Article
Gastroenterology & Hepatology
Lena W. Y. Thin, Sherman Picardo, Shanela Sooben, Kevin Murray, Jennifer Ryan, Marina H. Wallace
Summary: The study compared the risk of early post-operative endoscopic recurrence in Crohn's disease patients undergoing end-to-end anastomosis (ETEA) versus side-to-side anastomosis (STSA). The results showed that in emergency surgeries, ETEA was associated with a higher risk of EPER, while early initiation of biologics and/or immunosuppressants and smoking cessation were crucial for this high-risk group of patients.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Aditi Kanth, Kanlaya Ditthakasem, Morley Herbert, Jeffrey A. Fearon
Summary: This retrospective study reviewed the medical records of all patients undergoing primary and secondary remodeling corrections between 2010 and 2020. It found that a higher proportion of primary procedures received allogeneic blood compared to secondary corrections. The length of hospital stay and surgical infection rate were similar between the two groups. The age at primary correction and strip craniectomies may be associated with a higher likelihood of subsequent secondary correction.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Michele Pagnanelli, Francesco De Gaetano, Gennaro Nappo, Giovanni Capretti, Maria Laura Costantino, Alessandro Zerbi
Summary: The choice of suture threads is crucial for pancreatic anastomoses to reduce the occurrence of post-operative pancreatic fistula. This study analyzed the mechanical characteristics of four different suture materials and found that polydioxanone and poliglecaprone 25 could be the best suture materials for pancreatic anastomoses.
Review
Medicine, General & Internal
Xiangwei Li, Yujia Xiao, Han Shu, Xianding Sun, Mao Nie
Summary: As the population ages, the incidence of rotator cuff tears is increasing. Arthroscopic suture-anchor repair has become the preferred method for rotator cuff repair. However, there is limited knowledge about anchor pullout after repair, making it difficult for clinicians to predict and manage the risk comprehensively.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Joanna Machowicz, Maciej Wolkowski, Beata Jablonska, Slawomir Mrowiec
Summary: This study retrospectively analyzed the medical records of 72 patients undergoing right hemicolectomy to assess the association between anastomotic type and postoperative complications. The results showed that side-to-end anastomosis was associated with the highest incidence of complications, but there is still no definitive conclusion on the best choice of anastomosis.
Article
Biochemistry & Molecular Biology
Samantha Lapehn, Jonas A. Gustafson, Andrew E. Timms, Michael L. Cunningham, Alison G. Paquette
Summary: This study aimed to compare gene expression differences between patients with different phenotypes of single-suture craniosynostosis and controls, using primary calvarial cell lines. The results showed differentially expressed genes associated with each type of craniosynostosis, as well as differences between males and females. Pathway analysis also identified relevant signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Pauline Riviere, Gabriele Bislenghi, Nassim Hammoudi, Bram Verstockt, Steven Brown, Melissa Oliveira-Cunha, Willem Bemelman, Gianluca Pellino, Paulo Gustavo Kotze, Marc Ferrante, Yves Panis
Summary: This paper provides an overview of the pathophysiology and risk factors for postoperative recurrence (POR) in patients with Crohn's disease. The role of the microbiome, mesentery, immune system, and genetic background in POR is discussed, along with the identification of risk factors and the development of preventive strategies based on individual patient profiles.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Multidisciplinary Sciences
D'Juan T. Farmer, Hana Mlcochova, Yan Zhou, Nils Koelling, Guanlin Wang, Neil Ashley, Helena Bugacov, Hung-Jhen Chen, Riana Parvez, Kuo-Chang Tseng, Amy E. Merrill, Robert E. Maxson, Andrew O. M. Wilkie, J. Gage Crump, Stephen R. F. Twigg
Summary: The authors utilized scRNA-seq and expression validation to uncover the cellular diversity within the murine embryonic coronal suture, shedding light on possible mechanisms for its loss in craniosynostosis.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Julia Treuheit, Christian Krautz, Georg F. Weber, Robert Gruetzmann, Maximilian Brunner
Summary: This study aimed to identify risk factors associated with postoperative outcomes in patients undergoing surgery for gastroduodenal perforation. The analysis of 273 adult patients revealed that general condition, preoperative hemoglobin level, preoperative creatinine level, intake of preoperative steroids, perforation localization, age, and preoperative CRP level were independent risk factors for different outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Applied
Sami Jouttijarvi, Muhammad Imran Asghar, Peter D. Lund
Summary: A large set of single-layer fuel cells using LNZ as the semiconducting material and doped ceria-based ionic conductors were fabricated and characterized. The ionic conductivity was found to be the most crucial performance-limiting factor. Controlling the porosity and optimizing the mass ratio of semiconductor and ionic conductor affected the cell performance.
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcello Napolitano, Alice Marianna Munari, Giovanni Di Leo, Nicol Antonina Rita Panarisi, Giovanna Zuin, Giorgio Fava, Marta Vecchi, Francesco Sardanelli, Gian Vincenzo Zuccotti
Summary: This study proposed a simplified MRE score, PCDMRI, to evaluate active inflammation in children with CD. The results showed positive correlations between PCDMRI and global score with PCDAI, SES-CD, CRP, and fC, with high inter-reader reproducibility. The PCDMRI may be a useful non-invasive tool for grading disease activity in children with ileocolonic CD.
Article
Medicine, General & Internal
Claire Le Gal, Marie Carbonnel, Vincent Balaya, Christophe Richard, Valerie Gelin, Laurent Galio, Olivier Sandra, Barbara Hersant, Romain Bosc, Johanna Charton, Pascale Chavatte-Palmer, Francois Vialard, Raphael Coscas, Jean-Marc Ayoubi
Summary: Uterine transplantation is a realistic therapy for uterine infertility, and surgical training on animal models is necessary for human programs. This study analyzed predictive factors for successful vascular anastomoses and found that warm ischemia time, absence of complications, and experience of the surgeon were associated with successful vein anastomoses.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Julian Thomas Schweer, Philipp-Alexander Neumann, Philipp Doebler, Anna Doebler, Andreas Pascher, Rudolf Mennigen, Emile Rijcken
Summary: Anastomotic leakage is a serious complication in colorectal resections, especially in patients with Crohn's disease. A retrospective analysis of an IBD database showed that CD might be independently associated with anastomotic complications and have a detrimental effect on postoperative healing, indicating the need for treatment in dedicated centers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Business
Sulin Pang, Lianhu Xia
Summary: This article introduces an algorithm for layer-by-layer classification and automatic identification of single-environment risks, based on multi-rule, multi-standard, multi-level, multi-factor, and multi-dimension classification principles. The algorithm is applied to a real case involving the sudden assault of a woman in Dalian, China in order to identify and evaluate risks in a single environment. The research is practical and offers a new approach to risk assessment in social environmental safety.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2021)
Article
Orthopedics
Hyungsuk Kim, Soo Bin Park, Hyun Seok Song
Summary: This study compared the clinical outcomes and tendon integrity between conventional en masse repair technique and knotless layer-by-layer technique for delaminated rotator cuff tears. The results showed that the knotless layer-by-layer technique had superior results in terms of Constant score, tendon thickness, and signal intensity in the articular layer.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Oncology
Axel Wein, Robert Stoehr, Stephan Kersting, Juergen Siebler, Susanne Merkel, Dagmar Busse, Kerstin Wolff, Nicola Ostermeier, Clemens Neufert, Francesco Vitali, Markus Eckstein, Jan-Peter Roth, Peter Anhut, Waldemar Schreiner, Michael Uder, Arndt Hartmann, Markus F. Neurath, Robert Gruetzmann
Summary: This study aimed to evaluate the clinical outcomes of a new molecular biomarker panel for palliative first-line treatment of colorectal cancer. The results indicate that using FOLFIRI plus cetuximab for quintuple-wildtype patients led to higher response rates compared to RAS-mutations population, showing promise for this treatment approach.
Article
Gastroenterology & Hepatology
Naoyoshi Nagata, Suguru Nishijima, Yasushi Kojima, Yuya Hisada, Koh Imbe, Tohru Miyoshi-Akiyama, Wataru Suda, Moto Kimura, Ryo Aoki, Katsunori Sekine, Mitsuru Ohsugi, Kuniko Miki, Tsuyoshi Osawa, Kohjiro Ueki, Shinichi Oka, Masashi Mizokami, Ece Kartal, Thomas S. B. Schmidt, Esther Molina-Montes, Lidia Estudillo, Nuria Malats, Jonel Trebicka, Stephan Kersting, Melanie Langheinrich, Peer Bork, Naomi Uemura, Takao Itoi, Takashi Kawai
Summary: This study identified gut and oral metagenomic signatures that accurately predict pancreatic ductal carcinoma (PDAC) and validated their effectiveness in independent cohorts. Patients with certain microbial species in the gut and oral microbiomes were found to have higher risk of PDAC-related mortality. These findings provide valuable information for the diagnosis and prognosis of PDAC.
Article
Gastroenterology & Hepatology
Ece Kartal, Thomas S. B. Schmidt, Esther Molina-Montes, Sandra Rodriguez-Perales, Jakob Wirbel, Oleksandr M. Maistrenko, Wasiu A. Akanni, Bilal Alashkar Alhamwe, Renato J. Alves, Alfredo Carrato, Hans-Peter Erasmus, Lidia Estudillo, Fabian Finkelmeier, Anthony Fullam, Anna M. Glazek, Paulina Gomez-Rubio, Rajna Hercog, Ferris Jung, Stefanie Kandels, Stephan Kersting, Melanie Langheinrich, Mirari Marquez, Xavier Molero, Askarbek Orakov, Thea Van Rossum, Raul Torres-Ruiz, Anja Telzerow, Konrad Zych, Vladimir Benes, Georg Zeller, Jonel Trebicka, Francisco X. Real, Nuria Malats, Peer Bork
Summary: This study explored the potential of fecal and salivary microbiota as diagnostic biomarkers for pancreatic ductal adenocarcinoma (PDAC). Results showed that fecal metagenomic classifiers performed better than saliva-based classifiers, accurately identifying PDAC patients based on a set of 27 microbial species. The accuracy was further improved when combined with serum levels of carbohydrate antigen (CA) 19-9. The study also found that fecal PDAC marker species were detectable in pancreatic tumor and non-tumor tissue. These findings suggest that non-invasive fecal microbiota-based screening for early detection of PDAC is feasible.
Article
Multidisciplinary Sciences
Lea Miebach, Eric Freund, Ramona Clemen, Stephan Kersting, Lars-Ivo Partecke, Sander Bekeschus
Summary: Gas plasma technology can generate reactive oxygen and nitrogen species that cause lethal oxidative damage to tumor cells. The study suggests that gas plasma-oxidized liquids and concentration-matched control liquids have the same therapeutic efficacy in peritoneal carcinomatosis. Additionally, the treatment can increase tumor cell immunogenicity and enhance immune cell uptake and maturation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Maximilian Brunner, Henriette Golcher, Christian Krautz, Stephan Kersting, Georg F. Weber, Robert Gruetzmann
Summary: This study aims to evaluate the safety and efficiency of two commonly used suture techniques in hepaticojejunostomy during pancreatoduodenectomy. The study will compare the interrupted suture technique and the continuous suture technique in terms of the occurrence of anastomotic leakage, other perioperative parameters, and healthcare costs.
Article
Emergency Medicine
Bruno Leonardo Bancke Laverde, Matthias Maak, Melanie Langheinrich, Stephan Kersting, Axel Denz, Christian Krautz, Georg Ferdinand Weber, Robert Gruetzmann, Maximilian Brunner
Summary: The purpose of this study was to identify risk factors associated with postoperative morbidity, major morbidity, prolonged length of hospital stay, and readmission in patients undergoing appendectomy for acute appendicitis. The study found that higher age, higher preoperative WBC-count and CRP, lower preoperative hemoglobin, longer time to surgery, and longer duration of surgery were independent risk factors for morbidity. Higher age, higher preoperative CRP, lower preoperative hemoglobin, and longer time to surgery were identified as independent risk factors for major morbidity. Higher age, higher preoperative WBC-count and CRP, lower preoperative hemoglobin, need for conversion, longer surgery duration, presence of intraoperative complicated appendicitis, and postoperative morbidity were independent risk factors for a prolonged length of hospital stay. Presence of malignancy and higher preoperative WBC-count were independent risk factors for readmission.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Medicine, General & Internal
Melanie Langheinrich, Alexander Reinhard Siebenhuener, Justus Baecker, Maximilian Miragall, Felix Wiesmueller, Vera Schellerer, Susanne Merkel, Maximilian Brunner, Christian Krautz, Klaus Weber, Robert Gruetzmann, Stephan Kersting
Summary: This study aimed to evaluate the value of different blood-based markers and assess the significance of a newly developed inflammatory-nutrition-related biomarker (NCR = BMI x albumin/CRP) in colon cancer patients. Lower preoperative NCR levels were associated with worse prognosis, tumor sidedness, undifferentiated histology, nodal involvement, and advanced UICC stage. The NCR proved to be a reliable indicator of poor prognosis for colon cancer patients and could be used for risk stratification and treatment selection.
Letter
Gastroenterology & Hepatology
Maximilian Brunner, Klaus Weber, Axel Denz, Melanie Langheinrich, Stephan Kersting, Georg F. Weber, Robert Gruetzmann, Christian Krautz
COLORECTAL DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Barbara Kneis, Stefan Wirtz, Klaus Weber, Axel Denz, Matthias Gittler, Carol Geppert, Maximilian Brunner, Christian Krautz, Alexander Reinhard Siebenhuener, Robert Schierwagen, Olaf Tyc, Abbas Agaimy, Robert Gruetzmann, Jonel Trebicka, Stephan Kersting, Melanie Langheinrich
Summary: In the current era of precision oncology, it is recognized that colorectal cancer (CRC) is a heterogeneous disease. The tumor location is crucial in determining disease progression and prognosis. The microbiome has been identified as an important factor in CRC, but previous studies have shown inconsistent results due to the heterogeneous nature of microbiomes and the lack of separate analysis of colon cancer (CC) and rectal cancer (RC). Our prospective study aimed to map the colon cancer landscape using 16S rRNA amplicon sequencing, and we found distinct microbiomes in right- and left-sided colon cancers, as well as a significant increase in potentially pathogenic bacteria in stool samples after surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aydar Khabipov, Dung Nguyen Trung, Julia van der Linde, Lea Miebach, Maik Lenz, Felix Erne, Wolfram von Bernstorff, Tobias Schulze, Stephan Kersting, Sander Bekeschus, Lars Ivo Partecke
Summary: Pancreatic cancer is characterized by a tumor microenvironment rich in stromal and immune cells that support cancer growth and resistance to therapy. Tumor-associated macrophages (TAMs), specifically, have properties that promote angiogenesis and metastasis, leading to the failure of conventional therapies. This study explores the effects of blocking the C-C chemokine receptor type 4 (CCR4) in pancreatic cancer-bearing mice through genetic or immunotherapeutic methods. The results show that CCR4 is critical for TAM generation and tumor progression in pancreatic cancer, and blockade of CCR4 may improve prognosis and extend the relapse-free period after curative surgery.
Article
Medicine, General & Internal
Bruno Leonardo Bancke Laverde, Matthias Maak, Melanie Langheinrich, Stephan Kersting, Axel Denz, Christian Krautz, Georg F. Weber, Robert Gruetzmann, Maximilian Brunner
Summary: The aim of this study was to identify risk factors for conversion from laparoscopic to open appendectomy in cases of acute appendicitis. The study found that a higher preoperative WBC count, presence of intraoperative perforation, necrosis or gangrene, perityphlitic abscess and peritonitis were all independent risk factors for conversion. Conversion was also associated with higher morbidity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Bruno Leonardo Bancke Laverde, Matthias Maak, Melanie Langheinrich, Stephan Kersting, Axel Denz, Christian Krautz, Georg F. Weber, Robert Grutzmann, Maximilian Brunner
Summary: This study investigated the impact of intraoperative swab during appendectomy on the postoperative outcome in patients with uncomplicated and complicated appendicitis. The results showed that a positive swab was significantly associated with worse postoperative outcomes and was an independent risk factor for postoperative morbidity and the need for adjustment of postoperative antibiotic therapy. However, the frequency of antibiotic regime changes based on the swab analysis was low.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Meeting Abstract
Oncology
Britta Buchhold, Stine Lutze, Jennis Freyer-Adam, Michael Juenger, Claudia Nordt, Sebastian Peters, Stephan Kersting
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Meeting Abstract
Oncology
Melanie C. Langheinrich, Stefan Wirtz, Barbara Kneis, Klaus Weber, Maximilian Brunner, Christian Krautz, Jonel Trebicka, Abbas Agaimy, Robert Gruetzmann, Stephan Kersting
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Article
Gastroenterology & Hepatology
Maximilian Brunner, Alaa Zu'bi, Klaus Weber, Axel Denz, Melanie Langheinrich, Stephan Kersting, Georg F. Weber, Robert Gruetzmann, Christian Krautz
Summary: This study compared the use of single-stapling technique (SST) and double-stapling technique (DST) in minimally invasive rectal anastomosis and found that using SST is associated with a lower rate of anastomotic complications, including leakage and stenosis. This suggests that SST may be an effective technique for reducing anastomotic complications.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)