Article
Biochemistry & Molecular Biology
Hai-Yan Cao, Jing-Yi Zhao, Cheng Yi, Sen-Feng Sun, Ke-liang Chen, Zhi-min Qin, Yun-Bao Liu
Summary: Six undescribed meleagrin analogues were isolated from a toxic medicinal plant, and their structures were elucidated through spectroscopic analysis. Among them, iso-meleagrin exhibited selective cytotoxicity against HGC27 cells.
Article
Microbiology
Reyna Murry, Lea Traxler, Jessica Poetschner, Thomas Krueger, Olaf Kniemeyer, Katrin Krause, Erika Kothe
Summary: Intracellular signaling, especially inositol phosphate signaling, plays vital roles in growth, reproduction, and metabolic adaptation in fungi. The up-regulation of inositol monophosphatase in Schizophyllum commune during sexual development indicates its importance in inositol cycling and cell wall integrity. The altered inositol signaling also contributes to metal tolerance and interactions with known signal transduction pathways.
Article
Biochemistry & Molecular Biology
Jia-Peng Wang, Yan Shu, Rui Liu, Jun-Li Gan, Si-Ping Deng, Xue-Yun Cai, Jun-Tao Hu, Le Cai, Zhong-Tao Ding
Summary: Seven previously undescribed sesterterpenes were isolated from Penicillium roqueforti YJ-14 through solid fermentation. These compounds exhibited cytotoxicity against breast cancer and lung cancer cell lines, with one of them showing inhibitory effect on nitric oxide production in activated macrophages.
Article
Engineering, Environmental
Lea Traxler, Jenny Shrestha, Martin Richter, Katrin Krause, Thorsten Schafer, Erika Kothe
Summary: Fungi living in heavy metals and radionuclides contaminated environments, such as the Chernobyl Exclusion Zone, have developed mechanisms to cope with these pollutants. The wood-rot fungus Schizophyllum commune was studied for its metal tolerance mechanisms and ability to transport metals through its hyphae. Adapted strains showed specific metal transport and a lack of changes in morphology, indicating metal stress avoidance mechanisms. Transporter genes were downregulated while genes involved in the secretory pathway were upregulated under metal stress.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Food Science & Technology
Juliana Ramos-Pereira, Juliana Mareze, Domingo Fernandez, Edson A. Rios, Jesus A. Santos, Teresa-Maria Lopez-Diaz
Summary: Penicillium spp. is a major spoilage fungus in cheeses, but lactic acid bacteria (LAB) with antifungal activity, especially from goat and cow milk, have shown potential in biopreservation. Among 57 strains active against P. nordicum, Lacticaseibacillus casei, L. paracasei, and L. rhamnosus were dominant. Two strains (L. casei Lc-51/3 and L. paracasei Lp-25/1) displayed high antifungal activity against Penicillium species and reduced mycotoxin production. These LAB strains could be developed as protective adjunct starters in cheese processing to prevent spoilage and toxigenic contamination.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tao Chen, Yufeng Liu, Yun Huang, Wencong Yang, Bing Sun, Qi Tan, Tianyu Wei, Bo Wang, Jie Yuan, Zhigang She
Summary: Ten new meroterpenoids and ten known analogues were isolated from a mangrove-associated fungus. Their structures and absolute configurations were determined through various analysis methods. Four compounds exhibited cytotoxicity against multiple cancer cell lines.
Article
Chemistry, Medicinal
Yingying Song, Jianglian She, Weihao Chen, Jiamin Wang, Yanhui Tan, Xiaoyan Pang, Xuefeng Zhou, Junfeng Wang, Yonghong Liu
Summary: Five new fusarin derivatives and two known natural products were isolated from a marine algicolous fungus. These compounds showed various activities including antioxidant, antibacterial, and anti-inflammatory effects, with compound 1 exhibiting good radical scavenging and anti-inflammatory activity.
Article
Biochemistry & Molecular Biology
Yi Zang, Yihua Gong, Zhengyi Shi, Changxing Qi, Chunmei Chen, Qingyi Tong, Junjun Liu, Jianping Wang, Hucheng Zhu, Yonghui Zhang
Summary: The OSMAC strategy led to the discovery of seven unreported multioxidized aromatic polyketides from a soil-derived fungus Penicillium canescens. Among them, (-)-penicanesin A showed potential cytotoxicity against human cancer cell lines, while its enantiomer (+)-penicanesin A was less active.
Article
Plant Sciences
Chang-Zheng Wu, Gang Li, Yu-Han Zhang, Shuang-Zhi Yuan, Ke-Min Dong, Hong-Xiang Lou, Xiao-Ping Peng
Summary: Eleven new pyridone alkaloids and three new tetramic acids were isolated from a marine-derived fungus. The structures and absolute configurations were determined through various analyses. Intriguingly, some of the pyridone alkaloids exhibited interconversions between hydroxy and methoxy groups at C-4 in acidic MeOH solution, and OH-4 could be replaced by various substituent groups in acidic aqueous solution. Additionally, several compounds showed moderate inhibitory effects on NO production in LPS-induced macrophages.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Microbiology
Wei Wang, Mei Wang, Xian-Bo Wang, Yi-Qiang Li, Ji-Lin Ding, Ming-Xian Lan, Xi Gao, Dong-Lin Zhao, Cheng-Sheng Zhang, Guo-Xing Wu
Summary: New leading compounds with potent phytotoxicity were discovered from the mangrove-derived fungus, Penicillium sclerotiorum HY5, providing potential for the research and development of marine-derived bioherbicides.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yi Zang, Muyuan Yu, Zhengyi Shi, Chunmei Chen, Junjun Liu, Jianping Wang, Hucheng Zhu, Yonghui Zhang
Summary: In this study, two pairs of undescribed enantiomers were isolated from the crude extract of Penicillium griseofulvum and one of them showed potential weak inhibitory activity against α-glucosidase.
Article
Chemistry, Medicinal
Hui-Chun Wang, Tzu-Yi Ke, Ya-Chen Ko, Jue-Jun Lin, Jui-Sheng Chang, Yuan-Bin Cheng
Summary: The study discovered a new medical entity from edible marine algae through continuous natural product investigation, focusing on endophytes from marine macroalgae. Two new azaphilones were isolated from alga-derived fungus Penicillium sclerotiorum, along with five known azaphilones. The compounds showed bioactivity in cytotoxic, anti-inflammatory, and anti-fibrosis activities.
Article
Chemistry, Medicinal
Jinwei Ren, Ruiyun Huo, Gaoran Liu, Ling Liu
Summary: Three new andrastin-type meroterpenoids, penimeroterpenoids A-C (1-3), along with two known analogs, were isolated from the cultures of marine-derived Penicillium species. The structures of the new compounds were identified through NMR and mass spectrometry, while the absolute configurations were determined using experimental and calculated ECD spectra. Compound 1 exhibited moderate cytotoxicity against A549, HCT116, and SW480 cell lines.
Article
Biotechnology & Applied Microbiology
Mingshuang Wang, Ruoxin Ruan, Hongye Li
Summary: The study presents a finished genome sequence for the P. digitatum strain PDW03, revealing key proteins and gene clusters. Genomic re-analyses and pangenome analysis highlight the utility of this genome for investigating the driving forces of fungal host switch and the role of effectors in plant-pathogen interaction.
Article
Biotechnology & Applied Microbiology
Joao Carlos Silva Conceicao, Augusto D. Alvarega, Luiza A. Mercante, Daniel S. Correa, Eliane Oliveira Silva
Summary: The widespread use of endocrine-disrupting compounds (EDCs) in everyday products poses a severe risk to human health and the environment. Fungal bioremediation and immobilizing fungal cells onto nanofibrous membranes provide a green and cost-effective approach to remove pollutants from water resources. In this study, a novel nanostructured bioremediation platform based on polyacrylonitrile nanofibrous membrane (PAN NFM) was developed to immobilize an endophytic fungus for the removal of bisphenol A (BPA), a typical EDC. The platform showed high BPA removal efficiency through simultaneous adsorption and biotransformation, making it a promising tool for the bioremediation of EDCs and other pollutants in water resources.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Elahe Zahedi, Akbar Esmaeili, Niloofar Eslahi, Mohammad Ali Shokrgozar, Abdolreza Simchi
Article
Engineering, Biomedical
Faranak Bahramimehr, Akbar Esmaeili
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2019)
Article
Chemistry, Physical
Akbar Esmaeili, Fatemeh Pourkhodabakhshi
Article
Chemistry, Applied
Fatemeh Khalili Amand, Akbar Esmaeili
CARBOHYDRATE POLYMERS
(2020)
Article
Biophysics
Negin Hormozi, Akbar Esmaeili
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Environmental Sciences
A. Esmaeili, S. Shirzad Nagadehi
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2020)
Article
Materials Science, Biomaterials
Meisam Khodaei, Akbar Esmaeili
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Environmental Sciences
Ali Aghababai Beni, Akbar Esmaeili
Article
Nanoscience & Nanotechnology
Sara Masoumi, Akbar Esmaeili
APPLIED NANOSCIENCE
(2020)
Article
Environmental Sciences
S. Fereidouni Velasejerdi, A. Esmaeili, A. Rustaiyan
Summary: This research aims to optimize the industrial production process of 6-APA by eliminating certain steps to increase yield and reduce production costs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Fateme Dadashi, Akbar Esmaeili
Summary: Bismuth-hyaluronic acidmelittin-chitosan nanoparticles were synthesized for cancerous eye cell radiotherapy, with optimized conditions achieved for ideal nanoparticle performance.
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Mahnoosh Aliahmadi, Akbar Esmaeili
Summary: This study synthesized new modified imaging nanocapsules containing Morus nigra extract by selenium nanoparticles prepared from Lactobacillus acidophilus. The antibacterial activities of the modified contrast agents were investigated, and the influence of various factors on the activity was studied. The structure and morphology of the synthesized contrast agents were characterized using multiple techniques.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Sahar Heydari, Akbar Esmaeili
Summary: This study synthesized a new scaffold of polyurethane/chitosan/Vicia ervilia protein/gelatin/heparin-coated with Astragalus gossypinus for cardiovascular tissue engineering. The nanofibers loaded with heparin showed a high release rate and low toxicity, with good cell survival rate and adhesion of endothelial cells on the vessel's inner wall.
PROCESS BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Roghaye Mahmoudi, Akbar Esmaeili, Ali Nematollahzadeh
Summary: Gold nanoparticles have high detection potential with advantages such as high viability, selective accumulation in cancer cells, and low toxicity. This study investigates the characteristics of a new process using (Fe3O4/Ag3VO4/Au NPs) modified with oleyl chitosan and its application in diagnostic fields. The nanoparticle obtained has been used as an imaging contrast-enhancing agent, showing targeted and pH-sensitive release of MTX due to chitosan modification. The evaluation of magnetic resonance imaging/computed tomography scan shows improved signal strength and T2 time. The coated nanocomposite with chitosan-oleic acid demonstrates non-toxicity and potential for advanced biomedical imaging applications.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Chemistry, Multidisciplinary
Soheila Naderi, Akbar Esmaeili
NEW JOURNAL OF CHEMISTRY
(2020)
