Article
Pharmacology & Pharmacy
Amelia Rodriguez, Irene Garcia-Garcia, Lucia Martinez de Soto, Arturo Gomez Lopez De Las Huertas, Alberto M. Borobia, Andrea Gonzalez-Torbay, Ibtissam Akatbach-Bousaid, Miguel Gonzalez-Munoz, Elena Ramirez
Summary: The lymphocyte transformation test (LTT) can be used as an add-on tool to strengthen the assessment of causality in suspected idiosyncratic drug-induced liver injury (DILI). It is especially useful for patients with multiple suspected drugs and a hepatocellular phenotype.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ling Ye, Zeying Feng, Longjian Huang, Chengjun Guo, Xiong Wu, Li He, Wei Tan, Yi Wang, Xuehong Wu, Biwen Hu, Tong Li, Guoping Yang, Guo Chengxian, Qingnan He
Summary: This study identified drugs associated with Drug-induced liver injury (DILI) in neonates and children in China through the Pediatric Intensive Care database (PIC). It found that medium and long chain fat emulsions, sodium glycerophosphate, omeprazole, and methylprednisolone sodium succinate were primary culprits of DILI in newborns and children. Attention should be paid to drug combinations that may affect CYP enzyme metabolism when treating patients with DILI.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Dongqin Sun, Zhenzhen Chen, Jiali Hu, Huajin Zeng, Lingbo Qu, Ran Yang
Summary: Drug-induced liver injury (DILI) is commonly diagnosed using the RUCAM method, while fluorescent probes have shown great advantages in detecting DILI markers. Understanding the design and practical application of these probes will contribute to the further development of detection sensors for DILI markers.
CHINESE CHEMICAL LETTERS
(2022)
Article
Pharmacology & Pharmacy
Xiaoping Shi, Chengchun Zuo, Lingling Yu, Donghui Lao, Xiaoyu Li, Qing Xu, Qianzhou Lv
Summary: The study investigated the incidence, characteristics, and risk factors of tigecycline-associated drug-induced liver injury (DILI), revealing a slightly higher incidence in patients with high maintenance dose, prolonged regimen, and concomitant use of multiple hepatotoxic drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Marlene Pluess, Desiree Tampe, Harald Schwoerer, Sebastian Christopher Benjamin Bremer, Bjoern Tampe
Summary: Potassium para-aminobenzoate (POTABA) is used to treat Peyronie's disease by reducing fibrosis and plaque size progression. However, there have been reports of drug-induced liver injury (DILI) caused by POTABA, possibly due to immune hypersensitivity. This study investigated clinical, biochemical, and serological features, and used the Roussel Uclaf Causality Assessment Method (RUCAM) to confirm that POTABA is highly likely to cause liver injury. Additionally, activated CD3(+) T lymphocytes were observed during the acute phase of liver injury, and the improvement of liver injury after POTABA withdrawal was associated with a decline in CD3(+) HLA-DR+ immune cells. These findings suggest that activated T lymphocytes play a specific role in POTABA-induced liver injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
JunSeok Kim, WooSeok Jang
Summary: This study retrospectively investigated the safety of simultaneous use of herbal medicines and conventional medicines in stroke patients receiving polypharmacy. The results showed that herbal medicines were safe for stroke patients taking multiple conventional medicines, but consulting an herbal medicine expert is crucial to avoid adverse effects.
Review
Medicine, General & Internal
Rolf Teschke, Gaby Danan
Summary: Causality assessment in drug and herb-induced liver injury remains a debated issue, with RUCAM being an effective and widely-used diagnostic algorithm due to its quantitative features and specific data elements. Studies show that RUCAM outperforms other methods in assessing causality in liver injury cases.
Article
Biochemistry & Molecular Biology
Barbara Kramar, Tinkara Pirc Marolt, Maria Monsalve, Dusan Suput, Irina Milisav
Summary: The study reveals that aripiprazole, in contrast to olanzapine, can protect liver cells against oxidative stress, which could be crucial for schizophrenia patients with high-oxidative-stress-risk lifestyles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Rolf Teschke, Noudeng Vongdala, Nguyen Van Quan, Tran Ngoc Quy, Tran Dang Xuan
Summary: Saturated and unsaturated pyrrolizidine alkaloids are present in over 6000 plant species worldwide, with most plants containing non-toxic saturated PAs. However, consumption of plants with unsaturated PAs could potentially lead to severe liver injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Rolf Teschke, Nahum Mendez-Sanchez, Axel Eickhoff
Summary: This systematic review found that drug-induced liver injury (DILI) is common in COVID-19 patients, especially due to the use of antiviral drugs. Most patients have a favorable outcome, but there are also fatal cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Jia-Bo Wang, Ang Huang, Yijin Wang, Dong Ji, Qing-Sheng Liang, Jun Zhao, Guangde Zhou, Shuhong Liu, Ming Niu, Ying Sun, Hui Tian, Guang-Ju Teng, Bin-Xia Chang, Jing-Feng Bi, Xiao-Xia Peng, Shaojie Xin, Huan Xie, Xiong Ma, Yi-Min Mao, Suthat Liangpunsakul, Romil Saxena, Guruprasad P. Aithal, Xiao-He Xiao, Jingmin Zhao, Zhengsheng Zou
Summary: This study provides clinical evidence that corticosteroid plus glycyrrhizin therapy for chronic drug-induced or herb-induced liver injury can achieve both biochemical response and histological improvements with good safety.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cell Biology
Can Tu, Ziying Xu, Lichun Tian, Zihui Yu, Tieshang Wang, Zhaojuan Guo, Jingxuan Zhang, Ting Wang
Summary: Recent studies have shown that dictamnine induces dose-dependent hepatotoxicity in mice, impairing lipid metabolism and exacerbating oxidative stress.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Maw Ho, Chi-Ling Chen, Chia-Hao Chang, Meng-Rui Lee, Jann-Yuan Wang, Rey-Heng Hu, Po-Huang Lee
Summary: IL-22 binding protein (IL-22BP) was found to be a protective biomarker against the development of drug-induced liver injury (DILI) in tuberculosis patients, while additional risk factors like IP-10 and sCD163 proved to be effective in predicting the occurrence of DILI.
Article
Biochemistry & Molecular Biology
Zhi-Tao Ma, Zhuo Shi, Xiao-He Xiao, Jia-Bo Wang
Summary: Herbs are widely used worldwide, but inappropriate use can cause herb-induced liver injury (HILI). HILI incidents are increasing and our understanding of the underlying causes is still progressing, making it appropriate to update the current status and understanding of HILI incidents.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Pharmacology & Pharmacy
Laura Pedraza, Olga Laosa, Leocadio Rodriguez-Manas, Diego F. Gutierrez-Romero, Jesus Frias, Jose Antonio Carnicero, Elena Ramirez
Summary: A prospective evaluation of drug-induced liver injury (DILI) in elderly patients over 65 years old showed a higher-than-expected incidence rate, with risk factors including polypharmacy, specific drug use, and patient age.
FRONTIERS IN PHARMACOLOGY
(2021)
