Article
Oncology
Aline Van der Vorst, Isabelle Kindts, Annouschka Laenen, Patrick Neven, Hilde Janssen, Caroline Weltens
Summary: This study validated a scoring system based on 4 prognostic factors for locoregional recurrence (LRR) in order to identify breast cancer patients who would benefit from post-mastectomy radiotherapy (PMRT). Further validation by other independent institutions is recommended before applying this scoring system in clinical practice.
Article
Oncology
Chunyan Li, Jiangfeng Wang, Miao Mo, Jing Yuan, Jurui Luo, Kairui Jin, Xuanyi Wang, Yilan Yang, Jinli Ma, Xin Mei, Zhaozhi Yang, Xiaoli Yu, Xiaomao Guo, Xingxing Chen
Summary: This study suggests that adjuvant postmastectomy radiotherapy (PMRT) may reduce the risk of locoregional recurrence in pT3N0M0 breast cancer patients, but does not impact breast cancer-specific survival. Patients with family history, TNBC subtype, LVI positivity, or grade 3 disease are more likely to experience locoregional recurrence.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Xiangdi Meng, Nan Wang, Peiyan Qin, Qingyu Jia, Zhuojun Ju, Yingxiao Jiang
Summary: This study aimed to identify the patients who would benefit from postmastectomy radiotherapy (PMRT) using a novel risk stratification model. The results showed that PMRT improved overall survival (OS) in young patients in the high-risk group and OS and breast-cancer-specific survival (BCSS) in elderly patients in the high-risk group. However, PMRT did not improve OS and BCSS in the low-risk group.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Lina Zhang, Mengli Zhou, Yueping Liu, Furong Du, Jiyu Tang, Ning Wang, Chao Song, Cuizhi Geng, Huijun Duan
Summary: This study retrospectively analyzed the clinical data of 213 pT1-2N1M0 breast cancer patients and found that high-risk patients, especially those not receiving PMRT, had a significantly increased risk of recurrence and metastasis, leading to worse survival rates compared to low-risk patients. PMRT did not show benefits for low-risk patients, but demonstrated survival benefits for high-risk patients in terms of local-regional recurrence-free interval, distance recurrence-free interval, and overall survival rates.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Lina Zhang, Tiantian Tang, Lei Liu, Chunxiao Li, Yuntao Li, Cuizhi Geng
Summary: This study aimed to investigate the association between tumor-infiltrating lymphocytes (TILs) and the efficacy of postoperative radiotherapy in breast cancer patients. The results showed that patients with low TILs infiltration benefited significantly from postoperative radiotherapy in terms of overall survival, while those with high TILs infiltration did not.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Sung Uk Lee, Kwan Ho Cho, Jin Ho Kim, Young Seok Kim, Taek-Keun Nam, Jae-Sung Kim, Jaeho Cho, Seo Hee Choi, Su Jung Shim, Jin Hee Kim, Ah Ram Chang
Summary: SRT for locoregional CR after RP can achieve favorable outcomes with acceptable long-term toxicities. Higher Gleason's scores and pre-radiotherapy PSA level are unfavorable prognostic variables. Combined ADT may decrease the risks of metastases.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Oncology
Dong-Yun Kim, Eonju Park, Chan Yeong Heo, Ung Sik Jin, Eun Kyu Kim, Wonshik Han, Kyung Hwan Shin, In Ah Kim
Summary: This study aimed to compare breast-related complications between hypofractionated adjuvant postmastectomy radiation therapy (PMRT) and conventional fractionated radiation therapy (RT) in patients with breast cancer undergoing reconstruction. The results showed that there was no significant difference in major breast complications between the two fractionation regimens. Hypofractionated RT did not increase the occurrence of major wound problems, and significantly reduced major contracture.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Rinat Bernstein-Molho, Yael Laitman, Shira Galper, Galia Jacobson, Ben Boursi, Einav Nili Gal-Yam, Bella Kaufman, Eitan Friedman, Orit Kaidar-Person
Summary: This study found that BRCA1/2 mutation carriers with breast cancer who did not receive postmastectomy radiation therapy had higher rates of ipsilateral breast tumor recurrence. Despite earlier disease stages, their recurrence rates were higher compared to those who received postmastectomy radiation therapy or breast-conserving treatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Review
Health Care Sciences & Services
Carlo Ronsini, Irene Iavarone, Antonella Reino, Maria Giovanna Vastarella, Pasquale De Franciscis, Angelo Sangiovanni, Luigi Della Corte
Summary: Radiation therapy (RT) is the standard treatment for patients with locoregional or isolated vaginal recurrence who have not previously received radiation. It is often combined with brachytherapy (BT), while chemotherapy (CT) is rarely used. A systematic review was conducted and a total of 15 studies met the inclusion criteria. The results showed varying rates of disease-free survival (DFS), overall survival (OS), recurrence rate (RR), and major complications for RT and CT.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Oncology
Sonja Murchison, Pauline Truong
Summary: Neoadjuvant chemotherapy is increasingly used in breast cancer patients to achieve disease downstaging and assess chemosensitivity, leading to evolving impact on subsequent locoregional treatment decisions. Despite challenges, the focus remains on improving survival, minimizing toxicity, and optimizing function and cosmesis while awaiting prospective data.
EXPERT REVIEW OF ANTICANCER THERAPY
(2021)
Article
Multidisciplinary Sciences
Lin-Yu Xia, Wei-Yun Xu, Yan Zhao
Summary: The study aimed to investigate the survival outcomes of T1-2N1M0 TNBC patients who underwent PMRT or not, using data from the SEER database. Results showed that radiotherapy significantly improved BCSS in patients with three positive lymph nodes, but did not provide significant advantage in those with one or two positive lymph nodes. Additionally, PMRT was beneficial for TNBC patients with T2 tumors and three positive lymph nodes in terms of BCSS.
Article
Multidisciplinary Sciences
Lin-Yu Xia, Wei-Yun Xu, Yan Zhao
Summary: The study shows that TNBC patients with T2 tumor concomitant with three positive lymph nodes can benefit from PMRT.
Review
Oncology
Claudia A. Bargon, Danny A. Young-Afat, Mehmet Ikinci, Assa Braakenburg, Hinne A. Rakhorst, Marc A. M. Mureau, Helena M. Verkooijen, Annemiek Doeksen
Summary: The oncological safety of different types and timings of postmastectomy breast reconstruction (PMBR) remains controversial. This study found that delayed autologous PMBR leads to similar (loco)regional recurrence rates as immediate autologous PMBR. Current evidence suggests that oncological concerns should not be a reason to withhold patients from certain reconstructive timings or techniques, and patients should be offered all technically qualified reconstructive options equally.
Article
Multidisciplinary Sciences
Priyanka Narayan, Jessica Flynn, Zhigang Zhang, Erin F. Gillespie, Boris Mueller, Amy J. Xu, John Cuaron, Beryl McCormick, Atif J. Khan, Oren Cahlon, Simon N. Powell, Hannah Wen, Lior Z. Braunstein
Summary: This study explored the association between perineural invasion (PNI) and locoregional recurrence (LRR) in breast cancer patients, finding that PNI significantly increases the risk of LRR. Multivariable Fine-Gray regression modeling confirmed the potentiated association between PNI and LRR. Propensity score matching analysis further supported the significant link between PNI and LRR.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Michail Sorotos, Guido Paolini, Gennaro D'Orsi, Guido Firmani, Floyd Wilhelmus Timmermans, Fabio Santanelli di Pompeo
Summary: This study analyzed the impact of autologous fat transfer on local recurrence in breast reconstruction surgery. The results showed that autologous fat transfer did not increase the risk of local recurrences. Invasive ductal carcinoma subtype and lymph node metastases were found to have an increased risk of local recurrences, while positive hormonal receptor status was associated with a reduced risk.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)