Article
Environmental Sciences
Alison G. Paquette, James MacDonald, Samantha Lapehn, Theo Bammler, Laken Kruger, Drew B. Day, Nathan D. Price, Christine Loftus, Kurunthachalam Kannan, Carmen Marsit, W. Alex Mason, Nicole R. Bush, Kaja Z. LeWinn, Daniel A. Enquobahrie, Bhagwat Prasad, Catherine J. Karr, Sheela Sathyanarayana
Summary: This study examined the relationship between prenatal phthalate exposure and the placental transcriptome at birth, identifying numerous genes and lncRNAs associated with prenatal phthalate exposure. The findings provide insight into the biological pathways affected by phthalate exposure, contributing to a better understanding of the mechanisms of action during fetal development.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Biochemistry & Molecular Biology
Natalia Yeste, Nestor Gomez, Marta Vazquez-Gomez, Consolacion Garcia-Contreras, Marti Pumarola, Antonio Gonzalez-Bulnes, Anna Bassols
Summary: The study showed that under IUGR conditions, LBW fetuses had reduced numbers of mature neurons in the hippocampus and Dentate Gyrus regions, along with an increase in immature neurons and alterations in neuronal morphology. Additionally, LBW fetuses exhibited changes in neurotransmitter profiles, with an increase in the serotonin pathway. Supplementation with HTX was able to reverse these morphological and neurochemical changes in LBW fetuses.
Article
Biochemistry & Molecular Biology
Mohammed H. Sarikahya, Samantha L. Cousineau, Marta De Felice, Hanna J. Szkudlarek, Karen K. W. Wong, Marieka V. DeVuono, Kendrick Lee, Mar Rodriguez-Ruiz, Dana Gummerson, Emma Proud, Tsun Hay Jason Ng, Roger Hudson, Tony Jung, Daniel B. Hardy, Ken K. -C. Yeung, Susanne Schmid, Walter Rushlow, Steven R. Laviolette
Summary: With increasing maternal cannabis use, it is important to investigate the long-term effects of prenatal exposure to THC on cognitive/memory function. This study using a rodent model found that male and female offspring displayed long-term deficits in cognitive domains, but the underlying mechanisms differed between sexes. The ECS and specific PUFA signaling abnormalities in the PFC and hippocampus may contribute to these outcomes.
MOLECULAR PSYCHIATRY
(2023)
Article
Environmental Sciences
Alison G. Paquette, James MacDonald, Samantha Lapehn, Theo Bammler, Laken Kruger, Drew B. Day, Nathan D. Price, Christine Loftus, Kurunthachalam Kannan, Carmen Marsit, W. Alex Mason, Nicole R. Bush, Kaja Z. LeWinn, Daniel A. Enquobahrie, Bhagwat Prasad, Catherine J. Karr, Sheela Sathyanarayana
Summary: This study examined the associations between prenatal phthalate exposure in the second and third trimesters and the placental transcriptome at birth, identifying numerous genes and lncRNAs associated with phthalate exposure. These associations may provide insight into biological pathways affected by phthalate exposure during fetal development, as supported by other epidemiological and in vitro analyses.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Cell Biology
Carter Norton, Derek Clarke, Joshua Holmstrom, Isaac Stirland, Paul R. Reynolds, Tim G. Jenkins, Juan A. Arroyo
Summary: The objective of this study was to analyze methylation patterns in placental DNA from normal pregnancies, preeclampsia (PE) and intrauterine growth restriction (IUGR) affected pregnancies. DNA was extracted, bisulfite converted and hybridized for methylation array. Differentially methylated regions were identified using the USEQ program, and gene promoters were identified using UCSC's Genome browser and Stanford's GREAT analysis. Western blot confirmed differential protein expression of commonly regulated genes. The study found some common methylation alterations between PE and IUGR, which may explain the clinical similarities observed with these obstetric complications.
Article
Environmental Sciences
Kuan-Chih Chiu, Fran Sisca, Jen-Hao Ying, Wan-Ju Tsai, Wu-Shiun Hsieh, Pau-Chung Chen, Chen-Yu Liu
Summary: The study revealed that prenatal chlorpyrifos exposure was associated with an increase in PPAR gamma DNA methylation levels and poorer performance in cognitive and language domains at 2 years old, especially in boys. Additionally, PPAR gamma H3K4me3 levels were positively associated with gestational age, birth weight, birth length, and gross-motor performance.
ENVIRONMENTAL POLLUTION
(2021)
Article
Neurosciences
Ingrid Dudink, Petra S. Huppi, Stephane V. Sizonenko, Margie Castillo-Melendez, Amy E. Sutherland, Beth J. Allison, Suzanne L. Miller
Summary: Fetal growth restriction (FGR) is mainly caused by suboptimal placental function, leading to limited nutrient and oxygen supply to the developing fetus, particularly affecting brain development. FGR results in altered brain morphology, disrupted connectivity, and region-specific brain network disturbances, which are associated with cognitive and behavioral impairments.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Claire Stenhouse, Yennifer Cortes-Araya, F. Xavier Donadeu, Cheryl J. Ashworth
Summary: This study aimed to investigate the temporal changes in testicular gene expression during testes development in fetuses of different size. The results showed that testes weight and testes weight as a percentage of fetal weight were not associated with fetal size at gestational days 60 and 90. Fetal size was not associated with seminiferous tubule area and number, as well as the number of germ or Sertoli cells per tubule. The expression of DMRT1 and SPP1 mRNA was lower in testes associated with the lightest fetuses compared to the closest to mean litter weight fetuses at gestational day 90. These findings provide insights into the expression profiles of genes associated with testicular development and function.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Georgios Moros, Theodora Boutsikou, Charalambos Fotakis, Zoe Iliodromiti, Rozeta Sokou, Theodora Katsila, Theodoros Xanthos, Nicoletta Iacovidou, Panagiotis Zoumpoulakis
Summary: The study found a clear association between altered metabolomic profiles in maternal and cord blood in IUGR pregnancies. Elevated levels of amino acids alanine, leucine, valine, isoleucine, and phenylalanine in IUGR pregnancies suggest a connection with impaired amino acid metabolism and transplacental flux. The increased levels of branched chain amino acids in intrauterine growth restricted pregnancies were linked with increased insulin resistance. Lower glycerol levels were attributed to imbalance between gluconeogenesis and glycolysis pathways, indicating poor glycolysis.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Tai-Ho Hung, Yu-Cheng Liu, Chun-Hu Wu, Chien-Cheng Chen, Hsien Chao, Feng-Yi Yang, Szu-Fu Chen
Summary: This study suggests that antenatal LIPUS treatment may reduce brain injury in IUGR by enhancing BDNF/CaMKII/Akt signaling, leading to increased neuronal number and myelin protein expression, and attenuated neurodevelopmental deficits. These effects are associated with upregulation of BDNF and PlGF protein expression in the brain and enhanced production of glucose transporter 1 and BDNF in the placenta.
Article
Biochemistry & Molecular Biology
Jing Li, Xiaojie Quan, Saifei Lei, Zhenyao Huang, Qi Wang, Pengfei Xu
Summary: The study revealed that PFOS induced placental cell toxicity and functional damage through the PPAR gamma pathway, confirming this through experiments.
Article
Acoustics
Wesley Lee, Lauren M. Mack, Roxanna Miremadi, Betul Yilmaz Furtun, Haleh Sangi-Haghpeykar, Greggory R. DeVore
Summary: The objective of this study was to investigate cardiac size, shape, and ventricular contractility in fetuses with estimated fetal weight (EFW) <10th centile at sea level. The results showed that fetuses with EFW <10th centile at sea level often had enlarged and globular-shaped hearts, with increased ventricular contractility. In comparison, fetuses at higher altitude had similar heart shape but a higher proportion with decreased ventricular contractility.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Ai Wei, Qi Gao, Fang Chen, Xiaobo Zhu, Xingren Chen, Lijun Zhang, Xin Su, Jinghong Dai, Yi Shi, Wangsen Cao
Summary: This study investigates the role of DNA methylation aberration-associated suppression of PPAR gamma in pulmonary fibrosis. The researchers found that aberrant DNA methylation and subsequent suppression of PPAR gamma significantly contribute to the development of pulmonary fibrosis. Restoring PPAR gamma expression through the use of demethylating agents or natural compounds can alleviate the pathological changes associated with fibrosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Miguel Hernandez-Quiles, Rosalie Baak, Alba Orea-Soufi, Anouska Borgman, Suzanne den Haan, Paula Sobrevals Alcaraz, Aldo Jongejan, Robert van Es, Guillermo Velasco, Harmjan Vos, Eric Kalkhoven
Summary: This study reveals the regulatory role of TRIB3 in the expression of PPAR gamma, suggesting its involvement in breast cancer initiation and metastasis. The researchers found that TRIB3 interferes with the MLL complex, leading to reduced H3K4 trimethylation of the PPARG locus and decreased PPAR gamma mRNA expression. These findings provide insights into potential therapeutic targets for breast cancer treatment using PPAR gamma ligands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Igor Y. Iskusnykh, Nikolai Fattakhov, Randal K. Buddington, Victor V. Chizhikov
Summary: The study reveals that IUGR affects the developmental program of the cerebellum, leading to decreased size and altered cell behaviors in pigs. The abnormal proliferation, migration, and apoptosis of granule cells in the cerebellum may be attributed to disrupted expression of signaling genes in IUGR.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Obstetrics & Gynecology
Isabella Lambert, Sergey Tarima, Michael Uhing, Susan S. Cohen
AMERICAN JOURNAL OF PERINATOLOGY
(2019)
Article
Neurosciences
Kelly Staricha, Nicholas Meyers, Jodi Garvin, Qiuli Liu, Kevin Rarick, David Harder, Susan Cohen
Article
Obstetrics & Gynecology
Corinne Swearingen, Pippa Simpson, Erwin Cabacungan, Susan Cohen
JOURNAL OF PERINATOLOGY
(2020)
Article
Obstetrics & Gynecology
Susan Cohen, Ulrike Mietzsch, Carl Coghill, Narendra Dereddy, Katerina Ducis, Nathalie El Ters, Gregory G. Heuer, Elizabeth Sewell, John Flibotte
Summary: This study reveals that there are variations and inconsistencies in the clinical care practices for infants at risk of posthemorrhagic hydrocephalus in level IV neonatal intensive care units, despite the presence of standard guidelines.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Joanne Lagatta, Margaret Malnory, Elizabeth Fischer, Mary Davis, Patti Radke-Connell, Cheryl Weber, Susan Cohen
Summary: This study describes an electronic parent support tool for the neonatal intensive care unit (NICU) and evaluates the impact of staff availability on support requests. The study found that the use of the electronic tool increased parent support availability in the NICU and following discharge.
JOURNAL OF PERINATOLOGY
(2022)
Article
Physiology
Jodi Garvin, Marharyta Semenikhina, Qiuli Liu, Kevin Rarick, Elena Isaeva, Vladislav Levchenko, Alexander Staruschenko, Oleg Palygin, David Harder, Susan Cohen
Summary: Under high-glucose conditions, the expression of Cx43 in astrocytes is decreased while VEGF secretion is increased, leading to impaired barrier properties in cerebral microvessel endothelial cells.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Sarah C. Yale, Susan S. Cohen, Robert M. Kliegman, Brett J. Bordini
Summary: Diagnostic time-out is a feasible solution that helps healthcare providers to change their mindset, counter cognitive biases, and potentially reduce diagnostic errors in the pediatric inpatient setting.
Article
Clinical Neurology
Benjamin J. Best, Erwin T. Cabacungan, Susan S. Cohen, Irene Kim, Eileen C. Sherburne, Kathleen J. Sawin, Audrey Roach, Andrew B. Foy
Summary: This study used a national administrative database to investigate the prevalence and early care of children with myelomeningocele. The results showed that the prevalence of myelomeningocele was 3.94 per 10,000 live births, and there was an increasing number of children without neonatal repair of the defect, indicating a higher utilization of fetal surgery. Children without neonatal repair had a higher risk of death, prematurity, and low birth weight, but were more likely to have commercial insurance and reside in high-income zip codes.
CHILDS NERVOUS SYSTEM
(2023)
Article
Cardiac & Cardiovascular Systems
David E. Segar, Jian Zhang, Ke Yan, Aidan Reid, Michele Frommelt, Susan Cohen
Summary: This study investigated the correlation between placental pathology and impaired neurodevelopmental outcomes in patients with complex congenital heart disease (CCHD). The results showed that placental abnormalities were associated with lower scores in cognitive and motor performance, but not in language scores. These findings highlight the significance of placental factors in neurodevelopmental impairments in infants with CCHD.
PEDIATRIC CARDIOLOGY
(2023)
Article
Obstetrics & Gynecology
Katherine Carlton, Samuel Adams, Elizabeth Fischer, Andrew Foy, Amy Heffelfinger, Jenna Jozwik, Irene Kim, Jennifer Koop, Lauren Miller, Stacy Stibb, Susan Cohen
Summary: The objective is to evaluate long-term neurodevelopmental outcomes in the same patient population as inpatient-focused neonatal neurocritical care (NNCC) programs. A dedicated and collaborative team is necessary to provide personalized medicine and developmental assessments for NNCC graduates. Two clinic models, HOPE and DREAM, have been devised at Children's Wisconsin to achieve this goal.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Clinical Neurology
Erwin Cabacungan, Samuel Adams, Benjamin Best, Andrew B. Foy, Avantika Singh, Susan S. Cohen
Summary: This study used a large national inpatient care data set to investigate the comorbidities and complications associated with posthemorrhagic hydrocephalus (PHH) management in premature infants. The timing of interventions was found to have an impact on the associated morbidities and complications, highlighting the need for national consensus guidelines. The development of these guidelines should be informed by data on treatment timing and patient outcomes available in large national data sets.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Obstetrics & Gynecology
Hannah Kieffer, Katherine Carlton, Samuel Adams, Jenna Jozwik, Erwin Cabacungan, Susan S. Cohen
Summary: This study aims to investigate the sustainability of Quality Improvement (QI) methods to decrease therapeutic hypothermia (TH) misuse. The results showed a sustained decrease in TH misuse, despite inconsistent use of electronic medical record-smart phrase. It is speculated that culture change involving increased awareness of guidelines through education may have contributed more to a lasting change.
JOURNAL OF PERINATAL MEDICINE
(2023)
Editorial Material
Pediatrics
Elizabeth Sewell, Susan S. Cohen
Article
Obstetrics & Gynecology
Katherine Carlton, Erwin Cabacungan, Samuel J. Adams, Susan S. Cohen
Summary: The study revealed that a significant number of infants who received therapeutic hypothermia did not actually meet the intervention criteria, mostly due to incomplete medical documentation. Through quality improvement methods, data sharing, and engagement of key stakeholders, adherence to therapeutic hypothermia guidelines was improved.
JOURNAL OF PERINATAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Susan Cohen, Qiuli Liu, Matthew Wright, Jodi Garvin, Kevin Rarick, David Harder
