Article
Immunology
Matheus Vieira, Paul Regnier, Anna Maciejewski-Duval, Alexandre Le Joncour, Guillaume Darasse-Jeze, Michelle Rosenzwajg, David Klatzmann, Patrice Cacoub, David Saadoun
Summary: This study investigates the molecular mechanisms of large-vessel involvement in giant cell arteritis (LV-GCA) by analyzing transcriptome and interferon gene signature in inflamed aortas from LV-GCA patients. The study reveals the critical involvement of pro-inflammatory signaling pathways, including interferon, JAK/STAT signaling, cytokines, and chemokines, in both aorta and T cells from LV-GCA patients. Furthermore, the study identifies a clear type I interferon signature in the aortas of LV-GCA patients and highlights the significant role of STAT3 in related gene networks. The findings suggest the potential for tailored therapeutic targeting in LV-GCA.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Immunology
Mahmut S. Kaymakci, Nicholas A. Boire, Melanie C. Bois, Mohanad M. Elfishawi, Hannah E. Langenfeld, Andrew C. Hanson, Cynthia S. Crowson, Matthew J. Koster, Yuki Sato, Cornelia M. Weyand, Kenneth J. Warrington
Summary: This study investigated the clinicopathologic features of patients with giant cell arteritis (GCA) who had thoracic aorta aneurysm or dissection surgery. Histopathologic evaluation of the thoracic aorta obtained during surgery revealed active aortitis in most patients with GCA despite being considered in clinical remission several years after GCA diagnosis. The overall mortality compared to age and sex-matched general population was significantly increased.
AUTOIMMUNITY REVIEWS
(2023)
Article
Immunology
Jingfeng Yu, Sihan Sheng, Xiaosu Zou, Zhengwu Shen
Summary: A novel artemisinin derivative (compound 4) showed strong immunosuppressive activity. Various methods were used to evaluate its immunosuppressive activity and mechanism of action. The results suggest that it has potential application as an anti-inflammatory bowel disease drug.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Chao Ye, Wenyuan Li, Lei Li, Kaiguang Zhang
Summary: Liver failure is characterized by severe liver decompensation and high mortality. The activation of systemic immune responses and systemic inflammation are widely accepted as the core pathogenesis of liver failure. However, there is still controversy regarding the feasibility and application of glucocorticoid treatment in liver failure.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
George Joseph, Ruchika Goel, Viji S. Thomson, Elizabeth Joseph, Debashish Danda
Summary: Takayasu arteritis is a rare inflammatory disease that primarily affects young women. Early diagnosis and prompt treatment are crucial for long-term outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, Research & Experimental
Huocheng Liao, Suzhen Ou, Xiaoyan Dong, Jianping Liu, Chun Xiao
Summary: The study evaluated the association between Etoricoxib treatment and incident hypoxia among type-B aortic dissection patients undergoing endovascular aortic repair. Patients treated with Etoricoxib had lower incidence of hypoxia, potentially due to its anti-inflammatory effects.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Rheumatology
Jeremy Clement, Pierre Duffau, Joel Constans, Thierry Schaeverbeke, Jean-Francois Viallard, Damien Barcat, Jean-Philippe Vernhes, Laurent Sailler, Fabrice Bonnet
Summary: This study evaluated the real-world effectiveness, safety, and long-term outcomes of TCZ treatment in patients with giant cell arteritis. Results showed TCZ was effective in reducing corticosteroid use, but less than 50% of patients maintained long-term remission after discontinuation. Factors associated with relapse included delayed initiation of TCZ treatment after diagnosis and insufficient tapering of corticosteroids before inclusion.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Olivier Espitia, Jeremy Schanus, Christian Agard, Francoise Kraeber-Bodere, Jeanne Hersant, Jean-Michel Serfaty, Bastien Jamet
Summary: The study compared FDG uptake characteristics in patients with GCA aortitis and aortic atheroma using FDG-PET/CT, finding higher levels of FDG uptake in GCA aortitis patients, particularly in the aortic wall, compared to aortic atheroma. This suggests that FDG uptake patterns may help distinguish GCA aortitis from aortic atheroma in clinical practice.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Hakki Zafer Iscan, Gorkem Yigit, Ferit Cetinkaya, Kemal Erdogan, Naim Boran Tumer, Anil Ozen, Levent Mavioglu, Ertekin Utku Unal
Summary: This retrospective study evaluated the early and mid-term outcomes of endovascular treatment in 21 patients with Vasculo-Behcet disease. The results showed that endovascular therapy is an effective treatment option for VBD with low morbidity and mortality.
ANNALS OF VASCULAR SURGERY
(2023)
Article
Multidisciplinary Sciences
Anne Claire Desbois, Dragos Ciocan, David Saadoun, Gabriel Perlemuter, Patrice Cacoub
Summary: Recent studies have shown a close link between specific microbiota and inflammatory disorders, especially in patients with large vessel vasculitis (LVV). This study aimed to analyze the blood microbiome profile in Takayasu's arteritis (TAK) and giant cell arteritis (GCA) patients compared to healthy donors. Significant differences in blood microbiome profiles were found between TAK patients and healthy donors, as well as between TAK and GCA patients, with potential associations with specific metabolic functions.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Olivier Espitia, Jeremy Schanus, Christian Agard, Francoise Kraeber-Bodere, Alexis F. Guedon, Antoine Benichou, Jean-Michel Serfaty, Sandrine Coudol, Matilde Karakachoff, Bastien Jamet
Summary: This study aims to diagnose large vessel vasculitis in giant cell arteritis using [F-18]fluorodeoxyglucose-positron emission tomography/computed tomography ([F-18]FDG-PET/CT) and to define a semi-quantitative threshold for distinguishing GCA aortitis from aortic atheroma or the control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Xin-Chi Jiang, Hong-Hui Wu, Tianyuan Zhang, Yun-Fei Dong, Yao-Sheng Li, Ting Huang, An-Hao Tian, Peng-Xiang Chen, Xian-Ming Lin, Ying-Zhi Huang, Chong Liu, Xiang-Nan Zhang, Zhong Chen, Yasuhiko Tabata, Jian-Qing Gao
Summary: Hypoxic preconditioning of neural stem cells (NSCs) can produce hypoxic exosomes, which can effectively treat ischemic stroke. These exosomes can target the injured brain and regulate the microenvironment to inhibit neuroinflammation and promote blood-brain barrier permeability recovery. Furthermore, they can also activate autologous NSCs and facilitate nerve regeneration. Hypoxic exosomes have therapeutic effects on both survival and behavioral outcomes in ischemic stroke mice.
Article
Cardiac & Cardiovascular Systems
Ayaz Aghayev, Camden P. Bay, Sara Tedeschi, Paul A. Monach, Umberto Campia, Marie Gerhard-Herman, Michael L. Steigner, Richard N. Mitchell, William P. Docken, Marcelo DiCarli
Summary: The study compared the imaging features and clinical outcomes of patients with carotid artery inflammation (CIA) and giant cell arteritis/aortitis (GCA), showing that CIA patients mainly presented with cardiovascular symptoms without systemic inflammatory symptoms, and there was no significant difference in clinical outcomes between the two groups.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Medicine, General & Internal
Mutong Zhao, Ying Liu, Zhihai Hu, Juan Sun, Zhou Yang, Li Wei, Zigang Xu, Lin Ma
Summary: This case report describes a rare case of a young girl with coexisting Takayasu arteritis and leishmaniasis infection. The patient's condition was controlled, but complications of Takayasu arteritis arose during treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Li Li, Yuan-Qiang Lu
Summary: HMGB1 is a crucial player in the inflammatory response and immunosuppression of sepsis, mediating the release of inflammatory factors and potentially contributing to the pathogenesis of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)