Article
Multidisciplinary Sciences
Dominika Radostova, Daniela Kuncicka, Branislav Krajcovic, Lukas Hejtmanek, Tomas Petrasek, Jan Svoboda, Ales Stuchlik, Hana Brozka
Summary: We designed a behavioral task called OTTER to study the incidental formation of associations between temporally discontinuous stimuli in rats. The rats were habituated to two similar contexts and then experienced a sequence of acoustic cue and aversive stimulus in one of the contexts. The recall test showed that 59% of the rats responded to the cue by escaping to a different context. The OTTER task provides a flexible tool to study memory acquired incidentally after a single experience, which may be essential for episodic memory formation.
Article
Environmental Sciences
Sergei Redondo-Lopez, Enrique Gonzalez-Ortegon, Freylan Mena, Cristiano V. M. Araujo
Summary: Behavioral changes in two shrimp species, P. vannamei and P. varians, exposed to copper were studied. The locomotion of the shrimps showed opposite trends, with P. varians reducing movements above 50 mu g/L and P. vannamei exhibiting hyperactivity. Both species significantly avoided the highest concentrations of copper in a non-forced exposure scenario, but the repellence of copper was stronger for P. vannamei.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Skyler Younger, Sydney Boutros, Francesca Cargnin, Shin Jeon, Jae W. Lee, Soo-Kyung Lee, Jacob Raber
Summary: FOXG1 syndrome is a rare and devastating neurodevelopmental disorder characterized by various symptoms. Mouse models with Foxg1 gene mutation displayed phenotypes similar to symptoms of human FS individuals, including anxiety, cognitive impairments, and fear memory deficits.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
J. Correa, R. Tintorelli, P. Budriesi, H. Viola
Summary: Spaced training has positive effects on memory persistence. The promotion of memory persistence involves the Behavioral Tagging mechanism and plasticity-related proteins. Retraining can reset the tagging and utilize proteins to maintain persistent memory traces.
Article
Engineering, Environmental
Xiangsheng Hong, Rui Chen, Le Zhang, Liang Yan, Jiajing Xin, Jiasu Li, Jinmiao Zha
Summary: This study investigated the long-term neurotoxic effects of residual antidepressant citalopram on zebrafish. The results showed that continuous exposure to citalopram led to decreased motor function, learning, and memory in both larval and adult zebrafish. However, the effects were reversible in larval zebrafish after transferring to a clean medium. The study provides insights into the neurotoxic mechanisms of citalopram and its potential environmental and health risks.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Biology
Gabor Hajdu, Eszter Gecse, Istvan Taisz, Istvan Mora, Csaba Soti
Summary: Exposure to food-derived odors benzaldehyde and diacetyl induces toxicity and food avoidance behavior in Caenorhabditis elegans. Preconditioning with benzaldehyde activates cytoprotective stress responses and increases survival while reducing food avoidance. Reinforcement of stressful experiences through spaced training forms stable stress-specific memories.
Article
Biochemistry & Molecular Biology
Bettina Reka Laszlo, Erika Kertes, Tamas Ollmann, Laszlo Peczely, Anita Kovacs, Zoltan Karadi, Laszlo Lenard, Kristof Laszlo
Summary: The neurotransmitter and neuromodulator neurotensin (NT) has been found to facilitate spatial learning and memory through the activation of DA D2 receptors in the central nucleus of amygdala (CeA).
Article
Environmental Sciences
Hristina Ivanova Zlatanova, Maria Todorova Georgieva-Kotetarova, Natalia Borisova Vilmosh, Ilin Kostadinov Kandilarov
Summary: This study evaluated the therapeutic effects of cariprazine on memory impairment and found that it can improve learning, recognition, and spatial memory in rats. The drug's beneficial effects on cognition are likely mediated by its affinity for D3 receptors and agonism at 5-HT1A receptors, resulting in integrated modulation in the amygdala, hippocampus, and prefrontal cortex.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Neurosciences
Audrey Bonnan, Ke Zhang, Michael A. Gaffield, Jason M. Christie
Summary: The study reveals that changes in the activity of molecular layer interneurons (MLIs) play a crucial role in the expression of motor memory induced by error-driven learning.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Pamela Lopes da Cunha, Ramiro Tintorelli, Julieta Correa, Pablo Budriesi, Haydee Viola
Summary: The behavioral tagging hypothesis suggests that weak learning experiences can benefit from events that provide plasticity-related proteins to establish long-term memories. Acute stressful experiences may have different impacts on the formation of aversive memories, possibly due to competition for necessary proteins.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Food Science & Technology
Julianne Elba Cunha Azevedo, Alex Luiz Menezes da Silva, Luana Rodrigues Vieira, Chirlene Pinheiro Nascimento, Rafaela Garcia Pereira, Sofia de Franca Rodrigues, Akira Otake Hamoy, Vanessa Joia de Mello, Daniella Bastos de Araujo, Luis Andre Luz Barbas, Maria Elena Crespo Lopez, Dielly Catrina Favacho Lopes, Moises Hamoy
Summary: This study analyzed the effects of a toxic dose of caffeine on behavior and electrocorticographic (ECoG) patterns in rats. Caffeine caused seizures and the ECoG changes were consistent with the observed behavior. The ECoG patterns differed between caffeine and pentylenetetrazole-induced seizures, with beta-band oscillations being predominant. Caffeine-induced seizures were resistant to phenytoin and phenobarbital, but responsive to diazepam.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Neurosciences
Tanita Pairojana, Sarayut Phasuk, Pavithra Suresh, Shun-Ping Huang, Narawut Pakaprot, Supin Chompoopong, Tsung-Cheng Hsieh, Ingrid Y. Liu
Summary: The study found that performing TFC tests on male 3xTg-AD mice is optimal for studying memory performance in AD. Sensory and locomotor functions in 3xTg-AD mice of both genders appear normal before 6 months, but decline in fear memory afterwards. There are significant differences in contextual and cued memory between control and 3xTg-AD male mice, making them ideal for evaluating treatment effects.
Review
Ecology
Andrew Sih, Hee Jin Chung, Isabelle Neylan, Chelsea Ortiz-Jimenez, Osamu Sakai, Richard Szeligowski
Summary: Animals exhibit consistent-individual differences in fearfulness, and fear generalization plays an ecologically important role, yet it is understudied. While fear correlation has been studied for some dangers, there is a lack of research on correlated fears between humans, familiar predators, and exotic predators.
TRENDS IN ECOLOGY & EVOLUTION
(2023)
Review
Ecology
Caroline R. Amoroso
Summary: The conceptual parallels between physiological and behavioral forms of resistance to parasites have led to the development of terminology like the behavioral immune system. Research suggests that behavioral resistance may follow similar evolutionary dynamics to physiological resistance, but further studies are needed to understand the costs and mechanisms of behavioral resistance. Additionally, there is a need to explore how individual experiences may shape anti-parasite behaviors.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Article
Psychology
Nicholas Ichien, Katherine L. Alfred, Sophia Baia, David J. M. Kraemer, Keith J. Holyoak, Silvia A. Bunge, Hongjing Lu
Summary: This study examined the role of different types of similarity in both analogical reasoning and recognition memory. The findings suggest that explicit relations, known to play a central role in analogical reasoning, also have an important impact on episodic memory. The results support the possibility that explicit relation representations are necessary for modeling analogical reasoning and play a significant role in episodic memory.
COGNITIVE PSYCHOLOGY
(2023)
Article
Neurosciences
Karine Ramires Lima, Ana Carolina de Souza da Rosa, Steffanie Severo Picua, Shara Souza E. Silva, Nathaly Marks Soares, Pamela Billig Mello-Carpes
Summary: This study demonstrated that exposure to novelty and activation of D1Rs can promote memory persistence in rats, with this effect depending on the activation of the PKA pathway.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Food Science & Technology
Paola Zambelli Moraes, Jose Eudes Gomes Pinheiro Junior, Caroline Silveira Martinez, Camila Rodrigues Moro, Grazielly Caroline da Silva, Marina Diaz Rodriguez, Maylla Ronacher Simoes, Fernando Barbosa Junior, Franck Maciel Pecanha, Dalton Valentim Vassallo, Marta Miguel, Giulia Alessandra Wiggers
Summary: This study found that EWH can prevent cardiovascular damage caused by high levels of Cd exposure by reducing blood pressure, vascular dysfunction, inflammation, and oxidative stress through multiple mechanisms.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Edina da Luz Abreu, Camila Rodrigues Moro, Samia Hassan Husein Kanaan, Ricardo Bernardino de Paula, Camila Teixeira Herrera, Pedro Henrique Dorneles Costa, Franck Maciel Pecanha, Dalton Valentim Vassallo, Luciana Venturini Rossoni, Marta Miguel-Castro, Giulia Alessandra Wiggers
Summary: This study aimed to evaluate the potential antihypertensive effect of egg white hydrolysate (EWH) and its beneficial effects on blood vessels in rats with severe hypertension. The results showed that EWH significantly reduced blood pressure and improved vascular function. This effect may be attributed to the antioxidant and anti-inflammatory properties of EWH.
Article
Biochemistry & Molecular Biology
Caroline Silveira Martinez, Jose Antonio Uranga-Ocio, Franck Maciel Pecanha, Dalton Valentim Vassallo, Christopher Exley, Marta Miguel-Castro, Giulia Alessandra Wiggers
Summary: The study found that egg white hydrolysate (EWH) can protect rats from the effects of long-term exposure to high and low levels of aluminum in the diet on reproductive function. The supplementation of EWH can reduce inflammation and oxidative stress in the reproductive organs, and maintain normal sperm production and quality.
Editorial Material
Education, Scientific Disciplines
Natali Valim Oliver Bento-Torres, Joao Bento-Torres, Andrea Camaz Deslandes, Carlos Alexandre Netto, Luiz Fernando Freire Royes, Felipe Schuch, Ionara Rodrigues Siqueira, Pamela Billig Mello-Carpes
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Education, Scientific Disciplines
Guilherme Salgado Carrazoni, Amanda Dalla'corte Chaves, Claudio Felipe Kolling da Rocha, Pamela Billig Mello-Carpes
Summary: We developed a 3D synaptic puzzle (3Dsp) as an educational tool for teaching synaptic transmission in physiology. We conducted a study to assess the effectiveness of using 3Dsp. University students were divided into two groups: control group (only exposed to traditional teaching methods) and test group (exposed to 3Dsp in addition to traditional teaching). The results showed that both groups improved their knowledge of synaptic transmission, with the test group showing additional improvement.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Cardiac & Cardiovascular Systems
Filipe Martinuzo Filetti, Ingridy Reinholz Grafites Schereider, Giulia Alessandra Wiggers, Marta Miguel, Dalton Valentim Vassallo, Maylla Ronacher Simoes
Summary: This study aimed to evaluate the effects of copper exposure at different doses on the vascular reactivity and cardiac contraction of male Wistar rats. The results showed that copper exposure did not affect weight gain, vascular reactivity, or cardiac mass. However, higher doses of copper impaired cardiac contraction and had negative effects on various aspects of muscle contractions. Treatment with an antioxidant peptide from egg white hydrolysate was able to reverse these harmful effects.
CARDIOVASCULAR TOXICOLOGY
(2023)
Article
Food Science & Technology
Janaina Trindade Piagette, Jose Eudes Gomes Pinheiro Junior, Samia Hassan Husein Kanaan, Camila Teixeira Herrera, Leandro Ortiz Bastilhos, Franck Maciel Pecanha, Dalton Valentim Vassallo, Marta Miguel-Castro, Giulia Alessandra Wiggers
Summary: In this study, we investigated the protective effects of pretreatment with egg white hydrolysate (EWH) on the cardiovascular system, especially resistance vessels, against damage caused by high levels of Cd exposure. The results showed that EWH pretreatment reduced the increased vascular contractile response and protected mesenteric resistance arteries (MRA) from vascular damage induced by Cd exposure. EWH pretreatment also maintained normal blood pressure, reduced oxidative stress through the NOX1 pathway, prevented inflammatory cascades (COX-2, TNF alpha, NF-kappa B), and protected MRA from Caspase-3 activation induced by Cd.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Humanities, Multidisciplinary
Fernanda Staniscuaski, Arthur V. Machado, Rossana C. Soletti, Fernanda Reichert, Eugenia Zandona, Pamela B. Mello-Carpes, Camila Infanger, Zelia M. C. Ludwig, Leticia de Oliveira
Summary: Worldwide, discrimination against mothers based on stereotypes and misconceptions surrounding motherhood remains a major factor for women's reduced participation in the job market. In academia, mothers, especially women scientists, face negative bias that negatively affects their commitment and dedication. A survey conducted among Brazilian scientists revealed that mothers self-reported a higher prevalence of negative bias in the workplace compared to fathers, with the perception influenced by gender and career status, but not race, scientific field or number of children.
HUMANITIES & SOCIAL SCIENCES COMMUNICATIONS
(2023)
Article
Education & Educational Research
Guilherme Salgado Carrazoni, Amanda Dalla'Corte Chaves, Lucas Gazzani Araujo Silva, Claudio Felipe Kolling da Rocha, Pamela Billig Mello-Carpes
Summary: This study evaluated the impact of the educational game "Synaptic Board Game (SBG)" on students' knowledge. The results showed that students who used SBG had higher knowledge scores and better understanding of synaptic transmission after the intervention. Therefore, SBG is an effective teaching material to reinforce learning about synaptic transmission.
SIMULATION & GAMING
(2023)
Letter
Multidisciplinary Sciences
Fernanda Staniscuaski, Eugenia Zandona, Fernanda Reichert, Rossana C. Soletti, Pamela B. Mello-Carpes, Giulia A. Wiggers, Ida V. D. Schwartz, Fernanda P. Werneck, Zelia M. c Ludwig, Adriana Neumann, Camila Infanger Almeida, Leticia De Oliveira
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2023)
Article
Psychology, Biological
Karine Ramires Lima, Ben-Hur Souto das Neves, Guilherme Salgado Carrazoni, Ana Carolina de Souza da Rosa, Murilo Ricardo Sigal Carrico, Rafael Roehrs, Pamela Billig Mello-Carpes
Summary: This study investigated the impact of acute physical exercise on memory and the role of the ventral tegmental area (VTA) and locus coeruleus (LC). The results suggest that acute physical exercise can improve memory persistence, and this effect is dependent on LC activity.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Medicine, General & Internal
Caroline Silveira Martinez, Jose Antonio Uranga Ocio, Franck Maciel Pecanha, Dalton Valentim Vassallo, Marta Miguel, Giulia Alessandra Wiggers
Summary: This study investigated the effects of an egg-white hydrolysate (EWH) on the gastrointestinal tract and organs related to aluminum (Al) metabolism after both low and high levels of Al exposure. The results showed that high doses of Al caused liver and kidney damage and negatively affected colon morphology. However, EWH prevented oxidative stress and colon damage, as well as reducing the presence of Al in the tissue.
Article
Biochemistry & Molecular Biology
Danize Aparecida Rizzetti, Patricia Corrales, Jose Antonio Uranga-Ocio, Gema Medina-Gomez, Franck Maciel Pecanha, Dalton Valentim Vassallo, Marta Miguel, Giulia Alessandra Wiggers
Summary: The study found that egg white hydrolysate (EWH) can prevent and treat lipid and glycemic metabolism disruption induced by mercury exposure. EWH intake improves antioxidant defenses, inhibits apoptotic pathways, and normalizes the gene expression levels of PPARs and adiponectin.
