Article
Microbiology
Aline Barth, Mohammad Hossain, Darin B. Brimhall, Caroline R. Perry, Courtney A. Tiffany, Sherry Xu, Etienne F. Dumont
Summary: Gepotidacin is a promising novel antibiotic for antibiotic-resistant pathogens. Pharmacokinetic evaluations showed that its mesylate salt tablet formulation had good characteristics and was effective in both adults and adolescents. Safety profiles were similar between the two age groups.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Rajendra P. Singh, Kimberly K. Adkison, Mark Baker, Ridhi Parasrampuria, Allen Wolstenholme, Mark Davies, Nicola Sewell, Cindy Brothers, Ann M. Buchanan
Summary: This article outlines the development of pediatric formulations of dolutegravir and evaluates their relative bioavailability through pharmacokinetic studies. The results show that dolutegravir administered as dispersion has higher bioavailability compared to conventional tablets. These studies demonstrate the successful development of pediatric dolutegravir-containing formulations that align with WHO recommendations.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Michael Tagen, Linda E. Klumpers, Alexey Peshkovsky
Summary: The use of Delta(8)-THC has increased recently, and nanoemulsions are found to be a better delivery vehicle. A study on rats showed that nanoemulsions, despite different droplet sizes, had similar pharmacokinetics to MCT oil, but had faster absorption and higher exposure.
Review
Pharmacology & Pharmacy
Ines Garcia Del Valle, Carmen Alvarez-Lorenzo
Summary: Atropine, an old-known drug, has gained increasing attention for its therapeutic effects on eye structures. When administered topically, attention should be paid to atropine ocular pharmacokinetics and its ability to access the posterior segment. There is an urgent need to design formulations that can selectively deliver atropine to the target tissue for each specific application.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Pharmacology & Pharmacy
Benjamin A. Kuzma, Sharareh Senemar, Tannaz Ramezanli, Priyanka Ghosh, Sam G. Raney, Grazia Stagni
Summary: This study investigates the effect of dose-duration on dermal exposure of metronidazole-containing drug products and characterizes metronidazole dermal elimination using a retrodialysis/microdialysis approach. The results suggest that truncating dose-duration can reduce experimental duration, but careful selection of dose-duration is necessary to discriminate between formulations.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Marcelo Gomes Davanco, Jessica Meulman, Thalita Martins da Silva, Fernando Costa, Karini Bruno Bellorio, Iram Moreira Mundim, Ana Carolina Costa Sampaio, Leonardo de Souza Teixeira, Celso Francisco Pimentel Vespasiano
Summary: This study aimed to evaluate the bioequivalence between two methylphenidate extended-release tablets and found that the test formulation was considered bioequivalent to the reference formulation in both fasting and fed conditions. Both formulations were safe and well tolerated.
Article
Biochemistry & Molecular Biology
Haruna Kanae, Koji Teshima, Tamotsu Shiroma, Kazuo Noguchi
Summary: The pharmacokinetics of novel curcumin formulations mixed with squalene and docosahexaenoic acid were studied and compared to a standardized curcumin extract and a solid lipid curcumin particle. The fish oil formulations, squalene mixed with curcumin and docosahexaenoic acid mixed with curcumin, significantly improved curcumin absorption compared to the standardized extract. The docosahexaenoic acid formulation was bioequivalent or superior to the solid lipid curcumin particle. No gender differences were observed in curcumin absorption.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Manoli Vourvahis, Wonkyung Byon, Cheng Chang, Vu Le, Annette Diehl, Daniela Graham, Sakambari Tripathy, Nancy Raha, Lina Luo, Sumathy Mathialagan, Martin Dowty, A. David Rodrigues, Bimal Malhotra
Summary: Abrocitinib has the potential to inhibit certain drug transporters, leading to increased plasma exposure of certain medications when co-administered. However, not all drug transporters are affected by abrocitinib.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Tim Becker, Anna K. Krome, Sahel Vahdati, Andrea Schiefer, Kenneth Pfarr, Alexandra Ehrens, Tilman Aden, Miriam Grosse, Rolf Jansen, Silke Alt, Thomas Hesterkamp, Marc Stadler, Marc P. Huebner, Stefan Kehraus, Gabriele M. Koenig, Achim Hoerauf, Karl G. Wagner
Summary: The in vivo studies in mice are a valuable model for testing new drug ingredients, but the lack of preclinical in vitro evaluations of drug formulations in mice is a gap in research. The development of novel in vitro and in silico models has supported the evaluation of the anti-infective drug CorA. The study found that the solubility of CorA in mice was lower compared to human-specific media, and the solubility was limited by the formulation. The pharmacokinetic studies in mice correlated with the in vitro dissolution prediction and ruled out intestinal efflux transport.
Article
Veterinary Sciences
Antonia Sanchez de Medina, Juan Manuel Serrano-Rodriguez, Elisa Diez de Castro, Maria Teresa Garcia-Valverde, Aritz Saitua, Mireia Becero, Ana Munoz, Carlos Ferreiro-Vera, Veronica Sanchez de Medina
Summary: The study investigated the pharmacokinetics and oral bioavailability of cannabidiol (CBD) in horses, and simulated different treatment regimens. The results showed that CBD had a high volume of distribution, high clearance, and long half-lives in horses. Oral bioavailability was low but within the range described for horses and other species. The micellar formulation showed faster absorption and higher concentration peak, while the oil formulation had lower levels but a more sustained effect. These findings suggest that CBD could be of interest in horse medicine, but further studies are needed to evaluate its clinical use.
EQUINE VETERINARY JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Benjamin A. Kuzma, Sharareh Senemar, Tannaz Ramezanli, Priyanka Ghosh, Sam G. Raney, Grazia Stagni
Summary: Dermal microdialysis (dMD) can accurately measure the availability of a topically administered active pharmaceutical ingredient (API) in the dermis. The study aimed to assess the dMD methodology in terms of sensitivity, discriminative ability, and reproducibility, showing that it is selective, sensitive, and stable over a 48-hour period.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Clinical Neurology
Thomas W. Lategan, Laurene Wang, Tiffany N. Sprague, Franck S. Rousseau
Summary: The study confirmed the bioequivalence between two Bafiertam(TM) capsules and one Tecfidera(R) capsule, both of which were found to be safe and generally well tolerated.
Article
Pharmacology & Pharmacy
Lydia de Salazar, Ignacio Segarra, Francisco Javier Lopez-Roman, Antonio Torregrosa-Garcia, Silvia Perez-Pinero, Vicente Avila-Gandia
Summary: The novel controlled-release powder blend shows 100% higher bioavailability of beta-alanine, opening a new paradigm that shifts from chronic to short or mid-term supplementation strategies to increase carnosine stores in sports nutrition.
Article
Pharmacology & Pharmacy
Halley Gora Ravuri, Nana Satake, Alexandra Balmanno, Jazmine Skinner, Samantha Kempster, Paul C. Mills
Summary: This study evaluated the pharmacokinetic parameters of ketoprofen after intravenous and transdermal administration in healthy dogs. The results showed that transdermal administration of ketoprofen in dogs had a longer elimination half-life, higher AUC, and longer residence time compared to intravenous administration. It took 30 minutes to reach effective plasma concentrations after transdermal application.
Article
Food Science & Technology
Mangala Hegde, Aviral Kumar, Sosmitha Girisa, Babu Santha Aswani, Ravichandran Vishwa, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Cancer is a complex disease with diverse characteristics and treatment responses. Overcoming the recurrence and resistance to therapy, as well as minimizing side effects, is crucial for improving the quality of life in cancer patients. This review explores the potential benefits of nanocurcumin, a nanotechnology-based formulation of the natural compound curcumin, in cancer treatment. Various types of curcumin nanoformulations are discussed, along with their anticancer activities and cellular mechanisms. The review also highlights the potential of nanocurcumin as a preventive or adjuvant therapy with conventional drugs.