Journal
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
Volume 13, Issue 3, Pages 206-211Publisher
SPRINGER TOKYO
DOI: 10.1007/s10147-008-0786-y
Keywords
CYP2A6; thymidylate synthase; dihydropyrimidine dehydrogenase; thymidine phosphorylase; orotate phosphoribosyltransferase; pharmacogenetics
Categories
Ask authors/readers for more resources
S-1 has been considered to be a key drug in the treatment of advanced gastric cancer in Japan as a standard option of chemotherapy. Interindividual variation in the enzymes of the S-1 metabolic pathway can affect the extent of S-1 metabolism and impact the efficacy of S-1-based chemotherapy. In this review, the role of the candidate genetic factors affecting the therapeutic efficacy of S-1 is discussed with a special emphasis on polymorphism and gene expressions involved in the S-1 metabolic pathway, including CYP2A6, thymidylate synthase, thymidine phosphorylase, and orotate phosphoribosyltransferase. The predictive values of these candidates might be overcome with drugs combined with S-1. Pharmacogenetic studies based on a global approach by DNA microarray are promising to identify gastric cancer patients with both survival benefit and clinical benefit more accurately than those based on the candidate approach, especially for S-1 combination therapy. Large and controlled studies are needed to justify changes in the chemotherapeutic strategies, from one-size fits all to tailor-made.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available