Review
Medicine, Research & Experimental
Shubham Sharma, Vineet Kumar Rai, Raj K. Narang, Tanmay S. Markandeywar
Summary: Wound healing requires extra effort, and collagen is a widely used biomaterial with excellent physical properties and natural sources. Collagen formulations play a significant role in wound healing and tissue engineering.
Review
Pharmacology & Pharmacy
Saiqing Tang, Zhen Ruan, Axue Ma, Dong Wang, Jiushe Kou
Summary: Vitamin K has a positive impact on wound healing, but its effects differ in animal models and cell experiments. Larger scale studies are needed to determine the mechanisms and safe dosage of vitamin K for wound healing.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Emergency Medicine
Jessica Salvo, Cristian Sandoval
Summary: This review aims to explore the importance of copper nanoparticles in wound healing. Copper nanoparticles combat infection through multiple mechanisms and play a significant role in various stages of wound healing by modulating cytokines and growth factors.
Review
Nutrition & Dietetics
Alexandra Bekiaridou, Eleni Karlafti, Ilias Marios Oikonomou, Aristidis Ioannidis, Theodossis S. Papavramidis
Summary: Skin tissue repair is essential for maintaining homeostasis, with wound healing being a complex process that can be affected by infections. The combination of probiotics and nanotechnology has shown promising results in promoting surgical wound healing.
Article
Biochemistry & Molecular Biology
Bharati Kadamb Patel, Kadamb Haribhai Patel, Ryan Yuki Huang, Chuen Neng Lee, Shabbir M. Moochhala
Summary: Diabetic foot ulcers are a growing concern worldwide and can pose complications in diagnosis and treatment. The interaction of bacteria on the skin surface plays a vital role in the pathophysiology of these ulcers. Commensal microbiota interacts with skin cells involved in wound healing and enhances barrier regeneration. The gut-skin axis shows the connection between the gut and skin health through immunological and metabolic properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Dong Wang, Zhen Ruan, Rongchao Zhang, Xuejing Wang, Ruihui Wang, Zhishu Tang
Summary: The meta-analysis demonstrated the effectiveness of earthworm extracts on wound healing, showing improvements in healing rate and reduction in healing time. By utilizing earthworm extracts appropriately, it could be a promising natural product for wound healing, potentially aiding in the development of wound healing drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Polymer Science
Xu Zhang, Bowen Tan, Yanting Wu, Min Zhang, Jinfeng Liao
Summary: Photothermal hydrogels show potential in antibacterial action, angiogenesis, and osteogenesis, and could be promising in wound healing and bone regeneration applications.
Article
Nutrition & Dietetics
Camille Togo, Ana Paula Zidorio, Vivian Goncalves, Patricia Botelho, Kenia de Carvalho, Eliane Dutra
Summary: This systematic review summarizes the current evidence on the effect of oral or enteral probiotic therapy on wound healing in humans. The results indicate that probiotic therapy may have a positive impact on wound improvement, but strong evidence is still lacking. Further controlled clinical research is needed to explore the effects of specific probiotic strains, wound types, and target populations.
Review
Chemistry, Medicinal
Paulo R. Gabbai-Armelin, Luciana S. Sales, Tulio Morandin Ferrisse, Analu Barros De Oliveira, Juliana R. De Oliveira, Elisa M. A. Giro, Fernanda L. Brighenti
Summary: Thymol has antibacterial, antioxidant, anti-inflammatory, and wound healing properties. In vitro and in vivo studies have shown its effectiveness as an anti-inflammatory agent. However, there are biases in the studies, and more research is needed to understand the dose-response relationship and mechanism of action of thymol as a healing agent.
PHYTOTHERAPY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Yuan Jia, Jia-Hao Shao, Kai-Wen Zhang, Ming-Li Zou, Ying-Ying Teng, Fan Tian, Meng-Nan Chen, Wei-Wei Chen, Zheng-Dong Yuan, Jun-Jie Wu, Feng-Lai Yuan
Summary: This review explores the role and mechanisms of Resveratrol in wound healing, focusing on its different forms of action. It provides directions and references for further research.
Review
Pharmacology & Pharmacy
Thambirajoo Maheswary, Asma Abdullah Nurul, Mh Busra Fauzi
Summary: The diversity of normal flora on human skin varies between individuals and parts of the skin. A symbiotic relationship has been formed over time between humans and normal flora. In chronic wounds, particularly in patients with diabetes, the conditions become favorable for microbes to colonize and establish infections within the skin. Antibiotics and wound dressings are the targeted therapy to treat chronic wounds, although prolonged usage may lead to ineffectiveness or resistance. Further studies are needed to comprehensively understand the role of human skin normal flora in chronic injuries at the cellular and molecular level.
Review
Biochemistry & Molecular Biology
Hui Ma, Wing-Sum Siu, Ping-Chung Leung
Summary: A wound disrupts the normal structure and function of the skin, which plays a crucial role in protection, temperature regulation, and water balance. Wound healing is a complex process involving various stages, and factors like infection and chronic diseases can hinder it. Mesenchymal stem cells (MSCs) have shown potential in treating wounds due to their secretome and exosomes, which contain various molecules. Studies suggest that MSCs-based cell-free therapy may be safer and more effective than MSCs in regenerative medicine. This review provides an overview of wound pathophysiology and the potential of MSCs-based cell-free therapy in different stages of wound healing, along with clinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nanoscience & Nanotechnology
Feng Wang, Wenyao Zhang, Hao Li, Xiaonan Chen, Sining Feng, Ziqing Mei
Summary: Developing dressings that can accelerate the healing of diabetic wounds is of great clinical significance. Nanoparticles have significant advantages in promoting wound healing due to their antibacterial properties, low cytotoxicity, good biocompatibility, and drug delivery ability. Adding nanoparticles to dressings and using them to deliver drugs and cytokines has been proven to be effective.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Ebrahim Astaneh, Narges Fereydouni
Summary: Diabetic wounds pose a significant clinical challenge due to impaired healing and increased risk of complications. Nanofiber-based wound dressings, particularly those containing hyaluronic acid, show promise in promoting wound healing by enhancing skin hydration, controlling inflammation, and facilitating revascularization. However, challenges and limitations, such as reproducibility and proper characterization, exist in the field of nanofiber technology. Future directions involve addressing these issues and optimizing nanofiber formulations for improved efficacy in diabetic wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Lubomir Petrov, Olya Stoilova, Georgi Pramatarov, Hristiyana Kanzova, Elina Tsvetanova, Madlena Andreeva, Almira Georgieva, Dimitrinka Atanasova, Stanislav Philipov, Albena Alexandrova
Summary: The study aimed to investigate the effect of the combined application of chitosan and diosgenin on a mouse skin wound model. The results showed that the combined application significantly reduced wound area and maintained high levels of total glutathione in wound tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rehabilitation
Helena Fernandez-Lago, Olalla Bello, Virginia Lopez-Alonso, Jose Andres Sanchez, Luis Morenilla, Miguel Angel Fernandez-del-Olmo
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2015)
Article
Geriatrics & Gerontology
Olalla Bello, Gonzalo Marquez, Miguel Fernandez-Del-Olmo
REJUVENATION RESEARCH
(2019)
Article
Neurosciences
O. Bello, J. A. Sanchez, V. Lopez-Alonso, G. Marquez, L. Morenilla, X. Castro, M. Giraldez, D. Santos-Garcia, M. Fernandez-del-Olmo
Article
Clinical Neurology
Miguel Fernandez-Del-Olmo, Olalla Bello, Virginia Lopez-Alonso, Jose Andres Sanchez, Diego Santos-Garcia, Josep Valls-Sole
MOVEMENT DISORDERS
(2012)
Article
Neurosciences
Miguel Fernandez-Del-Olmo, Olalla Bello, Virginia Lopez-Alonso, G. Marquez, Jose A. Sanchez, Luis Morenilla, Josep Valls-Sole
NEUROSCIENCE LETTERS
(2013)
Article
Clinical Neurology
Miguel Angel Fernandez-del-Olmo, Jose Andres Sanchez, Olalla Bello, Virginia Lopez-Alonso, Gonzalo Marquez, Luis Morenilla, Xabier Castro, Manolo Giraldez, Diego Santos-Garcia
FRONTIERS IN NEUROLOGY
(2014)
Article
Rehabilitation
Beatriz Rodriguez-Romero, Olalla Bello, Jamile Vivas Costa, Lidia Carballo-Costa
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2019)
Article
Clinical Neurology
Helena Fernandez-Lago, Olalla Bello, Antia Vidal Salgado, Miguel Fernandez-del-Olmo
NEUROREHABILITATION
(2019)
Article
Obstetrics & Gynecology
Sandra Martinez-Bustelo, Asuncion Ferri-Morales, Lis Corral-Gomez, Fernando J. Castillo-Garcia, Vanessa Castro-Varela, M. Amalia Jacome
Summary: The study found that during simultaneous submaximal contraction of pelvic floor and transversus abdominis muscles with axial elongation of the back, the bladder base significantly elevated in postpartum women compared to nulliparous women, while it descended during a curl-up contraction. Different effects were observed in perineal and superficial abdominal contractions in parous and nulliparous women.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Article
Medicine, General & Internal
Sandra Martinez-Bustelo, Asuncion Ferri-Morales, Fernando J. Castillo-Garcia, Antonio Madrid, M. Amalia Jacome
Summary: This study analyzed the validity and reliability of a new ultrasound algorithm to measure the displacement of the bladder base during abdominal exercises in women, and found it to be a valid and reliable tool for assessing the effect of abdominal contractions on the female pelvic floor.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Sport Sciences
Miguel Fernandez-del-Olmo, Jose Andres Sanchez-Molina, Luis Morenilla, Joaquin Gomez-Varela, Helena Fernandez-Lago, Olalla Bello, Diego Santos-Garcia
EUROPEAN JOURNAL OF HUMAN MOVEMENT
(2018)
Article
Rehabilitation
Helena Fernandez-Lago, Olalla Bello, Francina Mora-Cerda, Jorge Montero-Camara, Miguel Angel Fernandez-del-Olmo
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2017)
Article
Neurosciences
Olalla Bello, Jose Andres Sanchez, Cristina Vazquez-Santos, Miguel Fernandez-Del-Olmo
JOURNAL OF PARKINSONS DISEASE
(2014)