Review
Cell Biology
Yuelong Zhang, Huangming Zhuang, Xunshan Ren, Fuze Jiang, Panghu Zhou
Summary: Osteoarthritis is a common and disabling disease, and surgical treatment is the main approach. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are self-regenerative pluripotent cells that promote cartilage regeneration through the secretion of various trophic factors. The combination of hUC-MSCs with other substances also shows a significant synergistic effect on osteoarthritis treatment. Some scholars have suggested transplanting stem cells into damaged cartilage to slow down the progression of osteoarthritis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Yufeng Shang, Haotong Guan, Fuling Zhou
Summary: Umbilical cord mesenchymal stem cells (UC-MSCs) have the characteristics of inhibiting tumor cell proliferation and migration, supporting hematopoietic microenvironment, and suppressing the immune system, showing great potential in the treatment of hematologic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jingyue Zhang, Shiheng Zhang, Yueming Yang, Ling Liu
Summary: The study found that umbilical cord blood-derived mesenchymal stem cells (UCBMSCs) can effectively treat adriamycin-induced cardiomyopathy by restoring myocardial function and alleviating inflammatory response.
Article
Cell & Tissue Engineering
Wei Zhang, Qing Ling, Bin Wang, Kai Wang, Jianbo Pang, Jing Lu, Yan Bi, Dalong Zhu
Summary: Both UC-MSCs and BM-MSCs showed comparable therapeutic effects in improving T1D, with similar results in lowering blood glucose levels and preserving beta-cell function.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yang Li, Jiantao Dong, Ye Zhou, Xueshuai Ye, Ziqi Cai, Xueqian Zhang, Li Shen, Mengya Zhang, Wanxing Zhang, Jianhui Cai
Summary: Overexpression of CXCL9 in UC-MSCs can significantly improve the therapeutic effect on liver fibrosis. The CXCL9-UC-MSCs show enhanced homing ability and persistence in injured liver tissues, suggesting a potential synergistic anti-fibrosis effect.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Anahita Tavakoli, Mohammad Saeed Kahrizi, Kimia Safa, Reza ArefNezhad, Fatemeh Rezaei-Tazangi
Summary: Breast cancer is one of the most common cancers among women and has a negative impact on their health and quality of life. Recently, umbilical cord-derived mesenchymal stem cells have emerged as a promising therapy for breast cancer due to their advantages. This review focuses on the influences of these stem cells on breast cancer and the molecular mechanisms involved in its pathogenesis and treatment.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cell & Tissue Engineering
Yi-Chao Ye, Zhe-Han Chang, Peng Wang, You-Wei Wang, Jun Liang, Chong Chen, Jing-Jing Wang, Hong-Tao Sun, Yi Wang, Xiao-Hong Li
Summary: This study demonstrated that infarct-preconditioned exosomes enhanced vascular endothelial remodeling, promoting neurological recovery and reducing brain damage after stroke.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Tao Chen, Ting Xu, Mingye Cheng, Hao Fang, Xianjuan Shen, Zhiyuan Tang, Jianmei Zhao
Summary: The study evaluated the expression levels of CD31(+) CD54(+) and CD31(+) CD105(+) endothelial microparticles in Kawasaki disease patients before and after treatment, finding that hucMSCs can inhibit endothelial inflammation in KD patients and show similar effects in mouse experiments.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Reproductive Biology
Meriem Baouche, Agnieszka Krawczenko, Maria Paprocka, Aleksandra Klimczak, Pascal Mermillod, Yann Locatelli, Malgorzata Ochota, Wojciech Nizanski
Summary: This study investigates whether cells derived from the feline umbilical cord exhibit mesenchymal stromal/stem cells (MSCs) characteristics. The results show that MSCs derived from Wharton's jelly have the best proliferation ability, pluripotency gene expressions, and differentiation potential, making them the most valuable for feline regenerative medicine.
Article
Immunology
Hongwu Wang, Junlin Luo, Aijia Li, Xing Su, Chuiqin Fang, Lichun Xie, Yi Wu, Feiqiu Wen, Yufeng Liu, Tianyou Wang, Yong Zhong, Lian Ma
Summary: The study conducted proteomic and phosphorylated proteomic analysis of lung tissue of juvenile septic rats after HUMSCs intervention, revealing potential therapeutic targets of HUMSCs in alleviating lung injury. Results highlighted the significance of ECM receptor interaction pathway and tight junction pathway in immune inflammatory reaction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Qi Chen, Meixian Jin, Simin Wang, Kexin Wang, Liqin Chen, Xiaojuan Zhu, Ying Zhang, Yi Wang, Yang Li, Shao Li, Youmin Zeng, Lei Feng, Wanren Yang, Yi Gao, Shuqin Zhou, Qing Peng
Summary: Acute liver failure (ALF) is a severe disease with high mortality, but therapy using mesenchymal stem cells (MSCs) or MSCs-derived exosomes has shown promise in animal experiments and clinical application. To address limitations of MSCs, an immortalized MSC cell line called hTERT-UCMSC was constructed and shown to retain key characteristics over long-term culture. Inoculation of hTERT-UCMSC and its exosomes improved the survival rate and liver function in ALF mice, suggesting their potential use in clinical treatment of liver failure.
JOURNAL OF TISSUE ENGINEERING
(2023)
Review
Cell Biology
Shengnan Yang, Peipei Liu, Yale Jiang, Zai Wang, Huaping Dai, Chen Wang
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with unknown causes, and currently the only medications that can slow down the progression of the disease and improve survival rate are pirfenidone and nintedanib. The use of mesenchymal stem cells (MSCs) provides a new hope for treating interstitial lung disease, but optimal treatment protocols are still lacking.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Chuan He, Chao Yang, Qiang Zeng, Zhigang Liu, Fangfang Wang, Qiang Chen, Ting Liu
Summary: Umbilical cord-derived MSCs cultured in different media showed the general characteristics of MSCs. HGF, ANG-1, and TGF-beta 1 secretion by MSCs in the MCL was higher than in the other media, while PGE2 secretion was lower in the MCL. MSCs in the MCL inhibited IFN-gamma and TNF-alpha more effectively. MSC treatment promoted recovery of peripheral blood cells, increased Treg ratio and VEGF level, and significantly improved bone marrow.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell Biology
Xiaobo Li, Qijing Huang, Xiangxiang Zhang, Changfeng Xie, Muyun Liu, Yueming Yuan, Jianjia Feng, Haoyu Xing, Li Ru, Zheng Yuan, Zhiyong Xu, YaoXiang Yang, Yan Long, Chengfeng Xing, Jianping Song, Xiang Hu, Qin Xu
Summary: The study evaluated the effects of intravenous injection of hUC-MSCs on reproduction and development in rats, finding no significant adverse effects within a certain dosage range, but high doses may lead to mortality in pregnant female rats, highlighting the importance of cautious use.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Santhosh Kacham, Tejal Sunil Bhure, Sindhuja D. Eswaramoorthy, Gaurav Naik, Subha Narayan Rath, Sreenivasa Rao Parcha, Sayan Basu, Virender Singh Sangwan, Sachin Shukla
Summary: Umbilical cord-derived mesenchymal stem cells promote the repair of injured corneal epithelium by stimulating the proliferation of corneal epithelial cells, potentially serving as a non-ocular source of stem cells for treating injury-induced bilateral corneal diseases.
Article
Cardiac & Cardiovascular Systems
Victoria Vilalta, German Cediel, Siamak Mohammadi, Helena Lopez, Dimitri Kalavrouziotis, Helena Resta, Eric Dumont, Pierre Voisine, Francois Philippon, Claudia Escabia, Andrea Borrellas, Alberto Alperi, Eduard Fernandez-Nofrerias, Xavier Carrillo, Vassili Panagides, Antoni Bayes-Genis, Josep Rodes-Cabau
Summary: This study evaluated the incidence, predictive factors, and prognostic value of new-onset persistent left bundle branch block (NOP-LBBB) in patients undergoing sutureless surgical aortic valve replacement (SU-SAVR). The results showed that NOP-LBBB occurred in approximately a quarter of the patients and was associated with a decrease in left ventricular ejection fraction (LVEF) and an increased risk of permanent pacemaker implantation (PPI).
Letter
Cardiac & Cardiovascular Systems
Miguel Lorenzo, Rafael de la Espriella, Ingrid Cardells, JoseLuis Gorriz, Antoni Bayes-Genis, Julio Nunez
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Review
Medicine, Research & Experimental
Gemma Ferrer-Curriu, Carolina Soler-Botija, Sandra Charvatova, Benjamin Motais, Santiago Roura, Carolina Galvez-Monton, Marta Monguio-Tortajada, Oriol Iborra-Egea, Michele Emdin, Josep Lupon, Alberto Aimo, Juli R. Bago, Antoni Bayes Genis
Summary: Fibrosis is a common feature in myocardial disorders and can lead to heart failure. Current therapies targeting excessive fibrosis are limited, making the development of more effective treatments necessary. CAR T cell immunotherapy, which redirects T lymphocytes to eliminate target cells, has shown efficacy in mouse models of hypertensive cardiac fibrosis. Although associated with toxicities, CAR natural killer cells provide a potential alternative with improved safety and efficacy. CAR immunotherapy offers promise for reducing fibrosis and restoring cardiac function in patients with myocardial fibrosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Antoni Bayes-Genis, Julio Nunez
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Marco Metra, Daniela Tomasoni, Marianna Adamo, Antoni Bayes-Genis, Gerasimos Filippatos, Magdy Abdelhamid, Stamatis Adamopoulos, Stefan D. Anker, Laura Antohi, Michael Boehm, Frieder Braunschweig, Tuvia Ben Gal, Javed Butler, John G. F. Cleland, Alain Cohen-Solal, Kevin Damman, Finn Gustafsson, Loreena Hill, Ewa A. Jankowska, Mitja Lainscak, Lars H. Lund, Theresa McDonagh, Alexandre Mebazaa, Brenda Moura, Wilfried Mullens, Massimo Piepoli, Piotr Ponikowski, Amina Rakisheva, Arsen Ristic, Gianluigi Savarese, Petar Seferovic, Rajan Sharma, Carlo Gabriele Tocchetti, Mehmet Birhan Yilmaz, Cristiana Vitale, Maurizio Volterrani, Stephan von Haehling, Ovidiu Chioncel, Andrew J. S. Coats, Giuseppe Rosano
Summary: Episodes of worsening symptoms and signs are common in patients with chronic heart failure and are associated with negative outcomes. Diuretic therapy is often necessary, along with additional treatments such as guideline-recommended medical therapy. Prevention of worsening heart failure is crucial, and early and rapid administration of appropriate treatments can help achieve this goal. The clinical consensus statement by the Heart Failure Association of the European Society of Cardiology provides an update on the management and prevention of worsening heart failure in clinical practice.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, General & Internal
Miguel Lorenzo, Gonzalo Nunez, Laura Fuertes-Kenneally, Rafael de la Espriella, Sandra Villar, Oscar Miro, Pere Llorens, Enrique Santas, Gema Minana, Vicent Bodi, Juan Sanchis, Arturo Carratala, Antoni Bayes-Genis, Julio Nunez
Summary: Early changes in estimated glomerular filtration rate (eGFR) in acute heart failure (AHF) are only associated with long-term mortality in patients with renal dysfunction on admission and no early decline in natriuretic peptides (NT-proBNP).
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Pathology
Gonzalo Nunez-Marin, Diego Iraola, Miguel Lorenzo, Rafael De la Espriella, Sandra Villar, Enrique Santas, Gema Minana, Juan Sanchis, Arturo Carratala, Oscar Miro, Antoni Bayes-Genis, Julio Nunez
Summary: Heart failure is a serious health issue with a poor prognosis, and natriuretic peptides have been used extensively for diagnosis and risk stratification in HF.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ana Ayesta, Beatriz Diaz-Molina, Antoni Bayes-Genis, Adrian Baranchuk, Manuel Martinez-Selles
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Victor Marcos-Garces, Nerea Perez, Jose Gavara, Maria P. Lopez-Lereu, Jose V. Monmeneu, Cesar Rios-Navarro, Elena de Dios, Hector Merenciano-Gonzalez, Ana Gabaldon-Perez, Angel Ferrero-De-Loma-Osorio, Angel Martinez-Brotons, Lourdes Bondanza, Juan Miguel Sanchez-Gomez, Cristina Albiach, Julio Nunez, Antoni Bayes-Genis, Francisco J. Chorro, Ricardo Ruiz-Granell, Vicente Bodi
Summary: The study investigated the use of cardiac magnetic resonance (CMR) in predicting appropriate therapies for implantable cardioverter defibrillators (ICD) in patients with ST-segment elevation myocardial infarction (STEMI). The results showed that CMR evaluation of left ventricular ejection fraction (LVEF) outperformed echocardiography in predicting the subsequent use of appropriate ICD therapies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Gemma Ferrer-Curriu, Ferran Rueda, Elena Revuelta-Lopez, Cosme Garcia-Garcia, Pau Codina, Carolina Galvez-Monton, Santiago Roura, Alberto Aimo, Michele Emdin, Anna Planavila, Antoni Bayes-Genis
Summary: Circulating levels of Metrnl are associated with complications during the acute phase of ST-segment elevation myocardial infarction (STEMI) and independently predict a worse outcome in these patients.
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Antoni Bayes-Genis, Kieran F. Docherty, Mark C. Petrie, James L. Januzzi, Christian Mueller, Lisa Andreson, Biykem Bozkurt, Javed Butler, Ovidiu Chioncel, John G. F. Cleland, Ruxandra Christodorescu, Stefano Del Prato, Finn Gustafsson, Carolyn S. P. Lam, Brenda Moura, Rodica Pop-Busui, Petar Seferovic, Maurizio Volterrani, Muthiah Vaduganathan, Marco Metra, Giuseppe Rosano
Summary: Diagnosing heart failure is often difficult due to non-specific symptoms. This document explores the use of NT-proBNP as a biomarker for diagnosing heart failure in different clinical scenarios. Validated cut-points are provided for ruling in or ruling out acute and de novo heart failure. The concept of 'heart stress' is introduced, and a simple acronym FIND-HF is proposed for early diagnosis of heart failure.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Antoni Bayes-Genis, Giuseppe Rosano
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Brenda Moura, Alberto Aimo, Abdallah Al-Mohammad, Kalliopi Keramida, Tuvia Ben Gal, Sharmila Dorbala, Giancarlo Todiere, Matteo Cameli, Andrea Barison, Antoni Bayes-Genis, Ralph Stephan von Bardeleben, Chiara Bucciarelli-Ducci, Victoria Delgado, Ify R. Mordi, Petar Seferovic, Gianluigi Savarese, Jelena Celutkiene, Claudio Rapezzi, Michele Emdin, Andrew Coats, Marco Metra, Giuseppe Rosano
Summary: Left ventricular (LV) hypertrophy can be either secondary or primary, and primary LV hypertrophy may be caused by gene mutations or abnormal substance deposition. Cardiovascular imaging, including echocardiography and cardiovascular magnetic resonance, plays a key role in the diagnosis and management of LV hypertrophy, providing important clues to the final diagnosis and guiding therapy. This consensus document by the Heart Failure Association of the European Society of Cardiology provides an overview of the role of different cardiac imaging techniques in the differential diagnosis and management of LV hypertrophy.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Review
Biochemistry & Molecular Biology
Susana Ravassa, Begona Lopez, Thomas A. Treibel, Gorka San Jose, Blanca Losada-Fuentenebroa, Leire Tapia, Antoni Bayes-Genis, Javier Diez, Arantxa Gonzalez
Summary: Heart failure is a major cause of mortality and hospitalization worldwide. Cardiac fibrosis, characterized by excessive collagen deposition, is common in heart failure and contributes to its development and poor clinical outcomes. However, specific cardiac antifibrotic therapies are currently lacking, making it an urgent unmet medical need. This review discusses the importance of phenotyping cardiac fibrosis in heart failure and the potential use of imaging techniques and circulating biomarkers for non-invasive characterization and tracking of this condition, as well as summarizes existing drugs with antifibrotic effects and potential strategies for targeting cardiac fibroblasts and extracardiac processes.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Damia Pereferrer, Roger Villuendas, Victor Bazan, Axel Sarrias, Felipe Bisbal, Julia Aranyo, Antoni Bayes-Genis
Summary: In the past decades, cardiac electronic implantable devices (CEID) have evolved with numerous technological capabilities, not easily captured by conventional coding systems like ICHD and NBG. To address this limitation, we propose a new coding system, the C-ARL-A coding system.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2023)