Review
Cardiac & Cardiovascular Systems
Mohamed Abuelazm, Othman Saleh, Abdul Rhman Hassan, Soban Ahmad, Majd M. Albarakat, Hassan Abdalshafy, Basant E. Katamesh, Basel Abdelazeem, Timir K. Paul
Summary: Takotsubo syndrome (TTS) is more common in women, but men have higher rates of morbidity and mortality. This study investigated the sex differences in clinical outcomes of TTS patients and found that men had a higher risk of in-hospital mortality, long-term mortality, cardiogenic shock, arrhythmia, and acute kidney injury compared to women. However, there was no significant difference in stroke, left ventricular thrombus, and TTS recurrence between men and women. Further studies are needed to understand the underlying factors contributing to these sex differences in clinical outcomes.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Karan H. Pahuja, Natale Wasef, Syed Hasan, Tehreem Fatima, Steven Hamilton, Marc Seelagy
Summary: Takotsubo cardiomyopathy is a reversible cardiomyopathy caused by acute emotional stress, characterized by regional systolic dysfunction without coronary artery disease. In this case, the use of milrinone facilitated diuresis and improved patient outcomes more effectively than norepinephrine.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Medicine, General & Internal
John E. Madias
Summary: The management of TTS is currently empirical and supportive, with therapies being extrapolated from principles used for other cardiovascular diseases. While the pathophysiology of TTS remains elusive, treatment strategies may be targeted at addressing common consequences shared with coronary artery disease and other cardiovascular disorders. New therapeutic hypotheses are being considered based on animal studies and limited patient applications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Eric Landa, Erika Vigandt, Luis Moron, Manveer Ubhi, Basilides Fermin
Summary: Takotsubo cardiomyopathy, commonly seen in postmenopausal women, is a condition characterized by left ventricular dysfunction induced by emotional stress. It mimics acute coronary syndrome in presentation, leading to clean or nonobstructive coronary arteries in most patients after left heart catheterization.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Oyvind H. Lie, Lars Gunnar Klaboe, Lars A. Dejgaard, Eystein T. Skjolsvik, Jostein Grimsmo, Gerhard Bosse, Einar Hopp, Thor Edvardsen, Kristina H. Haugaa
Summary: In this study, athletes with ventricular arrhythmias were found to have impaired right ventricular function and increased myocardial fibrosis compared to healthy athletes. Furthermore, athletes who experienced life-threatening arrhythmic events had additional left ventricular contraction abnormalities, indicating potential susceptibility to arrhythmogenic cardiomyopathy induced by high doses of exercise.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Trisha Singh, Hilal Khan, David T. Gamble, Caroline Scally, David E. Newby, Dana Dawson
Summary: “Takotsubo syndrome is an acute condition with transient dysfunction of the left ventricle, which is challenging to differentiate from acute myocardial infarction. Recent studies have shown that patients with this syndrome have persistent cardiac dysfunction and limiting symptoms. They also have a substantial burden of morbidity and mortality, similar to patients with acute coronary syndrome. The underlying pathophysiology of this condition remains unclear, and further research is needed to inform evidence-based management strategies.”
Article
Medicine, General & Internal
Alexander Benyovszky, Lorin Berman, Noelle Provenzano, Bharghava Nelluri, Scott Fredd
Summary: Takotsubo cardiomyopathy, characterized by left ventricular apical akinesis and transient systolic dysfunction, is often associated with acute coronary syndrome. It is believed to be caused by a surge in catecholamines following intense physical or emotional stress.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Cardiac & Cardiovascular Systems
Fawzi Zghyer, W. Savindu Pasan Botheju, Joshua E. Kiss, Erin D. Michos, Mary C. Corretti, Monica Mukherjee, Allison G. Hays
Summary: Stress cardiomyopathy is a reversible syndrome caused by myocardial injury, usually occurring in response to a stressful event. Neurocardiogenic mechanisms may play an important role in its pathophysiology. Although initially considered relatively benign, research has brought attention to its association with cardiovascular complications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sarah Chiu, Rohith Nayak, Bryan Lin, Lewei Duan, Albert Yuh-Jer Shen, Ming-Sum Lee
Summary: Patients with takotsubo syndrome, compared to those with acute myocardial infarction (AMI), tend to be older, more likely to be women, and have better long-term outcomes.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Review
Health Care Sciences & Services
Xintian Shou, Yumeng Wang, Qiulei Jia, Jingjing Shi, Xuesong Zhang, Shuai Shi, Shu-Qing Shi, Guozhen Yuan, Ruoning Chai, Wenjing Xue, Yihan Yang, Chenglin Duan, Yuanhui Hu
Summary: This study analyzed the research status, hotspots, and trends in Takotsubo cardiomyopathy (TTC) using CiteSpace V.5.7 R5W. The research found that TTC is in a hot development period and identified hotspots in disease features, auxiliary diagnostic methods, epidemiology, and pathophysiological mechanisms. The study also highlighted complications related to prognosis. The findings will help clinicians and researchers to better understand TTC and provide a foundation for scientific management, diagnosis, and treatment, ultimately improving patient prognosis.
ANNALS OF PALLIATIVE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Verena Bill, Ibrahim El-Battrawy, Marvin Kummer, Andreas Muegge, Assem Aweimer, Michael Behnes, Ibrahim Akin
Summary: Impaired kidney function worsens the outcome of patients with Takotsubo syndrome (TTS). TTS patients with concomitant kidney dysfunction experience more adverse events compared to myocardial infarction (MI) patients with concomitant kidney dysfunction. TTS patients with kidney dysfunction have higher all-cause mortality compared to MI patients with kidney dysfunction. Recurrence rate of TTS is lower than MI.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Albert Topf, Moritz Mirna, Nina Bacher, Vera Paar, Lukas J. Motloch, Bernhard Ohnewein, Robert Larbig, Janine Grueninger, Uta C. Hoppe, Michael Lichtenauer, Rudin Pistulli
Summary: Among patients with diagnosed cardiomyopathy, the differentiation between Takotsubo cardiomyopathy (TTC) and ischemic cardiomyopathy (ICMP) or dilated cardiomyopathy (DCMP) can be challenging. Biomarkers such as sST-2 may play a crucial role in predicting and distinguishing these conditions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Trisha Singh, Shruti Joshi, Lucy E. Kershaw, Andy H. Baker, Gerry P. McCann, Dana K. Dawson, Marc R. Dweck, Scott I. Semple, David E. Newby
Summary: Patients with takotsubo syndrome exhibit significant myocardial manganese uptake abnormality, most pronounced in the acute phase but persisting for at least 3 months despite apparent restoration of normal left ventricular ejection fraction.
Article
Clinical Neurology
Fajun Wang, Joseph Darby
Summary: A 30-year-old male developed Takotsubo cardiomyopathy 3 days after severe traumatic brain injury. The diagnosis was confirmed by Cardiology consultation and he was started on beta-blocker and ACE inhibitor therapy for treatment.
FRONTIERS IN NEUROLOGY
(2021)
Review
Immunology
Kenji Rowel Q. Lim, Douglas L. Mann, Tsuneaki Kenzaka, Tomohiro Hayashi
Summary: Takotsubo syndrome (TTS) is characterized by the temporary dysfunction of the heart with abnormal regional wall motion, primarily caused by a sudden increase in catecholamines. Inflammation plays a crucial role in determining patient outcomes and the early pathogenesis of the disorder.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Saraschandra Vallabhajosyula, Sri Harsha Patlolla, Shannon M. Dunlay, Abhiram Prasad, Malcolm R. Bell, Allan S. Jaffe, Bernard J. Gersh, Charanjit S. Rihal, David R. Holmes, Gregory W. Barsness
CIRCULATION-HEART FAILURE
(2020)
Article
Cardiac & Cardiovascular Systems
Fabrizio D'Ascenzo, Sebastiano Gili, Maurizio Bertaina, Mario Iannaccone, Victoria L. Cammann, Davide Di Vece, Ken Kato, Andrea Saglietto, Konrad A. Szawan, Antonio H. Frangieh, Beatrice Boffini, Margherita Annaratone, Annahita Sarcon, Rena A. Levinson, Jennifer Franke, L. Christian Napp, Milosz Jaguszewski, Michel Noutsias, Thomas Muenzel, Maike Knorr, Susanne Heiner, Hugo A. Katus, Christof Burgdorf, Heribert Schunkert, Holger Thiele, Johann Bauersachs, Carsten Tschoepe, Burkert M. Pieske, Lawrence Rajan, Guido Michels, Roman Pfister, Alessandro Cuneo, Claudius Jacobshagen, Gerd Hasenfuss, Mahir Karakas, Wolfgang Koenig, Wolfgang Rottbauer, Samir M. Said, Ruediger C. Braun-Dullaeus, Adrian Banning, Florim Cuculi, Richard Kobza, Thomas A. Fischer, Tuija Vasankari, K. E. Juhani Airaksinen, Grzegorz Opolski, Rafal Dworakowski, Philip MacCarthy, Christoph Kaiser, Stefan Osswald, Leonarda Galiuto, Filippo Crea, Wolfgang Dichtl, Wolfgang M. Franz, Klaus Empen, Stephan B. Felix, Clement Delmas, Olivier Lairez, Ibrahim El-Battrawy, Ibrahim Akin, Martin Borggrefe, John D. Horowitz, Martin Kozel, Petr Tousek, Petr Widimsky, Ekaterina Gilyarova, Alexandra Shilova, Mikhail Gilyarov, Giuseppe Biondi-Zoccai, David E. Winchester, Christian Ukena, Michael Neuhaus, Jeroen J. Bax, Abhiram Prasad, Carlo Di Mario, Michael Boehm, Mauro Gasparini, Frank Ruschitzka, Eduardo Bossone, Rodolfo Citro, Mauro Rinaldi, Gaetano Maria De Ferrari, Thomas Luscher, Jelena R. Ghadri, Christian Templin
EUROPEAN JOURNAL OF HEART FAILURE
(2020)
Article
Cardiac & Cardiovascular Systems
Saraschandra Vallabhajosyula, Vinayak Kumar, Saarwaani Vallabhajosyula, Anna Subramaniam, Harsha Patlolla, Dhiran Verghese, Lina Ya'Qoub, John M. Stulak, Gurpreet S. Sandhu, Abhiram Prasad, David R. Holmes, Gregory W. Barsness
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Jaskanwal D. S. Sara, Michel T. Corban, Megha Prasad, Abhiram Prasad, Rajiv Gulati, Lilach O. Lerman, Amir Lerman
Editorial Material
Cardiac & Cardiovascular Systems
Madeline K. Mahowald, Erin A. Fender, Abhiram Prasad, Rick A. Nishimura
CIRCULATION-CARDIOVASCULAR IMAGING
(2020)
Article
Cardiac & Cardiovascular Systems
Saraschandra Vallabhajosyula, Aditi Shankar, Sri Harsha Patlolla, Abhiram Prasad, Malcolm R. Bell, Jacob C. Jentzer, Shilpkumar Arora, Saarwaani Vallabhajosyula, Bernard J. Gersh, Allan S. Jaffe, David R. Holmes, Shannon M. Dunlay, Gregory W. Barsness
Article
Cardiac & Cardiovascular Systems
Saraschandra Vallabhajosyula, Stephanie R. Payne, Jacob C. Jentzer, Lindsey R. Sangaralingham, Xiaoxi Yao, Kianoush Kashani, Nilay D. Shah, Abhiram Prasad, Shannon M. Dunlay
AMERICAN JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Saraschandra Vallabhajosyula, Gregory W. Barsness, Joerg Herrmann, Nandan S. Anavekar, Rajiv Gulati, Abhiram Prasad
AMERICAN JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
L. Christian Napp, Victoria L. Cammann, Milosz Jaguszewski, Konrad A. Szawan, Manfred Wischnewsky, Sebastiano Gili, Maike Knorr, Susanne Heiner, Rodolfo Citro, Eduardo Bossone, Fabrizio D'Ascenzo, Michael Neuhaus, Jennifer Franke, Ioana Sorici-Barb, Michel Noutsias, Christof Burgdorf, Wolfgang Koenig, Behrouz Kherad, Annahita Sarcon, Lawrence Rajan, Guido Michels, Roman Pfister, Alessandro Cuneo, Claudius Jacobshagen, Mahir Karakas, Alexander Pott, Philippe Meyer, Jose D. Arroja, Adrian Banning, Florim Cuculi, Richard Kobza, Thomas A. Fischer, Tuija Vasankari, K. E. Juhani Airaksinen, Christian Hauck, Carla Paolini, Claudio Bilato, Yoichi Imori, Ken Kato, Yoshio Kobayashi, Grzegorz Opolski, Monika Budnik, Rafal Dworakowski, Philip MacCarthy, Christoph Kaiser, Stefan Osswald, Leonarda Galiuto, Wolfgang Dichtl, Christina Chan, Paul Bridgman, Daniel Beug, Clement Delmas, Olivier Lairez, Ibrahim El-Battrawy, Ibrahim Akin, Ekaterina Gilyarova, Alexandra Shilova, Mikhail Gilyarov, John D. Horowitz, Karolina Polednikova, Petr Tousek, Petr Widimsky, David E. Winchester, Jan Galuszka, Christian Ukena, Gregor Poglajen, Pedro Carrilho-Ferreira, Carlo Di Mario, Abhiram Prasad, Charanjit S. Rihal, P. Christian Schulze, Matteo Bianco, Filippo Crea, Martin Borggrefe, Lars S. Maier, Fausto J. Pinto, Ruediger C. Braun-Dullaeus, Wolfgang Rottbauer, Hugo A. Katus, Gerd Hasenfuss, Carsten Tschoepe, Burkert M. Pieske, Holger Thiele, Heribert Schunkert, Michael Boehm, Stephan B. Felix, Thomas Muenzel, Jeroen J. Bax, Johann Bauersachs, Eugene Braunwald, Thomas F. Luescher, Frank Ruschitzka, Jelena R. Ghadri, Christian Templin
EUROPEAN HEART JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Simon Walker, Edward Cox, Ben Rothwell, Colin Berry, Gerry P. McCann, Chiara Bucciarelli-Ducci, Erica Dall'Armellina, Abhiram Prasad, James Robert John Foley, Kenneth Mangion, Petra Bijsterveld, Colin Everett, Deborah Stocken, Sven Plein, John P. Greenwood, Mark Sculpher
Summary: The study found that CMR-guided care is cost-effective overall and across all pretest likelihood subgroups, compared with MPS and NICE guidelines.
Article
Cardiac & Cardiovascular Systems
Michel T. Corban, Abhiram Prasad, Rajiv Gulati, Lilach O. Lerman, Amir Lerman
Summary: In patients with signs/symptoms of ischemia and non-obstructive CAD, women have lower CFVR, higher rCBF, and lower hCBF compared to men. Female sex is a predictor of these sex-specific differences. The clinical implications of sex differences in coronary physiology require further evaluation.
Article
Cardiac & Cardiovascular Systems
Saraschandra Vallabhajosyula, Dhiran Verghese, Malcolm R. Bell, Dennis H. Murphree, Wisit Cheungpasitporn, Paul Elliott Miller, Shannon M. Dunlay, Abhiram Prasad, Gurpreet S. Sandhu, Rajiv Gulati, Mandeep Singh, Amir Lerman, Bernard J. Gersh, David R. Holmes, Gregory W. Barsness
Summary: This study compared the outcomes of patients with STEMI-CS receiving initial fibrinolysis versus PPCI, and found that the in-hospital mortality rate was comparable between the two groups.
Article
Cardiac & Cardiovascular Systems
Ken Kato, Victoria L. Cammann, L. Christian Napp, Konrad A. Szawan, Jozef Micek, Sara Dreiding, Rena A. Levinson, Vanya Petkova, Michael Wurdinger, Alexandru Patrascu, Rafael Sumalinog, Sebastiano Gili, Christian F. Clarenbach, Malcolm Kohler, Manfred Wischnewsky, Rodolfo Citro, Carmine Vecchione, Eduardo Bossone, Michael Neuhaus, Jennifer Franke, Benjamin Meder, Milosz Jaguszewski, Michel Noutsias, Maike Knorr, Susanne Heiner, Fabrizio D'Ascenzo, Wolfgang Dichtl, Christof Burgdorf, Behrouz Kherad, Carsten Tschope, Annahita Sarcon, Jerold Shinbane, Lawrence Rajan, Guido Michels, Roman Pfister, Alessandro Cuneo, Claudius Jacobshagen, Mahir Karakas, Wolfgang Koenig, Alexander Pott, Philippe Meyer, Marco Roffi, Adrian Banning, Mathias Wolfrum, Florim Cuculi, Richard Kobza, Thomas A. Fischer, Tuija Vasankari, K. E. Juhani Airaksinen, Monika Budnik, Rafal Dworakowski, Philip MacCarthy, Christoph Kaiser, Stefan Osswald, Leonarda Galiuto, Christina Chan, Paul Bridgman, Daniel Beug, Clement Delmas, Olivier Lairez, Ekaterina Gilyarova, Alexandra Shilova, Mikhail Gilyarov, Ibrahim El-Battrawy, Ibrahim Akin, Martin Kozel, Petr Tousek, David E. Winchester, Jan Galuszka, Christian Ukena, Gregor Poglajen, Pedro Carrilho-Ferreira, Christian Hauck, Carla Paolini, Claudio Bilato, Masanori Sano, Iwao Ishibashi, Masayuki Takahara, Toshiharu Himi, Yoshio Kobayashi, Abhiram Prasad, Charanjit S. Rihal, Kan Liu, P. Christian Schulze, Matteo Bianco, Lucas Jorg, Hans Rickli, Goncalo Pestana, Thanh H. Nguyen, Michael Bohm, Lars S. Maier, Fausto J. Pinto, Petr Widimsky, Stephan B. Felix, Grzegorz Opolski, Ruediger C. Braun-Dullaeus, Wolfgang Rottbauer, Gerd Hasenfuss, Burkert M. Pieske, Heribert Schunkert, Martin Borggrefe, Holger Thiele, Johann Bauersachs, Hugo A. Katus, John D. Horowitz, Carlo Di Mario, Thomas Munzel, Filippo Crea, Jeroen J. Bax, Thomas F. Luscher, Frank Ruschitzka, Jelena R. Ghadri, Christian Templin
Summary: The study found that 7% of all TTS patients are associated with acute pulmonary triggers, accounting for 21% of patients with physical triggers. The presence of acute pulmonary trigger is associated with a severe in-hospital course and a worse long-term outcome.
Article
Cardiac & Cardiovascular Systems
Saraschandra Vallabhajosyula, Jacob C. Jentzer, Abhiram Prasad, Lindsey R. Sangaralingham, Kianoush Kashani, Nilay D. Shah, Shannon M. Dunlay
Summary: The study found that the combination of cardiogenic shock and cardiac arrest has a significant impact on patients with non-ST-segment elevation myocardial infarction (NSTEMI), leading to higher in-hospital mortality and rates of acute non-cardiac organ failure.
Article
Cardiac & Cardiovascular Systems
Saraschandra Vallabhajosyula, Abhiram Prasad, Gurpreet S. Sandhu, Malcolm R. Bell, Rajiv Gulati, Mackram F. Eleid, Patricia J. M. Best, Bernard J. Gersh, Mandeep Singh, Amir Lerman, David R. Holmes, Charanjit S. Rihal, Gregory W. Barsness
Summary: This study aimed to assess the use, temporal trends, and outcomes of percutaneous MCS-assisted early PCI in AMI-CS. MCS-assisted PCI identified a sicker AMI-CS cohort, with a decrease in IABP and an increase in pLVAD/ECMO from 2009 to 2014. MCS use was independently predicted by younger age, male sex, lower comorbidity, and cardiac arrest, and was predictive of higher in-hospital mortality and greater resource utilisation.