Journal
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
Volume 19, Issue 4, Pages 622-628Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s10147-013-0593-y
Keywords
Hepatocellular carcinoma; Aurora B; Prognostic factor
Categories
Funding
- Japan Society for the Promotion of Science [20390359, 22591506, 22659233, 22659243]
- Cancer Research Project involving cooperation by TAIHO Pharmaceutical Co.
- University of Tokushima
- Grants-in-Aid for Scientific Research [22659233, 20390359, 22591506, 22659243] Funding Source: KAKEN
Ask authors/readers for more resources
Aurora B is a serine-threonine kinase and chromosomal passenger protein involved in the control of chromosome assembly and segregation during mitosis. Aberrant expression of Aurora B has been reported in some tumors, including lung and hepatocellular carcinoma (HCC). We investigated the role of Aurora B expression in both HCC and matched adjacent non-tumor tissue. Sixty-three patients with HCC who underwent hepatic resection were enrolled in this study. Aurora B expression in tumor and non-tumor tissue was examined by use of quantitative reverse transcription-polymerase chain reaction. The patients were divided into high and low gene expression groups by median value, and clinicopathological data were compared between the two groups. Aurora B expression was significantly higher in tumor tissue than in non-cancerous tissue (P < 0.001). Disease-free survival was not significantly different between groups with high and low expression in the tumor tissues. For non-tumor tissues, disease-free survival of the low-expression group was significantly better than that of the high-expression group (P < 0.05). The gene expression level of Aurora B correlated with results from liver function tests, for example prothrombin time. Aurora B expression in non-cancerous tissues may be a prognostic factor for HCC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available