Article
Food Science & Technology
A. Cimbalo, M. Frangiamone, C. Juan, G. Font, M. Lozano, L. Manyes
Summary: This study evaluated the hepatic toxicity of ENs exposure at different concentrations in Wistar rats using a proteomic approach. The results showed that ENs acute exposure caused protein expression changes related to major cellular processes in rats, hinting its involvement in liver disturbance. Bioinformatic analysis revealed metabolism as the most significant and enriched pathway in terms of overrepresentation in Reactome.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Neurosciences
Aruvi Vijikumar, Pushkar Saralkar, Scott D. Saylor, Patrick G. Sullivan, Jason D. Huber, Werner J. Geldenhuys
Summary: NL-1 is a potential drug target for treating ischemic stroke, as it reduces neuronal cell loss and brain injury, leading to improved survival rates. Encapsulating NL-1 in nanoparticles enhances its protective effects. Targeting the mitoNEET pathway may be a promising avenue for further research.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lina Cao, Jingjing Zhang, Yan Du, Min Sun, Yue Xiang, Yulu Sheng, Xiangmei Ren, Jihong Shao
Summary: Sodium selenite (Na2SeO3) exhibits anti-tumor activity in MCF7 cells by inducing apoptosis and activating the endoplasmic reticulum stress pathway. Oxidative stress and endoplasmic reticulum stress interact to regulate the survival of cancer cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Beatriz Ferrer, Harshini Suresh, Abel Santamaria, Joao Batista Rocha, Aaron B. Bowman, Michael Aschner
Summary: This study found that exposure to MeHg can induce STAT3 activation in mouse hypothalamic neuronal cells, exacerbating oxidative stress and antioxidant responses. It suggests that the STAT3 signaling pathway plays an important role in responding to MeHg-induced oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Latika Nagpal, Michael D. Kornberg, Lauren K. Albacarys, Solomon H. Snyder
Summary: The study reveals the significant role of inositol hexakisphosphate kinase 2 (IP6K2) in brain function, demonstrating its interaction with creatine kinase-B (CK-B) to regulate cellular energy homeostasis and neuroprotection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Shaoqi Guan, Xijian Liu, Chunlin Li, Xingyan Wang, Dongmiao Cao, Jinxia Wang, Lizhou Lin, Jie Lu, Guoying Deng, Junqing Hu
Summary: An intelligent biodegradable nanocomposite, mZMD, has been developed to enhance sonodynamic therapy (SDT), chemodynamic therapy (CDT), and chemotherapy by promoting oxidative stress and overcoming multidrug resistance.
Review
Biochemistry & Molecular Biology
Gurjit Kaur Bhatti, Anshika Gupta, Paras Pahwa, Naina Khullar, Satwinder Singh, Umashanker Navik, Shashank Kumar, Sarabjit Singh Mastana, Arubala P. Reddy, P. Hemachandra Reddy, Jasvinder Singh Bhatti
Summary: Mitochondria, the powerhouses of cells, play a vital role in maintaining normal cell functioning and human health. Dysfunctional mitochondria can lead to various diseases, affecting organs with high energy demand. Drugs or compounds targeting mitochondria are considered effective and safe for treating these diseases.
BIOMEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Weina Kong, Qianqian Tian, Qiaoli Yang, Yu Liu, Gongting Wang, Yanjun Cao, Liping Wang, Sizhe Xia, Yanmei Sun, Cheng Zhao, Shiwei Wang
Summary: Sodium selenite can increase the lethality rate of Pseudomonas aeruginosa PAO1 with antibiotics and reduce its antibiotic resistance, while also inhibiting the expression of virulence factors.
Article
Environmental Sciences
Aline Finger-Teixeira, Emy Luiza Ishii-Iwamoto, Rogerio Marchiosi, Erica Marusa Pergo Coelho, Rodrigo Polimeni Constantin, Wanderley Dantas dos Santos, Anderson Ricardo Soares, Osvaldo Ferrarese-Filho
Summary: Cadmium inhibits soybean root growth by uncoupling oxidative phosphorylation, leading to oxidative cellular stress and an antioxidant response.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Ami Kobayashi, Toshihiko Takeiwa, Kazuhiro Ikeda, Satoshi Inoue
Summary: The mitochondrial electron transport chain (ETC) is crucial for energy production and drives various biochemical processes in eukaryotic cells through oxidative phosphorylation (OXPHOS). Recent studies have shown that noncoding RNAs (ncRNAs), including microRNAs (miRNAs), transfer-RNA-derived fragments (tRFs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), play important roles in regulating ETC and OXPHOS systems. This review highlights the emerging roles of ncRNAs in the regulation of mitochondrial ETC and OXPHOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
James P. Bennett, Isaac G. Onyango
Summary: The adult human brain consumes a disproportionate amount of energy substrates, with ATP being the universal energy currency. Neurodegenerative diseases may result from factors such as stress damage, genetic mutations, epigenetic modifications, and mitochondrial dysfunction. Mitochondrial therapeutics aims to correct deficiencies in energy production processes.
Article
Biochemistry & Molecular Biology
Murat Boyacioglu, Ozay Gules, Hande Sultan Sahiner
Summary: The study found that Sodium selenite (SS) may have a protective effect against 4-nonylphenol (4-NP)-induced hepato-nephrotoxicity in rats by significantly reducing DNA damage, improving antioxidant/oxidant status in liver and kidney tissues, and alleviating histological changes.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Engineering, Environmental
Wen-Yu Qi, Qiang Li, Hui Chen, Jun Liu, Su-Fang Xing, Meng Xu, Zhen Yan, Chao Song, Shu-Guang Wang
Summary: Both selenium nanoparticles (SeNPs) and selenite (SeO32-) have a positive impact on the growth of Brassica napus L. under Cd stress conditions, by reducing oxidative damage and improving resistance mechanisms such as gene regulation and intracellular calcium homeostasis. SeNPs show a wider beneficial concentration range compared to SeO32-.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Medicine, General & Internal
Ramana Vaka, Evangeline Deer, Mark Cunningham, Kristen M. McMaster, Kedra Wallace, Denise C. Cornelius, Lorena M. Amaral, Babbette LaMarca
Summary: Preeclampsia is associated with oxidative stress, placental ischemia, and autoantibodies to angiotensin II type I receptor. This study found that mitochondrial dysfunction plays a role in the pathophysiology of preeclampsia, particularly in affecting placental function. Antioxidants may not be an effective treatment for the oxidative stress in preeclampsia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Toxicology
Nga T. Nguyen, Kuo Du, Jephte Y. Akakpo, David S. Umbaugh, Hartmut Jaeschke, Anup Ramachandran
Summary: APAP overdose is the most common cause of acute liver failure in the United States. The formation of APAP-protein adducts, mitochondrial oxidant stress, and activation of the MAP kinase cascade are critical features of APAP-induced cell death.
TOXICOLOGY LETTERS
(2021)
Review
Food Science & Technology
Flavia Barbosa Schappo, Camila Duarte Ferreira Ribeiro, Marcelo Farina, Itaciara Larroza Nunes
Summary: This research provides an overview of the toxicity of oil nanocapsules (ONP) for food applications. It suggests that while ONP may have potential beneficial effects such as antioxidant and anti-cancer properties, there is limited knowledge about its safety. Further studies are needed to ensure the safe use of this innovative technology.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Sport Sciences
Fernanda Christina de Souza Guidarini, Isabela Carlos Back Giuliano, Alexandra Susana Latini, Adriano Ferreti Borgatto, Aloisio Luiz Benedetti, Marina Christofoletti, Karina Ghisoni de Oliveira, Leticia Muraro Wildner, Tania Rosane Bertoldo Benedetti
Summary: This study aims to analyze the association between physical activity performed at balls and neopterin levels in older women's urine. The results indicate a negative correlation between dance activity and neopterin levels.
SPORT SCIENCES FOR HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Opeyemi Babatunde Ogunsuyi, Folorunsho Bright Omage, Olawande Chinedu Olagoke, Ganiyu Oboh, Joao Batista Teixeria Rocha
Summary: This study tested the inhibitory effects of African eggplant and black nightshade leaf extracts on human erythrocyte AChE and investigated their potential molecular mechanisms using molecular docking and MD simulation. The findings suggest that certain compounds with dual-binding properties may serve as potential inhibitors of human AChE.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Mauricio Tavares Jacques, Luciano Saso, Marcelo Farina
Summary: Neuron-glia interactions are crucial for maintaining the central nervous system's stability. Microglial cells, as important support cells in the brain, play a role in responding to disruptions in this stability. In this study, the researchers investigated the potential protective effects of activated microglia on neuronal cells against ferroptosis, an iron-dependent form of cell death. The findings suggest that activated microglial cell-derived molecules may contribute to the protection of neuronal cells against ferroptosis, highlighting the potential for controlling this cell death mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pedro Pauletto, Marco Bortoli, Folorunsho Omage Bright, Cassia Pereira Delgado, Pablo Andrei Nogara, Laura Orian, Joao Batista Teixeira da Rocha
Summary: Acid Sphingomyelinase (ASM), involved in plasma membrane cell repair, is activated during SARS-CoV-2 infection. In silico analysis suggests that drugs like fluoxetine might inhibit ASM by breaking its interactions and disrupting its structure.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Pedro Jose Tronco Pauletto, Cassia Pereira Delgado, Joao Batista Teixeira da Rocha
Summary: In the past two years, various drugs have been identified as potential inhibitors of SARS-CoV-2 in laboratory studies. Among them, drugs known as functional inhibitors of acid sphingomyelinase (FIASMAs) have been shown to effectively inhibit the replication of SARS-CoV-2 in different types of cells. These drugs have similar chemical structures, with examples including fluoxetine, escitalopram, and fluvoxamine. They are already used as therapeutic agents for other diseases and can be considered as candidates for drug repositioning. This review summarizes two proposed mechanisms by which FIASMAs inhibit the replication of SARS-CoV-2 by targeting acid sphingomyelinase (ASM).
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Environmental Sciences
Mauricio Tavares Jacques, Marcell Valandro Soares, Marcelo Farina, Julia Bornhorst, Tanja Schwerdtle, Daiana Silva Avila
Summary: The excessive and indiscriminate use of agrochemicals has raised great concerns due to its toxic consequences on the environment and human health. This study compared the toxicity of pure chlorpyrifos (CPF) with that of a commercial formulation containing supposedly inert ingredients (CBCF) using Caenorhabditis elegans as a model organism. The results showed that after a 48-hour exposure, CBCF was 14 times more lethal than CPF, with significantly greater negative effects on hatching, brood size, body length, and motor-related behavioral parameters in worms exposed to CBCF. Additionally, CBCF induced morphological changes in cholinergic neurons associated with motor-related behavioral parameters, and the analysis of CBCF also revealed the presence of potentially toxic metals not specified on the label.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Folorunsho Bright Omage, Andrea Madabeni, Amanda Resende Tucci, Pablo Andrei Nogara, Marco Bortoli, Alice dos Santos Rosa, Vivian Neuza dos Santos Ferreira, Joao Batista Teixeira Rocha, Milene Dias Miranda, Laura Orian
Summary: This study investigates the mechanism of SARS-CoV-2 inhibition by (PhSe)2 and reveals its potential as a therapeutic agent. The results show that (PhSe)2 effectively inhibits viral replication in a cell culture model and provides insights into the non-covalent and covalent inhibition modes of the viral proteases.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Biochemistry & Molecular Biology
Tuany Eichwald, Alexandre Francisco Solano, Jennyffer Souza, Tais Browne de Miranda, Liebert Bernardes Carvalho, Paula Lemes dos Santos Sanna, Rodrigo A. Foganholi da Silva, Alexandra Latini
Summary: Caffeine administration reduces expression of pro-inflammatory biomarkers and promotes an anti-inflammatory response. It also upregulates adenosinergic receptors and affects DNA methylation patterns. Caffeine treatment attenuates the catabolic state induced by lipopolysaccharide. These effects suggest that caffeine's anti-inflammatory effects in muscle may be mediated through epigenetic modifications.
Article
Biochemistry & Molecular Biology
Mauricio Tavares Jacques, Viviane de Souza, Flavio Augusto Rocha Barbosa, Romulo Faria Santos Canto, Samantha Cristiane Lopes, Rui Daniel Prediger, Antonio Luiz Braga, Michael Aschner, Marcelo Farina
Summary: Oxidative glutamate toxicity is a harmful mechanism in ischemic stroke. Two new probucol analogues (C1 and C2) were designed and synthesized, and their effects against glutamate-induced neuronal oxidative toxicity were investigated. C2 showed the lowest toxicity and provided significant protection against glutamate-induced cytotoxicity both in vitro and in vivo. This study presents a promising neuroprotective drug for ischemic stroke.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Environmental Sciences
Isaac A. Adedara, Oluwadarasimi E. Atanda, Camila Sant'Anna Monteiro, Denis B. Rosemberg, Michael Aschner, Ebenezer O. Farombi, Joao B. T. Rocha, Ana Flavia Furian, Tatiana Emanuelli
Summary: This review discusses the neurotoxicity of Aflatoxin B1 (AFB1) and its impact on the nervous system. Mechanisms of AFB1-induced neuronal dysregulation and neurotoxic effects are uncovered through studies using brain homogenates, neuroblastoma cell line IMR-32, human brain microvascular endothelial cells, microglial cells, and astrocytes, as well as mammalian and non-mammalian models. Furthermore, naturally occurring bioactive compounds with therapeutic effects on AFB1-induced neurotoxicity are reviewed.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Blessing A. Obafemi, Isaac A. Adedara, Ana L. A. Segatto, Diogo O. Souza, Joao B. T. da Rocha, Olawande C. Olagoke
Summary: In this study, the mechanism of inflammatory response to organometallic cation methylmercury, common cooking seasoning (NaCl and MSG), and their crosstalk with redox signaling were investigated using the lobster cockroach as a model. The activation of Nox/Duox NADPH oxidases, along with JNK and Rel signaling pathways, was found to play crucial roles during methylmercury and MSG exposure.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Review
Behavioral Sciences
Juliete Palandi, Josiel Mileno Mack, Isabela Longo de Araujo, Marcelo Farina, Franciane Bobinski
Summary: This study provides a comprehensive framework of animal models used to investigate CRPS by reviewing 93 preclinical studies. The results show that the main objective of the included studies was to understand the CRPS model, with the most common characteristics being rats, males, and adults exposed to ischemia/reperfusion or tibia fracture. The most widely adopted method for nociceptive evaluation was the use of von Frey monofilaments. However, future studies should include more heterogeneous animals, multiple assessment tools, and improve measures to reduce bias for better translational science between animal models and individuals with CRPS.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Pablo A. A. Nogara, Meire E. Pereira, Claudia S. Oliveira, Laura Orian, Joao B. T. Rocha
Summary: Organoselenium compounds (OSeCs) have significant therapeutic applications, but their mechanisms are still unclear. By using models and analytical methods, it is possible to elucidate the metabolism, reactivity, and specificity of OSeCs in vivo, leading to further advancements in their pharmacological applications.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Environmental Sciences
Maria Vitoria Takemura Mariano, Luana Paganotto Leandro, Karen Kich Gomes, Ana Beatriz dos Santos, Vitor Oliveira de Rosso, Alcir Luiz Dafre, Marcelo Farina, Thais Posser, Jeferson Luis Franco
Summary: This study evaluated the toxicity of copper at environmentally relevant concentrations on zebrafish larvae and found adverse effects on morphology, biochemistry, and behavior. Therefore, the permissible copper concentrations in Brazil need to be reevaluated.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2024)