Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group

Recent Clinical Trials for the Etiological Treatment of Chronic Chagas Disease: Advances, Challenges and Perspectives

(2014) Julio A. Urbina   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme

(2014) Alcione Silva de Carvalho et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects

(2014) Stephen Patterson et al.   TRENDS IN PARASITOLOGY

Fexinidazole: A Potential New Drug Candidate for Chagas Disease

(2012) Maria Terezinha Bahia et al.   PLoS Neglected Tropical Diseases

Bioactivation of Drugs: Risk and Drug Design

(2011) John S. Walsh et al.   Annual Review of Pharmacology and Toxicology

Synthesis and antitubercular activity of monocyclic nitroimidazoles: Insights from econazole

(2011) Sang-Ho Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In Vitro and In Vivo Activities of 1,3,4-Thiadiazole-2-Arylhydrazone Derivatives of Megazol against Trypanosoma cruzi

(2010) K. Salomao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness

(2010) Els Torreele et al.   PLoS Neglected Tropical Diseases

Chagas disease: A Latin American health problem becoming a world health problem

(2009) Gabriel A. Schmunis et al.   ACTA TROPICA

Chagas disease in Spain, the United States and other non-endemic countries

(2009) Joaquim Gascon et al.   ACTA TROPICA

Synthesis and Electrochemistry of 2-Ethenyl and 2-Ethanyl Derivatives of 5-Nitroimidazole and Antimicrobial Activity againstGiardia lamblia

(2009) Carlos A. Valdez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aspectos mecanísticos da bioatividade e toxicidade de nitrocompostos

(2009) Fávero Reisdorfer Paulai et al.   QUIMICA NOVA

Studies toward the structural optimization of new brazilizone-related trypanocidal 1,3,4-thiadiazole-2-arylhydrazone derivatives

(2007) Samir A. Carvalho et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases

(2007) Ruth Brenk et al.   ChemMedChem