Article
Clinical Neurology
Manuel Alcaraz-Ibanez, Adrian Paterna, Mark D. Griffiths
Summary: This study examines the relationship between social comparisons and depressive symptomatology among adolescents. It finds that low self-esteem, being female, being at risk for eating disorders, social-physique anxiety, and social comparisons related to body and exercise are all uniquely associated with depressive symptomatology. The relationship between eating-related and exercise-related comparisons and depressive symptomatology is stronger in females at risk for eating disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Biochemistry & Molecular Biology
Yue Jin, Da Song, Yan Yan, Zhenzhen Quan, Hong Qing
Summary: Early-life stress can have long-term effects on physical and mental health by altering the oxytocin system. Oxytocin is a critical hormone that regulates social behaviors and alleviates diseases. Stress-related neuropsychiatric disorders, such as anxiety and depression, can be treated by targeting the oxytocin system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Nathalia de Azevedo Camin, Guillermo Andrey Ariza Traslavina, Procopio Cleber Gama de Barcellos Filho, Celso Rodrigues Franci
Summary: The study revealed that acute or chronic stress during adolescence can have negative effects on stress responses and behavior in adult rats. The use of MR or GR antagonists after stress in early adolescence can prevent these changes and improve behavioral outcomes.
Article
Behavioral Sciences
Fatemeh Sadat Zolfaghari, Fardad Pirri, Evan Gauvin, Maghsoud Peeri, Shayan Amiri
Summary: This study shows that exercise and FLX treatment during adolescence can alleviate depressive and anxiety-like symptoms induced by maternal separation stress in adult male rats, while treadmill exercise has anxiolytic effects but fails to produce antidepressant-like effects.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Neurosciences
Sora Shin, In-Jee You, Minju Jeong, Yeeun Bae, Xiao-Yun Wang, Mikel Leann Cawley, Abraham Han, Byung Kook Lim
Summary: Early-life trauma (ELT) is shown to cause binge eating and obesity later in life, and a study in mice has identified the neural circuits involved in this association. Downregulation of the leptin receptor in the lateral hypothalamus and increased activity of Lepr-expressing neurons are found to be crucial in ELT-induced binge-like eating and obesity. Inhibition of these neurons and activation of certain neurons in the ventrolateral periaqueductal gray can normalize the maladaptive eating habits caused by ELT. This study provides insights into the underlying mechanisms of ELT-induced eating disorders and may lead to the development of new therapeutic targets.
NATURE NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Viviane C. Ceschim, Paula Sumaran, Andrea A. Borges, Carlos Eduardo N. Girardi, Deborah Suchecki
Summary: Social behaviour impairment is a characteristic of emotional disorders, resulting in increased avoidance of social contact. The study investigated the long-term effects of maternal deprivation (DEP) at postnatal days 3 (DEP3) or 11 (DEP11) on anxiety-like behaviour in rats, focusing on neurobiological outcomes. The results suggest that DEP during certain developmental phases does not alter social investigation, but leads to distinct neurobiological changes.
HORMONES AND BEHAVIOR
(2021)
Article
Behavioral Sciences
Juliano Viana Borges, Vivian Naziaseno Pires, Betania Souza de Freitas, Gabriel Ruebensam, Vitoria Correa Vieira, Cristophod de Souza dos Santos, Nadja Schroder, Elke Bromberg
Summary: Social deprivation can cause stress in group-living mammals, but they have an amazing response of seeking social contact as a form of protection. This study explored the effects of social isolation and support on behavioral and epigenetic responses to chronic stress in middle-aged adult rats. The results showed that isolation led to decreased corticosterone levels, impaired long-term memory, and decreased BDNF gene expression, along with altered epigenetic markers. The chronic unpredictable stress protocol had different effects, mainly on epigenetic alterations, but social support prevented the adverse effects on HPA axis functioning and gene expressions.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Ian H. Gotlib, Lauren R. Borchers, Rajpreet Chahal, Anthony J. Gifuni, Giana I. Teresi, Tiffany C. Ho
Summary: This study found that severity of early life stress predicted levels of depressive symptoms during the pandemic, which were higher in females than males. Importantly, the association between early life stress and depression was mediated by adolescents' reported levels of stress, even after controlling for demographic variables. These findings highlight the importance of monitoring the mental health of vulnerable children and adolescents during the pandemic and targeting perceived stress in high-risk youth.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Clinical
Jose Francisco Lopez-Gil, Sitong Chen, Estela Jimenez-Lopez, Jose Abellan-Huerta, Eva Herrera-Gutierrez, Josefa Maria Panisello Royo, Arthur Eumann Mesas, Pedro J. Tarraga-Lopez
Summary: The objective of this study was to examine the relationship between social network use and addiction and disordered eating among Spanish adolescents. The study found that adolescents with high social network use and addictive behaviors were more likely to have disordered eating. This highlights the importance of considering social network use and addiction as factors related to disordered eating among adolescents.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2023)
Article
Behavioral Sciences
Hector Miguel Mancha-Gutierrez, Erika Estrada-Camarena, Lilian Mayagoitia-Novales, Elena Lopez-Pacheco, Carolina Lopez-Rubalcava
Summary: Chronic social defeat during early adolescence leads to depression-like behaviors, cognitive deficits, and neuroendocrine abnormalities, with long-term effects causing persistent psychological and physiological impacts.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Psychology, Clinical
Bridget Kenny, Steven J. Bowe, C. Barr Taylor, Marj Moodie, Vicki Brown, Elizabeth Hoban, Joanne Williams
Summary: This study aimed to explore the bi-directional relationships between depressive symptoms, eating disorder (ED) symptoms, and health-related quality of life (HRQOL) in young adolescents. The results showed that HRQOL predicted depressive symptoms, while depressive symptoms predicted ED symptoms. Components of HRQOL, such as social relationships and ability to cope, were found to have a differential relationship with depressive symptoms. ED symptoms predicted reduced HRQOL and negative social relationships.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Pediatrics
Yoshiki Katsumi, Kazuki Kodo, Sachiko Goto
Summary: The COVID-19 pandemic has increased stress levels for children and their parents, resulting in a higher diagnosis of various disorders. The case presented in this article is about a nine-year-old girl whose condition rapidly worsened due to stress and isolation during the pandemic. The patient's parents noticed her significant weight loss, and she was diagnosed with an eating disorder. After a family meeting, where the girl expressed feeling anxious during the pandemic, her parents adjusted their schedules to have dinner together every night. This change resulted in the patient's improved eating habits and weight gain at the one-year follow-up.
FRONTIERS IN PEDIATRICS
(2022)
Article
Clinical Neurology
Milica Potrebic, Zeljko Pavkovic, Natasa Loncarevic-Vasiljkovic, Selma Kanazir, Vesna Pesic
Summary: This study used a peripubertal rat model to investigate the effects of early social isolation, revealing a range of behavioral and physiological changes in peripubertal rats, including anxiety, risk-taking behavior, reduced response to rewards, etc. These features deepen over time as a stable marker of the outcomes of reduced direct social contact during adolescence.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Paige I. Webb, Timothy J. Hill, Nicholas A. Everett, Jade L. Thornton, Jennifer L. Cornish, Sarah J. Baracz
Summary: Adolescent social isolation stress alters various methamphetamine addiction-like behaviors in female rats.
PSYCHOPHARMACOLOGY
(2022)
Article
Pediatrics
Salvatore Ferdinando Aruta, Jacopo Pruccoli, Nicole Bandini, Paola Rucci, Antonia Parmeggiani
Summary: The prevalence of Specific Learning Disorder (SLD) is higher among patients with Anorexia Nervosa (AN) compared to the Italian reference values. Comorbidity with SLD is more frequent in male patients. A diagnosis of SLD is not significantly associated with any specific ED diagnosis or psychiatric comorbidity in general.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
