4.7 Article

A 3-D framework for arterial growth and remodeling in response to altered hemodynamics

Journal

INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
Volume 48, Issue 11, Pages 1357-1372

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ijengsci.2010.06.033

Keywords

Constrained mixture model; Finite elasticity; Adaptation; Hypertension

Funding

  1. Fulbright Fellowship
  2. NIH [HL086418]

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We present a three-dimensional mathematical framework for modeling the evolving geometry, structure, and mechanical properties of a representative straight cylindrical artery subjected to changes in mean blood pressure and flow. We show that numerical predictions recover prior findings from a validated two-dimensional framework, but extend those findings by allowing effects of transmural gradients in wall constituents and vasoactive molecules to be simulated directly. Of particular note, we show that the predicted evolution of the residual stress related opening angle in response to an abrupt, sustained increase in blood pressure is qualitatively similar to measured changes when one accounts for a nonlinear transmural distribution of pre-stretched elastin. We submit that continuum-based constrained mixture models of arterial adaptation hold significant promise for deepening our basic understanding of arterial mechanobiology and thus for designing improved clinical interventions to treat many different types of arterial disease and injury. (C) 2010 Elsevier Ltd. All rights reserved.

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