Article
Cardiac & Cardiovascular Systems
Charlene A. Mauger, Sachin Govil, Radomir Chabiniok, Kathleen Gilbert, Sanjeet Hegde, Tarique Hussain, Andrew D. McCulloch, Christopher J. Occleshaw, Jeffrey Omens, James C. Perry, Kuberan Pushparajah, Avan Suinesiaputra, Liang Zhong, Alistair A. Young
Summary: The study quantified the relationships between biventricular morphology and wall motion with pulmonary regurgitation in rTOF patients. Regional RV dilation, LV reduction, LV septal-lateral flattening, and increased RV strain were all associated with increased PRV.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Cardiac & Cardiovascular Systems
Jenna Keelan, Nikhil Pasumarti, Sarah Crook, Grace Decost, Yan Wang, Matthew A. Crystal, Amee Shah, Emile Bacha, Laura Mercer-Rosa, Michael DiLorenzo
Summary: This study aimed to assess the mid-term trajectory of right ventricular global longitudinal strain (RV GLS) in patients with ductal-dependent tetralogy of Fallot (TOF). The results showed that RV GLS improved over time but remained worse compared to control subjects. There was no difference in RV GLS between different repair strategies, and a shorter intensive care unit length of stay after complete repair was associated with improved RV GLS trajectory.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Computer Science, Information Systems
Carlos Martin-Isla, Victor M. Campello, Cristian Izquierdo, Kaisar Kushibar, Carla Sendra-Balcells, Polyxeni Gkontra, Alireza Sojoudi, Mitchell J. Fulton, Tewodros Weldebirhan Arega, Kumaradevan Punithakumar, Lei Li, Xiaowu Sun, Yasmina Al Khalil, Di Liu, Sana Jabbar, Sandro Queiros, Francesco Galati, Moona Mazher, Zheyao Gao, Marcel Beetz, Lennart Tautz, Christoforos Galazis, Marta Varela, Markus Huellebrand, Vicente Grau, Xiahai Zhuang, Domenec Puig, Maria A. Zuluaga, Hassan Mohy-ud-Din, Dimitris Metaxas, Marcel Breeuwer, Rob J. van der Geest, Michelle Noga, Stephanie Bricq, Mark E. Rentschler, Andrea Guala, Steffen E. Petersen, Sergio Escalera, Jose F. Rodriguez Palomares, Karim Lekadir
Summary: In recent years, deep learning models have been proposed to accurately quantify and diagnose cardiac pathologies, but the segmentation of the right ventricle remains challenging. The M&Ms-2 challenge was organized to promote research on right ventricle segmentation in multi-disease, multi-view, and multi-center cardiac MRI. The solutions provided by the participants show that nnU-Net achieved the best overall results, but multi-view approaches were able to capture additional information, highlighting the need for integrating multiple factors for reliable automatic cardiac segmentation algorithms.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Cardiac & Cardiovascular Systems
Sachin Govil, Brendan T. Crabb, Yu Deng, Laura Dal Toso, Esther Puyol-Anton, Kuberan Pushparajah, Sanjeet Hegde, James C. Perry, Jeffrey H. Omens, Albert Hsiao, Alistair A. Young, Andrew D. McCulloch
Summary: Researchers have developed a fully automated pipeline for cardiac shape modeling using deep learning, which significantly reduces the manual input and time required. This approach enables the rapid analysis of large-scale datasets and has potential applications in clinical settings.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)
Article
Cardiac & Cardiovascular Systems
Jouke P. Bokma, Tal Geva, Lynn A. Sleeper, Ji Hae Lee, Minmin Lu, Tehila Sompolinsky, Sonya V. Babu-Narayan, Rachel M. Wald, Barbara J. M. Mulder, Anne Marie Valente
Summary: The study aimed to determine whether pulmonary valve replacement (PVR) is associated with improved survival and freedom from sustained ventricular tachycardia (VT) in patients with repaired tetralogy of Fallot (rTOF). The results showed that patients who received PVR had a lower risk of death or sustained VT compared to those who did not receive PVR.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Jiang, Yuan Li, Shan Huang, Pei-Lun Han, Wei-Feng Yan, Han Fang, Zhi-Gang Yang
Summary: In patients with repaired Tetralogy of Fallot, cardiac MRI showed that there was a gradual decrease in right ventricular, left ventricular, and septal strain. The correlation between left ventricular deformation and right ventricular function was strongest in patients with right ventricular heart failure.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Nuria Rivas-Gandara, Laura Dos-Subira, Jaume Francisco-Pascual, Julian Rodriguez-Garcia, Antonia Pijuan-Domenech, Begona Benito, Filipa Valente, Gabriel Pascual-Gonzalez, Alba Santos-Ortega, Berta Miranda, Jordi Perez-Rodon, Aida Ribera-Sole, Gemma Burcet-Rodriguez, Ferran Roses-Noguer, Blanca Gordon, Jose Rodriguez-Palomares, Ignacio Ferreira-Gonzalez
Summary: This study validates the feasibility of postprocessing RV LE-CMR images for characterizing the RV substrate in rTOF patients and confirms the technique against RV EAM, aiding in planning target ablation.
Article
Cardiac & Cardiovascular Systems
Heiner Latus, Jana Stammermann, Inga Voges, Birgit Waschulzik, Matthias Gutberlet, Gerhard-Paul Diller, Dietmar Schranz, Peter Ewert, Philipp Beerbaum, Titus Kuhne, Samir Sarikouch
Summary: The study aimed to evaluate the hemodynamic impact and prognostic relevance of right ventricular pressure load in patients with repaired tetralogy of Fallot. The results showed that higher right ventricular outflow tract (RVOT) gradients were associated with smaller right ventricular volumes and less pulmonary regurgitation, but lower biventricular longitudinal strain and increased risk of adverse events. Mild residual pressure gradients did not protect from pulmonary valve replacement.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
S. Buddhe, V Jani, S. Sarikouch, L. Gaur, A. Schuster, P. Beerbaum, M. Lewin, S. Kutty
Summary: This study aimed to compare VVCR between patients with repaired standard TOF and TOF-PA, finding a significantly higher VVCR in the TOF-PA group. VVCR showed association with NYHA class and may serve as an indicator of cardiovascular function in this cohort.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2021)
Review
Cardiac & Cardiovascular Systems
Ayah Elsayed, Kathleen Gilbert, Miriam Scadeng, Brett R. Cowan, Kuberan Pushparajah, Alistair A. Young
Summary: 4D flow CMR shows potential in assessing rTOF, particularly in retrospective valve tracking for flow evaluation, velocity profiling, intra-cardiac kinetic energy quantification, and vortex visualization. Protocols should be targeted to pathology. Prospective, randomized, multi-centered studies are required to validate these new characteristics and establish their clinical use.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Cardiac & Cardiovascular Systems
O. I. Woudstra, A. Ghanam, H. W. Vliegen, A. P. J. van Dijk, J. P. van Melle, M. Groenink, F. J. Meijboom, M. C. Post, B. J. M. Mulder, B. J. Bouma, J. P. Bokma
Summary: Aortic root dilatation is common in adults with repaired tetralogy of Fallot, with about one-third of patients affected. Larger left ventricular stroke volume is associated with both baseline aortic root size and ongoing growth. The study found no significant treatment effect of losartan.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Neurosciences
Sarah U. Morton, Lara Maleyeff, David Wypij, Hyuk Jin Yun, Caitlin K. Rollins, Christopher G. Watson, Jane W. Newburger, David C. Bellinger, Amy E. Roberts, Michael J. Rivkin, P. Ellen Grant, Kiho Im
Summary: The study found that in patients with tetralogy of Fallot, the similarity of right-hemispheric sulcal patterns to the control group was decreased, and was positively correlated with neuropsychological testing values including executive function. This suggests that sulcal pattern analysis may be a useful marker of neurodevelopmental risk in patients with congenital heart disease. Further research may help elucidate the mechanisms leading to different alterations in sulcal patterning.
Article
Environmental Sciences
Benedetta Leonardi, Camilla Calvieri, Marco Alfonso Perrone, Arianna Di Rocco, Adriano Carotti, Massimo Caputo, Aurelio Secinaro, Davide Curione, Maria Giulia Gagliardi, Paolo Guccione, Sonia Albanese, Lorenzo Galletti, Fabrizio Drago
Summary: This study evaluates risk factors associated with RV dilation and dysfunction in rToF patients, finding that male gender and surgical history significantly impact long-term outcomes and should be considered in follow-up management and PVR timing.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bjoern P. Schoennagel, Kai Muellerleile, Enver Tahir, Jitka Starekova, Regine Grosse, Jin Yamamura, Peter Bannas, Gerhard Adam, Roland Fischer
Summary: The study investigates the impact of TPM on diastolic function parameters by differentiating the time-volume curve and overcomes methodological artifacts by standardizing the inclusion of TPM into the myocardium. Inclusion of TPM into the myocardium allows precise assessment of diastolic measures and prediction of peak filling rate ratios and filling volume ratios by age. The introduction of a third phase (mid-diastole) and fitting of early and atrial peaks in the differentiated time-volume curve help to overcome standardization problems.
INSIGHTS INTO IMAGING
(2021)
Article
Pharmacology & Pharmacy
L. A. Ali, F. Gentili, P. Festa, M. A. Perrone, D. Curione, M. Caputo, R. Wald, A. Secinaro, A. Carotti, M. Chinali, C. Marrone, V Pak, D. Federici, M. G. Gagliardi, M. Bianco, L. Galletti, F. Drago, B. Leonardi
Summary: The study revealed that changes in right ventricular geometry and function in repaired Tetralogy of Fallot patients are minimal and slow, with only a small percentage experiencing significant worsening in a short period of time without identified risk factors. Arrhythmias appear to occur in a small percentage of cases in the late follow-up.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)