Article
Cardiac & Cardiovascular Systems
Rosangela A. Hoshi, Yanyan Liu, Heike Luttmann-Gibson, Saumya Tiwari, Franco Giulianini, Allen M. Andres, Jeramie D. Watrous, Nancy R. Cook, Karen H. Costenbader, Olivia Okereke, Paul M. Ridker, JoAnn E. Manson, I-Min Lee, Manickavasagar Vinayagamoorthy, Susan Cheng, Trisha Copeland, Mohit Jain, Daniel Chasman, Olga Demler, Samia Mora
Summary: This study identified a profile of bioactive lipids associated with physical activity, and 12 of these lipids were found to have opposite associations with incident cardiovascular disease events.
CIRCULATION RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Meng Sun, Rong Wang, Rui Xia, Zhengyuan Xia, Zhilin Wu, Tingting Wang
Summary: Mechanisms contributing to myocardial ischemia-reperfusion (I/R) injury are complex, but Dexmedetomidine (DEX) shows potential in ameliorating this injury in diabetic states. DEX activates the PI3K/Akt and associated GSK-3 beta pathway, alleviates endoplasmic reticulum stress, and inhibits apoptosis. Additionally, DEX up-regulates autophagy, reduces ROS production, and inhibits inflammation via HMGB1 pathways, leading to the protection against diabetic myocardial I/R injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Khoshkhouy, Alieh Farshbaf, Maryam Mahmoudabady, Zahra Gholamnezhad
Summary: Moderate exercise can improve the detrimental effects of lipopolysaccharide on cardiac tissue by attenuating proinflammatory cytokine levels, apoptosis, and oxidative damage to protect heart health.
Article
Biochemistry & Molecular Biology
Paulo H. C. Mesquita, Donald A. Lamb, Joshua S. Godwin, Shelby C. Osburn, Bradley A. Ruple, Johnathon H. Moore, Christopher G. Vann, Kevin W. Huggins, Andrew D. Fruge, Kaelin C. Young, Andreas N. Kavazis, Michael D. Roberts
Summary: The study found that 6 weeks of resistance training reduced oxidative damage and increased antioxidant enzyme activities in skeletal muscle of older adults. The responses of older adults to resistance training involve multi-level control (transcriptional, post-transcriptional, and post-translational) of the redox status of skeletal muscle.
Article
Biochemistry & Molecular Biology
Mari Carmen Gomez-Cabrera, Aitor Carretero, Fernando Millan-Domingo, Esther Garcia-Dominguez, Angela G. Correas, Gloria Olaso-Gonzalez, Jose Vina
Summary: This review highlights the major research findings and advancements in the field of exercise redox biology, as well as discusses the biomarkers for assessing health, performance, and recovery in the sport population during exercise training. The focus is on four categories of redox biomarkers and their methodological considerations.
Article
Plant Sciences
Yang Zhang, Shan Liu, Jiu-Long Ma, Chen Chen, Peng Huang, Jia-Hua Ji, Di Wu, Li-Qun Ren
Summary: Apocynum venetum L. leaf extract alleviates doxorubicin-induced cardiomyocyte apoptosis by suppressing oxidative stress and apoptosis through the AKT/Bcl-2 signaling pathway.
Article
Environmental Sciences
Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Gao
Summary: Cadmium, a highly toxic heavy metal pollutant, can induce mitochondrial dysfunction and endoplasmic reticulum stress (ERS) in a dose-dependent manner, leading to apoptosis in MC3T3-E1 cells. The PERK-EIF2 alpha-ATF4-CHOP signaling pathway is upregulated, while the Nrf2/NQO1 pathway is inhibited by Cd-induced oxidative stress. Moreover, NAC and 4-PBA can alleviate ERS and attenuate cell apoptosis caused by Cd.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Debora Melissa Petry Moecke, Gisele Henrique Cardoso Martins, Thaine Cristina Garlet, Kelly Cattelan Bonorino, Marilia Gabriela Luciani, Monique Bion, Barbara dos Santos, Monique da Silva Gevaerd, Jamil Assreuy Filho, Adair Roberto Soares dos Santos, Daniella Serafin Couto Vieira, Alcir Luiz Dafre, Deborah de Camargo Hizume Kunzler
Summary: The study found that aerobic exercise can improve lung function in CKD patients, reduce kidney damage, and enhance antioxidant defenses. Although aerobic exercise did not significantly affect pulmonary damage, it significantly improved physical performance in CKD patients.
Article
Cell Biology
Debora Melissa Petry Moecke, Gisele Henrique Cardoso Martins, Thaine Cristina Garlet, Kelly Cattelan Bonorino, Marilia Gabriela Luciani, Monique Bion, Barbara dos Santos, Monique da Silva Gevaerd, Jamil Assreuy Filho, Adair Roberto Soares dos Santos, Daniella Serafin Couto Vieira, Alcir Luiz Dafre, Deborah de Camargo Hizume Kunzler
Summary: The effects of aerobic exercise (AE) on lungs of chronic kidney disease (CKD) were investigated in this study. The results showed that AE improved kidney injury and enhanced antioxidant defenses in the lungs. However, there were no significant changes in pulmonary damage.
Review
Biochemistry & Molecular Biology
Abrar Alhebshi, Nehal Alsharif, Josh Thorley, Lewis J. James, Tom Clifford
Summary: This systematic review examined the effects of dietary protein/amino acid interventions on exercise-induced oxidative stress and inflammation and found weak and inconsistent evidence, calling for further research.
Article
Biochemistry & Molecular Biology
Yong Kwon Han, Ji Su Kim, GiBong Jang, Kwon Moo Park
Summary: Cisplatin induces lung cell damage, ciliary fragmentation, and increased oxidative stress, but these effects can be prevented by the mitochondria-specific antioxidant Mito-TEMPO.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, Research & Experimental
Ghorbannejad Hadi, Tofighi Asghar, Tolouei Azar Javad, Razi Mazdak
Summary: Long-term consumption of tramadol negatively affects spermatogenesis development, while exercise training protocols (ETPs) can reduce the damage caused by tramadol on antioxidant and endocrine capacities, with low-intensity training showing the best results.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Chung-Yi Chen, Yan-Ning Chen, Jun-Ping Shiau, Jen-Yang Tang, Ming-Feng Hou, Hsueh-Wei Chang
Summary: This study found that 3HDT has an antiproliferative effect on triple-negative breast cancer cells, while having less impact on normal cells. Through various tests, it was found that 3HDT mainly acts on TNBC cells through oxidative stress and causes DNA damage. Therefore, 3HDT is an effective drug with selective antiproliferative and therapeutic effects on TNBC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yizi Zhang, Lingli Sun, Xingfei Lai, Xingjia Peng, Shuai Wen, Zhenbiao Zhang, Yinzheng Xie, Qiuhua Li, Ruohong Chen, Xi Zheng, Kun Zhang, Shili Sun, Dongli Li
Summary: The study found that flower extracts of Jasminum grandiflorum could alleviate gastric ulcers in mice by increasing PGE2 production, enhancing antioxidant enzyme activity, and suppressing ROS, lipid peroxidation, apoptosis-related proteins, pro-inflammatory cytokines, and NO production.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, General & Internal
David S. Kim, Tobias Weber, Ulrich Straube, Christine E. Hellweg, Mona Nasser, David A. Green, Anna Fogtman
Summary: Physical exercise can decrease radiation-induced DNA damage, oxidative stress, and inflammation, while increasing antioxidant activity. Despite high heterogeneity in results, there is evidence for a beneficial effect of exercise in cellular, clinical, and functional outcomes.
FRONTIERS IN MEDICINE
(2021)
Review
Sport Sciences
Jose Afonso, Jesus Olivares-Jabalera, Ricardo J. Fernandes, Filipe Manuel Clemente, Silvia Rocha-Rodrigues, Joao Gustavo Claudino, Rodrigo Ramirez-Campillo, Cristina Valente, Renato Andrade, Joao Espregueira-Mendes
Summary: The effectiveness of different conservative interventions for acute hamstring injuries in athletes is unclear. This study compared the effects of various conservative interventions on the time to return to sport or full training and reinjury rates. The results showed that no single intervention or combination of interventions demonstrated superior outcomes in terms of faster recovery time or reduced risk of reinjury.
Article
Environmental Sciences
Jelena Stevanovic-Silva, Jorge Beleza, Pedro Coxito, Paulo J. Oliveira, Antonio Ascensao, Jose Magalhaes
Summary: Maternal high-caloric nutrition and gestational diabetes mellitus (GDM) increase the risk of liver metabolic alterations in mothers and offspring. Exercise is recommended in GDM treatment. This study showed that gestational exercise protected mothers from diet-induced GDM metabolic consequences and ameliorated liver mitochondrial alterations in offspring.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Ines Ramos Rego, Daniela Silverio, Maria Isabel Eufrasio, Sandra Sofia Pinhancos, Bruna Lopes da Costa, Jose Teixeira, Hugo Fernandes, Yang Kong, Yao Li, Stephen H. Tsang, Paulo J. Oliveira, Rosa Fernandes, Peter M. J. Quinn, Paulo Fernando Santos, Antonio Francisco Ambrosio, Celso Henrique Alves
Summary: Age-related macular degeneration (AMD) is a major cause of visual impairment and blindness in the elderly. The damage to retinal pigment epithelium (RPE) caused by oxidative stress is a key factor in the development of AMD, and this damage is caused by the accumulation of reactive oxygen species (ROS) primarily produced by mitochondria. The protein TRAP1, found in mitochondria, helps maintain mitochondrial integrity and reduces ROS production. This study found that TRAP1 is present in human RPE cells and its levels decrease when exposed to hydrogen peroxide. Silencing TRAP1 leads to increased ROS production and decreased mitochondrial respiratory capacity in RPE cells.
Article
Biology
Maximiliano Espinosa-Ramirez, Santiago Riquelme, Felipe Araya, Guido Rodriguez, Fernanda Figueroa-Martinez, Luigi Gabrielli, Gines Viscor, W. Darlene Reid, Felipe Contreras-Briceno
Summary: Respiratory muscle training (RMT) improves physical performance by increasing the efficiency of respiratory muscles. This study compared the effects of two different types of RMT (VIH and ITL) on the deoxygenation of intercostal and vastus lateralis muscles during exercise. The results showed that both types of training decreased the deoxygenation of intercostal muscles, but had no effect on the deoxygenation of vastus lateralis muscles.
Article
Sport Sciences
Ivone Carneiro, Peter Krustrup, Carlo Castagna, Magni Mohr, Jose Magalhaes, Rita Pereira, Rute Santos, Sandra Martins, Joao Tiago Guimaraes, Eduardo Coelho, Susana Povoas
Summary: This study aimed to examine the dose-response of a recreational team handball exercise-based programme on cardiometabolic health and physical fitness in inactive middle-aged-to-elderly males without TH experience. The results showed that performing three 60-minute team handball exercise sessions per week can improve aerobic performance in middle-aged-to-elderly men, and it is more effective than training with a lower weekly frequency.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Rita Pereira, Peter Krustrup, Carlo Castagna, Eduardo Coelho, Eva Wulff Helge, Niklas Rye Jorgensen, Carolina Vila-Cha, Sandra Martins, Joao Tiago Guimaraes, Jose Magalhaes, Susana Povoas
Summary: A multicomponent exercise training protocol (recreational team handball training) has long-term positive effects on global health status in inactive postmenopausal women. After 36 weeks of training, participants in the exercise group showed improvements in cardiovascular, bone, metabolic health, body composition, and physical fitness markers.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Physiology
Eloi Gomez-Albareda, Gines Viscor, Iker Garcia
Summary: The purpose of this study was to analyze the effect of inspiratory muscle training (IMT) on maximal inspiratory mouth pressure (MIP) and performance in elite swimmers. The results showed that IMT can increase inspiratory muscle strength in elite swimmers, but it does not have a significant impact on swimming performance.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Chemistry, Analytical
Manuel Alvear-Catalan, Claudio Montiglio, Ignacio Perales, Gines Viscor, Oscar F. Araneda
Summary: The recognition of hypoxia symptoms is essential in military aviation training. Currently, there is a lack of computer systems specifically designed to analyze physiological variables obtained during hypoxia testing. This paper presents a computational tool developed for this purpose, which can generate graphs, statistical parameters, and heat maps to visualize data. It also has the potential to incorporate other signals during testing, such as oxygenation levels in vital organs, electrocardiogram, or electroencephalogram, enabling a better understanding of complex physiological phenomena.
Review
Nutrition & Dietetics
Karenia Lorenzo, Garoa Santocildes, Joan Ramon Torrella, Jose Magalhaes, Teresa Pages, Gines Viscor, Josep Lluis Torres, Sara Ramos-Romero
Summary: This paper reviews the bioactivities of proteins, fiber, and polysaccharides in Chlorella, as well as their role in exercise-related nutrition. It highlights the beneficial effects of Chlorella on performance, physical stamina, and fatigue reduction. It also emphasizes the importance of Chlorella as a dietary source of essential nutrients for athletes and recreational exercisers.
Review
Chemistry, Medicinal
Mario P. Marques, Laura Mendonca, Beatriz G. Neves, Carla Varela, Paulo Oliveira, Celia Cabral
Summary: This review investigates the traditional applications of Lamiaceae medicinal plants used by local communities in the Iberian Peninsula for wound healing. The information from Iberian ethnobotanical surveys is summarized, and the pharmacological evidence for eight out of twenty-nine Lamiaceae species is presented. Future studies should focus on isolating and identifying the active molecules of these plants, followed by robust clinical trials to confirm their safety and effectiveness in wound healing.
Review
Biology
Oscar F. Araneda, Cristian Rosales-Antequera, Felipe Contreras-Briceno, Marcelo Tuesta, Rafael Rossi-Serrano, Jose Magalhaes, Gines Viscor
Summary: Damage to the spinal cord affects the voluntary control of skeletal muscles and the autonomic nervous system, which in turn affects the cardiorespiratory system. Physical exercise may be a potential therapeutic strategy to improve lung functionality and control systemic and pulmonary inflammation. Specific respiratory muscular training or combined with general exercise protocols may positively contribute to the function of the respiratory system.
Article
Medicine, General & Internal
Carolina Tocantins, Joao D. Martins, oscar M. Rodrigues, Luis F. Grilo, Mariana S. Diniz, Jelena Stevanovic-Silva, Jorge Beleza, Pedro Coxito, David Rizo-Roca, Estela Santos-Alves, Manoel Rios, Lina Carvalho, Antonio J. Moreno, Antonio Ascensao, Jose Magalhaes, Paulo J. Oliveira, Susana P. Pereira
Summary: This study evaluated the effects of exercise cessation after a short period training on the cardiac metabolic and mitochondrial function of female rats. The results showed that endurance exercise modulated cardiac redox balance and mitochondrial efficiency in female rats fed a high-fat, high-sugar diet.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Sport Sciences
Michal Boraczynski, Jose Magalhaes, Jacek J. Nowakowski, James J. Laskin
Summary: This study investigated the effects of 8-week heavy-resistance or plyometric training on neuromuscular functional performance in professional soccer players. The results showed that both training methods significantly improved speed, strength, and jumping ability. The heavy-resistance training performed better in terms of relative strength and muscle peak torque. Additionally, a significant proportion of participants showed knee muscular strength imbalance.
Article
Medicine, General & Internal
Aryane Cruz Oliveira Pinho, Diana Santos, Paulo J. Oliveira, Ermelindo Carreira Leal, Eugenia Carvalho
Summary: This study investigated the effects of diabetes on mitochondrial respiration in wounded and non-wounded skin using high-resolution respirometry. The results showed that the oxidative phosphorylation capacity of the wounded skin was decreased at day 3 post-wounding and increased at day 10 post-wounding in diabetic mice. The relative contribution of pyruvate, malate, and glutamate oxidation to the oxidative phosphorylation capacity was higher in wounded skin, while fatty acid oxidation contributed more to the non-wounded skin. This study provides important insights into the impact of diabetes on wound healing.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)