
Article
Medicine, Research & Experimental
Maria-Corina Stanciulescu, Marius-Calin Popoiu, Anca Maria Cimpean, Vlad-Laurentiu David, Rodica Heredea, Simona Cerbu, Eugen-Sorin Boia
Summary: This study demonstrates for the first time the heterogeneous expression of beta 1-AR among pediatric vascular malformations, supporting the need for beta 1-AR assessment to select cases with a robust response to beta 1-selective blockers. The assessment of beta 1-AR may have a significant impact on therapeutic refinement for pediatric vascular anomalies by selecting cases with a stronger response to beta-blockers.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Raluca Amalia Ceausu, Alexandru Ciolofan, Alexandru Blidisel, Octavian Marius Cretu, Anca Maria Cimpean, Marius Raica
Summary: This study found that metastatic cells change their phenotype during the metastatic process, which may explain why not all metastases respond similarly to therapy.