Review
Cardiac & Cardiovascular Systems
Shaurya Srivastava, Majid Yavari, Abdullah Al-abcha, Sandeep Banga, George Abela
Summary: LVNC is a rare and unclassified cardiomyopathy that can lead to heart failure, arrhythmias, and embolic events in adults. Diagnosis is based on various imaging criteria, but there is no standardized diagnostic criteria. Previous studies have shown that LVNC may present in different forms, requiring individualized treatment strategies.
HEART FAILURE REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Attila Nemes, Gergely Racz, Arpad Kormanyos
Summary: This study evaluated tricuspid annular (TA) morphological and functional abnormalities using three-dimensional speckle-tracking echocardiography (3DSTE) in patients with isolated LVNC. The results showed that patients with isolated LVNC had dilated TA with preserved function, and the extent of TA dilation was associated with increased right atrial volumes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jay Ramchand, Pooja Podugu, Nancy Obuchowski, Serge C. Harb, Michael Chetrit, Alex Milinovich, Brian Griffin, Louise M. Burrell, W. H. Wilson Tang, Deborah H. Kwon, Scott D. Flamm
Summary: This study aimed to evaluate whether the presence of a thin compacted myocardial layer leads to poorer outcomes in patients with left ventricular non-compaction. The results showed that the risk of adverse clinical events is increased in the presence of significant compacted myocardial thinning, an elevated B-type natriuretic peptide, or increased left ventricular dimensions. These markers could enhance risk assessment and help reduce overdiagnosis of left ventricular non-compaction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Health Care Sciences & Services
Massimiliano Cantinotti, Pietro Marchese, Marco Scalese, Paola Medino, Vivek Jani, Eliana Franchi, Pak Vitali, Giuseppe Santoro, Cecilia Viacava, Nadia Assanta, Shelby Kutty, Martin Koestenberger, Raffaele Giordano
Summary: STE epsilon analysis revealed significant LV systolic impairment after surgery, with improvement thereafter but incomplete normalization at discharge. Differences between base and apex emerged, with apical segments showing relative hypercontractility after surgery. Slower recovery of LV epsilon values compared to LVEF suggests that STE epsilon analysis may be more accurate for follow-up of mild LV post-surgical impairment.
Review
Medicine, General & Internal
Jerzy Paluszkiewicz, Hendrik Milting, Marta Kaluzna-Oleksy, Malgorzata Pyda, Magdalena Janus, Hermann Koerperich, Misagh Piran
Summary: Left ventricular non-compaction (LVNC) refers to the excessive trabeculation and formation of a deep recess filled with blood in the left ventricle. Due to the lack of a standardized definition and criteria, it is difficult to accurately estimate the incidence of the disease, and overdiagnosis is a common issue. Non-compacted myocardium can be a disease representation, a variant of normal, or an adaptive phenomenon. This article covers different approaches to the incidence, pathogenesis, diagnostics, and treatment of LVNC, as well as recommendations for patient follow-up.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Simon F. Staempfli, Alexander Gotschy, Pascal Kiarostami, Tardu Oezkartal, Christiane Gruner, Markus Niemann, Robert Manka, Felix C. Tanner
Summary: This study compared the morphology and function of the right ventricle (RV) in patients with left ventricular non-compaction cardiomyopathy (LVNC) using cardiac magnetic resonance (CMR) and transthoracic echocardiography (TTE). The results showed that RV trabeculation was more extensive in LVNC patients compared to normal individuals, but there was significant overlap, making it difficult to distinguish between the two groups.
CARDIOLOGY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Hilla Gerard, Nicolas Iline, Helene Martel, Karine Nguyen, Pascale Richard, Erwan Donal, Jean-Christophe Eicher, Olivier Huttin, Christine Selton-Suty, Pascale Raud-Raynier, Guillaume Jondeau, Nicolas Mansencal, Caroline Sawka, Flavie Ader, Jean-Francois Pruny, Anne-Claire Casalta, Nicolas Michel, Valeria Donghi, Laurence Faivre, Roch Giorgi, Philippe Charron, Gilbert Habib
Summary: The prognosis of LVNC and DCM patients is similar, but LVNC patients have higher left ventricular ejection fractions (LVEF). Among patients with LVEF <= 45%, the LVNC group had a higher occurrence of the primary endpoint, especially hospitalization for heart failure and heart transplantation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Paula Morlanes-Gracia, Guido Antoniutti, Jorge Alvarez-Rubio, Laura Torres-Juan, Damian Heine-Suner, Tomas Ripoll-Vera
Summary: This study describes a family with a novel missense mutation in the NKX2-5 gene, with several ancestors affected by various heart diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Hyun-Jung Lee, Hyung-Kwan Kim, Tae-Min Rhee, You-J Ung Choi, In-Chang Hwang, Yeonyee E. Yoon, Jun-Bean Park, Seung-Pyo Lee, Yong-Jin Kim, Goo-Yeong Cho
Summary: LARS can be used to categorize LV diastolic function and predict HF events in patients with hypertrophic cardiomyopathy.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Maciej Stapor, Adam Pilat, Andrzej Gackowski, Agnieszka Misiuda, Izabela Gorkiewicz-Kot, Michal Kaleta, Pawel Kleczynski, Krzysztof Zmudka, Jacek Legutko, Boguslaw Kapelak, Karol Wierzbicki
Summary: This study evaluates the feasibility of physiological pump speed optimization based on aortic valve opening (AVO) imaging during a cardiopulmonary exercise test (CPET) in LVAD patients. The results show that dynamic echo-guided pump speed adjustment based on AVO improves exercise tolerance and augments peak oxygen consumption and maximum workload.
Article
Biochemistry & Molecular Biology
Roman Myasnikov, Andreas Brodehl, Alexey Meshkov, Olga Kulikova, Anna Kiseleva, Greta Marie Pohl, Evgeniia Sotnikova, Mikhail Divashuk, Marina Klimushina, Anastasia Zharikova, Maria Pokrovskaya, Sergey Koretskiy, Maria Kharlap, Elena Mershina, Valentin Sinitsyn, Elena Basargina, Leila Gandaeva, Vladimir Barskiy, Sergey Boytsov, Hendrik Milting, Oxana Drapkina
Summary: Left ventricular non-compaction cardiomyopathy is a rare heart disease characterized by a two-layer structure of the myocardium and increased trabeculae. Studying familial forms of LVNC can help in predicting risks and offering genetic counseling to relatives. In a family with LVNC, two likely pathogenic mutations were identified through genetic testing, and in vitro experiments confirmed the pathogenicity of one of the mutations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Sabine Klaassen, Jirko Kuehnisch, Alina Schultze-Berndt, Franziska Seidel
Summary: Left ventricular noncompaction (LVNC) is a ventricular wall anomaly characterized by numerous prominent trabeculations and deep intertrabecular recesses. The outcome of pediatric LVNC is determined by the interplay of genetics, morphology, and function.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Genetics & Heredity
Olga Kulikova, Andreas Brodehl, Anna Kiseleva, Roman Myasnikov, Alexey Meshkov, Caroline Stanasiuk, Anna Gaertner, Mikhail Divashuk, Evgeniia Sotnikova, Sergey Koretskiy, Maria Kharlap, Viktoria Kozlova, Elena Mershina, Polina Pilus, Valentin Sinitsyn, Hendrik Milting, Sergey Boytsov, Oxana Drapkina
Summary: A study of a small Russian family with LVNC revealed a potential association between DES gene mutations and the disease. Genetic analysis of the DES gene may be important for LVNC patients in the future.
Article
Medicine, General & Internal
Esiemoghie J. Akhigbe, Ebubechukwu Ezeh, Nadew Sebro, Olalekan Olanipekun, Carlos Rueda Rios
Summary: Left ventricular non-compaction (LVNC) is a rare form of cardiomyopathy characterized by two-layered myocardium and high rates of mortality and morbidity. We present a case of acquired LVNC during pregnancy in a patient with a previous history of dilated cardiomyopathy secondary to post-viral myocarditis. This case highlights the unique combination of cardiac genetics, normal physiology, and infection in the development of LVNC.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Cristian Izquierdo, Guillem Casas, Carlos Martin-Isla, Victor M. Campello, Andrea Guala, Polyxeni Gkontra, Jose F. Rodriguez-Palomares, Karim Lekadir
Summary: The study proposed a radiomics approach to automatically encode differences in shape, grayscale, and textural information in the myocardium and trabeculae, improving the capacity to differentiate between LVNC, HCM, and DCM. By analyzing CMR imaging of 118 subjects and using machine learning models, it was demonstrated that radiomics models can achieve automated diagnosis of LVNC, HCM, and DCM with excellent ROC-AUC values without the need for tracing trabeculae.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Elia von Felten, Dominik C. Benz, Georgios Benetos, Andreas A. Giannopoulos, Michael Messerli, Christoph Graeni, Tobias A. Fuchs, Catherine Gebhard, Ronny R. Buechel, Philipp A. Kaufmann, Aju P. Pazhenkottil
Summary: "This study aimed to assess the diagnostic value of TAG in predicting ischemia in SPECT-MPI and the correlation between TAG and TCG. However, the results showed that TAG and TCG in CCTA do not offer any value in predicting ischemia assessed by SPECT-MPI. Additionally, TAG is partly affected by differences in the coronary luminal area."
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Adam Bakula, Dimitri Patriki, Elia von Felten, Georgios Benetos, Aleksandra Sustar, Dominik C. Benz, Muriel Wiedemann-Buser, Valerie Treyer, Aju P. Pazhenkottil, Christoph Grani, Catherine Gebhard, Philipp A. Kaufmann, Ronny R. Buechel, Tobias A. Fuchs
Summary: This study assessed the feasibility of detecting splenic switch-off (SSO) in nitrogen-13 ammonia PET MPI and found that SSO can be detected in this setting, similar to cardiac magnetic resonance (CMR). This finding may help differentiate adenosine non-responders from patients with truly reduced myocardial flow reserve (MFR).
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan Skawran, Antonio G. Gennari, Manuel Dittli, Valerie Treyer, Urs J. Muehlematter, Alexander Maurer, Irene A. Burger, Cacilia Mader, Olivia Messerli, Hannes Grunig, Catherine Gebhard, Martin W. Huellner, Alessandra Curioni-Fontecedro, Christoph Berger, Michael Messerli
Summary: FDG-avid axillary lymph nodes are common after COVID-19 vaccination, with a higher frequency observed in patients who received the Moderna vaccine compared to the Pfizer-BioNTech vaccine. Clinical management was affected in some cases due to the presence of FDG-avid lymph nodes.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ahmed Haider, Susan Bengs, Angela Portmann, Alexia Rossi, Hazem Ahmed, Dominik Etter, Geoffrey Warnock, Nidaa Mikail, Muriel Gramer, Alexander Meisel, Livio Gisler, Caitlin Jie, Claudia Keller, Sebastian Kozerke, Bruno Weber, Roger Schibli, Linjing Mu, Philipp A. Kaufmann, Vera Regitz-Zagrosek, Simon M. Ametamey, Catherine Gebhard
Summary: This study aimed to assess the impact of female and male sex hormones on myocardial perfusion and coronary flow reserve. The experimental data in mice indicate that testosterone plays a primary role in sex differences in myocardial perfusion.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dominik C. Benz, Sara Ersoezlue, Francois L. A. Mojon, Michael Messerli, Anna K. Mitulla, Domenico Ciancone, David Kenkel, Jan A. Schaab, Catherine Gebhard, Aju P. Pazhenkottil, Philipp A. Kaufmann, Ronny R. Buechel
Summary: DLIR enables a 43% reduction in radiation dose from CCTA without significant impacts on image noise, stenosis severity, plaque composition, and quantitative plaque volume.
EUROPEAN RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Antonio G. Gennari, Hannes Grunig, Dominik C. Benz, Stephan Skawran, Alexander Maurer, Ahmad M. A. Abukwaik, Alexia Rossi, Catherine Gebhard, Ronny R. Buechel, Michael Messerli
Summary: This study aimed to assess the effectiveness of low-dose CT for attenuation correction of myocardial perfusion SPECT in identifying anemic patients and grading anemia severity. The results showed that quantitative analysis derived from low-dose CT images had similar diagnostic accuracy to hematocrit for detecting anemia and could discriminate different anemia severities.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Georgios P. Rampidis, Polydoros N. Kampaktsis, Konstantinos Kouskouras, Athanasios Samaras, Georgios Benetos, Andreas A. Giannopoulos, Theodoros Karamitsos, Alexandros Kallifatidis, Antonios Samaras, Ioannis Vogiatzis, Stavros Hadjimiltiades, Antonios Ziakas, Ronny R. Buechel, Catherine Gebhard, Nathaniel R. Smilowitz, Konstantinos Toutouzas, Konstantinos Tsioufis, Panagiotis Prassopoulos, Haralambos Karvounis, Harmony Reynolds, George Giannakoulas
Summary: This study aims to explore the potential role of cardiac CT angiography (CCTA) in patients with myocardial infarction with non-obstructive coronary arteries (MINOCA). By combining CCTA with cardiac MR (CMR) and invasive coronary angiography (ICA), it will evaluate the extent and characteristics of coronary atherosclerosis and its correlation with pericoronary fat attenuation in MINOCA patients. This will assist in diagnostic evaluation and prognosis of patients with MINOCA.
Article
Cardiac & Cardiovascular Systems
Gabrielle Norrish, Chen Qu, Ella Field, Elena Cervi, Diala Khraiche, Sabine Klaassen, Tiina H. Ojala, Gianfranco Sinagra, Hirokuni Yamazawa, Chiara Marrone, Anca Popoiu, Fernando Centeno, Sylvie Schouvey, Iacopo Olivotto, Sharlene M. Day, Steve Colan, Joseph Rossano, Samuel G. Wittekind, Sara Saberi, Mark Russell, Adam Helms, Jodie Ingles, Christopher Semsarian, Perry M. Elliott, Carolyn Y. Ho, Rumana Z. Omar, Juan P. Kaski
Summary: This study conducted the first external validation of the HCM Risk-Kids model in a large and geographically diverse patient population. A 5-year predicted risk of >= 6% identified over 70% of events, confirming the model's ability to provide individualized risk predictions and shared decision-making in children with HCM.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Clara Stammnitz, Doerte Huscher, Ulrike M. M. Bauer, Aleksandra Urban, Johannes Nordmeyer, Stephan Schubert, Joachim Photiadis, Felix Berger, Sabine Klaassen
Summary: This study aimed to identify specific long-term risk factors for infective endocarditis (IE) in patients with congenital heart disease after pulmonary valve replacements. The study found that bovine jugular vein valves had the highest risk of IE, while Edwards Sapien and mechanical valves were used less frequently and remained without IE.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Endocrinology & Metabolism
Nicola Lott, Caroline E. Gebhard, Susan Bengs, Ahmed Haider, Gabriela M. Kuster, Vera Regitz-Zagrosek, Catherine Gebhard
Summary: This review summarizes the roles of androgens, estrogens, and progesterone in the regulation of virus entry receptors and disease progression of COVID-19, as well as their therapeutic value. Currently, there is no clear evidence for a sex-specific expression of virus entry receptors, and the impact of sex hormones on COVID-19 varies widely. The conflicting evidence and lack of consensus may be due to a lack of mechanistic studies and clinical trials reporting sex-disaggregated data. Furthermore, the influence of sociocultural factors (gender) on COVID-19 manifestations has not been investigated.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Catherine Gebhard, Noe Corpataux, Christoph Grani, Ahmed Haider
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Franziska Seidel, Kai Thorsten Laser, Karin Klingel, Josephine Dartsch, Simon Theisen, Thomas Pickardt, Manuel Holtgrewe, Anna Gaertner, Felix Berger, Dieter Beule, Hendrik Milting, Stephan Schubert, Sabine Klaassen, Jirko Kuehnisch
Summary: This study analyzed pediatric myocarditis patients with the dilated cardiomyopathy phenotype using whole-exome sequencing. They found likely pathogenic variants in cardiomyopathy genes and immune disorder genes, suggesting a genetic impact on pediatric myocarditis with the dilated cardiomyopathy phenotype. The presence of heterozygous variants in immune-related genes may also play a role in promoting myocarditis.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Review
Cardiac & Cardiovascular Systems
Sabine Klaassen, Jirko Kuehnisch, Alina Schultze-Berndt, Franziska Seidel
Summary: Left ventricular noncompaction (LVNC) is a ventricular wall anomaly characterized by numerous prominent trabeculations and deep intertrabecular recesses. The outcome of pediatric LVNC is determined by the interplay of genetics, morphology, and function.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Fabiola A. Bechtiger, Marvin Grossmann, Adam Bakula, Dimitri Patriki, Elia von Felten, Tobias A. Fuchs, Catherine Gebhard, Aju P. Pazhenkottil, Philipp A. Kaufmann, Ronny R. Buechel
Summary: Reducing tube voltage for calcium scoring allows for accurate risk stratification if adapted tube voltage thresholds are applied. Reclassification rates vary depending on body mass index.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Judy M. Luu, Catherine Gebhard, Chinthanie Ramasundarahettige, Dipika Desai, Karleen Schulze, Francois Marcotte, Philip Awadalla, Philippe Broet, Trevor Dummer, Jason Hicks, Eric Larose, Alan Moody, Eric E. Smith, Jean-Claude Tardif, Tiago Teixeira, Koon K. Teo, Jennifer Vena, Douglas S. Lee, Sonia S. Anand, Matthias G. Friedrich
Summary: This study provides sex and age-specific normal reference values for cardiovascular magnetic resonance (CMR) parameters using an anatomically correct contouring method. These values are derived from the largest, multi-ethnic population free of cardiovascular disease (CVD) to date.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2022)