Article
Engineering, Biomedical
Wenjiao Lin, Hongjie Zhang, Wanqian Zhang, Haiping Qi, Gui Zhang, Jie Qian, Xin Li, Li Qin, Haifeng Li, Xiang Wang, Hong Qiu, Xiaoli Shi, Wei Zheng, Deyuan Zhang, Runlin Gao, Jiandong Ding
Summary: The study proposed a semi-quantitative approach based on optical coherence tomography images to measure the degradation of a new generation coronary stent, which was consistent with current weight-loss measurements. The experiment demonstrated that the iron degradation rate of the new scaffold in the rabbit model was much faster than in the porcine model.
BIOACTIVE MATERIALS
(2021)
Article
Cardiac & Cardiovascular Systems
Josep Gomez-Lara, Loreto Oyarzabal, Luis Ortega-Paz, Salvatore Brugaletta, Rafael Romaguera, Neus Salvatella, Gerard Roura, Fernando Rivero, Lara Fuentes, Fernando Alfonso, Imanol Otaegui, Bert Vandeloo, Beatriz Vaquerizo, Manel Sabate, Josep Comin-Colet, Joan-Antoni Gomez-Hospital
Summary: This study investigated the impact of different stents on endothelial function, finding variations in vasomotor responses and neointimal healing between devices, but no significant differences in endothelial dysfunction issues.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Omar Abdul-Jawad Altisent, Luis Renier Goncalves-Ramirez, Leticia Fernandez, David Vilades, Enrique Gutierrez, Satoru Mitomo, Azeem Latib, Juan Gabriel Cordoba-Soriano, Raquel Adelino, Ignacio Amat-Santos, Juan Francisco Munoz, Jaime Elizaga, Hiram Bezzera, Gabriel Tensol Rodrigues Pereira, Armando Perez de Prado, Xavier Carrillo, Eduard Fernandez-Nofrerias, Victoria Vilalta, Oriol Rodriguez-Leor, Cinta Llibre, Edgar Fadeuilhe, Aaron Trujillo, Josepa Mauri, Jose M. de la Torre Hernandez, Antoni Bayes-Genis, Rishi Puri
Summary: This study systematically categorized the long-term structural and functional characteristics of the ABSORB bioresorbable vascular scaffold (BVS) using optical coherence tomography imaging and coronary vasomotor reactivity testing and compared them with remote coronary segments. The results showed that after more than 3 years post-ABSORB BVS insertion, the rate of complete scaffold resorption was low and residual strut presence was high, with a dominant fibrous healing response contributing toward neointimal hyperplasia and endothelium-dependent and-independent vasomotor dysfunction.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Hyung Oh Kim, Bo Jiang, Eric K. W. Poon, Vikas Thondapu, Chong-Jin Kim, Osamu Kurihara, Makoto Araki, Akihiro Nakajima, Chris Mamon, Jouke Dijkstra, Hang Lee, Andrew Ooi, Peter Barlis, Ik-Kyung Jang
Summary: This study investigated the evolution of hemodynamic parameters at the plaque erosion site in conservatively treated patients. The results showed that the erosion site had higher values of endothelial shear stress (ESS) and ESS gradient (ESSG), which persisted up to 12 months.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Engineering, Biomedical
Wanling Liu, Junyang Huang, Shicheng He, Ruolin Du, Wen Shi, Yang Wang, Dingyuan Du, Yan Du, Qing Liu, Yazhou Wang, Guixue Wang, Tieying Yin
Summary: This study investigates the impact of aged arteries on in-stent restenosis (ISR) after the implantation of bioresorbable scaffolds (BRS) in Sprague-Dawley rats. Results show that aged abdominal aortas exhibit significant scaffold degradation and deformation, leading to larger lumen loss and ISR. Additionally, early thrombosis, inflammation, and delayed re-endothelialization are observed in aged arteries. A better understanding of the relationship between BRS and senescent cells can provide guidance for age-related scaffold design.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Allan John R. Barcena, Joy Vanessa D. Perez, Marvin R. Bernardino, Jossana A. Damasco, Andrea Cortes, Huckie C. Del Mundo, Erin Marie D. San Valentin, Carleigh Klusman, Gino Martin Canlas, Francisco M. Heralde III, Rony Avritscher, Natalie Fowlkes, Richard R. Bouchard, Jizhong Cheng, Steven Y. Huang, Marites P. Melancon
Summary: Bioresorbable perivascular scaffolds loaded with antiproliferative agents can enhance arteriovenous fistula maturation by inhibiting neointimal hyperplasia. In this study, an electrospun perivascular scaffold from polycaprolactone was fabricated to support mesenchymal stem cell attachment and elution at the AVF's outflow vein. The addition of MSCs promotes greater luminal expansion and potentially reduces the inflammatory process underlying NIH, supporting AVF maturation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Tom Adriaenssens, Marc P. Allard-Ratick, Vikas Thondapu, Tomoyo Sugiyama, O. Christopher Raffel, Peter Barlis, Eric K. W. Poon, Makoto Araki, Akihiro Nakajima, Yoshiyasu Minami, Masamichi Takano, Osamu Kurihara, Valentin Fuster, Tsunekazu Kakuta, Ik-Kyung Jang
Summary: The development of optical coherence tomography (OCT) technology has significantly impacted our understanding of coronary artery disease by revealing unique mechanisms of plaque growth and stability through the study of different hemodynamic factors. Recent research has introduced a new concept of plaque healing, changing the way we perceive coronary artery disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
D. Chen, R. Gadeley, A. Wang, N. Jepson
Summary: This case report presents a rare but potentially lethal complication of coronary artery perforation during PCI with Absorb BVS implantation. The report highlights the technical challenges associated with managing this life-threatening complication.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Engineering, Biomedical
Yu Shi Lau, Li Kuo Tan, Chow Khuen Chan, Kok Han Chee, Yih Miin Liew
Summary: This paper proposes a deep learning framework for automated segmentation of stents, showing performance comparable to independent human observers and feasibility for both metal stents and bioresorbable vascular scaffolds. The combination of cropped input and architectures like MobileNetV2 and DenseNet121 in U-Net has improved speed and accuracy.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Luis Renier Goncalves-Ramirez, Ignacio J. Amat-Santos, Omar Abdul-Jawad Altisent, Hipolito Gutierrez, Armando Perez de Prado, Raquel Adelino, Itziar Gomez, Felipe Fernandez-Vazquez, Alberto San Roman, Rishi Puri
Summary: This study followed up patients treated with ABSORB-BVS for 5 years and found that while the absorbed scaffolds demonstrated complete structural healing, there were impaired vasomotor responses in the treated segments.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Chemistry, Analytical
Yuqian Zhao, Zhibo Zhu, Huiwen Jiang, Yao Yu, Jian Liu, Jingmin Luan, Yi Wang, Zhenhe Ma
Summary: This article proposes a novel method for measuring the stress phase angle (SPA) using spectral domain optical coherence tomography (SD-OCT). The method is validated by measuring SPA in the outflow tract (OFT) of chick embryonic hearts and the common carotid artery of mice. This is the first time that OCT has been used for SPA measurement.
Article
Cardiac & Cardiovascular Systems
Runlin Gao, Bo Xu, Zhongwei Sun, Changdong Guan, Lei Song, Lijian Gao, Chongjian Li, Jingang Cui, Yin Zhang, Kefei Dou, Jue Chen, Chaowei Mu, Haibo Liu, Ang Li, Zihao Li, Lihua Xie, Yuejin Yang, Shubin Qiao, Yongjian Wu, Gregg W. Stone
Summary: This study assessed the safety and performance of a novel ultrathin bioresorbable scaffold in treating non-complex coronary lesions, and found it to be safe and effective up to 3-year follow-up.
Article
Cardiac & Cardiovascular Systems
Trine O. Barkholt, Omeed Neghabat, Emil N. Holck, Lene N. Andreasen, Evald H. Christiansen, Niels R. Holm
Summary: Implanting a magnesium scaffold using the provisional technique in nontrue bifurcation lesions was associated with scaffold fracture, embolization of scaffold fragments, and a high need for bailout stenting.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Biochemical Research Methods
Shan Ling, Brecken J. Blackburn, Michael W. Jenkins, Michiko Watanabe, Stephanie M. Ford, Maryse Lapierre-Landry, Andrew M. Rollins
Summary: Optical coherence tomography (OCT) is used to investigate heart development and can image both structure and function. An automatic image-processing pipeline was developed to segment beating embryonic heart structures from a 4-D OCT dataset, reducing segmentation time and labor. This method allows for cohort studies to quantify complex cardiac motion and function.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Cardiac & Cardiovascular Systems
Chongying Jin, Ryo Torii, Anantharaman Ramasamy, Vincenzo Tufaro, Callum D. Little, Klio Konstantinou, Yi Ying Tan, Nathan A. L. Yap, Jackie Cooper, Tom Crake, Constantinos O'Mahony, Roby Rakhit, Mohaned Egred, Javed Ahmed, Grigoris Karamasis, Lorenz Raeber, Andreas Baumbach, Anthony Mathur, Christos V. Bourantas
Summary: This study revealed significant morphological and physiological differences between culprit ruptured plaques in native and stented segments, highlighting the need for further research to better understand the causes of these differences and the mechanisms regulating neoatherosclerotic lesion destabilization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Craig M. Jarrett, Marc Pelletier, Yasir Abu-Omar, Cristian Baeza, Yakov Elgudin, Alan Markowitz, Pablo Ruda Vega, Ovidiu Dressler, Arie Pieter Kappetein, Patrick W. Serruys, Gregg W. Stone, Joseph F. Sabik
Summary: The study compared the outcomes of coronary artery bypass grafting (CABG) with endoscopic vein harvest (EVH) vs open vein harvest (OVH). The patients with different vein harvesting methods had different rates of ischemia-driven revascularization at 5 years. No significant differences were found in other endpoints, such as graft stenosis or occlusion, death, stroke, myocardial infarction, bleeding, blood product transfusion, major arrhythmia, and infection.
ANNALS OF THORACIC SURGERY
(2023)
Letter
Cardiac & Cardiovascular Systems
Hesham Elzomor, Hendrik Wienemann, Tanja K. Rudolph, Matti Adam, Osama Soliman, Ashok Seth, Martin B. Leon, Hans R. Figulla, Patrick W. Serruys
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Review
Clinical Neurology
Christos S. Katsouras, Michail I. Papafaklis, Sotirios Giannopoulos, Theodoros Karapanayiotides, Georgios Tsivgoulis, Lampros K. Michalis
Summary: Numerous observational studies have shown a decline in cerebro-/cardiovascular admissions during the early phase of the COVID-19 pandemic, but recent studies suggest that the overall decrease is smaller than initially reported. The main cause of this decline is believed to be collateral damage from the COVID-19 outbreak, including the effects of imposed measures such as social distancing and self-isolation. However, there may also be a smaller true decline in CV events due to a lack of triggers associated with acute syndromes. It is important to prepare healthcare systems for a potential increase in CV hospitalizations in the future.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Murat Cap, Ryo Torii, Yoshinobu Onuma, Rob Krams, Martin R. Bennett, Peter H. Stone, Patrick W. Serruys, Christos V. Bourantas
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Laust Dupont Rasmussen, Simon Winther, Salma Raghad Karim, Jelmer Westra, Jane Kirk Johansen, Hanne Maare Sondergaard, Osama Hammid, Emelyne Sevestre, Yoshinobu Onuma, Mette Nyegaard, June Anita Ejlersen, Evald Christiansen, Ashkan Eftekhari, Niels Ramsing Holm, Samuel Emil Schmidt, Morten Bottcher
Summary: Objective Validation studies found that 35%-40% of patients with coronary artery disease have low pretest probability and acoustic detection could potentially improve clinical likelihood stratification. The aims were to investigate the diagnostic performance of an acoustic-based CAD score and study the reclassification potential of a dual likelihood strategy.
Letter
Cardiac & Cardiovascular Systems
Shigetaka Kageyama, Yoshinobu Onuma, Scot Garg, Patrick W. Serruys
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Health Care Sciences & Services
Paraskevi Zotou, Aris Bechlioulis, Spyridon Tsiouris, Katerina K. Naka, Xanthi Xourgia, Konstantinos Pappas, Lampros Lakkas, Aidonis Rammos, John Kalef-Ezra, Lampros K. Michalis, Andreas Fotopoulos
Summary: Myocardial perfusion imaging via single-photon emission computed tomography (SPECT MPI) is a well-established method for diagnosing coronary artery disease (CAD). However, the role of SPECT MPI in predicting major cardiovascular events remains uncertain. In this study, the presence of extensive perfusion defects in SPECT MPI was found to be independently associated with mortality at 1 year in high-risk patients with suspected stable CAD.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Mahmoud Abdelshafy, Patrick W. Serruys, Tsung-Ying Tsai, Pruthvi Chenniganahosahalli Revaiah, Scot Garg, Jean-Paul Aben, Carl J. Schultz, Mohammad Abdelghani, Pim A. L. Tonino, Yosuke Miyazaki, Marcel C. M. Rutten, Martijn Cox, Cherif Sahyoun, Justin Teng, Hiroki Tateishi, Mohamed Abdel-Wahab, Nicolo Piazza, Michele Pighi, Rodrigo Modolo, Martijn van Mourik, Joanna Wykrzykowska, Robbert J. de Winter, Pedro A. Lemos, Fabio S. de Brito Jr, Hideyuki Kawashima, Lars Sondergaard, Liesbeth Rosseel, Rutao Wang, Chao Gao, Ling Tao, Andreas Rueck, Won-Keun Kim, Niels van Royen, Christian J. Terkelsen, Henrik Nissen, Matti Adam, Tanja K. Rudolph, Hendrik Wienemann, Ryo Torii, Franz Josef Neuman, Simon Schoechlin, Mao Chen, Ahmed Elkoumy, Hesham Elzomor, Ignacio J. Amat-Santos, Darren Mylotte, Osama Soliman, Yoshinobu Onuma
Summary: Paravalvular leak (PVL) is a drawback in transcatheter valve replacement (TAVR), and a readily applicable method to accurately quantify PVL (aortography) is appealing to operators. The regurgitation fraction (RF) is determined by the ratio between the time-density curves in the aorta and left ventricular outflow tract (LVOT-AR). This technique has been validated in mock circulation and tested in animal models, and compared with echocardiography and cardiac magnetic resonance imaging in clinical settings.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Dan Nguyen, Nobuhiro Ikemura, Khaja Chinnakondepalli, Elizabeth Magnuson, Adam Christopher Salisbury, Patrick W. Serruys, David J. Cohen, Suzanne Arnold
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Pruthvi Chenniganahosahalli Revaiah, Asishkumar Mandalay, Gunasekaran Sengottuvelu, Ahmed Elkoumy, Hesham Elzomor, Mahmoud Abdelshafy, Sanjeev Bhatt, Yoshinobu Onuma, Osama Soliman, Patrick W. Serruys
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Nozomi Kotoku, Daixin Ding, Kai Ninomiya, Neil O' Leary, William Wijns, Shengxian Tu, Nicolo Piazza, Yoshinobu Onuma, Patrick W. Serruys
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kai Ninomiya, Patrick Serruys, Shinichiro Masuda, Jiayue Huang, Ding Daixin, Nozomi Kotoku, Shigetaka Kageyama, Manish Doshi, William Wijns, Shengxian Tu, Faisal Sharif, Bernardo Cortese, Sandeep Basavarajaiah, Bernhard Reimers, Antonio Colombo, Yoshinobu Onuma
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Bo Wang, Randall Lee, Yoshinobu Onuma, Patrick W. J. C. Serruys, Ling Tao
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick W. Serruys, Nozomi Kotoku, Bjarne L. Norgaard, Scot Garg, Koen Nieman, Marc R. Dweck, Jeroen J. Bax, Juhani Knuuti, Jagat Narula, Divaka Perera, Charles A. Taylor, Jonathon A. Leipsic, Edward D. Nicol, Nicolo Piazza, Carl J. Schultz, Kakuya Kitagawa, Bernard De Bruyne, Carlos Collet, Kaoru Tanaka, Saima Mushtaq, Marta Belmonte, Darius Dudek, Adriana Zlahoda-Huzior, Shengxian Tu, William Wijns, Faisal Sharif, Matthew J. Budoff, Johan de Mey, Daniele Andreini, Yoshinobu Onuma
Summary: Coronary computed tomographic angiography (CCTA) has become the preferred investigation for determining the presence and haemodynamic significance of coronary artery disease. It can rule out atherosclerosis or detect subclinical plaque in patients without significant epicardial obstruction, and provide risk classification. For ischaemic non-obstructive coronary arteries, non-invasive imaging, including CCTA, is also expected. In patients with significant epicardial obstruction, CCTA can assist in planning revascularisation by determining disease complexity, vessel size, lesion length, tissue composition of the atherosclerotic plaque, and the best fluoroscopic viewing angle.
Article
Biochemistry & Molecular Biology
Anila Duni, Marta Greco, Pierangela Presta, Roberta Arena, Ethymios Pappas, Lampros Lakkas, Katerina K. Naka, Antonio Brunetti, Daniela Patrizia Foti, Michele Andreucci, Giuseppe Coppolino, Evangelia Dounousi, Davide Bolignano
Summary: Patients undergoing chronic hemodialysis (HD) are at high risk of cardiovascular (CV) events, but risk prediction in this population is challenging. Recent research has shown that circulating miRNA 122-5p is related to the onset and progression of CV disease. This study found that HD patients had lower levels of circulating miRNA 122-5p compared to healthy controls. ALT, E/e', and CRP were identified as independent predictors of miRNA 122-5p levels. Additionally, higher baseline levels of circulating miRNA 122-5p predicted a significantly increased risk of composite endpoint occurrence in HD patients.
