Review
Endocrinology & Metabolism
Jaya Mehta, Juliana M. Kling, JoAnn E. Manson
Summary: Prescribing practices for menopausal hormone therapy have evolved in recent decades based on changing understanding of the treatment's risks and benefits. Recent research suggests that the risks of HT are low for healthy women under 60 or within ten years of menopause, while the benefits may outweigh the risks for those experiencing bothersome vasomotor symptoms. HT also plays a role in preventing osteoporosis for appropriate candidates.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, Research & Experimental
Hui-Hui Shen, Tao Zhang, Hui-Li Yang, Zhen-Zhen Lai, Wen-Jie Zhou, Jie Mei, Jia-Wei Shi, Rui Zhu, Feng-Yuan Xu, Jin Li, Jiang-Feng Ye, Ming-Qing Li
Summary: Menstruation is a cyclic physiological phenomenon controlled by ovarian hormones, and a proper understanding of normal endometrial physiology is crucial for regulating menstrual disorders. Autophagy in the endometrium, regulated by ovarian hormones, plays a key role in immune cell infiltration, tissue repair, and infection prevention during menstruation. Abnormal autophagy levels and dysregulated immune system function are associated with the pathogenesis and progression of endometriosis, suggesting the potential value of autophagy as a target for the treatment of menstrual-related and endometrium-related disorders.
Article
Oncology
Emanuele Perrone, Riccardo Tudisco, Pia Clara Pafundi, Davide Guido, Alessandra Ciucci, Enrica Martinelli, Gian Franco Zannoni, Alessia Piermattei, Saveria Spadola, Giulia Ferrante, Claudia Marchetti, Giovanni Scambia, Anna Fagotti, Daniela Gallo
Summary: This study explored the relationship between hormone receptor status and BRCA1/2 mutation in high-grade serous ovarian carcinoma (HGSOC) patients. The results showed interesting differences in receptor expression patterns and their association with outcomes between BRCA-mutated and BRCA wild-type women. The findings suggest a potential role of estrogen-mediated pathways in BRCA1/2-associated HGSOC tumorigenesis, revealing a possible therapeutic potential for targeting this interaction.
Article
Biochemistry & Molecular Biology
Jiahong Tan, Chunyan Song, Daoqi Wang, Yigang Hu, Dan Liu, Ding Ma, Qinglei Gao
Summary: High-grade serous ovarian cancer (HGSOC) with high expression of hormone receptors, including androgen receptor (AR), estrogen receptor alpha (ER), and progesterone receptor (PR), is associated with longer progression-free survival (PFS), overall survival (OS), and platinum-free interval (PFI). Correlation analysis shows significant positive correlations between hormone receptor expression and survival, indicating that AR, ER, and PR could serve as feasible prognostic biomarkers for HGSOC through immunohistochemical analysis. Co-expression of AR, ER, and PR has an improved predictive performance with an area under the curve (AUC) value of 0.945.
BIOSCIENCE REPORTS
(2021)
Article
Cell Biology
Melissa C. McHann, Henry L. Blanton, Josee Guindon
Summary: Breast and ovarian cancer are hormone dependent cancers, with high incidence of pain. Studies on the modulation of pain by hormones, specifically estrogen and progesterone, are still debated. Treatment options for pain associated with these cancers are limited and often ineffective.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tomasz Jasinski, Lukasz Zdrojkowski, Graca Ferreira-Dias, Ewa Kautz, Edyta Juszczuk-Kubiak, Malgorzata Domino
Summary: Endometrosis, a common disease that affects mares' fertility, is associated with alterations in epithelial and stromal cells, as well as degeneration and fibrosis of the endometrium. The study reveals a potential involvement of the NF-kappa B pathway in the pathogenesis of endometrosis, showing differential transcription of profibrotic genes between different phases of the estrous cycle. Additionally, the transcription of estrogen and progesterone receptors is found to be decreased with the severity of fibrosis and degeneration of the endometrium in horses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Zaher Merhi, Serin Seckin, Marco Mouanness
Summary: This case report presents a patient with very low ovarian reserve who inadvertently reported significant improvement in menopausal symptoms, including hot flashes, for 14 weeks following intra-ovarian PRP injection. The findings suggest that PRP may serve as a potential alternative therapy for hot flashes in women with contraindications for hormone replacement therapy.
REPRODUCTIVE SCIENCES
(2022)
Article
Cell Biology
Sylvia C. Hewitt, San-Pin Wu, Tianyuan Wang, Steven L. Young, Thomas E. Spencer, Francesco J. DeMayo
Summary: The study demonstrates that uterine cells respond to estrogen and progesterone through their nuclear receptors ESR1 and PGR, with the involvement of chromatin structures. The organoids model provides insights into the regulatory mechanisms of hormone responsiveness.
Article
Cell Biology
Myung Jae Jeon, Young Sik Choi, James J. Yoo, Anthony Atala, John D. Jackson
Summary: The study aimed to develop an optimized culture system for maintaining ovarian cell growth and functionality. By isolating granulosa cells and theca cells from female rats and adding follicle-stimulating hormone or luteinizing hormone to the basal culture media, secretion of estradiol and androstenedione hormones could be significantly enhanced. Additionally, growth differentiation factor 9, bone morphogenic protein 15, BMP7 and basic fibroblast growth factor were found to enhance granulosa cell proliferation and estradiol production.
CELL AND TISSUE RESEARCH
(2021)
Article
Oncology
Cornelia Liedtke, Chafika Mazouni, Kenneth R. Hess, Fabrice Andre, Attila Tordai, Jaime A. Mejia, W. Fraser Symmans, Ana M. Gonzalez-Angulo, Bryan Hennessy, Marjorie Green, Massimo Cristofanilli, Gabriel N. Hortobagyi, Lajos Pusztai
Summary: This study compared the response to neoadjuvant chemotherapy and survival between patients with triple-negative breast cancer (TNBC) and non-TNBC. The results showed that TNBC patients had higher pathologic complete response rates but lower 3-year progression-free survival rates and 3-year overall survival rates. TNBC was associated with increased risk for visceral metastases, lower risk for bone recurrence, and shorter postrecurrence survival. Patients with TNBC had worse survival if they had residual disease after neoadjuvant chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Psychology, Clinical
Megan E. Mikhail, Pamela K. Keel, S. Alexandra Burt, Cheryl L. Sisk, Michael Neale, Steven Boker, Kelly L. Klump
Summary: Ovarian hormones significantly influence dysregulated eating in females, particularly when combined with high trait negative affect and certain hormonal environments. The risk of emotional eating is highest in women with high trait negative affect and low estradiol or high progesterone, especially those with a history of clinically significant binge-eating episodes. These findings suggest that affective and hormonal risk factors interact to promote emotional eating, with a heightened effect in women with clinically significant binge eating.
CLINICAL PSYCHOLOGICAL SCIENCE
(2021)
Article
Endocrinology & Metabolism
Imane Lalami, Julie Labrosse, Isabelle Cedrin-Durnerin, Marjorie Comtet, Claire Vinolas, Fabien Krief, Christophe Sifer, Maeliss Peigne, Michael Grynberg
Summary: Letrozole supplementation during ovarian stimulation may reduce serum progesterone levels in breast cancer patients undergoing fertility preservation after GnRH-agonist (GnRHa) trigger, which is significant for preserving fertility in breast cancer patients.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Genoa R. Warner, Diana C. Pacyga, Rita S. Strakovsky, Rebecca Smith, Tamarra James-Todd, Paige L. Williams, Russ Hauser, Daryl D. Meling, Zhong Li, Jodi A. Flaws
Summary: The study revealed associations between phthalates and hot flashes in midlife women, suggesting a potential impact on hot flash risk. Factors such as menopause status, BMI, race/ethnicity, and depressive symptoms may influence these associations.
ENVIRONMENTAL RESEARCH
(2021)
Review
Clinical Neurology
Annika Haufe, Fiona C. Baker, Brigitte Leeners
Summary: Sleep disturbances are common among women during the menopausal transition. The decline in estrogen and progesterone levels contributes to these disturbances, and timely hormone therapy can improve overall sleep quality.
SLEEP MEDICINE REVIEWS
(2022)
Article
Neurosciences
Hamed Ghazvini, Fatemeh Tirgar, Mehdi Khodamoradi, Zeinab Akbarnejad, Raheleh Rafaiee, Seyedeh Masoumeh Seyedhosseini Tamijani, Majid Asadi-Shekaari, Khadijeh Esmaeilpour, Vahid Sheibani
Summary: The study found that treatment with estrogen or progesterone alone in METH-exposed OVX rats significantly improved neuronal damage and inflammation, while treatment with estrogen plus progesterone improved hyperthermia and brain edema.
NEUROSCIENCE LETTERS
(2021)
Article
Geriatrics & Gerontology
Catheryne Chiang, Lisa Gallicchio, Howard Zacur, Sue Miller, Jodi A. Flaws, Rebecca L. Smith
Article
Reproductive Biology
Chan Jin Park, Radwa Barakat, Alexander Ulanov, Zhong Li, Po-Ching Lin, Karen Chiu, Sherry Zhou, Pablo Perez, Jungyeon Lee, Jodi Flaws, ChemYong Jay Ko
REPRODUCTIVE TOXICOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Andressa Gonsioroski, Vasiliki E. Mourikes, Jodi A. Flaws
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Environmental Sciences
Karen Chiu, Shah Tauseef Bashir, Liying Gao, Jessica Gutierrez, Maria R. C. de Godoy, Jenny Drnevich, Christopher J. Fields, Isaac Cann, Jodi A. Flaws, Romana A. Nowak
Summary: Subacute exposure to DEHP during pregnancy significantly affected the cecal microbiome in pregnant mice, increasing alpha diversity and altering beta diversity. DEHP exposure led to an increase in the relative abundance of Bacteroidetes and a decrease in the relative abundance of Firmicutes and Deferribacteres. In addition, DEHP exposure significantly altered 14 functional pathways, but did not have a significant impact on fertility and birth outcomes.
Article
Environmental Sciences
Karen K. Chiu, Shah Tauseef Bashir, Ahmed M. Abdel-Hamid, Lindsay V. Clark, Mary J. Laws, Isaac Cann, Romana A. Nowak, Jodi A. Flaws
Summary: This study examines the impact of DiNP exposure on the gut microbiota and immune-related factors, revealing that DiNP exposure can alter the composition of the gut microbiota and that the gut contains microbes capable of degrading DiNP.
Article
Environmental Sciences
Diana C. Pacyga, Brad A. Ryva, Romana A. Nowak, Serdar E. Bulun, Ping Yin, Zhong Li, Jodi A. Flaws, Rita S. Strakovsky
Summary: This study investigated the association between phthalates and fibroids and found that each two-fold increase in sigma DEHP or sigma AA was associated with a 13% and 16% greater risk of prior fibroid diagnosis in women. These associations were strongest in women who were overweight/obese and in those diagnosed with fibroids within 5 years before phthalate assessment.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Environmental Sciences
Endia J. Fletcher, Ramses Santacruz-Marquez, Vasiliki E. Mourikes, Alison M. Neff, Mary J. Laws, Jodi A. Flaws
Summary: This review discusses the effects of phthalate mixtures on the female reproductive system. Phthalates have been found to target the ovaries, disrupting normal reproductive function and potentially affecting folliculogenesis and steroidogenesis. Additionally, phthalates can cross the placental barrier and impact fetal development. However, the specific effects of phthalate mixtures on the ovary and female reproduction are still not well understood.
Review
Biochemistry & Molecular Biology
Nitya Shree, Zehuan Ding, Jodi Flaws, Mahua Choudhury
Summary: The prevalence of poor metabolic health is increasing exponentially worldwide, with exposure to environmental chemicals, such as endocrine-disrupting chemicals (EDCs), gaining attention as a contributing factor. Recent reports suggest that non-coding RNAs, specifically microRNAs (miRs), may play a vital role in this phenomenon.
Review
Environmental Sciences
Xing Zhang, Jodi A. Flaws, Michael J. Spinella, Joseph Irudayaraj
Summary: Endocrine disrupting chemicals (EDCs) are exogenous substances that can alter the endocrine function of an organism, leading to adverse effects on growth, development, metabolism, and reproductive function. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in both animals and humans. This review discusses the renal accumulation of specific EDCs, such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and explores how exposure to these EDCs can result in renal lesions and diseases, including cancer. The regulation of target genes and activation of related pathways by typical EDCs are also summarized.
Article
Environmental Sciences
Vasiliki E. Mourikes, Ramses Santacruz Marquez, Ashley Deviney, Alison M. Neff, Mary J. Laws, Jodi A. Flaws
Summary: Imidacloprid is a neonicotinoid pesticide used in agriculture, gardening, and veterinary medicine. It has the potential to accumulate in the environment and harm non-targeted species. Imidacloprid and its metabolite desnitro-imidacloprid have different effects on follicle growth and steroidogenesis. These compounds also alter the expression of genes related to hormone regulation and apoptosis.
Article
Genetics & Heredity
Clotilde Maurice, Mathieu Dalvai, Romain Lambrot, Astrid Deschenes, Marie-Pier Scott-Boyer, Serge McGraw, Donovan Chan, Nancy Cote, Ayelet Ziv-Gal, Jodi A. Flaws, Arnaud Droit, Jacquetta Trasler, Sarah Kimmins, Janice L. Bailey
Summary: The study found that paternal exposure to POPs pollutants can impact the development and pregnancy outcomes of offspring, with this effect potentially explained by sperm DNA methylation. Experimental results suggest that the paternal methylome is sensitive to the environment, with some perturbations persisting for at least two subsequent generations.
Article
Neurosciences
Jiang Li, Jordyn A. Robare, Liying Gao, M. Amin Ghane, Jodi A. Flaws, Mark E. Nelson, Catherine A. Christian
Article
Endocrinology & Metabolism
Quanxi Li, Catherine R. Lawrence, Romana A. Nowak, Jodi A. Flaws, Milan K. Bagchi, Indrani C. Bagchi
Article
Endocrinology & Metabolism
Emily Brehm, Saniya Rattan, Liying Gao, Jodi A. Flaws
Article
Reproductive Biology
Saniya Rattan, Emily Brehm, Liying Gao, Sarah Niermann, Jodi A. Flaws
BIOLOGY OF REPRODUCTION
(2018)