Article
Biochemistry & Molecular Biology
Nerea Ugartondo, Nuria Martinez-Gil, Monica Esteve, Natalia Garcia-Giralt, Neus Roca-Ayats, Diana Ovejero, Xavier Nogues, Adolfo Diez-Perez, Raquel Rabionet, Daniel Grinberg, Susanna Balcells
Summary: Osteoporosis, a common metabolic bone disorder, is often treated with nitrogen-containing bisphosphonates. Prolonged use of bisphosphonates may lead to rare atypical femoral fractures, possibly due to rare mutations in the CYP1A1 gene.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
SeokJoon Hwang, Minsu Seo, Dongin Lim, Min Suk Choi, Jin-Woo Park, Kiyeun Nam
Summary: This literature review investigated the characteristics and management of bisphosphonate-associated bilateral atypical femoral fractures (AFFs). A comprehensive analysis of 43 patients with bilateral AFFs revealed that 67% had prodromal symptoms, 49% occurred simultaneously, and 51% occurred sequentially. X-ray was used for initial diagnosis, with 53% having complete fractures. Surgical treatment was performed for all patients, except for those with incomplete fractures who received either surgical or medical treatments. Teriparatide was the most commonly used medication after bisphosphonate discontinuation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Dennis M. Black, Katherine Condra, Annette L. Adams, Richard Eastell
Summary: Bisphosphonate use is associated with an increased risk of atypical femur fractures (AFFs), but it significantly reduces the risk of hip fractures and osteoporosis. The risk of AFFs varies between Asians and Caucasians, potentially due to differences in femoral geometry.
Article
Endocrinology & Metabolism
J. Everts-Graber, S. Reichenbach, B. Gahl, H. R. Ziswiler, U. Studer, T. Lehmann
Summary: Patients who received zoledronate after denosumab discontinuation had fewer vertebral fractures, while all subsequent therapies were able to maintain bone mineral density to some extent. Factors such as age, BMI, treatment duration, prior therapy, and BMD gains during denosumab treatment influenced bone mineral density loss, while bone turnover markers correlated with total hip bone loss and treatment duration.
Article
Endocrinology & Metabolism
Gareth Crouch, Nitesh D. Dhanekula, Karen Byth, Emma Burn, Sue Lynn Lau, Lillias Nairn, Liza Nery, Jean Doyle, Edward Graham, Andrew Ellis, Roderick J. Clifton-Bligh, Christian M. Girgis
Summary: The Sydney AFF score, based on demographic and femoral geometry variables, provides a quantitative means of identifying female patients with atypical femur fractures. In an independent validation set at a different center in Sydney, a score ≥ 2 demonstrated 73.3% sensitivity and 69.6% specificity for AFF.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Medicine, Research & Experimental
Faisal I. Almohaileb, Zafar Rasheed
Summary: This systematic review compared the efficacies of bisphosphonates therapies for patient persistence and compliance in the treatment of osteoporosis. The analysis showed that alendronate therapy had the highest patient persistence, while etidronate therapy had the highest patient compliance.
CURRENT MOLECULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ambika Gupta, Mu Lin, Finlay A. McAlister, Carrie Ye
Summary: Prior adherence to statins predicts subsequent short-term and long-term adherence and persistence with oral bisphosphonates, but not with parenteral osteoporosis therapies. Other factors associated with oral bisphosphonate adherence at 1 year include older age, history of bone mineral density scan, and history of pap smear.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Endocrinology & Metabolism
Ian R. Reid, Anne M. Horne, Borislav Mihov, Sonja Bastin, Gregory D. Gamble
Summary: Bisphosphonates are commonly used for osteoporosis prevention and treatment, while NSAIDs are widely used by older adults at high fracture risk. A study reanalyzed data from a clinical trial of zoledronate and found that NSAID use did not affect the bone density or fracture risk reduction effects of zoledronate. The study concluded that NSAIDs do not interfere with the efficacy of potent bisphosphonates in terms of bone density or fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Medicine, General & Internal
YuLong Ouyang, ShuiLin Chen, Ting Wan, GuiHao Zheng, GuiCai Sun
Summary: The study found that teriparatide was more effective than bisphosphonates in preventing fractures in postmenopausal women with osteoporosis, including vertebral and non-vertebral fractures, with similar rates of adverse effects. More high-quality studies are needed to compare other factors such as costs and adverse reactions.
Review
Endocrinology & Metabolism
Wei Zhou, Jeroen G. J. van Rooij, Peter R. Ebeling, Annemieke J. M. H. Verkerk, M. Carola Zillikens
Summary: Recent studies suggest that atypical femur fractures (AFFs) may be associated with genetic components, with possible genetic variants identified in relation to AFF. Further research is needed to confirm these findings and explore additional gene variants involved in the pathogenesis of AFFs.
CURRENT OSTEOPOROSIS REPORTS
(2021)
Article
Environmental Sciences
Bastien Bourrion, Cecile Souty, Lucie Fournier, Ana-Maria Vilcu, Thierry Blanchon, Pierre-Yves Boelle, Thomas Hanslik, Mathilde Francois
Summary: The study found that in real life, the use of bisphosphonates does not appear to reduce hospitalization rates for hip fractures, possibly due to it being prescribed for primary prevention and for a duration too short to be effective.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Medicine, General & Internal
Kaleen N. Hayes, Elizabeth M. Winter, Suzanne M. Cadarette, Andrea M. Burden
Summary: Bisphosphonates are the primary treatment for osteoporosis, and a drug holiday of two to three years is recommended for most patients after long-term use to reduce the risk of adverse events. Duration of bisphosphonate effects during the drug holiday and individual patient factors should be considered when determining the appropriate time to stop therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Jordan S. Cohen, Amil R. Agarwal, Matthew J. Kinnard, Savyasachi C. Thakkar, Gregory J. Golladay
Summary: The study aimed to evaluate the impact of antiosteoporotic medical therapy on the risk of periprosthetic fractures (PPFs) following hip arthroplasty for femoral neck fractures in older adults. Patients who initiated antiosteoporotic therapy within 1 year of surgery had a lower incidence of PPFs compared to those who did not receive treatment.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Endocrinology & Metabolism
Jeremy Keng Meng Goh, Joyce Suang Bee Koh, Alvin Choong Meng Ng, Meng Ai Png, Tet Sen Howe
Summary: This case report presents a patient who developed bilateral atypical femur fractures after receiving denosumab treatment, despite having no prior history of bisphosphonate use. The patient's symptoms resolved with conservative management, but radiographic abnormalities persisted.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: Bone mineral density (BMD) loss shows greater variability at shorter testing intervals, but this variability diminishes over longer intervals. Using reports of rapid BMD loss as an indication for antifracture medication initiation may not be accurate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Christoph Ohlmeier, Holger Gothe, Judith Haas, Ulrike Osowski, Carina Weinhold, Sarah Blauwitz, Niklas Schmedt, Wolfgang Galetzka, Fabian Berkemeier, Bjoern Tackenberg, Martin Stangel
Article
Clinical Neurology
Jens Bohlken, Steffi Riedel-Heller, Holger Gothe, Karel Kostev
Summary: This study investigated almost a thousand general practitioner offices to determine the target population for dementia prevention, focusing on common diagnoses like hypertension, diabetes, and depression. The results showed that patients with hypertension, diabetes, and depression were treated most frequently, while patients with obesity and hearing loss were treated less frequently. By identifying specific diagnoses, a manageable group of patients eligible for dementia preventive interventions can be identified.
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
(2021)
Article
Genetics & Heredity
Markus Magerl, Holger Gothe, Simon Krupka, Anja Lachmann, Christoph Ohlmeier
ORPHANET JOURNAL OF RARE DISEASES
(2020)
Correction
Genetics & Heredity
Markus Magerl, Holger Gothe, Simon Krupka, Anja Lachmann, Christoph Ohlmeier
Summary: An amendment has been published for this paper and can be accessed through the original article.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Editorial Material
Public, Environmental & Occupational Health
Enno Swart, Holger Gothe, Peter Ihle
Article
Public, Environmental & Occupational Health
Holger Gothe, Peter Ihle, Enno Swart
Summary: Data are crucial for health services research, serving as both material and product. They play a significant role as a substrate or starting point for health-related analyses, and are essential for the assessment, control, and development of services in the health care system. The meaning of the term data, particularly secondary data, is often overlooked in scientific research work that utilizes this raw material.
Article
Public, Environmental & Occupational Health
Enno Swart, Holger Gothe, Falk Hoffmann, Peter Ihle, Sebastian Claudius Semler, Stefanie March
Summary: This article aims to support the establishment and development of a research health data centre by laying the foundation for a future information and data platform, following established standards and regulations, and providing various data on the health care system in the short term.
Editorial Material
Public, Environmental & Occupational Health
Enno Swart, Holger Gothe, Peter Ihle
Correction
Public, Environmental & Occupational Health
Enno Swart, Holger Gothe, Falk Hoffmann, Peter Ihle, Sebastian Claudius Semler, Stefanie March
Article
Health Care Sciences & Services
Felicitas Kuehne, Marjan Arvandi, Lisa M. Hess, Douglas E. Faries, Raffaella Matteucci Gothe, Holger Gothe, Julie Beyrer, Alain Gustave Zeimet, Igor Stojkov, Nikolai Muehlberger, Willi Oberaigner, Christian Marth, Uwe Siebert
Summary: This study systematically assessed potential biases in analyzing real-world data using the case of progressive ovarian cancer. The importance of thorough causal design and analysis for RWD to emulate clinical trial results was demonstrated.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
E. Hradetzky, C. Ohlmeier, C. Brinkmann, M. Schild, W. Galetzka, N. Schmedt, T. John, D. Kaleth, H. Gothe
Summary: This study analyzes German claims data from the InGef Research Database over a 6-year period to estimate the prevalence of musculoskeletal diseases such as chronic low back pain (CLBP) and hip/knee osteoarthritis (OA) in Germany, as well as the applied treatment patterns. The study reveals that CLBP and hip/knee OA are common chronic pain conditions in Germany, often managed with pharmacological interventions.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2022)
Article
Public, Environmental & Occupational Health
H. Gothe, C. Brinkmann, N. Schmedt, J. Walker, C. Ohlmeier
Summary: This study aims to characterize palliative care patients in Germany and estimate the incidence, prevalence, and 1-year all-cause mortality. The study found that the incidence rate of palliative conditions was 41.3 and 34.9 per 10,000 persons in women and men, respectively. The prevalence per 10,000 persons was 61.3 in women and 51.1 in men. The 1-year all-cause mortality among patients receiving their first palliative care treatment was 67.5%.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2022)
Meeting Abstract
Economics
M. Schild, V Weber, W. Galetzka, D. Enders, F. S. Zuegel, H. Gothe
Article
Public, Environmental & Occupational Health
Jurgen Stausberg, Birga Maier, Kurt Bestehorn, Holger Gothe, Oliver Groene, Christian Jacke, Martina Janicke, Tanja Kostuj, Tim Mathes, Anna Niemeyer, Kerstin Olbrich, Jochen Schmitt, Edmund Neugebauer
Article
Public, Environmental & Occupational Health
Holger Gothe, Raffaella Matteucci Gothe, Marjan Arvandi, Katharina Hintringer, Thomas Toell, Willi Oberaigner, Sasa Rajsic, Joachim Kugler, Stefan Kiechl, Johann Willeit, Uwe Siebert