Article
Oncology
Myroslav Lutsyk, Tarek Taha, Salem Billan
Summary: The aim of this study is to identify factors that may predict the response of locally advanced rectal cancer tumors to neoadjuvant chemoradiotherapy. The study found that an absolute decrease in the level of circulating lymphocytes is associated with poorer tumor response to treatment, and may serve as a predictive biomarker for treatment resistance.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Albert Grinshpun, Anatoli Kustanovich, Daniel Neiman, Roni Lehmann-Werman, Aviad Zick, Karen Meir, Elez Vainer, Roy Z. Granit, Amit Arad, Noa Daskal, Ruth Schwartz, Eli Sapir, Myriam Maoz, Esther Tahover, Joshua Moss, Iddo Z. Ben-Dov, Tamar Peretz, Ayala Hubert, Ruth Shemer, Yuval Dor
Summary: The standard treatment approach for stage II/III rectal cancer is neoadjuvant chemoradiation therapy followed by surgery. However, better tools are still needed to personalize therapy for the individual patient. In this study, the researchers analyzed colon-derived cell-free DNA using a tissue-specific DNA methylation signature and found that it can predict treatment outcomes and help guide patient selection strategies.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Reem Mislati, Taylor P. Uccello, Zixi Lin, Katia T. Iliza, Kimani C. Toussaint, Scott A. Gerber, Marvin M. Doyley
Summary: This study found that shear wave elastography can provide valuable insights into tumor response to radiation therapy, helping distinguish radiation-responsive from radiation-non-responsive tumors and shedding light on changes in the tumor microenvironment that may affect radiation response.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jaeseung Shin, Nieun Seo, Song-Ee Baek, Nak-Hoon Son, Joon Seok Lim, Nam Kyu Kim, Woong Sub Koom, Sungwon Kim
Summary: This study evaluated radiomics models based on T2-weighted imaging and diffusion-weighted MRI for predicting pCR after nCRT in LARC and compared their performance with visual assessment by radiologists. The results showed that the MRI-based radiomics model had better classification performance than experienced radiologists for diagnosing pathologic complete response in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy.
Article
Oncology
Bum-Sup Jang, Yu Jin Lim, Changhoon Song, Seung Hyuck Jeon, Keun-Wook Lee, Sung-Bum Kang, Yoon Jin Lee, Jae-Sung Kim
Summary: A deep learning model based on post-chemoradiotherapy T2-weighted axial MR images showed acceptable performance in predicting pathological complete response (pCR) or good response (GR) in patients with rectal cancer, compared with human observers. The model had a superior predictive performance than the observers, with fair agreement between the ground truth and the model for pCR and GR prediction.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Francesco Caputo, Chiara Santini, Andrea Casadei-Gardini, Krisida Cerma, Camilla Bardasi, Ingrid Garajova, Elisabetta Lattanzi, Alessandro Passardi, Ilario Giovanni Rapposelli, Andrea Spallanzani, Massimiliano Salati, Luca Reggiani Bonetti, Roberta Gelmini, Bruno Meduri, Micaela Piccoli, Annarita Pecchi, Stefania Benatti, Federico Piacentini, Massimo Dominici, Gabriele Luppi, Fabio Gelsomino
Summary: The study found that concurrent use of statins in patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiation was associated with better tumor regression, despite increased chemoradiation-related toxicity.
Article
Oncology
Yanpeng Yang, Hao Xu, Guowei Chen, Yisheng Pan
Summary: Accumulated studies have shown that tumor regression is related to prognosis in rectal cancer. The study aimed to evaluate the impact of pathologic response on the survival of stage II and III rectal cancer patients after neoadjuvant chemoradiotherapy. It was found that pathologic response had a significant impact on the prognosis of stage III patients, especially in association with factors like early chemotherapy, surgical margin, and tumor differentiation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Darlene Rodrigues, Joana Simoes, Laetitia Teixeira, Fatima Aires, Catarina Fernandes, Carmen Rey, Cristina Sarmento, Margarida Marques
Summary: The study revealed a high prevalence of anemia among elderly rectal cancer patients, with baseline anemia associated with shorter LARC-free interval and significantly higher risks of mortality. Patients over 75 years old had a negative impact on overall survival and LARC-specific survival. No significant impact was found for age-adjusted Charlson comorbidity index on survival outcomes.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Yohan Lee, Sunghyun Kim, Hyejung Cha, Jae Hun Han, Hyun Joon Choi, Eun Go, Sei Hwan You
Summary: This study demonstrates the feasibility and potential therapeutic effects of using 13.56 MHz modulated electro-hyperthermia (mEHT) boost in neoadjuvant treatment for rectal cancer. It also suggests that mEHT could be a useful tool in combination treatment with radiotherapy due to its low thermotoxicity and improved treatment compliance.
Article
Biochemical Research Methods
Yixiao Lin, Sitai Kou, Haolin Nie, Hongbo Luo, Ahmed Eltahir, Will Chapman Jr, Steven Hunt, Mathew Mutch, Quing Zhu
Summary: A deep learning model combining ultrasound and photoacoustic imaging has been developed to accurately identify complete responders after rectal cancer preoperative treatment, improving clinical care for patients.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Oncology
Pritam Tayshetye, Andrew J. Friday, Ashten N. Omstead, Tanvi Verma, Stacey Miller, Ping Zheng, Prashant Jani, Ali Zaidi, Gene Finley
Summary: Localized rectal cancer is currently managed with neoadjuvant therapy before surgery, and immunotherapy has entered the treatment paradigm for advanced rectal cancer. Clinical trials incorporating immunotherapy in the neoadjuvant settings are underway, and better understanding of the tumor microenvironment and specific biomarkers is needed. This study analyzes changes in the tumor microenvironment following neoadjuvant chemoradiation and suggests that upregulated biomarkers could be used for clinical trials and targeted drug development.
Article
Radiology, Nuclear Medicine & Medical Imaging
Toru Tochigi, Sophia C. Kamran, Anushri Parakh, Yoshifumi Noda, Balaji Ganeshan, Lawrence S. Blaszkowsky, David P. Ryan, Jill N. Allen, David L. Berger, Jennifer Y. Wo, Theodore S. Hong, Avinash Kambadakone
Summary: This study assessed the use of CT-based fractal dimension and texture analysis in predicting the therapeutic response to nCRT in patients with locally advanced rectal cancer. The research found that fractal dimension was a significant parameter for predicting the efficacy of nCRT.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giuditta Chiloiro, Davide Cusumano, Paola de Franco, Jacopo Lenkowicz, Luca Boldrini, Davide Carano, Brunella Barbaro, Barbara Corvari, Nicola Dinapoli, Martina Giraffa, Elisa Meldolesi, Riccardo Manfredi, Vincenzo Valentini, Maria Antonietta Gambacorta
Summary: The study found that radiomics analysis performed well in identifying complete responders, and when combined with standard clinical evaluation, it improved the prediction of clinical response. The increase in performance was not statistically significant, but showed potential for enhancing predictive capabilities.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiandong Leng, K. M. Shihab Uddin, William Chapman, Hongbo Luo, Sitai Kou, Eghbal Amidi, Guang Yang, Deyali Chatterjee, Anup Shetty, Steve Hunt, Matthew Mutch, Quing Zhu
Summary: The study reported the development of an imaging system comprising an endorectal coregistered photoacoustic/US system and convolutional neural network for assessing rectal cancer treatment response. The PAM CNN model showed unique imaging markers in differentiating changes in tumor treatment response and demonstrated high diagnostic performance.
Article
Oncology
Georg Emons, Noam Auslander, Peter Jo, Julia Kitz, Azadeh Azizian, Yue Hu, Clemens F. Hess, Claus Roedel, Ulrich Sax, Gabriela Salinas, Philipp Stroebel, Frank Kramer, Tim Beissbarth, Marian Grade, Michael Ghadimi, Eytan Ruppin, Thomas Ried, Jochen Gaedcke
Summary: A gene-expression based classifier was developed to identify over 1/3 of rectal cancer patients with a pathological complete response (pCR), while ensuring no non-complete-responders were misclassified. The classifier's performance was validated in three independent datasets, suggesting it could help select patients for a watch and wait strategy.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Sang-Hyuk Jung, Jie Hao, Manu Shivakumar, Yonghyun Nam, Jaesik Kim, Min Jung Kim, Seung-Bum Ryoo, Eun Kyung Choe, Seung-Yong Jeong, Kyu Joo Park, Sung Chan Park, Dae Kyung Sohn, Jae Hwan Oh, Hong-Hee Won, Dokyoon Kim, Ji Won Park
Summary: A new prognostic index, named the Prognostic Immune and Nutritional Index (PINI), has been developed in this study, which shows improved discriminatory power in colon cancer patients and appears to be superior to existing prognostic inflammatory markers.
BRITISH JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Han-Ki Lim, Minjung Kim, Ji Won Park, Seung-Bum Ryoo, Kyu Joo Park, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Jai Young Cho, Dong-Woon Lee, Sung Chan Park, Jae Hwan Oh, Aesun Shin, Seung-Yong Jeong
Summary: This study aimed to compare the short- and long-term outcomes of simultaneous laparoscopic, hybrid, and open resection for colorectal cancer and synchronous liver metastases. The results showed that simultaneous laparoscopic resection can be performed safely with enhanced postoperative recovery and comparable long-term outcomes compared to hybrid and open resection.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Myoung-Hyun Song, Ji Won Park, Min Jung Kim, Young-Kyoung Shin, Soon-Chan Kim, Seung-Yong Jeong, Ku Ja-Luk
Summary: Organoid culture technique is a crucial ex-vivo model for studying intratumoral heterogeneity and optimizing therapeutic strategies for individual patients.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Jeong-ki Kim, Ye-Young Rhee, Jeong Mo Bae, Jung Ho Kim, Seong-Joon Koh, Hyun Jung Lee, Jong Pil Im, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park, Ji Won Park, Gyeong Hoon Kang
Summary: The optimal tumor budding cut-off number for estimating LN metastasis in submucosal CRC was determined and a composite scoring system (CSS) was developed.
Article
Oncology
Tung Hoang, Min Jung Kim, Ji Won Park, Seung-Yong Jeong, Jeeyoo Lee, Aesun Shin
Summary: This study aimed to investigate the association between diet and the overall diversity and different taxa levels of the gut microbiota in colorectal cancer patients. The results showed correlations between dietary intake and the relative abundance and enrichment of gut microbial taxa. High intake of seaweed was associated with lower relative abundance of certain bacteria, while overall beverage consumption was associated with higher relative abundance of certain bacteria.
Article
Genetics & Heredity
Nahyun Jeong, Soon-Chan Kim, Ji Won Park, Seul Gi Park, Ki-Hoan Nam, Ja Oh Lee, Young-Kyoung Shin, Jeong Mo Bae, Seung-Yong Jeong, Min Jung Kim, Ja-Lok Ku
Summary: This study presents a unique case of synchronous intestinal cancer (SIC) with tumors occurring along the entire bowel tract. Through extensive genomic, transcriptomic, and epigenomic sequencing, the researchers identified distinct clonal associations across different organs and consistent responses to various therapeutic compounds. The results highlight the limitations of single tumor-based diagnosis and emphasize the need for an in-depth molecular analysis of all tumor regions to prevent resistance to targeted therapies.
NPJ GENOMIC MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Seung Mi Lee, Manu Shivakumar, Ji Won Park, Young Mi Jung, Eun Kyung Choe, Soo Heon Kwak, Sohee Oh, Joong Shin Park, Jong Kwan Jun, Dokyoon Kim, Jae-Seung Yun
Summary: This study found that gestational diabetes mellitus (GDM) is associated with an increased risk of cardiovascular outcomes in elderly women, including coronary artery disease, myocardial infarction, and ischemic stroke. Additionally, overt diabetes, hypertension, and dyslipidemia partially explained the relationship between GDM and overall cardiovascular outcome.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Oncology
Saule Khamzina, Jongoh Lee, Seung-Bum Ryoo, Min Jung Kim, Ji Won Park, Hyun-Cheol Kang, Eui Kyu Chie, Dae-Won Lee, Sae-Won Han, Tae-You Kim, Seung-Yong Jeong, Kyu Joo Park
Summary: The interval between neoadjuvant chemoradiotherapy (nCRT) and surgery has been debated for its impact on oncological outcomes and postoperative complications. This study found that performing surgery >8 weeks after nCRT can increase tumor regression, but it does not significantly affect oncological outcomes and postoperative complications compared to surgery conducted at 6-8 weeks after nCRT.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Toxicology
J. -W. Park, Y. Heo, W. -S. Cho
TOXICOLOGY LETTERS
(2022)
Article
Surgery
Jung Wook Suh, Heung-Kwon Oh, Jeehye Lee, In Jun Yang, Hong-min Ahn, Duck-Woo Kim, Sung-Bum Kang, Rumi Shin, Seung Chul Heo, Dong Woon Lee, Sung-Chan Park, Dae Kyung Sohn, Jae Hwan Oh, Min Jung Kim, Ji Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park, Seoul Colorectal Res Grp SECOG
Summary: In obstructive left-sided colorectal cancer, the time interval between self-expanding metallic stenting (SEMS) and radical surgery does not significantly impact short- and long-term outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Meeting Abstract
Oncology
Dae-Won Lee, Sae-Won Han, Yoojoo Lim, Hwang-Phill Kim, Hanseong Roh, Min Jung Kim, Seung-Bum Ryoo, Ji Won Park, Seung-Yong Jeong, Kyu Joo Park, Gyeong Hoon Kang, Tae-You Kim
Meeting Abstract
Oncology
Dae-Won Lee, Sae-Won Han, Yoojoo Lim, Hwang-Phill Kim, Hanseong Roh, Min Jung Kim, Seung-Bum Ryoo, Ji Won Park, Seung-Yong Jeong, Kyu Joo Park, Gyeong Hoon Kang, Tae-You Kim
Meeting Abstract
Oncology
Tung Hoang, Mm Jung Kim, Ji Won Park, Seung-Yong Jeong, Jeeyoo Lee, Aesun Shin
Article
Oncology
Soo Jin Park, Eun Ji Lee, Aeran Seol, Sunwoo Park, Jiyeon Ham, Ga Won Yim, Seung-Hyuk Shim, Whasun Lim, Suk-Joon Chang, Gwonhwa Song, Ji Won Park, Hee Seung Kim
Summary: Using paclitaxel and cisplatin in a novel prototype of rotational intraperitoneal pressurized aerosol chemotherapy (RIPAC) in a pig model showed higher tissue concentrations and lower serum concentrations. Paclitaxel had a longer absorption time into the bloodstream compared to cisplatin, with higher tissue-to-serum concentration ratios. No renal and hepatic toxicities were observed after RIPAC.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Surgery
Roxane D. Staiger, Fabian Roessler, Min Jung Kim, Carl Brown, Loris Trenti, Takeshi Sasaki, Deniz Uluk, Juan P. Campana, Massimo Giacca, Boris Schiltz, Renu R. Bahadoer, Kai-Yin Lee, Bruna E. C. Kupper, Katherine Y. Hu, Francesco Corcione, Steven R. Paredes, Sebastiano Spampati, Kristjan Ukegjini, Bartlomiej Jedrzejczak, Daniel Langer, Aine Stakelum, Ji Won Park, P. Terry Phang, Sebastiano Biondo, Masaaki Ito, Felix Aigner, Carlos A. Vaccaro, Yves Panis, Alex Kartheuser, K. C. M. J. Peeters, Ker-Kan Tan, Samuel Aguiar, Kirk Ludwig, Umberto Bracale, Christopher J. Young, Adam Dziki, Miroslav Ryska, Des C. Winter, John T. Jenkins, Robin H. Kennedy, Pierre-Alain Clavien, Milo A. Puhan, Matthias Turina
Summary: Benchmark comparisons in colorectal cancer surgery can identify gaps in care quality, helping improve patient outcomes.
BRITISH JOURNAL OF SURGERY
(2022)