Article
Multidisciplinary Sciences
Robert A. Saxton, Naotaka Tsutsumi, Leon L. Su, Gita C. Abhiraman, Kritika Mohan, Lukas T. Henneberg, Nanda G. Aduri, Cornelius Gati, K. Christopher Garcia
Summary: By determining the structure of the IL-10 receptor complex and uncovering differences in IL-10 response thresholds across immune cell populations, this study provides a mechanistic blueprint for manipulating the pleiotropic actions of IL-10. Some IL-10 variants displayed myeloid-biased activity, suppressing macrophage activation without stimulating inflammatory CD8(+) T cells, thus uncoupling the major opposing functions of IL-10.
Article
Pharmacology & Pharmacy
Natalia Sanchez-Arribas, Maria Martinez-Negro, Clara Aicart-Ramos, Conchita Tros de Ilarduya, Emilio Aicart, Andres Guerrero-Martinez, Elena Junquera
Summary: The study demonstrates the efficient transfection of plasmid DNA encoding IL-12 into cells using a combination of gemini cationic lipids and zwitterionic helper lipids as nanovectors. The nanovectors show high cell viability and adsorb beneficial proteins on their surface, making them promising candidates for future in vivo applications of pCMV-IL12 transfection.
Article
Clinical Neurology
Zahra Aghelan, Saeed Karima, Seyed Hosein Abtahi, Habibolah Khazaie, Yahya Salimi, Reza Khodarahmi
Summary: A growing body of literature suggests that cytokines can play an important role in chronic insomnia disorder (CID). This study found that levels of proinflammatory mediators, including IL-12, IFN-gamma, and ICAM-1, were elevated in CID patients compared to healthy controls. The duration of REM sleep was also found to decrease with increased concentrations of IL-12 and IFN-gamma. Additionally, a lower serum concentration of IL-1ra was negatively correlated with the severity of insomnia in CID patients. These findings indicate that an imbalance of proinflammatory mediators and anti-inflammatory cytokines is important in the pathogenesis of CID.
Article
Clinical Neurology
Ryul Kim, Han-Joon Kim, Jung Hwan Shin, Chan Young Lee, Seung Ho Jeon, Beomseok Jeon
Summary: This study found that peripheral inflammation in early-stage Parkinson's disease (PD) may be related to the progression of nonmotor symptoms (NMSs), particularly mood symptoms. By measuring six inflammatory markers, the researchers found that elevated levels of IL-2 and IL-6 were associated with the progression of NMSs.
MOVEMENT DISORDERS
(2022)
Review
Virology
Muhammad Suhaib Qudus, Mingfu Tian, Summan Sirajuddin, Siyu Liu, Uzair Afaq, Muneeba Wali, Jinbiao Liu, Pan Pan, Zhen Luo, Qiwei Zhang, Ge Yang, Pin Wan, Yongkui Li, Jianguo Wu
Summary: In severe cases of COVID-19, a cytokine storm, characterized by excessive release of pro-inflammatory cytokines, can lead to acute respiratory distress syndrome (ARDS), multiple organ dysfunction syndrome (MODS), and even death. Key pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-2, IL-6, tumor necrosis factor-alpha, interferon (IFN)-gamma, and IL-10 have been found in severe COVID-19, and they play a role in amplifying pro-inflammatory responses through complex inflammatory networks. Understanding the involvement of these cytokines in SARS-CoV-2 infection and their role in triggering or regulating cytokine storm can provide insight into the pathogenesis of severe COVID-19. Currently, there are limited effective therapeutic strategies for cytokine storm, with glucocorticoids being used but also causing fatal side effects. Identifying key cytokines and developing targeted interventions, such as neutralizing antibodies or inhibitors of inflammatory signal pathways, may help improve treatment options.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Dermatology
Burak Aksan, Aysegul Basak Akadam-Teker
Summary: The TT genotype and T allele of IL-17A rs10484879 are associated with an increased risk of psoriasis in the Turkish population. This study suggests that IL-17A polymorphism may play a role in the pathogenesis of the disease. The IL-17A serum levels were also found to be associated with the genotype distribution.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Rosa Molfetta, Mario Lecce, Nadia D. Milito, Erisa Putro, Giuseppe Pietropaolo, Caterina Marangio, Gianluca Scarno, Marta Moretti, Enrico De Smaele, Tiziana Santini, Giovanni Bernardini, Giuseppe Sciume, Angela Santoni, Rossella Paolini
Summary: Mast cells (MCs) are innate immune cells that play a multifaceted role in the tumor microenvironment (TME). Recent studies have shown that MCs contribute to the transition from chronic inflammation to cancer. However, MC-derived mediators can either promote tumor progression or exert anti-tumorigenic effects, depending on the microenvironmental stimuli. This study focused on a specific subset of MCs in a murine model of colitis-associated colorectal cancer and found that these tumor-associated MCs have a connective tissue phenotype and release interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha. The presence of high levels of stem cell factor (SCF) and IL-33 in the tumor was found to shape the MC phenotype and promote the secretion of pro-inflammatory cytokines. This study highlights the importance of understanding the role of specific MC subsets in tumor progression.
CELL DEATH & DISEASE
(2023)
Article
Clinical Neurology
Anastasia Geladaris, Silke Haeusser-Kinzel, Roxanne Pretzsch, Nitzan Nissimov, Klaus Lehmann-Horn, Darius Haeusler, Martin S. Weber
Summary: B cells contribute to chronic inflammatory conditions, but removal of B cells may enhance the activity of monocytes. B cell-provided interleukin-10 (IL-10) plays a key role in controlling the pro-inflammatory activity of peripheral myeloid cells and microglia. Depleting B cells in a mouse model of multiple sclerosis (MS) accelerates disease severity, while adoptive transfer of IL-10-providing B cells reverses clinical exacerbation.
ACTA NEUROPATHOLOGICA
(2023)
Review
Immunology
Yan Wang, Jinxin Zang, Chen Liu, Zhongrui Yan, Dongmei Shi
Summary: Psoriasis is associated with an increased risk of cardiovascular disease. Clinical studies have shown that IL-17A inhibitors can effectively improve both psoriasis and atherosclerosis symptoms, suggesting that IL-17A may play a crucial role in the comorbidity of these two diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Anna Waskiel-Burnat, Marta Osinska, Anna Salinska, Leszek Blicharz, Mohamad Goldust, Malgorzata Olszewska, Lidia Rudnicka
Summary: Alopecia areata is characterized by dysregulation of various systemic cytokines including Th1, Th2, and Th17. The severity and duration of the disease are positively correlated with elevated levels of certain cytokines, while others may serve as potential predictors of therapeutic efficacy.
Article
Cell Biology
Min Wang, Yuqian Wang, Mengdi Zhang, Qiqi Duan, Caifeng Chen, Qiong Sun, Meng Liu, Yan Zheng, Yongping Shao
Summary: KYNU is upregulated in psoriatic skin samples and plays a crucial role in the production of inflammatory factors and the development of psoriasis-like skin inflammation. The microRNA miR-203a can inversely regulate KYNU and reduce psoriasis-related inflammatory factors. KYNU inhibitors can alleviate pathological phenotypes in IMQ-mice.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Maria Krajewska, Ewelina Witkowska-Sedek, Malgorzata Ruminska, Anna Stelmaszczyk-Emmel, Maria Sobol, Anna Majcher, Beata Pyrzak
Summary: The study found that vitamin D supplementation had beneficial effects in overweight and obese children, reducing inflammation levels and stabilizing anti-inflammatory cytokines.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O'Dowd, Laura O'Doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O'Halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm Bergin, Sean P. Kennelly, Seamas C. Donnelly, Nollaig M. Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh, Padraic G. Fallon
Summary: Clinical outcomes of SARS-CoV-2 infection show a wide range, from asymptomatic cases to severe pneumonia and death. This variability is influenced by differences in the immune response to the virus. A study measured inflammatory markers in patients with acute COVID-19 and found that most pro-inflammatory markers were significantly elevated, and specific markers were associated with disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Yiwei Zhao, Tao Zhang, Xi Guo, Chun Kwok Wong, Xiaoyan Chen, Yiu Leung Chan, Chi Chiu Wang, Susan Laird, Tin Chiu Li
Summary: This study found that among women who conceived after blastocyst transfer, there was a transient increase in pro-inflammatory cytokines (IFN-gamma and IL-17) 3 days after transfer, followed by a shift to anti-inflammatory cytokines (increased IL-10 and TGF-beta 1) by day 6 and sustained increase by day 9, when pregnancy was confirmed.
FERTILITY AND STERILITY
(2021)
Article
Neurosciences
Ewa Oglodek
Summary: This study found an association between depressive disorders and post-traumatic stress disorders with IL-1 beta, IL-4, IL-8, and IL-10 concentration levels. The levels of IL-1 beta, IL-4, and IL-8 increased with the severity of depression, while IL-10 levels decreased. These findings suggest that chronic inflammation may be a potential target or biomarker in the treatment of depression and PTSD.
Article
Multidisciplinary Sciences
Pavel Poczos, Tomas Cesak, Nad'a Jiraskova, Marketa Machackova, Petr Celakovsky, Jaroslav Adamkov, Filip Gabalec, Jiri Soukup, Jan Kremlacek
Summary: This study aimed to investigate the sensitivity of optical coherence tomography and visual evoked potentials to chiasmal compression and changes after decompression. The results revealed that motion-onset visual evoked potentials were more effective in detecting functional changes in the visual pathway.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Multidisciplinary
Drahomira Holmannova, Pavel Borsky, Tereza Svadlakova, Lenka Borska, Zdenek Fiala
Summary: Carbon nanoparticles have unique properties that make them widely applicable in various fields, but they may have toxic effects on different tissue types, including reproduction and offspring development.
Article
Biochemistry & Molecular Biology
Adam Karas, Drahomira Holmannova, Pavel Borsky, Zdenek Fiala, Ctirad Andrys, Kvetoslava Hamakova, Tereza Svadlakova, Vladimir Palicka, Jan Krejsek, Vit Rehacek, Monika Esterkova, Helena Kovarikova, Lenka Borska
Summary: The study investigates potential markers of psoriasis and aging, finding increased levels of CRP, AGEs, and RAGE, and reduced levels of NAD among psoriatic patients compared to controls. There is a negative correlation between AGEs and NAD. The study suggests that psoriasis and other immune-mediated diseases contribute to accelerated aging through sustained systemic damage.
Article
Surgery
Miroslav Sirovy, Marketa Krupova, Radomir Hyspler, Alena Ticha, Martina Kolackova, Ctirad Andrys, Vera Radochova, David Astapenko, Sarka Odlozilova, Jiri Kotek, Jan Zajak, Jiri Paral
Summary: Intraperitoneally administered lipid emulsions have a protective effect on the formation of adhesions after abdominal surgery. The lubricating effect of phospholipids, the mechanical barrier of the lipid component, and the anti-inflammatory effect of fish oil contribute to this effect. The administration of lipid emulsions significantly reduces the incidence of intra-abdominal adhesions, reduces inflammation and collagen content in the adhesions, and decreases neovascularization.
ASIAN JOURNAL OF SURGERY
(2023)
Review
Chemistry, Multidisciplinary
Drahomira Holmannova, Pavel Borsky, Tereza Svadlakova, Lenka Borska, Zdenek Fiala
Summary: This review summarizes the current and future applications of carbon nanoparticles in medicine. Carbon nanoparticles, such as graphene, graphene oxide, and carbon nanotubes, have unique physicochemical properties that make them suitable for clinical use. They are mainly used in medical diagnostics, including bioimaging and chemical/metabolite detection. However, their use in therapeutics, regenerative medicine, and vaccine production is still under research due to nanoparticle toxicity concerns. Preclinical studies show great potential for diagnosis and treatment, but caution is needed before their routine clinical use.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Drahomira Holmannova, Pavel Borsky, Ctirad Andrys, Kvetoslava Hamakova, Eva Cermakova, Gabriela Poctova, Zdenek Fiala, Jindra Smejkalova, Vladimir Blaha, Lenka Borska
Summary: This study aimed to demonstrate the genotoxic potential of chronic inflammation and investigate whether the presence of both psoriasis and metabolic syndrome (MetS) increases chromosomal damage. The results showed that patients with psoriasis and MetS had a higher rate of chromosomal aberrations compared to the healthy population. This suggests an increased risk of genomic instability and carcinogenesis in these patients.
Article
Dermatology
Martin Beranek, Pavel Borsky, Zdenek Fiala, Ctirad Andrys, Kvetoslava Hamakova, Marcela Chmelarova, Helena Kovarikova, Adam Karas, Jan Kremlacek, Vladimir Palicka, Lenka Borska
Summary: This study investigated oxidation damage, telomere length, and methylation status in the DNA of peripheral blood from psoriatic patients. The results showed higher levels of oxidative damage in patients' serum DNA/RNA compared to control group. Patients' whole-cell DNA exhibited longer telomeres, especially in females, compared to controls. The difference in global DNA methylation between psoriasis cases and controls was not significant.
ANAIS BRASILEIROS DE DERMATOLOGIA
(2023)
Article
Ophthalmology
Jana Nekolova, Jan Kremlacek, Jiri Lukavsky, Radovan Sikl, Martin Sin, Jana Langrova, Jana Szanyi, Nada Jiraskova
Summary: This study evaluated the effects of intraocular macular lens implantation and visual rehabilitation on the quality of life of patients with geographic atrophy secondary to age-related macular degeneration. The results showed that macular lens implantation followed by rehabilitation improved near vision and increased the quality of life of visually handicapped patients with macular degeneration.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Clinical Neurology
Maja Striteska, Martin Valis, Viktor Chrobok, Oliver Profant, Luigi Califano, Jaroslav Syba, Katerina Trnkova, Jan Kremlacek, Martin Chovanec
Summary: This study aimed to assess the accuracy of a head-shaking test (HST) in reflecting vestibular compensation in patients with unilateral peripheral vestibular loss, and to provide evidence on the characteristics of head-shaking-induced nystagmus (HSN) over a 2-year follow-up. The study found that the intensity of HSN decreased exponentially over time after unilateral vestibular loss. Compensated patients showed a gradual reduction of HSN towards the level of the control group, while poorly compensated patients maintained a detectable HSN. Therefore, HSN can serve as an indicator for evaluating unilateral vestibular loss.
FRONTIERS IN NEUROLOGY
(2022)
Article
Ophthalmology
Miroslav Kuba, Jan Kremlacek, Frantisek Vit, Zuzana Kubova, Jana Langrova, Jana Szanyi, Marie Chutna
Summary: In this study, a portable device called VEPpeak was developed to examine visual evoked potentials (VEPs). The device is inexpensive, easy to carry, and can be used for clinical diagnosis and various electrophysiological research purposes.
DOCUMENTA OPHTHALMOLOGICA
(2023)
Article
Obstetrics & Gynecology
R. Spacek, M. Kacerovsky, C. Andrys, O. Soucek, R. Kukla, R. Bolehovska, I. Musilova
Summary: This study aimed to determine the concentration of soluble CD93 (sCD93) in amniotic fluid from pregnancies complicated by preterm prelabor rupture of membranes (PPROM) based on the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation. The results showed that intra-amniotic inflammation, regardless of the presence of MIAC, is associated with elevated levels of sCD93 in amniotic fluid.
CESKA GYNEKOLOGIE-CZECH GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Ondrej Soucek, Marian Kacerovsky, Ivana Kacerovska Musilova, Jaroslav Stranik, Rudolf Kukla, Radka Bolehovska, Ctirad Andrys
Summary: The study aimed to evaluate CD36 concentrations in amniotic fluid in pregnancies complicated by PTL and PPROM with respect to the presence of intra-amniotic infection. In the PPROM group, women with intra-amniotic infection had higher CD36 concentrations compared to those without infection. In PTL pregnancies, there was no significant difference in CD36 concentration with respect to the presence of intra-amniotic infection.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Drahomira Holmannova, Pavel Borsky, Helena Parova, Tereza Stverakova, Milan Vosmik, Libor Hruska, Zdenek Fiala, Lenka Borska
Summary: Aging is a natural process that involves molecular, cellular, and tissue-level changes, which can increase the risk of diseases like cancer. The hallmarks of aging, including genomic and non-genomic changes, play a significant role in aging and cancer. Understanding the non-genomic hallmarks and their relationship with aging and cancer could help develop approaches to slow down aging and prevent cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
